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PDIA4 (protein disulfide isomerase family A member 4)

Identity

Alias_namesprotein disulfide isomerase-associated 4
protein disulfide isomerase family A, member 4
Alias_symbol (synonym)ERP70
ERP72
Other aliasERp-72
HGNC (Hugo) PDIA4
LocusID (NCBI) 9601
Atlas_Id 52569
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 149003062 and ends at 149028690 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LRRC8A (9q34.11) / PDIA4 (7q36.1)PDIA4 (7q36.1) / CBX5 (12q13.13)PDIA4 (7q36.1) / CRHR2 (7p14.3)
PDIA4 (7q36.1) / FAM41C (1p36.33)PDIA4 (7q36.1) / LOC440905 ()PDIA4 (7q36.1) / RPL18 (19q13.33)
PDIA4 (7q36.1) / SIAE (11q24.2)PDIA4 (7q36.1) / UBR4 (1p36.13)PTPRA (20p13) / PDIA4 (7q36.1)
PDIA4 7q36.1 / CBX5 12q13.13PDIA4 7q36.1 / SIAE 11q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDIA4   30167
Cards
Entrez_Gene (NCBI)PDIA4  9601  protein disulfide isomerase family A member 4
AliasesERP70; ERP72; ERp-72
GeneCards (Weizmann)PDIA4
Ensembl hg19 (Hinxton)ENSG00000155660 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155660 [Gene_View]  chr7:149003062-149028690 [Contig_View]  PDIA4 [Vega]
ICGC DataPortalENSG00000155660
TCGA cBioPortalPDIA4
AceView (NCBI)PDIA4
Genatlas (Paris)PDIA4
WikiGenes9601
SOURCE (Princeton)PDIA4
Genetics Home Reference (NIH)PDIA4
Genomic and cartography
GoldenPath hg38 (UCSC)PDIA4  -     chr7:149003062-149028690 -  7q36.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDIA4  -     7q36.1   [Description]    (hg19-Feb_2009)
EnsemblPDIA4 - 7q36.1 [CytoView hg19]  PDIA4 - 7q36.1 [CytoView hg38]
Mapping of homologs : NCBIPDIA4 [Mapview hg19]  PDIA4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK290971 AK313299 AU139362 BC000425 BC001928
RefSeq transcript (Entrez)NM_004911
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDIA4
Cluster EST : UnigeneHs.93659 [ NCBI ]
CGAP (NCI)Hs.93659
Alternative Splicing GalleryENSG00000155660
Gene ExpressionPDIA4 [ NCBI-GEO ]   PDIA4 [ EBI - ARRAY_EXPRESS ]   PDIA4 [ SEEK ]   PDIA4 [ MEM ]
Gene Expression Viewer (FireBrowse)PDIA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9601
GTEX Portal (Tissue expression)PDIA4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13667   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13667  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13667
Splice isoforms : SwissVarP13667
Catalytic activity : Enzyme5.3.4.1 [ Enzyme-Expasy ]   5.3.4.15.3.4.1 [ IntEnz-EBI ]   5.3.4.1 [ BRENDA ]   5.3.4.1 [ KEGG ]   
PhosPhoSitePlusP13667
Domaine pattern : Prosite (Expaxy)ER_TARGET (PS00014)    THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Disulphide_isomerase    Prot_disulphide_isomerase    Protein_diS-isomerase_A4    Thioredoxin-like_fold    Thioredoxin_CS    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)PDIA4
DMDM Disease mutations9601
Blocks (Seattle)PDIA4
PDB (SRS)3IDV   
PDB (PDBSum)3IDV   
PDB (IMB)3IDV   
PDB (RSDB)3IDV   
Structural Biology KnowledgeBase3IDV   
SCOP (Structural Classification of Proteins)3IDV   
CATH (Classification of proteins structures)3IDV   
SuperfamilyP13667
Human Protein AtlasENSG00000155660
Peptide AtlasP13667
HPRD06501
IPIIPI00009904   IPI00852730   
Protein Interaction databases
DIP (DOE-UCLA)P13667
IntAct (EBI)P13667
FunCoupENSG00000155660
BioGRIDPDIA4
STRING (EMBL)PDIA4
ZODIACPDIA4
Ontologies - Pathways
QuickGOP13667
Ontology : AmiGORNA binding  protein disulfide isomerase activity  protein disulfide isomerase activity  protein binding  extracellular space  endoplasmic reticulum  endoplasmic reticulum lumen  protein folding  protein secretion  cell surface  peptide disulfide oxidoreductase activity  response to endoplasmic reticulum stress  melanosome  cell redox homeostasis  oxidation-reduction process  chaperone-mediated protein folding  
Ontology : EGO-EBIRNA binding  protein disulfide isomerase activity  protein disulfide isomerase activity  protein binding  extracellular space  endoplasmic reticulum  endoplasmic reticulum lumen  protein folding  protein secretion  cell surface  peptide disulfide oxidoreductase activity  response to endoplasmic reticulum stress  melanosome  cell redox homeostasis  oxidation-reduction process  chaperone-mediated protein folding  
Pathways : KEGGProtein processing in endoplasmic reticulum    Thyroid hormone synthesis    Vibrio cholerae infection   
NDEx NetworkPDIA4
Atlas of Cancer Signalling NetworkPDIA4
Wikipedia pathwaysPDIA4
Orthology - Evolution
OrthoDB9601
GeneTree (enSembl)ENSG00000155660
Phylogenetic Trees/Animal Genes : TreeFamPDIA4
HOVERGENP13667
HOGENOMP13667
Homologs : HomoloGenePDIA4
Homology/Alignments : Family Browser (UCSC)PDIA4
Gene fusions - Rearrangements
Fusion : MitelmanPDIA4/CBX5 [7q36.1/12q13.13]  
Fusion : MitelmanPDIA4/SIAE [7q36.1/11q24.2]  [t(7;11)(q36;q24)]  
Fusion: TCGAPDIA4 7q36.1 CBX5 12q13.13 PRAD
Fusion: TCGAPDIA4 7q36.1 SIAE 11q24.2 THCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDIA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDIA4
dbVarPDIA4
ClinVarPDIA4
1000_GenomesPDIA4 
Exome Variant ServerPDIA4
ExAC (Exome Aggregation Consortium)PDIA4 (select the gene name)
Genetic variants : HAPMAP9601
Genomic Variants (DGV)PDIA4 [DGVbeta]
DECIPHERPDIA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDIA4 
Mutations
ICGC Data PortalPDIA4 
TCGA Data PortalPDIA4 
Broad Tumor PortalPDIA4
OASIS PortalPDIA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDIA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDIA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDIA4
DgiDB (Drug Gene Interaction Database)PDIA4
DoCM (Curated mutations)PDIA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDIA4 (select a term)
intoGenPDIA4
Cancer3DPDIA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPDIA4
Genetic Testing Registry PDIA4
NextProtP13667 [Medical]
TSGene9601
GENETestsPDIA4
Target ValidationPDIA4
Huge Navigator PDIA4 [HugePedia]
snp3D : Map Gene to Disease9601
BioCentury BCIQPDIA4
ClinGenPDIA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9601
Chemical/Pharm GKB GenePA142671190
Clinical trialPDIA4
Miscellaneous
canSAR (ICR)PDIA4 (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDIA4
EVEXPDIA4
GoPubMedPDIA4
iHOPPDIA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:10:21 CEST 2017

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