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PDIA5 (protein disulfide isomerase family A member 5)

Identity

Alias_namesprotein disulfide isomerase-associated 5
protein disulfide isomerase family A, member 5
Alias_symbol (synonym)PDIR
FLJ30401
Other alias
HGNC (Hugo) PDIA5
LocusID (NCBI) 10954
Atlas_Id 53962
Location 3q21.1  [Link to chromosome band 3q21]
Location_base_pair Starts at 122785856 and ends at 122880953 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PDIA5 (3q21.1) / DIRC2 (3q21.1)PDIA5 (3q21.1) / PDIA5 (3q21.1)PDIA5 (3q21.1) / SLC25A5 (Xq24)
PDIA5 3q21.1 / DIRC2 3q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDIA5   24811
Cards
Entrez_Gene (NCBI)PDIA5  10954  protein disulfide isomerase family A member 5
AliasesPDIR
GeneCards (Weizmann)PDIA5
Ensembl hg19 (Hinxton)ENSG00000065485 [Gene_View]  chr3:122785856-122880953 [Contig_View]  PDIA5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000065485 [Gene_View]  chr3:122785856-122880953 [Contig_View]  PDIA5 [Vega]
ICGC DataPortalENSG00000065485
TCGA cBioPortalPDIA5
AceView (NCBI)PDIA5
Genatlas (Paris)PDIA5
WikiGenes10954
SOURCE (Princeton)PDIA5
Genetics Home Reference (NIH)PDIA5
Genomic and cartography
GoldenPath hg19 (UCSC)PDIA5  -     chr3:122785856-122880953 +  3q21.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PDIA5  -     3q21.1   [Description]    (hg38-Dec_2013)
EnsemblPDIA5 - 3q21.1 [CytoView hg19]  PDIA5 - 3q21.1 [CytoView hg38]
Mapping of homologs : NCBIPDIA5 [Mapview hg19]  PDIA5 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK054963 BC001625 BM549365 CA414869 CB158962
RefSeq transcript (Entrez)NM_006810
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)PDIA5
Cluster EST : UnigeneHs.477352 [ NCBI ]
CGAP (NCI)Hs.477352
Alternative Splicing GalleryENSG00000065485
Gene ExpressionPDIA5 [ NCBI-GEO ]   PDIA5 [ EBI - ARRAY_EXPRESS ]   PDIA5 [ SEEK ]   PDIA5 [ MEM ]
Gene Expression Viewer (FireBrowse)PDIA5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10954
GTEX Portal (Tissue expression)PDIA5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14554   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14554  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14554
Splice isoforms : SwissVarQ14554
Catalytic activity : Enzyme5.3.4.1 [ Enzyme-Expasy ]   5.3.4.15.3.4.1 [ IntEnz-EBI ]   5.3.4.1 [ BRENDA ]   5.3.4.1 [ KEGG ]   
PhosPhoSitePlusQ14554
Domaine pattern : Prosite (Expaxy)ER_TARGET (PS00014)    THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Thioredoxin-like_fold    Thioredoxin_CS    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)PDIA5
DMDM Disease mutations10954
Blocks (Seattle)PDIA5
PDB (SRS)4I6X   
PDB (PDBSum)4I6X   
PDB (IMB)4I6X   
PDB (RSDB)4I6X   
Structural Biology KnowledgeBase4I6X   
SCOP (Structural Classification of Proteins)4I6X   
CATH (Classification of proteins structures)4I6X   
SuperfamilyQ14554
Human Protein AtlasENSG00000065485
Peptide AtlasQ14554
HPRD08334
IPIIPI00031479   IPI00796113   IPI00945196   IPI00945404   
Protein Interaction databases
DIP (DOE-UCLA)Q14554
IntAct (EBI)Q14554
FunCoupENSG00000065485
BioGRIDPDIA5
STRING (EMBL)PDIA5
ZODIACPDIA5
Ontologies - Pathways
QuickGOQ14554
Ontology : AmiGOprotein disulfide isomerase activity  protein binding  endoplasmic reticulum lumen  endoplasmic reticulum membrane  protein folding  oxidoreductase activity  response to endoplasmic reticulum stress  IRE1-mediated unfolded protein response  cell redox homeostasis  oxidation-reduction process  
Ontology : EGO-EBIprotein disulfide isomerase activity  protein binding  endoplasmic reticulum lumen  endoplasmic reticulum membrane  protein folding  oxidoreductase activity  response to endoplasmic reticulum stress  IRE1-mediated unfolded protein response  cell redox homeostasis  oxidation-reduction process  
NDEx NetworkPDIA5
Atlas of Cancer Signalling NetworkPDIA5
Wikipedia pathwaysPDIA5
Orthology - Evolution
OrthoDB10954
GeneTree (enSembl)ENSG00000065485
Phylogenetic Trees/Animal Genes : TreeFamPDIA5
HOVERGENQ14554
HOGENOMQ14554
Homologs : HomoloGenePDIA5
Homology/Alignments : Family Browser (UCSC)PDIA5
Gene fusions - Rearrangements
Fusion : MitelmanPDIA5/DIRC2 [3q21.1/3q21.1]  
Fusion: TCGAPDIA5 3q21.1 DIRC2 3q21.1 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDIA5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDIA5
dbVarPDIA5
ClinVarPDIA5
1000_GenomesPDIA5 
Exome Variant ServerPDIA5
ExAC (Exome Aggregation Consortium)PDIA5 (select the gene name)
Genetic variants : HAPMAP10954
Genomic Variants (DGV)PDIA5 [DGVbeta]
DECIPHER (Syndromes)3:122785856-122880953  ENSG00000065485
CONAN: Copy Number AnalysisPDIA5 
Mutations
ICGC Data PortalPDIA5 
TCGA Data PortalPDIA5 
Broad Tumor PortalPDIA5
OASIS PortalPDIA5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDIA5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDIA5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDIA5
DgiDB (Drug Gene Interaction Database)PDIA5
DoCM (Curated mutations)PDIA5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDIA5 (select a term)
intoGenPDIA5
Cancer3DPDIA5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPDIA5
Genetic Testing Registry PDIA5
NextProtQ14554 [Medical]
TSGene10954
GENETestsPDIA5
Huge Navigator PDIA5 [HugePedia]
snp3D : Map Gene to Disease10954
BioCentury BCIQPDIA5
ClinGenPDIA5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10954
Chemical/Pharm GKB GenePA142671191
Clinical trialPDIA5
Miscellaneous
canSAR (ICR)PDIA5 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDIA5
EVEXPDIA5
GoPubMedPDIA5
iHOPPDIA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:20:52 CET 2017

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