Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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PDHX (pyruvate dehydrogenase complex, component X)

Identity

Other namesDLDBP
E3BP
OPDX
PDX1
proX
HGNC (Hugo) PDHX
LocusID (NCBI) 8050
Location 11p13
Location_base_pair Starts at 34937677 and ends at 35017675 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PDHX   21350
Cards
Entrez_Gene (NCBI)PDHX  8050  pyruvate dehydrogenase complex, component X
GeneCards (Weizmann)PDHX
Ensembl hg19 (Hinxton)ENSG00000110435 [Gene_View]  chr11:34937677-35017675 [Contig_View]  PDHX [Vega]
Ensembl hg38 (Hinxton)ENSG00000110435 [Gene_View]  chr11:34937677-35017675 [Contig_View]  PDHX [Vega]
ICGC DataPortalENSG00000110435
cBioPortalPDHX
AceView (NCBI)PDHX
Genatlas (Paris)PDHX
WikiGenes8050
SOURCE (Princeton)PDHX
Genomic and cartography
GoldenPath hg19 (UCSC)PDHX  -     chr11:34937677-35017675 +  11p13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PDHX  -     11p13   [Description]    (hg38-Dec_2013)
EnsemblPDHX - 11p13 [CytoView hg19]  PDHX - 11p13 [CytoView hg38]
Mapping of homologs : NCBIPDHX [Mapview hg19]  PDHX [Mapview hg38]
OMIM245349   608769   
Gene and transcription
Genbank (Entrez)AA282215 AF001437 AF052166 AK301384 AK312463
RefSeq transcript (Entrez)NM_001135024 NM_001166158 NM_003477
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_013368 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)PDHX
Cluster EST : UnigeneHs.502315 [ NCBI ]
CGAP (NCI)Hs.502315
Alternative Splicing : Fast-db (Paris)GSHG0004751
Alternative Splicing GalleryENSG00000110435
Gene ExpressionPDHX [ NCBI-GEO ]     PDHX [ SEEK ]   PDHX [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00330 (Uniprot)
NextProtO00330  [Medical]
With graphics : InterProO00330
Splice isoforms : SwissVarO00330 (Swissvar)
Domaine pattern : Prosite (Expaxy)BIOTINYL_LIPOYL (PS50968)    LIPOYL (PS00189)   
Domains : Interpro (EBI)2-oxoA_DH_lipoyl-BS    2-oxoacid_DH_actylTfrase    Biotin_lipoyl    CAT-like_dom    E3-bd    Single_hybrid_motif   
Related proteins : CluSTrO00330
Domain families : Pfam (Sanger)2-oxoacid_dh (PF00198)    Biotin_lipoyl (PF00364)    E3_binding (PF02817)   
Domain families : Pfam (NCBI)pfam00198    pfam00364    pfam02817   
DMDM Disease mutations8050
Blocks (Seattle)O00330
PDB (SRS)1ZY8    2DNC    2F5Z    2F60   
PDB (PDBSum)1ZY8    2DNC    2F5Z    2F60   
PDB (IMB)1ZY8    2DNC    2F5Z    2F60   
PDB (RSDB)1ZY8    2DNC    2F5Z    2F60   
Human Protein AtlasENSG00000110435
Peptide AtlasO00330
HPRD02002
IPIIPI00298423   IPI00976943   IPI00913991   IPI00910682   IPI00980053   IPI00975492   
Protein Interaction databases
DIP (DOE-UCLA)O00330
IntAct (EBI)O00330
FunCoupENSG00000110435
BioGRIDPDHX
IntegromeDBPDHX
STRING (EMBL)PDHX
Ontologies - Pathways
QuickGOO00330
Ontology : AmiGOprotein binding  mitochondrial matrix  pyruvate metabolic process  regulation of acetyl-CoA biosynthetic process from pyruvate  transferase activity, transferring acyl groups  cellular metabolic process  small molecule metabolic process  
Ontology : EGO-EBIprotein binding  mitochondrial matrix  pyruvate metabolic process  regulation of acetyl-CoA biosynthetic process from pyruvate  transferase activity, transferring acyl groups  cellular metabolic process  small molecule metabolic process  
Protein Interaction DatabasePDHX
DoCM (Curated mutations)PDHX
Wikipedia pathwaysPDHX
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPDHX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDHX
dbVarPDHX
ClinVarPDHX
1000_GenomesPDHX 
Exome Variant ServerPDHX
SNP (GeneSNP Utah)PDHX
SNP : HGBasePDHX
Genetic variants : HAPMAPPDHX
Genomic Variants (DGV)PDHX [DGVbeta]
Mutations
ICGC Data PortalENSG00000110435 
Somatic Mutations in Cancer : COSMICPDHX 
CONAN: Copy Number AnalysisPDHX 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:34937677-35017675
Mutations and Diseases : HGMDPDHX
OMIM245349    608769   
MedgenPDHX
NextProtO00330 [Medical]
GENETestsPDHX
Disease Genetic AssociationPDHX
Huge Navigator PDHX [HugePedia]  PDHX [HugeCancerGEM]
snp3D : Map Gene to Disease8050
DGIdb (Drug Gene Interaction db)PDHX
General knowledge
Homologs : HomoloGenePDHX
Homology/Alignments : Family Browser (UCSC)PDHX
Phylogenetic Trees/Animal Genes : TreeFamPDHX
Chemical/Protein Interactions : CTD8050
Chemical/Pharm GKB GenePA134976445
Clinical trialPDHX
Cancer Resource (Charite)ENSG00000110435
Other databases
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
CoreMinePDHX
GoPubMedPDHX
iHOPPDHX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 16:53:07 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.