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PDK2 (pyruvate dehydrogenase kinase 2)

Identity

Alias (NCBI)PDHK2
PDKII
HGNC (Hugo) PDK2
HGNC Alias symbPDHK2
HGNC Previous namepyruvate dehydrogenase kinase, isoenzyme 2
 pyruvate dehydrogenase kinase, isozyme 2
LocusID (NCBI) 5164
Atlas_Id 41683
Location 17q21.33  [Link to chromosome band 17q21]
Location_base_pair Starts at 50095351 and ends at 50112152 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAP2K1 (15q22.31) / PDK2 (17q21.33)PDK2 (17q21.33) / CDK12 (17q12)PDK2 (17q21.33) / PDK2 (17q21.33)
VMP1 (17q23.1) / PDK2 (17q21.33)PDK2 17q21.33 / CDK12 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PDK2   8810
Cards
Entrez_Gene (NCBI)PDK2    pyruvate dehydrogenase kinase 2
AliasesPDHK2; PDKII
GeneCards (Weizmann)PDK2
Ensembl hg19 (Hinxton)ENSG00000005882 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000005882 [Gene_View]  ENSG00000005882 [Sequence]  chr17:50095351-50112152 [Contig_View]  PDK2 [Vega]
ICGC DataPortalENSG00000005882
TCGA cBioPortalPDK2
AceView (NCBI)PDK2
Genatlas (Paris)PDK2
SOURCE (Princeton)PDK2
Genetics Home Reference (NIH)PDK2
Genomic and cartography
GoldenPath hg38 (UCSC)PDK2  -     chr17:50095351-50112152 +  17q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDK2  -     17q21.33   [Description]    (hg19-Feb_2009)
GoldenPathPDK2 - 17q21.33 [CytoView hg19]  PDK2 - 17q21.33 [CytoView hg38]
ImmunoBaseENSG00000005882
Genome Data Viewer NCBIPDK2 [Mapview hg19]  
OMIM602525   
Gene and transcription
Genbank (Entrez)AK055119 AK290522 AK293600 AK297089 AW302405
RefSeq transcript (Entrez)NM_001199898 NM_001199899 NM_001199900 NM_002611
Consensus coding sequences : CCDS (NCBI)PDK2
Gene ExpressionPDK2 [ NCBI-GEO ]   PDK2 [ EBI - ARRAY_EXPRESS ]   PDK2 [ SEEK ]   PDK2 [ MEM ]
Gene Expression Viewer (FireBrowse)PDK2 [ Firebrowse - Broad ]
GenevisibleExpression of PDK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5164
GTEX Portal (Tissue expression)PDK2
Human Protein AtlasENSG00000005882-PDK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15119   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15119  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15119
Catalytic activity : Enzyme2.7.11.2 [ Enzyme-Expasy ]   2.7.11.22.7.11.2 [ IntEnz-EBI ]   2.7.11.2 [ BRENDA ]   2.7.11.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ15119
Domaine pattern : Prosite (Expaxy)HIS_KIN (PS50109)   
Domains : Interpro (EBI)AK/P_DHK_N_sf    BCDHK/PDK_N    BCKD/PDK    HATPase_C    HATPase_C_sf    His_kinase_dom   
Domain families : Pfam (Sanger)BCDHK_Adom3 (PF10436)    HATPase_c (PF02518)   
Domain families : Pfam (NCBI)pfam10436    pfam02518   
Domain families : Smart (EMBL)HATPase_c (SM00387)  
Conserved Domain (NCBI)PDK2
PDB (RSDB)2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26    5J6A    5J71    5M4K    5M4M    5M4N    5M4P    6LIL    6LIN    6LIO    6TMP    6TMQ    6TMZ    6TN0    6TN2   
PDB Europe2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26    5J6A    5J71    5M4K    5M4M    5M4N    5M4P    6LIL    6LIN    6LIO    6TMP    6TMQ    6TMZ    6TN0    6TN2   
PDB (PDBSum)2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26    5J6A    5J71    5M4K    5M4M    5M4N    5M4P    6LIL    6LIN    6LIO    6TMP    6TMQ    6TMZ    6TN0    6TN2   
PDB (IMB)2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26    5J6A    5J71    5M4K    5M4M    5M4N    5M4P    6LIL    6LIN    6LIO    6TMP    6TMQ    6TMZ    6TN0    6TN2   
Structural Biology KnowledgeBase2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26    5J6A    5J71    5M4K    5M4M    5M4N    5M4P    6LIL    6LIN    6LIO    6TMP    6TMQ    6TMZ    6TN0    6TN2   
SCOP (Structural Classification of Proteins)2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26    5J6A    5J71    5M4K    5M4M    5M4N    5M4P    6LIL    6LIN    6LIO    6TMP    6TMQ    6TMZ    6TN0    6TN2   
CATH (Classification of proteins structures)2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26    5J6A    5J71    5M4K    5M4M    5M4N    5M4P    6LIL    6LIN    6LIO    6TMP    6TMQ    6TMZ    6TN0    6TN2   
SuperfamilyQ15119
AlphaFold pdb e-kbQ15119   
Human Protein Atlas [tissue]ENSG00000005882-PDK2 [tissue]
HPRD03955
Protein Interaction databases
DIP (DOE-UCLA)Q15119
IntAct (EBI)Q15119
BioGRIDPDK2
STRING (EMBL)PDK2
ZODIACPDK2
Ontologies - Pathways
QuickGOQ15119
Ontology : AmiGOprotein kinase activity  pyruvate dehydrogenase (acetyl-transferring) kinase activity  pyruvate dehydrogenase (acetyl-transferring) kinase activity  protein binding  ATP binding  nucleoplasm  mitochondrion  mitochondrion  mitochondrial matrix  cytosol  mitochondrial pyruvate dehydrogenase complex  glucose metabolic process  regulation of gluconeogenesis  protein phosphorylation  regulation of pH  insulin receptor signaling pathway  regulation of acetyl-CoA biosynthetic process from pyruvate  regulation of acetyl-CoA biosynthetic process from pyruvate  regulation of cellular ketone metabolic process  regulation of glucose metabolic process  regulation of glucose metabolic process  cellular response to nutrient  cellular response to reactive oxygen species  glucose homeostasis  protein homodimerization activity  regulation of calcium-mediated signaling  intrinsic apoptotic signaling pathway by p53 class mediator  
Ontology : EGO-EBIprotein kinase activity  pyruvate dehydrogenase (acetyl-transferring) kinase activity  pyruvate dehydrogenase (acetyl-transferring) kinase activity  protein binding  ATP binding  nucleoplasm  mitochondrion  mitochondrion  mitochondrial matrix  cytosol  mitochondrial pyruvate dehydrogenase complex  glucose metabolic process  regulation of gluconeogenesis  protein phosphorylation  regulation of pH  insulin receptor signaling pathway  regulation of acetyl-CoA biosynthetic process from pyruvate  regulation of acetyl-CoA biosynthetic process from pyruvate  regulation of cellular ketone metabolic process  regulation of glucose metabolic process  regulation of glucose metabolic process  cellular response to nutrient  cellular response to reactive oxygen species  glucose homeostasis  protein homodimerization activity  regulation of calcium-mediated signaling  intrinsic apoptotic signaling pathway by p53 class mediator  
Pathways : BIOCARTARegulation of eIF4e and p70 S6 Kinase [Genes]    Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway [Genes]    mTOR Signaling Pathway [Genes]    PTEN dependent cell cycle arrest and apoptosis [Genes]   
NDEx NetworkPDK2
Atlas of Cancer Signalling NetworkPDK2
Wikipedia pathwaysPDK2
Orthology - Evolution
OrthoDB5164
GeneTree (enSembl)ENSG00000005882
Phylogenetic Trees/Animal Genes : TreeFamPDK2
Homologs : HomoloGenePDK2
Homology/Alignments : Family Browser (UCSC)PDK2
Gene fusions - Rearrangements
Fusion : MitelmanPDK2/CDK12 [17q21.33/17q12]  
Fusion : QuiverPDK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDK2
dbVarPDK2
ClinVarPDK2
MonarchPDK2
1000_GenomesPDK2 
Exome Variant ServerPDK2
GNOMAD BrowserENSG00000005882
Varsome BrowserPDK2
ACMGPDK2 variants
VarityQ15119
Genomic Variants (DGV)PDK2 [DGVbeta]
DECIPHERPDK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDK2 
Mutations
ICGC Data PortalPDK2 
TCGA Data PortalPDK2 
Broad Tumor PortalPDK2
OASIS PortalPDK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPDK2
Mutations and Diseases : HGMDPDK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPDK2
DgiDB (Drug Gene Interaction Database)PDK2
DoCM (Curated mutations)PDK2
CIViC (Clinical Interpretations of Variants in Cancer)PDK2
Cancer3DPDK2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602525   
Orphanet
DisGeNETPDK2
MedgenPDK2
Genetic Testing Registry PDK2
NextProtQ15119 [Medical]
GENETestsPDK2
Target ValidationPDK2
Huge Navigator PDK2 [HugePedia]
ClinGenPDK2
Clinical trials, drugs, therapy
MyCancerGenomePDK2
Protein Interactions : CTDPDK2
Pharm GKB GenePA33155
PharosQ15119
Clinical trialPDK2
Miscellaneous
canSAR (ICR)PDK2
HarmonizomePDK2
DataMed IndexPDK2
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPDK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:24:48 CEST 2021

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