PDIA5 (protein disulfide isomerase family A member 5)

2014-06-01  

Identity

HGNC
LOCATION
3q21.1
LOCUSID
ALIAS
PDIR
FUSION GENES

Other Information

Locus ID:

NCBI: 10954
MIM: 616942
HGNC: 24811
Ensembl: ENSG00000065485

Variants:

dbSNP: 10954
ClinVar: 10954
TCGA: ENSG00000065485
COSMIC: PDIA5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065485ENST00000316218Q14554
ENSG00000065485ENST00000469649H7C4F9
ENSG00000065485ENST00000484644C9JY10
ENSG00000065485ENST00000489923Q14554

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
207960292010A structural overview of the PDI family of proteins.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
246369892014Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance.50
146276992004Different contributions of the three CXXC motifs of human protein-disulfide isomerase-related protein to isomerase activity and oxidative refolding.12
220024442012Unfolded protein response is not activated in the mucopolysaccharidoses but protein disulfide isomerase 5 is deregulated.5
240370322014Protein disulfide isomerase P5-immunopositive inclusions in patients with Alzheimer's disease.4
292934532018Contribution of activated beta3 integrin in the PDI release from endothelial cells.2

Citation

Dessen P

PDIA5 (protein disulfide isomerase family A member 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53962/pdia5