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PDIA3 (protein disulfide isomerase family A member 3)

Identity

Alias_namesGRP58
glucose regulated protein, 58kDa
protein disulfide isomerase-associated 3
protein disulfide isomerase family A, member 3
Alias_symbol (synonym)P58
ERp61
ERp57
ERp60
GRP57
PI-PLC
HsT17083
Other aliasER60
HEL-S-269
HEL-S-93n
HGNC (Hugo) PDIA3
LocusID (NCBI) 2923
Atlas_Id 46338
Location 15q15.3  [Link to chromosome band 15q15]
Location_base_pair Starts at 43746392 and ends at 43772606 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PDIA3 (15q15.3) / AARS (16q22.1)PDIA3 (15q15.3) / ADAM12 (10q26.2)PDIA3 (15q15.3) / ARF1 (1q42.13)
PDIA3 (15q15.3) / GALK2 (15q21.1)PDIA3 (15q15.3) / MYO10 (5p15.1)PDIA3 (15q15.3) / PDIA3 (15q15.3)
PDIA3 (15q15.3) / PSMF1 (20p13)SERF2 (15q15.3) / PDIA3 (15q15.3)YWHAG (7q11.23) / PDIA3 (15q15.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(7;15)(q11;q15) YWHAG/PDIA3
SERF2/PDIA3 (15q15)

External links

Nomenclature
HGNC (Hugo)PDIA3   4606
Cards
Entrez_Gene (NCBI)PDIA3  2923  protein disulfide isomerase family A member 3
AliasesER60; ERp57; ERp60; ERp61; 
GRP57; GRP58; HEL-S-269; HEL-S-93n; HsT17083; P58; PI-PLC
GeneCards (Weizmann)PDIA3
Ensembl hg19 (Hinxton)ENSG00000167004 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167004 [Gene_View]  ENSG00000167004 [Sequence]  chr15:43746392-43772606 [Contig_View]  PDIA3 [Vega]
ICGC DataPortalENSG00000167004
TCGA cBioPortalPDIA3
AceView (NCBI)PDIA3
Genatlas (Paris)PDIA3
WikiGenes2923
SOURCE (Princeton)PDIA3
Genetics Home Reference (NIH)PDIA3
Genomic and cartography
GoldenPath hg38 (UCSC)PDIA3  -     chr15:43746392-43772606 +  15q15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDIA3  -     15q15.3   [Description]    (hg19-Feb_2009)
EnsemblPDIA3 - 15q15.3 [CytoView hg19]  PDIA3 - 15q15.3 [CytoView hg38]
Mapping of homologs : NCBIPDIA3 [Mapview hg19]  PDIA3 [Mapview hg38]
OMIM602046   
Gene and transcription
Genbank (Entrez)AI769725 AK075455 AK075481 AK293249 BC014433
RefSeq transcript (Entrez)NM_005313
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDIA3
Cluster EST : UnigeneHs.591095 [ NCBI ]
CGAP (NCI)Hs.591095
Alternative Splicing GalleryENSG00000167004
Gene ExpressionPDIA3 [ NCBI-GEO ]   PDIA3 [ EBI - ARRAY_EXPRESS ]   PDIA3 [ SEEK ]   PDIA3 [ MEM ]
Gene Expression Viewer (FireBrowse)PDIA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2923
GTEX Portal (Tissue expression)PDIA3
Human Protein AtlasENSG00000167004-PDIA3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30101   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30101  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30101
Splice isoforms : SwissVarP30101
Catalytic activity : Enzyme5.3.4.1 [ Enzyme-Expasy ]   5.3.4.15.3.4.1 [ IntEnz-EBI ]   5.3.4.1 [ BRENDA ]   5.3.4.1 [ KEGG ]   
PhosPhoSitePlusP30101
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Disulphide_isomerase    Prot_disulphide_isomerase    Thioredoxin-like_sf    Thioredoxin_CS    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)PDIA3
DMDM Disease mutations2923
Blocks (Seattle)PDIA3
PDB (SRS)2ALB    2DMM    2H8L    3F8U    6ENY   
PDB (PDBSum)2ALB    2DMM    2H8L    3F8U    6ENY   
PDB (IMB)2ALB    2DMM    2H8L    3F8U    6ENY   
PDB (RSDB)2ALB    2DMM    2H8L    3F8U    6ENY   
Structural Biology KnowledgeBase2ALB    2DMM    2H8L    3F8U    6ENY   
SCOP (Structural Classification of Proteins)2ALB    2DMM    2H8L    3F8U    6ENY   
CATH (Classification of proteins structures)2ALB    2DMM    2H8L    3F8U    6ENY   
SuperfamilyP30101
Human Protein Atlas [tissue]ENSG00000167004-PDIA3 [tissue]
Peptide AtlasP30101
HPRD03625
IPIIPI00025252   IPI01009528   IPI01012004   IPI00847663   IPI01012475   IPI00796736   IPI00879610   IPI00893541   
Protein Interaction databases
DIP (DOE-UCLA)P30101
IntAct (EBI)P30101
FunCoupENSG00000167004
BioGRIDPDIA3
STRING (EMBL)PDIA3
ZODIACPDIA3
Ontologies - Pathways
QuickGOP30101
Ontology : AmiGOantigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  RNA binding  protein disulfide isomerase activity  cysteine-type endopeptidase activity  phospholipase C activity  protein binding  extracellular space  nucleus  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum lumen  focal adhesion  protein folding  protein folding  proteolysis  cell surface  cell surface  disulfide oxidoreductase activity  peptide disulfide oxidoreductase activity  protein folding in endoplasmic reticulum  response to endoplasmic reticulum stress  melanosome  identical protein binding  MHC class I peptide loading complex  myelin sheath  phagocytic vesicle  cell redox homeostasis  recycling endosome membrane  oxidation-reduction process  extracellular exosome  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIantigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  RNA binding  protein disulfide isomerase activity  cysteine-type endopeptidase activity  phospholipase C activity  protein binding  extracellular space  nucleus  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum lumen  focal adhesion  protein folding  protein folding  proteolysis  cell surface  cell surface  disulfide oxidoreductase activity  peptide disulfide oxidoreductase activity  protein folding in endoplasmic reticulum  response to endoplasmic reticulum stress  melanosome  identical protein binding  MHC class I peptide loading complex  myelin sheath  phagocytic vesicle  cell redox homeostasis  recycling endosome membrane  oxidation-reduction process  extracellular exosome  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGGProtein processing in endoplasmic reticulum    Antigen processing and presentation   
NDEx NetworkPDIA3
Atlas of Cancer Signalling NetworkPDIA3
Wikipedia pathwaysPDIA3
Orthology - Evolution
OrthoDB2923
GeneTree (enSembl)ENSG00000167004
Phylogenetic Trees/Animal Genes : TreeFamPDIA3
HOVERGENP30101
HOGENOMP30101
Homologs : HomoloGenePDIA3
Homology/Alignments : Family Browser (UCSC)PDIA3
Gene fusions - Rearrangements
Fusion : MitelmanSERF2/PDIA3 [15q15.3/15q15.3]  [t(15;15)(q15;q15)]  
Fusion : MitelmanYWHAG/PDIA3 [7q11.23/15q15.3]  [t(7;15)(q11;q15)]  
Fusion : QuiverPDIA3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDIA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDIA3
dbVarPDIA3
ClinVarPDIA3
1000_GenomesPDIA3 
Exome Variant ServerPDIA3
ExAC (Exome Aggregation Consortium)ENSG00000167004
GNOMAD BrowserENSG00000167004
Varsome BrowserPDIA3
Genetic variants : HAPMAP2923
Genomic Variants (DGV)PDIA3 [DGVbeta]
DECIPHERPDIA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDIA3 
Mutations
ICGC Data PortalPDIA3 
TCGA Data PortalPDIA3 
Broad Tumor PortalPDIA3
OASIS PortalPDIA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDIA3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDIA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDIA3
DgiDB (Drug Gene Interaction Database)PDIA3
DoCM (Curated mutations)PDIA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDIA3 (select a term)
intoGenPDIA3
Cancer3DPDIA3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602046   
Orphanet
DisGeNETPDIA3
MedgenPDIA3
Genetic Testing Registry PDIA3
NextProtP30101 [Medical]
TSGene2923
GENETestsPDIA3
Target ValidationPDIA3
Huge Navigator PDIA3 [HugePedia]
snp3D : Map Gene to Disease2923
BioCentury BCIQPDIA3
ClinGenPDIA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2923
Chemical/Pharm GKB GenePA29000
Clinical trialPDIA3
Miscellaneous
canSAR (ICR)PDIA3 (select the gene name)
Probes
Litterature
PubMed207 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDIA3
EVEXPDIA3
GoPubMedPDIA3
iHOPPDIA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:29:14 CET 2018
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