Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PDHX (pyruvate dehydrogenase complex component X)

Identity

Alias (NCBI)DLDBP
E3BP
OPDX
PDHXD
PDX1
proX
HGNC (Hugo) PDHX
HGNC Alias symbE3BP
proX
PDX1
OPDX
DLDBP
LocusID (NCBI) 8050
Atlas_Id 43932
Location 11p13  [Link to chromosome band 11p13]
Location_base_pair Starts at 34916618 and ends at 34996128 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD44 (11p13)::PDHX (11p13)KDM6A (Xp11.3)::PDHX (11p13)PDHX (11p13)::CAT (11p13)
PDHX (11p13)::CTDSPL (3p22.2)PDHX (11p13)::EIF3M (11p13)PDHX (11p13)::KDM6A (Xp11.3)
PDHX (11p13)::PDHX (11p13)PDHX (11p13)::THRAP3 (1p34.3)PVT1 (8q24.21)::PDHX (11p13)
KDM6A Xp11.3::PDHX 11p13PDHX 11p13::CAT 11p13PDHX 11p13::EIF3M 11p13
PDHX 11p13::KDM6A Xp11.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PDHX   21350
Cards
Entrez_Gene (NCBI)PDHX    pyruvate dehydrogenase complex component X
AliasesDLDBP; E3BP; OPDX; PDHXD; 
PDX1; proX
GeneCards (Weizmann)PDHX
Ensembl hg19 (Hinxton)ENSG00000110435 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110435 [Gene_View]  ENSG00000110435 [Sequence]  chr11:34916618-34996128 [Contig_View]  PDHX [Vega]
ICGC DataPortalENSG00000110435
TCGA cBioPortalPDHX
AceView (NCBI)PDHX
Genatlas (Paris)PDHX
SOURCE (Princeton)PDHX
Genetics Home Reference (NIH)PDHX
Genomic and cartography
GoldenPath hg38 (UCSC)PDHX  -     chr11:34916618-34996128 +  11p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDHX  -     11p13   [Description]    (hg19-Feb_2009)
GoldenPathPDHX - 11p13 [CytoView hg19]  PDHX - 11p13 [CytoView hg38]
ImmunoBaseENSG00000110435
Genome Data Viewer NCBIPDHX [Mapview hg19]  
OMIM245349   608769   
Gene and transcription
Genbank (Entrez)AA282215 AF001437 AF052166 AK057123 AK301384
RefSeq transcript (Entrez)NM_001135024 NM_001166158 NM_003477
Consensus coding sequences : CCDS (NCBI)PDHX
Gene ExpressionPDHX [ NCBI-GEO ]   PDHX [ EBI - ARRAY_EXPRESS ]   PDHX [ SEEK ]   PDHX [ MEM ]
Gene Expression Viewer (FireBrowse)PDHX [ Firebrowse - Broad ]
GenevisibleExpression of PDHX in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8050
GTEX Portal (Tissue expression)PDHX
Human Protein AtlasENSG00000110435-PDHX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00330   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00330  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00330
PhosPhoSitePlusO00330
Domaine pattern : Prosite (Expaxy)BIOTINYL_LIPOYL (PS50968)    LIPOYL (PS00189)    PSBD (PS51826)   
Domains : Interpro (EBI)2-oxoA_DH_lipoyl-BS    2-oxoacid_DH_actylTfrase    Biotin_lipoyl    CAT-like_dom_sf    E3-bd_dom_sf    PSBD    Single_hybrid_motif   
Domain families : Pfam (Sanger)2-oxoacid_dh (PF00198)    Biotin_lipoyl (PF00364)    E3_binding (PF02817)   
Domain families : Pfam (NCBI)pfam00198    pfam00364    pfam02817   
Conserved Domain (NCBI)PDHX
PDB (RSDB)1ZY8    2DNC    2F5Z    2F60    6H60   
PDB Europe1ZY8    2DNC    2F5Z    2F60    6H60   
PDB (PDBSum)1ZY8    2DNC    2F5Z    2F60    6H60   
PDB (IMB)1ZY8    2DNC    2F5Z    2F60    6H60   
Structural Biology KnowledgeBase1ZY8    2DNC    2F5Z    2F60    6H60   
SCOP (Structural Classification of Proteins)1ZY8    2DNC    2F5Z    2F60    6H60   
CATH (Classification of proteins structures)1ZY8    2DNC    2F5Z    2F60    6H60   
SuperfamilyO00330
AlphaFold pdb e-kbO00330   
Human Protein Atlas [tissue]ENSG00000110435-PDHX [tissue]
HPRD02002
Protein Interaction databases
DIP (DOE-UCLA)O00330
IntAct (EBI)O00330
BioGRIDPDHX
STRING (EMBL)PDHX
ZODIACPDHX
Ontologies - Pathways
QuickGOO00330
Ontology : AmiGOprotein binding  mitochondrion  mitochondrial matrix  mitochondrial pyruvate dehydrogenase complex  acetyl-CoA biosynthetic process from pyruvate  acyltransferase activity  pyruvate dehydrogenase (NAD+) activity  pyruvate dehydrogenase complex  pyruvate dehydrogenase complex  mitochondrial acetyl-CoA biosynthetic process from pyruvate  
Ontology : EGO-EBIprotein binding  mitochondrion  mitochondrial matrix  mitochondrial pyruvate dehydrogenase complex  acetyl-CoA biosynthetic process from pyruvate  acyltransferase activity  pyruvate dehydrogenase (NAD+) activity  pyruvate dehydrogenase complex  pyruvate dehydrogenase complex  mitochondrial acetyl-CoA biosynthetic process from pyruvate  
NDEx NetworkPDHX
Atlas of Cancer Signalling NetworkPDHX
Wikipedia pathwaysPDHX
Orthology - Evolution
OrthoDB8050
GeneTree (enSembl)ENSG00000110435
Phylogenetic Trees/Animal Genes : TreeFamPDHX
Homologs : HomoloGenePDHX
Homology/Alignments : Family Browser (UCSC)PDHX
Gene fusions - Rearrangements
Fusion : MitelmanKDM6A::PDHX [Xp11.3/11p13]  
Fusion : MitelmanPDHX::KDM6A [11p13/Xp11.3]  
Fusion : MitelmanPVT1::PDHX [8q24.21/11p13]  
Fusion : QuiverPDHX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDHX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDHX
dbVarPDHX
ClinVarPDHX
MonarchPDHX
1000_GenomesPDHX 
Exome Variant ServerPDHX
GNOMAD BrowserENSG00000110435
Varsome BrowserPDHX
ACMGPDHX variants
VarityO00330
Genomic Variants (DGV)PDHX [DGVbeta]
DECIPHERPDHX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDHX 
Mutations
ICGC Data PortalPDHX 
TCGA Data PortalPDHX 
Broad Tumor PortalPDHX
OASIS PortalPDHX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDHX  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPDHX
Mutations and Diseases : HGMDPDHX
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPDHX
DgiDB (Drug Gene Interaction Database)PDHX
DoCM (Curated mutations)PDHX
CIViC (Clinical Interpretations of Variants in Cancer)PDHX
Cancer3DPDHX
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM245349    608769   
Orphanet19807   
DisGeNETPDHX
MedgenPDHX
Genetic Testing Registry PDHX
NextProtO00330 [Medical]
GENETestsPDHX
Target ValidationPDHX
Huge Navigator PDHX [HugePedia]
ClinGenPDHX
Clinical trials, drugs, therapy
MyCancerGenomePDHX
Protein Interactions : CTDPDHX
Pharm GKB GenePA134976445
PharosO00330
Clinical trialPDHX
Miscellaneous
canSAR (ICR)PDHX
HarmonizomePDHX
ARCHS4PDHX
DataMed IndexPDHX
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPDHX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:51:40 CET 2022

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