PDGFRA (platelet-derived growth factor receptor, alpha polypeptide)

Identity

Other names	CD140A
	MGC74795
	PDGFR2
	Rhe-PDGFRA
HGNC	PDGFRA
Location	4q12
Location_base_pair	Starts at 54790021 and ends at 54859169 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

Breakpoints

External links

	Nomenclature
HGNC	PDGFRA   8803
Entrez_Gene	PDGFRA  5156  platelet-derived growth factor receptor, alpha polypeptide
	Cards
GeneCards	PDGFRA
Ensembl	ENSG00000134853 [Gene_View]  PDGFRA [Vega]
Genatlas	PDGFRA
	Genomic and cartography
GoldenPath	PDGFRA  -  4q12   chr4:54790021-54859169 +  4q12   [Description]    (hg18-March_2006)
Ensembl	PDGFRA - 4q12 [CytoView]
NCBI	Mapview
OMIM	173490 Disease map [OMIM]
OMIM	606764 Disease map [OMIM]
OMIM	607685 Disease map [OMIM]
HomoloGene	PDGFRA
	Gene and transcription
Genbank	AA599881 [ ENTREZ ]
Genbank	AA625689 [ ENTREZ ]
Genbank	AK308353 [ ENTREZ ]
Genbank	AK311006 [ ENTREZ ]
Genbank	AK316578 [ ENTREZ ]
RefSeq	NM_006206 [ SRS ]    NM_006206 [ ENTREZ ]
RefSeq	AC_000047 [ SRS ]    AC_000047 [ ENTREZ ]
RefSeq	AC_000136 [ SRS ]    AC_000136 [ ENTREZ ]
RefSeq	NC_000004 [ SRS ]    NC_000004 [ ENTREZ ]
RefSeq	NT_022853 [ SRS ]    NT_022853 [ ENTREZ ]
RefSeq	NW_001838913 [ SRS ]    NW_001838913 [ ENTREZ ]
RefSeq	NW_922162 [ SRS ]    NW_922162 [ ENTREZ ]
CCDS	PDGFRA CCDS - NCBI
AceView	PDGFRA AceView - NCBI
Unigene	Hs.74615 [ SRS ]    Hs.74615 [ NCBI ]
Fast-db	4387 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P16234 [ SRS]    P16234 [ EXPASY ]     P16234 [ INTERPRO ]     P16234 [ UNIPROT ] P16234 [ VarSplice FASTA ]
Prosite	PS50835 IG_LIKE [ SRS ]    PS50835 IG_LIKE [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00109 PROTEIN_KINASE_TYR [ SRS ]    PS00109 PROTEIN_KINASE_TYR [ Expasy ]
Prosite	PS00240 RECEPTOR_TYR_KIN_III [ SRS ]    PS00240 RECEPTOR_TYR_KIN_III [ Expasy ]
Interpro	IPR013151 Ig [ SRS ]    IPR013151 Ig [ EBI ]
Interpro	IPR007110 Ig-like [ SRS ]    IPR007110 Ig-like [ EBI ]
Interpro	IPR013783 Ig-like_fold [ SRS ]    IPR013783 Ig-like_fold [ EBI ]
Interpro	IPR013098 Ig_I-set [ SRS ]    IPR013098 Ig_I-set [ EBI ]
Interpro	IPR003599 Ig_sub [ SRS ]    IPR003599 Ig_sub [ EBI ]
Interpro	IPR003598 Ig_sub2 [ SRS ]    IPR003598 Ig_sub2 [ EBI ]
Interpro	IPR015776 PDGFR_alpha [ SRS ]    IPR015776 PDGFR_alpha [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR001824 Recept_tyr_kinase-III_CS [ SRS ]    IPR001824 Recept_tyr_kinase-III_CS [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
Interpro	IPR008266 Tyr_pkinase_AS [ SRS ]    IPR008266 Tyr_pkinase_AS [ EBI ]
Interpro	IPR016243 TyrPK_CSF1-R [ SRS ]    IPR016243 TyrPK_CSF1-R [ EBI ]
Interpro	IPR009134 VEGFR_N [ SRS ]    IPR009134 VEGFR_N [ EBI ]
CluSTr	P16234
Pfam	PF07679 I-set [ SRS ]    PF07679 I-set [ Sanger ]    pfam07679 [ NCBI-CDD ]
Pfam	PF00047 ig [ SRS ]    PF00047 ig [ Sanger ]    pfam00047 [ NCBI-CDD ]
Pfam	PF07714 Pkinase_Tyr [ SRS ]    PF07714 Pkinase_Tyr [ Sanger ]    pfam07714 [ NCBI-CDD ]
Smart	SM00409 IG [EMBL]
Smart	SM00408 IGc2 [EMBL]
Smart	SM00219 TyrKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P16234 PGFRA_HUMAN [ Domain structure ]   P16234 PGFRA_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P16234
PDB	1GQ5 [ SRS ]    1GQ5 [ PdbSum ],   1GQ5 [ IMB ]   1GQ5 [ RSDB ]
HPRD	01429
	Protein Interaction databases
DIP	P16234
IntAct	P16234
	Polymorphism : SNP, mutations, diseases
OMIM	173490    [ map ]
OMIM	606764    [ map ]
OMIM	607685    [ map ]
GENETests	173490
GENETests	606764
GENETests	607685
SNP	PDGFRA [dbSNP-NCBI]
SNP	NM_006206 [SNP-NCI]
SNP	PDGFRA [GeneSNPs - Utah]  PDGFRA] [HGBASE - SRS]
HAPMAP	PDGFRA [HAPMAP]
COSMIC	PDGFRA [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	nucleotide [Translocation breakpoints In Cancer]
HGMD	PDGFRA
Genetic Association	PDGFRA
CDC HuGE	PDGFRA
	General knowledge
Family Browser	PDGFRA [UCSC Family Browser]
SOURCE	NM_006206
SMD	Hs.74615
SAGE	Hs.74615
Enzyme	2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	cell activation [Amigo]  cell activation
GO	receptor activity [Amigo]  receptor activity
GO	platelet-derived growth factor alpha-receptor activity [Amigo]  platelet-derived growth factor alpha-receptor activity
GO	vascular endothelial growth factor receptor activity [Amigo]  vascular endothelial growth factor receptor activity
GO	platelet-derived growth factor receptor binding [Amigo]  platelet-derived growth factor receptor binding
GO	ATP binding [Amigo]  ATP binding
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	organ morphogenesis [Amigo]  organ morphogenesis
GO	membrane [Amigo]  membrane
GO	transferase activity [Amigo]  transferase activity
GO	peptidyl-tyrosine phosphorylation [Amigo]  peptidyl-tyrosine phosphorylation
GO	extracellular matrix organization and biogenesis [Amigo]  extracellular matrix organization and biogenesis
GO	lung development [Amigo]  lung development
GO	positive regulation of cell migration [Amigo]  positive regulation of cell migration
GO	male genitalia development [Amigo]  male genitalia development
GO	odontogenesis of dentine-containing tooth [Amigo]  odontogenesis of dentine-containing tooth
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	positive regulation of DNA replication [Amigo]  positive regulation of DNA replication
GO	protein amino acid autophosphorylation [Amigo]  protein amino acid autophosphorylation
GO	protein heterodimerization activity [Amigo]  protein heterodimerization activity
GO	platelet-derived growth factor receptor signaling pathway [Amigo]  platelet-derived growth factor receptor signaling pathway
GO	positive regulation of fibroblast proliferation [Amigo]  positive regulation of fibroblast proliferation
GO	platelet-derived growth factor binding [Amigo]  platelet-derived growth factor binding
BIOCARTA	CBL mediated ligand-induced downregulation of EGF receptors    [Genes]
BIOCARTA	Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration    [Genes]
BIOCARTA	Phospholipids as signalling intermediaries    [Genes]
BIOCARTA	Erk1/Erk2 Mapk Signaling pathway    [Genes]
BIOCARTA	PDGF Signaling Pathway    [Genes]
BIOCARTA	Rac 1 cell motility signaling pathway    [Genes]
KEGG	MAPK signaling pathway
KEGG	Calcium signaling pathway
KEGG	Cytokine-cytokine receptor interaction
KEGG	Focal adhesion
KEGG	Gap junction
KEGG	Regulation of actin cytoskeleton
KEGG	Colorectal cancer
PubGene	PDGFRA
TreeFam	PDGFRA
CTD	5156 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PDGFRA Related clones (RZPD - Berlin)
	PubMed
PubMed	135 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 14:02:46 2008