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PDK4 (pyruvate dehydrogenase kinase 4)

Identity

Alias_namespyruvate dehydrogenase kinase, isoenzyme 4
pyruvate dehydrogenase kinase, isozyme 4
Other alias-
HGNC (Hugo) PDK4
LocusID (NCBI) 5166
Atlas_Id 41684
Location 7q21.3  [Link to chromosome band 7q21]
Location_base_pair Starts at 95212809 and ends at 95225925 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EHF (11p13) / PDK4 (7q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDK4   8812
Cards
Entrez_Gene (NCBI)PDK4  5166  pyruvate dehydrogenase kinase 4
Aliases
GeneCards (Weizmann)PDK4
Ensembl hg19 (Hinxton)ENSG00000004799 [Gene_View]  chr7:95212809-95225925 [Contig_View]  PDK4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000004799 [Gene_View]  chr7:95212809-95225925 [Contig_View]  PDK4 [Vega]
ICGC DataPortalENSG00000004799
TCGA cBioPortalPDK4
AceView (NCBI)PDK4
Genatlas (Paris)PDK4
WikiGenes5166
SOURCE (Princeton)PDK4
Genetics Home Reference (NIH)PDK4
Genomic and cartography
GoldenPath hg19 (UCSC)PDK4  -     chr7:95212809-95225925 -  7q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PDK4  -     7q21.3   [Description]    (hg38-Dec_2013)
EnsemblPDK4 - 7q21.3 [CytoView hg19]  PDK4 - 7q21.3 [CytoView hg38]
Mapping of homologs : NCBIPDK4 [Mapview hg19]  PDK4 [Mapview hg38]
OMIM602527   
Gene and transcription
Genbank (Entrez)AF334710 AK096428 AK098151 AK223328 AK312424
RefSeq transcript (Entrez)NM_002612
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)PDK4
Cluster EST : UnigeneHs.8364 [ NCBI ]
CGAP (NCI)Hs.8364
Alternative Splicing GalleryENSG00000004799
Gene ExpressionPDK4 [ NCBI-GEO ]   PDK4 [ EBI - ARRAY_EXPRESS ]   PDK4 [ SEEK ]   PDK4 [ MEM ]
Gene Expression Viewer (FireBrowse)PDK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5166
GTEX Portal (Tissue expression)PDK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16654   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16654  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16654
Splice isoforms : SwissVarQ16654
Catalytic activity : Enzyme2.7.11.2 [ Enzyme-Expasy ]   2.7.11.22.7.11.2 [ IntEnz-EBI ]   2.7.11.2 [ BRENDA ]   2.7.11.2 [ KEGG ]   
PhosPhoSitePlusQ16654
Domaine pattern : Prosite (Expaxy)HIS_KIN (PS50109)   
Domains : Interpro (EBI)BCDHK/PDK_N    HATPase_C    His_kinase_dom   
Domain families : Pfam (Sanger)BCDHK_Adom3 (PF10436)    HATPase_c (PF02518)   
Domain families : Pfam (NCBI)pfam10436    pfam02518   
Domain families : Smart (EMBL)HATPase_c (SM00387)  
Conserved Domain (NCBI)PDK4
DMDM Disease mutations5166
Blocks (Seattle)PDK4
PDB (SRS)2E0A    2ZDX    2ZDY    2ZKJ    3D2R   
PDB (PDBSum)2E0A    2ZDX    2ZDY    2ZKJ    3D2R   
PDB (IMB)2E0A    2ZDX    2ZDY    2ZKJ    3D2R   
PDB (RSDB)2E0A    2ZDX    2ZDY    2ZKJ    3D2R   
Structural Biology KnowledgeBase2E0A    2ZDX    2ZDY    2ZKJ    3D2R   
SCOP (Structural Classification of Proteins)2E0A    2ZDX    2ZDY    2ZKJ    3D2R   
CATH (Classification of proteins structures)2E0A    2ZDX    2ZDY    2ZKJ    3D2R   
SuperfamilyQ16654
Human Protein AtlasENSG00000004799
Peptide AtlasQ16654
HPRD03957
IPIIPI00003425   IPI01013551   
Protein Interaction databases
DIP (DOE-UCLA)Q16654
IntAct (EBI)Q16654
FunCoupENSG00000004799
BioGRIDPDK4
STRING (EMBL)PDK4
ZODIACPDK4
Ontologies - Pathways
QuickGOQ16654
Ontology : AmiGOpositive regulation of defense response to virus by host  protein kinase activity  pyruvate dehydrogenase (acetyl-transferring) kinase activity  pyruvate dehydrogenase (acetyl-transferring) kinase activity  ATP binding  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  glucose metabolic process  protein phosphorylation  protein phosphorylation  protein phosphorylation  protein phosphorylation  protein phosphorylation  regulation of pH  insulin receptor signaling pathway  cellular response to starvation  regulation of acetyl-CoA biosynthetic process from pyruvate  regulation of acetyl-CoA biosynthetic process from pyruvate  regulation of cellular ketone metabolic process  regulation of glucose metabolic process  regulation of fatty acid biosynthetic process  glucose homeostasis  response to starvation  regulation of bone resorption  regulation of fatty acid oxidation  cellular response to fatty acid  reactive oxygen species metabolic process  xenophagy  negative regulation of anoikis  
Ontology : EGO-EBIpositive regulation of defense response to virus by host  protein kinase activity  pyruvate dehydrogenase (acetyl-transferring) kinase activity  pyruvate dehydrogenase (acetyl-transferring) kinase activity  ATP binding  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  glucose metabolic process  protein phosphorylation  protein phosphorylation  protein phosphorylation  protein phosphorylation  protein phosphorylation  regulation of pH  insulin receptor signaling pathway  cellular response to starvation  regulation of acetyl-CoA biosynthetic process from pyruvate  regulation of acetyl-CoA biosynthetic process from pyruvate  regulation of cellular ketone metabolic process  regulation of glucose metabolic process  regulation of fatty acid biosynthetic process  glucose homeostasis  response to starvation  regulation of bone resorption  regulation of fatty acid oxidation  cellular response to fatty acid  reactive oxygen species metabolic process  xenophagy  negative regulation of anoikis  
NDEx NetworkPDK4
Atlas of Cancer Signalling NetworkPDK4
Wikipedia pathwaysPDK4
Orthology - Evolution
OrthoDB5166
GeneTree (enSembl)ENSG00000004799
Phylogenetic Trees/Animal Genes : TreeFamPDK4
HOVERGENQ16654
HOGENOMQ16654
Homologs : HomoloGenePDK4
Homology/Alignments : Family Browser (UCSC)PDK4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDK4
dbVarPDK4
ClinVarPDK4
1000_GenomesPDK4 
Exome Variant ServerPDK4
ExAC (Exome Aggregation Consortium)PDK4 (select the gene name)
Genetic variants : HAPMAP5166
Genomic Variants (DGV)PDK4 [DGVbeta]
DECIPHER (Syndromes)7:95212809-95225925  ENSG00000004799
CONAN: Copy Number AnalysisPDK4 
Mutations
ICGC Data PortalPDK4 
TCGA Data PortalPDK4 
Broad Tumor PortalPDK4
OASIS PortalPDK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PDK4
DgiDB (Drug Gene Interaction Database)PDK4
DoCM (Curated mutations)PDK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDK4 (select a term)
intoGenPDK4
Cancer3DPDK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602527   
Orphanet
MedgenPDK4
Genetic Testing Registry PDK4
NextProtQ16654 [Medical]
TSGene5166
GENETestsPDK4
Huge Navigator PDK4 [HugePedia]
snp3D : Map Gene to Disease5166
BioCentury BCIQPDK4
ClinGenPDK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5166
Chemical/Pharm GKB GenePA33157
Clinical trialPDK4
Miscellaneous
canSAR (ICR)PDK4 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDK4
EVEXPDK4
GoPubMedPDK4
iHOPPDK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:20:53 CET 2017

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