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PDHX (pyruvate dehydrogenase complex, component X)

Identity

Other namesDLDBP
E3BP
OPDX
PDX1
proX
HGNC (Hugo) PDHX
LocusID (NCBI) 8050
Location 11p13
Location_base_pair Starts at 34937677 and ends at 35017675 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PDHX   21350
Cards
Entrez_Gene (NCBI)PDHX  8050  pyruvate dehydrogenase complex, component X
GeneCards (Weizmann)PDHX
Ensembl (Hinxton)ENSG00000110435 [Gene_View]  chr11:34937677-35017675 [Contig_View]  PDHX [Vega]
ICGC DataPortalENSG00000110435
cBioPortalPDHX
AceView (NCBI)PDHX
Genatlas (Paris)PDHX
WikiGenes8050
SOURCE (Princeton)NM_001135024 NM_001166158 NM_003477
Genomic and cartography
GoldenPath (UCSC)PDHX  -  11p13   chr11:34937677-35017675 +  11p13   [Description]    (hg19-Feb_2009)
EnsemblPDHX - 11p13 [CytoView]
Mapping of homologs : NCBIPDHX [Mapview]
OMIM245349   608769   
Gene and transcription
Genbank (Entrez)AA282215 AF001437 AF052166 AK301384 AK312463
RefSeq transcript (Entrez)NM_001135024 NM_001166158 NM_003477
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_013368 NT_009237 NW_001838022 NW_004929378
Consensus coding sequences : CCDS (NCBI)PDHX
Cluster EST : UnigeneHs.502315 [ NCBI ]
CGAP (NCI)Hs.502315
Alternative Splicing : Fast-db (Paris)GSHG0004751
Alternative Splicing GalleryENSG00000110435
Gene ExpressionPDHX [ NCBI-GEO ]     PDHX [ SEEK ]   PDHX [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00330 (Uniprot)
NextProtO00330  [Medical]
With graphics : InterProO00330
Splice isoforms : SwissVarO00330 (Swissvar)
Domaine pattern : Prosite (Expaxy)BIOTINYL_LIPOYL (PS50968)    LIPOYL (PS00189)   
Domains : Interpro (EBI)2-oxoA_DH_lipoyl-BS [organisation]   2-oxoacid_DH_actylTfrase [organisation]   Biotin_lipoyl [organisation]   CAT-like_dom [organisation]   E3-bd [organisation]   Single_hybrid_motif [organisation]  
Related proteins : CluSTrO00330
Domain families : Pfam (Sanger)2-oxoacid_dh (PF00198)    Biotin_lipoyl (PF00364)    E3_binding (PF02817)   
Domain families : Pfam (NCBI)pfam00198    pfam00364    pfam02817   
DMDM Disease mutations8050
Blocks (Seattle)O00330
PDB (SRS)1ZY8    2DNC    2F5Z    2F60   
PDB (PDBSum)1ZY8    2DNC    2F5Z    2F60   
PDB (IMB)1ZY8    2DNC    2F5Z    2F60   
PDB (RSDB)1ZY8    2DNC    2F5Z    2F60   
Human Protein AtlasENSG00000110435 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO00330
HPRD02002
IPIIPI00298423   IPI00976943   IPI00913991   IPI00910682   IPI00980053   IPI00975492   
Protein Interaction databases
DIP (DOE-UCLA)O00330
IntAct (EBI)O00330
FunCoupENSG00000110435
BioGRIDPDHX
InParanoidO00330
Interologous Interaction database O00330
IntegromeDBPDHX
STRING (EMBL)PDHX
Ontologies - Pathways
Ontology : AmiGOmitochondrial matrix  pyruvate metabolic process  regulation of acetyl-CoA biosynthetic process from pyruvate  transferase activity, transferring acyl groups  cellular metabolic process  small molecule metabolic process  
Ontology : EGO-EBImitochondrial matrix  pyruvate metabolic process  regulation of acetyl-CoA biosynthetic process from pyruvate  transferase activity, transferring acyl groups  cellular metabolic process  small molecule metabolic process  
Protein Interaction DatabasePDHX
Wikipedia pathwaysPDHX
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PDHX
snp3D : Map Gene to Disease8050
SNP (GeneSNP Utah)PDHX
SNP : HGBasePDHX
Genetic variants : HAPMAPPDHX
Exome VariantPDHX
1000_GenomesPDHX 
ICGC programENSG00000110435 
Somatic Mutations in Cancer : COSMICPDHX 
CONAN: Copy Number AnalysisPDHX 
Mutations and Diseases : HGMDPDHX
Genomic VariantsPDHX  PDHX [DGVbeta]
dbVarPDHX
ClinVarPDHX
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM245349    608769   
MedgenPDHX
GENETestsPDHX
Disease Genetic AssociationPDHX
Huge Navigator PDHX [HugePedia]  PDHX [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePDHX
Homology/Alignments : Family Browser (UCSC)PDHX
Phylogenetic Trees/Animal Genes : TreeFamPDHX
Chemical/Protein Interactions : CTD8050
Chemical/Pharm GKB GenePA134976445
Clinical trialPDHX
Cancer Resource (Charite)ENSG00000110435
Other databases
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
CoreMinePDHX
iHOPPDHX
OncoSearchPDHX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:09:21 CEST 2014

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