Identity
HGNC
LOCATION
4q22.3
LOCUSID
ALIAS
ENH,ENH1,L9,LIM
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10611
MIM: 605904
HGNC: 17468
Ensembl: ENSG00000163110
Variants:
dbSNP: 10611
ClinVar: 10611
TCGA: ENSG00000163110
COSMIC: PDLIM5
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Neuronal System | REACTOME | R-HSA-112316 |
| Protein-protein interactions at synapses | REACTOME | R-HSA-6794362 |
| Interactions of neurexins and neuroligins at synapses | REACTOME | R-HSA-6794361 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34069539 | 2021 | Mechanical Sensing Element PDLIM5 Promotes Osteogenesis of Human Fibroblasts by Affecting the Activity of Microfilaments. | 4 |
| 34069539 | 2021 | Mechanical Sensing Element PDLIM5 Promotes Osteogenesis of Human Fibroblasts by Affecting the Activity of Microfilaments. | 4 |
| 31880413 | 2020 | Mutations in PDLIM5 are rare in dilated cardiomyopathy but are emerging as potential disease modifiers. | 9 |
| 32737199 | 2020 | PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells. | 18 |
| 31880413 | 2020 | Mutations in PDLIM5 are rare in dilated cardiomyopathy but are emerging as potential disease modifiers. | 9 |
| 32737199 | 2020 | PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells. | 18 |
| 31424159 | 2019 | Novel polymorphisms in PDLIM3 and PDLIM5 gene encoding Z-line proteins increase risk of idiopathic dilated cardiomyopathy. | 19 |
| 31424159 | 2019 | Novel polymorphisms in PDLIM3 and PDLIM5 gene encoding Z-line proteins increase risk of idiopathic dilated cardiomyopathy. | 19 |
| 29574154 | 2018 | PDLIM5 identified by label-free quantitative proteomics as a potential novel biomarker of papillary thyroid carcinoma. | 15 |
| 30404826 | 2018 | Enigma proteins regulate YAP mechanotransduction. | 29 |
| 29574154 | 2018 | PDLIM5 identified by label-free quantitative proteomics as a potential novel biomarker of papillary thyroid carcinoma. | 15 |
| 30404826 | 2018 | Enigma proteins regulate YAP mechanotransduction. | 29 |
| 27693979 | 2017 | Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension. | 8 |
| 28045035 | 2017 | PDLIM5 links kidney anion exchanger 1 (kAE1) to ILK and is required for membrane targeting of kAE1. | 5 |
| 28139119 | 2017 | Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms. | 10 |
Citation
Dessen P
PDLIM5 (PDZ and LIM domain 5)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41157/pdlim5
