Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PDHX (pyruvate dehydrogenase complex component X)

Identity

Other namesDLDBP
E3BP
OPDX
PDX1
proX
HGNC (Hugo) PDHX
LocusID (NCBI) 8050
Atlas_Id 43932
Location 11p13
Location_base_pair Starts at 34937677 and ends at 35017675 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CD44 (11p13) / PDHX (11p13)KDM6A (Xp11.3) / PDHX (11p13)PDHX (11p13) / CAT (11p13)
PDHX (11p13) / CTDSPL (3p22.2)PDHX (11p13) / EIF3M (11p13)PDHX (11p13) / KDM6A (Xp11.3)
PDHX (11p13) / PDHX (11p13)PDHX (11p13) / THRAP3 (1p34.3)PVT1 (8q24.21) / PDHX (11p13)
KDM6A Xp11.3 / PDHX 11p13PDHX 11p13 / CAT 11p13PDHX 11p13 / EIF3M 11p13
PDHX 11p13 / KDM6A Xp11.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDHX   21350
Cards
Entrez_Gene (NCBI)PDHX  8050  pyruvate dehydrogenase complex component X
GeneCards (Weizmann)PDHX
Ensembl hg19 (Hinxton)ENSG00000110435 [Gene_View]  chr11:34937677-35017675 [Contig_View]  PDHX [Vega]
Ensembl hg38 (Hinxton)ENSG00000110435 [Gene_View]  chr11:34937677-35017675 [Contig_View]  PDHX [Vega]
ICGC DataPortalENSG00000110435
TCGA cBioPortalPDHX
AceView (NCBI)PDHX
Genatlas (Paris)PDHX
WikiGenes8050
SOURCE (Princeton)PDHX
Genomic and cartography
GoldenPath hg19 (UCSC)PDHX  -     chr11:34937677-35017675 +  11p13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PDHX  -     11p13   [Description]    (hg38-Dec_2013)
EnsemblPDHX - 11p13 [CytoView hg19]  PDHX - 11p13 [CytoView hg38]
Mapping of homologs : NCBIPDHX [Mapview hg19]  PDHX [Mapview hg38]
OMIM245349   608769   
Gene and transcription
Genbank (Entrez)AA282215 AF001437 AF052166 AK057123 AK301384
RefSeq transcript (Entrez)NM_001135024 NM_001166158 NM_003477
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_013368 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)PDHX
Cluster EST : UnigeneHs.502315 [ NCBI ]
CGAP (NCI)Hs.502315
Alternative Splicing GalleryENSG00000110435
Gene ExpressionPDHX [ NCBI-GEO ]   PDHX [ EBI - ARRAY_EXPRESS ]   PDHX [ SEEK ]   PDHX [ MEM ]
Gene Expression Viewer (FireBrowse)PDHX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8050
GTEX Portal (Tissue expression)PDHX
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00330 (Uniprot)
NextProtO00330  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00330
Splice isoforms : SwissVarO00330 (Swissvar)
PhosPhoSitePlusO00330
Domaine pattern : Prosite (Expaxy)BIOTINYL_LIPOYL (PS50968)    LIPOYL (PS00189)   
Domains : Interpro (EBI)2-oxoA_DH_lipoyl-BS    2-oxoacid_DH_actylTfrase    Biotin_lipoyl    CAT-like_dom    E3-bd    Single_hybrid_motif   
Domain families : Pfam (Sanger)2-oxoacid_dh (PF00198)    Biotin_lipoyl (PF00364)    E3_binding (PF02817)   
Domain families : Pfam (NCBI)pfam00198    pfam00364    pfam02817   
DMDM Disease mutations8050
Blocks (Seattle)PDHX
PDB (SRS)1ZY8    2DNC    2F5Z    2F60   
PDB (PDBSum)1ZY8    2DNC    2F5Z    2F60   
PDB (IMB)1ZY8    2DNC    2F5Z    2F60   
PDB (RSDB)1ZY8    2DNC    2F5Z    2F60   
Structural Biology KnowledgeBase1ZY8    2DNC    2F5Z    2F60   
SCOP (Structural Classification of Proteins)1ZY8    2DNC    2F5Z    2F60   
CATH (Classification of proteins structures)1ZY8    2DNC    2F5Z    2F60   
SuperfamilyO00330
Human Protein AtlasENSG00000110435
Peptide AtlasO00330
HPRD02002
IPIIPI00298423   IPI00976943   IPI00913991   IPI00910682   IPI00980053   IPI00975492   
Protein Interaction databases
DIP (DOE-UCLA)O00330
IntAct (EBI)O00330
FunCoupENSG00000110435
BioGRIDPDHX
STRING (EMBL)PDHX
ZODIACPDHX
Ontologies - Pathways
QuickGOO00330
Ontology : AmiGOprotein binding  mitochondrial matrix  pyruvate metabolic process  regulation of acetyl-CoA biosynthetic process from pyruvate  transferase activity, transferring acyl groups  pyruvate dehydrogenase (NAD+) activity  pyruvate dehydrogenase complex  glyoxylate metabolic process  mitochondrial acetyl-CoA biosynthetic process from pyruvate  
Ontology : EGO-EBIprotein binding  mitochondrial matrix  pyruvate metabolic process  regulation of acetyl-CoA biosynthetic process from pyruvate  transferase activity, transferring acyl groups  pyruvate dehydrogenase (NAD+) activity  pyruvate dehydrogenase complex  glyoxylate metabolic process  mitochondrial acetyl-CoA biosynthetic process from pyruvate  
NDEx Network
Atlas of Cancer Signalling NetworkPDHX
Wikipedia pathwaysPDHX
Orthology - Evolution
OrthoDB8050
GeneTree (enSembl)ENSG00000110435
Phylogenetic Trees/Animal Genes : TreeFamPDHX
Homologs : HomoloGenePDHX
Homology/Alignments : Family Browser (UCSC)PDHX
Gene fusions - Rearrangements
Fusion: TCGAKDM6A Xp11.3 PDHX 11p13 BRCA
Fusion: TCGAPDHX 11p13 CAT 11p13 BRCA
Fusion: TCGAPDHX 11p13 EIF3M 11p13 BRCA
Fusion: TCGAPDHX 11p13 KDM6A Xp11.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerPDHX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDHX
dbVarPDHX
ClinVarPDHX
1000_GenomesPDHX 
Exome Variant ServerPDHX
ExAC (Exome Aggregation Consortium)PDHX (select the gene name)
Genetic variants : HAPMAP8050
Genomic Variants (DGV)PDHX [DGVbeta]
Mutations
ICGC Data PortalPDHX 
TCGA Data PortalPDHX 
Broad Tumor PortalPDHX
OASIS PortalPDHX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDHX 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PDHX
DgiDB (Drug Gene Interaction Database)PDHX
DoCM (Curated mutations)PDHX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDHX (select a term)
intoGenPDHX
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:34937677-35017675  ENSG00000110435
CONAN: Copy Number AnalysisPDHX 
Mutations and Diseases : HGMDPDHX
OMIM245349    608769   
MedgenPDHX
Genetic Testing Registry PDHX
NextProtO00330 [Medical]
TSGene8050
GENETestsPDHX
Huge Navigator PDHX [HugePedia]
snp3D : Map Gene to Disease8050
BioCentury BCIQPDHX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8050
Chemical/Pharm GKB GenePA134976445
Clinical trialPDHX
Miscellaneous
canSAR (ICR)PDHX (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDHX
EVEXPDHX
GoPubMedPDHX
iHOPPDHX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun May 8 18:59:51 CEST 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.