PDIA3 (protein disulfide isomerase family A member 3)

2007-02-01  

Identity

HGNC
LOCATION
15q15.3
LOCUSID
ALIAS
ER60,ERp57,ERp60,ERp61,GRP57,GRP58,HEL-S-269,HEL-S-93n,HsT17083,P58,PI-PLC
FUSION GENES

Other Information

Locus ID:

NCBI: 2923
MIM: 602046
HGNC: 4606
Ensembl: ENSG00000167004

Variants:

dbSNP: 2923
ClinVar: 2923
TCGA: ENSG00000167004
COSMIC: PDIA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167004ENST00000300289P30101
ENSG00000167004ENST00000300289V9HVY3
ENSG00000167004ENST00000434494F8WBS6
ENSG00000167004ENST00000446523F8WBW5
ENSG00000167004ENST00000455250H7BZJ3

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Antigen processing and presentationKEGGhsa04612
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycleREACTOMER-HSA-532668
Calnexin/calreticulin cycleREACTOMER-HSA-901042
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen Presentation: Folding, assembly and peptide loading of class I MHCREACTOMER-HSA-983170
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191190252009Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.91
171706992007ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.74
118422202002TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain.62
161930702005Tapasin and ERp57 form a stable disulfide-linked dimer within the MHC class I peptide-loading complex.50
148718962004ERp57 is a multifunctional thiol-disulfide oxidoreductase.49
221683342012The platelet-surface thiol isomerase enzyme ERp57 modulates platelet function.46
122392182002Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain.35
171881662007Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer.35
240303822013Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin.34
218375522011ERp57/GRP58: a protein with multiple functions.33

Citation

Dessen P

PDIA3 (protein disulfide isomerase family A member 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46338/pdia3