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PDHX (pyruvate dehydrogenase complex, component X)

Identity

Other namesDLDBP
E3BP
OPDX
PDX1
proX
HGNC (Hugo) PDHX
LocusID (NCBI) 8050
Location 11p13
Location_base_pair Starts at 34937677 and ends at 35017675 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PDHX   21350
Entrez_Gene (NCBI)PDHX  8050  pyruvate dehydrogenase complex, component X
Cards
GeneCards (Weizmann)PDHX
Ensembl (Hinxton)ENSG00000110435 [Gene_View]  chr11:34937677-35017675 [Contig_View]  PDHX [Vega]
AceView (NCBI)PDHX
Genatlas (Paris)PDHX
SOURCE (Stanford)NM_001135024 NM_001166158 NM_003477
Genomic and cartography
GoldenPath (UCSC)PDHX  -  11p13   chr11:34937677-35017675 +  11p13   [Description]    (hg19-Feb_2009)
EnsemblPDHX - 11p13 [CytoView]
Mapping of homologs : NCBIPDHX [Mapview]
OMIM245349   608769   
Gene and transcription
Genbank (Entrez)AA282215 AF001437 AF052166 AK301384 AK312463
RefSeq transcript (SRS)NM_001135024 NM_001166158 NM_003477
RefSeq transcript (Entrez)NM_001135024 NM_001166158 NM_003477
RefSeq genomic (SRS)AC_000143 NC_000011 NC_018922 NG_013368 NT_009237 NW_001838022 NW_004078070
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_013368 NT_009237 NW_001838022 NW_004078070
Consensus coding sequences : CCDS (NCBI)PDHX
Cluster EST : UnigeneHs.502315 [ SRS ] Hs.502315 [ NCBI ]
CGAP (NCI)Hs.502315
Alternative Splicing : Fast-db (Paris)GSHG0004751
Alternative Splicing GalleryENSG00000110435
Gene ExpressionPDHX [ NCBI-GEO ]   PDHX [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00330 (SRS) O00330 (Uniprot)
NextProtO00330
With graphics : InterProO00330
Splice isoforms : SwissVarO00330(Swissvar)
Domaine pattern : Prosite (SRS)BIOTINYL_LIPOYL (PS50968)    LIPOYL (PS00189)   
Domaine pattern : Prosite (Expaxy)BIOTINYL_LIPOYL (PS50968)    LIPOYL (PS00189)   
Domains : Interpro (SRS)2-oxoA_DH_lipoyl-BS    2-oxoacid_DH_actylTfrase    Biotin_lipoyl    CAT-like_dom    E3-bd    Single_hybrid_motif   
Domains : Interpro (EBI)2-oxoA_DH_lipoyl-BS    2-oxoacid_DH_actylTfrase    Biotin_lipoyl    CAT-like_dom    E3-bd    Single_hybrid_motif   
Related proteins : CluSTrO00330
Domain families : Pfam (SRS)2-oxoacid_dh (PF00198)    Biotin_lipoyl (PF00364)    E3_binding (PF02817)   
Domain families : Pfam (Sanger)2-oxoacid_dh (PF00198)    Biotin_lipoyl (PF00364)    E3_binding (PF02817)   
Domain families : Pfam (NCBI)pfam00198    pfam00364    pfam02817   
DMDM8050
Blocks (Seattle)O00330
PDB (SRS)1ZY8    2DNC    2F5Z    2F60   
PDB (PDBSum)1ZY8    2DNC    2F5Z    2F60   
PDB (IMB)1ZY8    2DNC    2F5Z    2F60   
PDB (RSDB)1ZY8    2DNC    2F5Z    2F60   
Human Protein AtlasENSG00000110435
HPRD02002
IPIIPI00298423   IPI00976943   IPI00913991   IPI00910682   IPI00980053   IPI00975492   
Protein Interaction databases
DIP (DOE-UCLA)O00330
IntAct (EBI)O00330
FunCoupENSG00000110435
REACTOMEPDHX
Protein Interaction Database8050
BioGRIDPDHX
InParanoidO00330
Interologous Interaction database O00330
IntegromeDBPDHX
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PDHX
SNP (GeneSNP Utah)PDHX
SNP : HGBasePDHX
Genetic variants : HAPMAPPDHX
Somatic Mutations in Cancer : COSMICPDHX 
CONAN: Copy Number AnalysisPDHX 
Mutations and Diseases : HGMDPDHX
OMIM245349    608769   
GENETests245349    608769   
Disease Genetic AssociationPDHX
Huge Navigator PDHX [HugePedia]  PDHX [HugeCancerGEM]
Genomic VariantsPDHX  PDHX [DGVbeta]
snp3D : Map Gene to Disease8050
General knowledge
Homologs : HomoloGenePDHX
Homology/Alignments : Family Browser (UCSC)PDHX
Phylogenetic Trees/Animal Genes : TreeFamPDHX
Chemical/Protein Interactions : CTD8050
Chemical/Pharm GKB GenePA134976445
Clinical trialPDHX
Cancer Resource (Charite)ENSG00000110435
Ontology : AmiGOmitochondrial matrix  pyruvate metabolic process  regulation of acetyl-CoA biosynthetic process from pyruvate  transferase activity, transferring acyl groups  small molecule metabolic process  
Ontology : EGO-EBImitochondrial matrix  pyruvate metabolic process  regulation of acetyl-CoA biosynthetic process from pyruvate  transferase activity, transferring acyl groups  small molecule metabolic process  
Pathways : KEGGPyruvate metabolismGlycolysis / GluconeogenesisAlanine and aspartate metabolism
Other databases
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
PubGenePDHX
iHOPPDHX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:35:09 CEST 2013
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