Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PDIA4 (protein disulfide isomerase family A member 4)

Identity

Alias (NCBI)ERP70
ERP72
ERp-72
HGNC (Hugo) PDIA4
HGNC Alias symbERP70
ERP72
HGNC Previous nameprotein disulfide isomerase-associated 4
 protein disulfide isomerase family A, member 4
LocusID (NCBI) 9601
Atlas_Id 52569
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 149003062 and ends at 149028505 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRRC8A (9q34.11) / PDIA4 (7q36.1)PDIA4 (7q36.1) / CBX5 (12q13.13)PDIA4 (7q36.1) / CRHR2 (7p14.3)
PDIA4 (7q36.1) / FAM41C (1p36.33)PDIA4 (7q36.1) / LOC440905 ()PDIA4 (7q36.1) / RPL18 (19q13.33)
PDIA4 (7q36.1) / SIAE (11q24.2)PDIA4 (7q36.1) / UBR4 (1p36.13)PTPRA (20p13) / PDIA4 (7q36.1)
PDIA4 7q36.1 / CBX5 12q13.13PDIA4 7q36.1 / SIAE 11q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PDIA4   30167
Cards
Entrez_Gene (NCBI)PDIA4    protein disulfide isomerase family A member 4
AliasesERP70; ERP72; ERp-72
GeneCards (Weizmann)PDIA4
Ensembl hg19 (Hinxton)ENSG00000155660 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155660 [Gene_View]  ENSG00000155660 [Sequence]  chr7:149003062-149028505 [Contig_View]  PDIA4 [Vega]
ICGC DataPortalENSG00000155660
TCGA cBioPortalPDIA4
AceView (NCBI)PDIA4
Genatlas (Paris)PDIA4
SOURCE (Princeton)PDIA4
Genetics Home Reference (NIH)PDIA4
Genomic and cartography
GoldenPath hg38 (UCSC)PDIA4  -     chr7:149003062-149028505 -  7q36.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDIA4  -     7q36.1   [Description]    (hg19-Feb_2009)
GoldenPathPDIA4 - 7q36.1 [CytoView hg19]  PDIA4 - 7q36.1 [CytoView hg38]
ImmunoBaseENSG00000155660
Genome Data Viewer NCBIPDIA4 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK290971 AK313299 AU139362 BC000425 BC001928
RefSeq transcript (Entrez)NM_001371244 NM_001371245 NM_004911
Consensus coding sequences : CCDS (NCBI)PDIA4
Gene ExpressionPDIA4 [ NCBI-GEO ]   PDIA4 [ EBI - ARRAY_EXPRESS ]   PDIA4 [ SEEK ]   PDIA4 [ MEM ]
Gene Expression Viewer (FireBrowse)PDIA4 [ Firebrowse - Broad ]
GenevisibleExpression of PDIA4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9601
GTEX Portal (Tissue expression)PDIA4
Human Protein AtlasENSG00000155660-PDIA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13667   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13667  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13667
PhosPhoSitePlusP13667
Domaine pattern : Prosite (Expaxy)ER_TARGET (PS00014)    THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Disulphide_isomerase    PDIA4_PDI_b    Prot_disulphide_isomerase    Protein_diS-isomerase_A4    Thioredoxin-like_sf    Thioredoxin_CS    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)PDIA4
PDB (RSDB)3IDV   
PDB Europe3IDV   
PDB (PDBSum)3IDV   
PDB (IMB)3IDV   
Structural Biology KnowledgeBase3IDV   
SCOP (Structural Classification of Proteins)3IDV   
CATH (Classification of proteins structures)3IDV   
SuperfamilyP13667
AlphaFold pdb e-kbP13667   
Human Protein Atlas [tissue]ENSG00000155660-PDIA4 [tissue]
HPRD06501
Protein Interaction databases
DIP (DOE-UCLA)P13667
IntAct (EBI)P13667
BioGRIDPDIA4
STRING (EMBL)PDIA4
ZODIACPDIA4
Ontologies - Pathways
QuickGOP13667
Ontology : AmiGORNA binding  protein disulfide isomerase activity  protein disulfide isomerase activity  protein binding  extracellular space  endoplasmic reticulum  endoplasmic reticulum lumen  protein folding  protein secretion  cell surface  cell surface  protein-disulfide reductase activity  response to endoplasmic reticulum stress  melanosome  chaperone-mediated protein folding  
Ontology : EGO-EBIRNA binding  protein disulfide isomerase activity  protein disulfide isomerase activity  protein binding  extracellular space  endoplasmic reticulum  endoplasmic reticulum lumen  protein folding  protein secretion  cell surface  cell surface  protein-disulfide reductase activity  response to endoplasmic reticulum stress  melanosome  chaperone-mediated protein folding  
Pathways : KEGGProtein processing in endoplasmic reticulum    Thyroid hormone synthesis    Vibrio cholerae infection   
NDEx NetworkPDIA4
Atlas of Cancer Signalling NetworkPDIA4
Wikipedia pathwaysPDIA4
Orthology - Evolution
OrthoDB9601
GeneTree (enSembl)ENSG00000155660
Phylogenetic Trees/Animal Genes : TreeFamPDIA4
Homologs : HomoloGenePDIA4
Homology/Alignments : Family Browser (UCSC)PDIA4
Gene fusions - Rearrangements
Fusion : MitelmanPDIA4/CBX5 [7q36.1/12q13.13]  
Fusion : MitelmanPDIA4/SIAE [7q36.1/11q24.2]  
Fusion : QuiverPDIA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDIA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDIA4
dbVarPDIA4
ClinVarPDIA4
MonarchPDIA4
1000_GenomesPDIA4 
Exome Variant ServerPDIA4
GNOMAD BrowserENSG00000155660
Varsome BrowserPDIA4
ACMGPDIA4 variants
VarityP13667
Genomic Variants (DGV)PDIA4 [DGVbeta]
DECIPHERPDIA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDIA4 
Mutations
ICGC Data PortalPDIA4 
TCGA Data PortalPDIA4 
Broad Tumor PortalPDIA4
OASIS PortalPDIA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDIA4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPDIA4
Mutations and Diseases : HGMDPDIA4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPDIA4
DgiDB (Drug Gene Interaction Database)PDIA4
DoCM (Curated mutations)PDIA4
CIViC (Clinical Interpretations of Variants in Cancer)PDIA4
Cancer3DPDIA4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPDIA4
MedgenPDIA4
Genetic Testing Registry PDIA4
NextProtP13667 [Medical]
GENETestsPDIA4
Target ValidationPDIA4
Huge Navigator PDIA4 [HugePedia]
ClinGenPDIA4
Clinical trials, drugs, therapy
MyCancerGenomePDIA4
Protein Interactions : CTDPDIA4
Pharm GKB GenePA142671190
PharosP13667
Clinical trialPDIA4
Miscellaneous
canSAR (ICR)PDIA4
HarmonizomePDIA4
DataMed IndexPDIA4
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPDIA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:24:48 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.