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PDK2 (pyruvate dehydrogenase kinase 2)

Identity

Alias_namespyruvate dehydrogenase kinase, isoenzyme 2
pyruvate dehydrogenase kinase, isozyme 2
Alias_symbol (synonym)PDHK2
Other aliasPDKII
HGNC (Hugo) PDK2
LocusID (NCBI) 5164
Atlas_Id 41683
Location 17q21.33  [Link to chromosome band 17q21]
Location_base_pair Starts at 48172101 and ends at 48188733 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MAP2K1 (15q22.31) / PDK2 (17q21.33)PDK2 (17q21.33) / CDK12 (17q12)PDK2 (17q21.33) / PDK2 (17q21.33)
VMP1 (17q23.1) / PDK2 (17q21.33)PDK2 17q21.33 / CDK12 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDK2   8810
Cards
Entrez_Gene (NCBI)PDK2  5164  pyruvate dehydrogenase kinase 2
AliasesPDHK2; PDKII
GeneCards (Weizmann)PDK2
Ensembl hg19 (Hinxton)ENSG00000005882 [Gene_View]  chr17:48172101-48188733 [Contig_View]  PDK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000005882 [Gene_View]  chr17:48172101-48188733 [Contig_View]  PDK2 [Vega]
ICGC DataPortalENSG00000005882
TCGA cBioPortalPDK2
AceView (NCBI)PDK2
Genatlas (Paris)PDK2
WikiGenes5164
SOURCE (Princeton)PDK2
Genetics Home Reference (NIH)PDK2
Genomic and cartography
GoldenPath hg19 (UCSC)PDK2  -     chr17:48172101-48188733 +  17q21.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PDK2  -     17q21.33   [Description]    (hg38-Dec_2013)
EnsemblPDK2 - 17q21.33 [CytoView hg19]  PDK2 - 17q21.33 [CytoView hg38]
Mapping of homologs : NCBIPDK2 [Mapview hg19]  PDK2 [Mapview hg38]
OMIM602525   
Gene and transcription
Genbank (Entrez)AK055119 AK290522 AK293600 AK297089 AW302405
RefSeq transcript (Entrez)NM_001199898 NM_001199899 NM_001199900 NM_002611
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)PDK2
Cluster EST : UnigeneHs.256667 [ NCBI ]
CGAP (NCI)Hs.256667
Alternative Splicing GalleryENSG00000005882
Gene ExpressionPDK2 [ NCBI-GEO ]   PDK2 [ EBI - ARRAY_EXPRESS ]   PDK2 [ SEEK ]   PDK2 [ MEM ]
Gene Expression Viewer (FireBrowse)PDK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5164
GTEX Portal (Tissue expression)PDK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15119   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15119  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15119
Splice isoforms : SwissVarQ15119
Catalytic activity : Enzyme2.7.11.2 [ Enzyme-Expasy ]   2.7.11.22.7.11.2 [ IntEnz-EBI ]   2.7.11.2 [ BRENDA ]   2.7.11.2 [ KEGG ]   
PhosPhoSitePlusQ15119
Domaine pattern : Prosite (Expaxy)HIS_KIN (PS50109)   
Domains : Interpro (EBI)BCDHK/PDK_N    HATPase_C    His_kinase_dom   
Domain families : Pfam (Sanger)BCDHK_Adom3 (PF10436)    HATPase_c (PF02518)   
Domain families : Pfam (NCBI)pfam10436    pfam02518   
Domain families : Smart (EMBL)HATPase_c (SM00387)  
Conserved Domain (NCBI)PDK2
DMDM Disease mutations5164
Blocks (Seattle)PDK2
PDB (SRS)2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26   
PDB (PDBSum)2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26   
PDB (IMB)2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26   
PDB (RSDB)2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26   
Structural Biology KnowledgeBase2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26   
SCOP (Structural Classification of Proteins)2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26   
CATH (Classification of proteins structures)2BTZ    2BU2    2BU5    2BU6    2BU7    2BU8    4MP2    4MP7    4MPC    4MPE    4MPN    4V25    4V26   
SuperfamilyQ15119
Human Protein AtlasENSG00000005882
Peptide AtlasQ15119
HPRD03955
IPIIPI01011342   IPI00797834   IPI00966780   IPI00966638   IPI00967739   IPI00967843   IPI00968252   IPI00966399   
Protein Interaction databases
DIP (DOE-UCLA)Q15119
IntAct (EBI)Q15119
FunCoupENSG00000005882
BioGRIDPDK2
STRING (EMBL)PDK2
ZODIACPDK2
Ontologies - Pathways
QuickGOQ15119
Ontology : AmiGOprotein kinase activity  pyruvate dehydrogenase (acetyl-transferring) kinase activity  pyruvate dehydrogenase (acetyl-transferring) kinase activity  ATP binding  nucleoplasm  cytoplasm  mitochondrion  mitochondrial matrix  mitochondrial pyruvate dehydrogenase complex  glucose metabolic process  regulation of gluconeogenesis  protein phosphorylation  protein phosphorylation  protein phosphorylation  protein phosphorylation  regulation of pH  insulin receptor signaling pathway  regulation of acetyl-CoA biosynthetic process from pyruvate  regulation of acetyl-CoA biosynthetic process from pyruvate  regulation of cellular ketone metabolic process  regulation of glucose metabolic process  cellular response to nutrient  cellular response to reactive oxygen species  glucose homeostasis  protein homodimerization activity  intrinsic apoptotic signaling pathway by p53 class mediator  
Ontology : EGO-EBIprotein kinase activity  pyruvate dehydrogenase (acetyl-transferring) kinase activity  pyruvate dehydrogenase (acetyl-transferring) kinase activity  ATP binding  nucleoplasm  cytoplasm  mitochondrion  mitochondrial matrix  mitochondrial pyruvate dehydrogenase complex  glucose metabolic process  regulation of gluconeogenesis  protein phosphorylation  protein phosphorylation  protein phosphorylation  protein phosphorylation  regulation of pH  insulin receptor signaling pathway  regulation of acetyl-CoA biosynthetic process from pyruvate  regulation of acetyl-CoA biosynthetic process from pyruvate  regulation of cellular ketone metabolic process  regulation of glucose metabolic process  cellular response to nutrient  cellular response to reactive oxygen species  glucose homeostasis  protein homodimerization activity  intrinsic apoptotic signaling pathway by p53 class mediator  
Pathways : BIOCARTARegulation of eIF4e and p70 S6 Kinase [Genes]    Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway [Genes]    mTOR Signaling Pathway [Genes]    PTEN dependent cell cycle arrest and apoptosis [Genes]   
NDEx NetworkPDK2
Atlas of Cancer Signalling NetworkPDK2
Wikipedia pathwaysPDK2
Orthology - Evolution
OrthoDB5164
GeneTree (enSembl)ENSG00000005882
Phylogenetic Trees/Animal Genes : TreeFamPDK2
HOVERGENQ15119
HOGENOMQ15119
Homologs : HomoloGenePDK2
Homology/Alignments : Family Browser (UCSC)PDK2
Gene fusions - Rearrangements
Fusion : MitelmanPDK2/CDK12 [17q21.33/17q12]  
Fusion: TCGAPDK2 17q21.33 CDK12 17q12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDK2
dbVarPDK2
ClinVarPDK2
1000_GenomesPDK2 
Exome Variant ServerPDK2
ExAC (Exome Aggregation Consortium)PDK2 (select the gene name)
Genetic variants : HAPMAP5164
Genomic Variants (DGV)PDK2 [DGVbeta]
DECIPHER (Syndromes)17:48172101-48188733  ENSG00000005882
CONAN: Copy Number AnalysisPDK2 
Mutations
ICGC Data PortalPDK2 
TCGA Data PortalPDK2 
Broad Tumor PortalPDK2
OASIS PortalPDK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PDK2
DgiDB (Drug Gene Interaction Database)PDK2
DoCM (Curated mutations)PDK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDK2 (select a term)
intoGenPDK2
Cancer3DPDK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602525   
Orphanet
MedgenPDK2
Genetic Testing Registry PDK2
NextProtQ15119 [Medical]
TSGene5164
GENETestsPDK2
Huge Navigator PDK2 [HugePedia]
snp3D : Map Gene to Disease5164
BioCentury BCIQPDK2
ClinGenPDK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5164
Chemical/Pharm GKB GenePA33155
Clinical trialPDK2
Miscellaneous
canSAR (ICR)PDK2 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDK2
EVEXPDK2
GoPubMedPDK2
iHOPPDK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:13:55 CEST 2017

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