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PDP1 (pyruvate dehyrogenase phosphatase catalytic subunit 1)

Identity

Other namesPDH
PDP
PDPC
PPM2A
PPM2C
HGNC (Hugo) PDP1
LocusID (NCBI) 54704
Atlas_Id 47314
Location 8q22.1  [Link to chromosome band 8q22]
Location_base_pair Starts at 94929175 and ends at 94938296 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PDP1 (8q22.1) / APPL1 (3p14.3)PDP1 (8q22.1) / ZNRD1-AS1 ()

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDP1   9279
Cards
Entrez_Gene (NCBI)PDP1  54704  pyruvate dehyrogenase phosphatase catalytic subunit 1
AliasesPDH; PDP; PDPC; PPM2A; 
PPM2C
GeneCards (Weizmann)PDP1
Ensembl hg19 (Hinxton)ENSG00000164951 [Gene_View]  chr8:94929175-94938296 [Contig_View]  PDP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164951 [Gene_View]  chr8:94929175-94938296 [Contig_View]  PDP1 [Vega]
ICGC DataPortalENSG00000164951
TCGA cBioPortalPDP1
AceView (NCBI)PDP1
Genatlas (Paris)PDP1
WikiGenes54704
SOURCE (Princeton)PDP1
Genomic and cartography
GoldenPath hg19 (UCSC)PDP1  -     chr8:94929175-94938296 +  8q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PDP1  -     8q22.1   [Description]    (hg38-Dec_2013)
EnsemblPDP1 - 8q22.1 [CytoView hg19]  PDP1 - 8q22.1 [CytoView hg38]
Mapping of homologs : NCBIPDP1 [Mapview hg19]  PDP1 [Mapview hg38]
OMIM605993   608782   
Gene and transcription
Genbank (Entrez)AF155661 AK022057 AK057079 AK126862 AK302651
RefSeq transcript (Entrez)NM_001161778 NM_001161779 NM_001161780 NM_001161781 NM_018444
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_012233 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)PDP1
Cluster EST : UnigeneHs.22265 [ NCBI ]
CGAP (NCI)Hs.22265
Alternative Splicing GalleryENSG00000164951
Gene ExpressionPDP1 [ NCBI-GEO ]   PDP1 [ EBI - ARRAY_EXPRESS ]   PDP1 [ SEEK ]   PDP1 [ MEM ]
Gene Expression Viewer (FireBrowse)PDP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54704
GTEX Portal (Tissue expression)PDP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P0J1 (Uniprot)
NextProtQ9P0J1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P0J1
Splice isoforms : SwissVarQ9P0J1 (Swissvar)
Catalytic activity : Enzyme3.1.3.43 [ Enzyme-Expasy ]   3.1.3.433.1.3.43 [ IntEnz-EBI ]   3.1.3.43 [ BRENDA ]   3.1.3.43 [ KEGG ]   
PhosPhoSitePlusQ9P0J1
Domaine pattern : Prosite (Expaxy)PPM_1 (PS01032)    PPM_2 (PS51746)   
Domains : Interpro (EBI)PP2C    PP2C_BS    PPM-type_phosphatase_dom   
Domain families : Pfam (Sanger)PP2C (PF00481)   
Domain families : Pfam (NCBI)pfam00481   
Domain families : Smart (EMBL)PP2C_SIG (SM00331)  PP2Cc (SM00332)  
DMDM Disease mutations54704
Blocks (Seattle)PDP1
SuperfamilyQ9P0J1
Human Protein AtlasENSG00000164951
Peptide AtlasQ9P0J1
HPRD16185
IPIIPI00218971   IPI00794806   IPI00977487   IPI00979563   IPI00980559   IPI00935529   IPI00980234   
Protein Interaction databases
DIP (DOE-UCLA)Q9P0J1
IntAct (EBI)Q9P0J1
FunCoupENSG00000164951
BioGRIDPDP1
STRING (EMBL)PDP1
ZODIACPDP1
Ontologies - Pathways
QuickGOQ9P0J1
Ontology : AmiGOmagnesium ion binding  protein serine/threonine phosphatase activity  magnesium-dependent protein serine/threonine phosphatase activity  [pyruvate dehydrogenase (lipoamide)] phosphatase activity  calcium ion binding  protein binding  mitochondrial matrix  regulation of acetyl-CoA biosynthetic process from pyruvate  protein complex binding  peptidyl-threonine dephosphorylation  
Ontology : EGO-EBImagnesium ion binding  protein serine/threonine phosphatase activity  magnesium-dependent protein serine/threonine phosphatase activity  [pyruvate dehydrogenase (lipoamide)] phosphatase activity  calcium ion binding  protein binding  mitochondrial matrix  regulation of acetyl-CoA biosynthetic process from pyruvate  protein complex binding  peptidyl-threonine dephosphorylation  
NDEx Network
Atlas of Cancer Signalling NetworkPDP1
Wikipedia pathwaysPDP1
Orthology - Evolution
OrthoDB54704
GeneTree (enSembl)ENSG00000164951
Phylogenetic Trees/Animal Genes : TreeFamPDP1
Homologs : HomoloGenePDP1
Homology/Alignments : Family Browser (UCSC)PDP1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPDP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDP1
dbVarPDP1
ClinVarPDP1
1000_GenomesPDP1 
Exome Variant ServerPDP1
ExAC (Exome Aggregation Consortium)PDP1 (select the gene name)
Genetic variants : HAPMAP54704
Genomic Variants (DGV)PDP1 [DGVbeta]
Mutations
ICGC Data PortalPDP1 
TCGA Data PortalPDP1 
Broad Tumor PortalPDP1
OASIS PortalPDP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDP1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PDP1
DgiDB (Drug Gene Interaction Database)PDP1
DoCM (Curated mutations)PDP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDP1 (select a term)
intoGenPDP1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:94929175-94938296  ENSG00000164951
CONAN: Copy Number AnalysisPDP1 
Mutations and Diseases : HGMDPDP1
OMIM605993    608782   
MedgenPDP1
Genetic Testing Registry PDP1
NextProtQ9P0J1 [Medical]
TSGene54704
GENETestsPDP1
Huge Navigator PDP1 [HugePedia]
snp3D : Map Gene to Disease54704
BioCentury BCIQPDP1
ClinGenPDP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54704
Chemical/Pharm GKB GenePA33607
Clinical trialPDP1
Miscellaneous
canSAR (ICR)PDP1 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDP1
EVEXPDP1
GoPubMedPDP1
iHOPPDP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:23:03 CEST 2016

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