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PDP1 (pyruvate dehyrogenase phosphatase catalytic subunit 1)

Identity

Other namesPDH
PDP
PDPC
PPM2C
HGNC (Hugo) PDP1
LocusID (NCBI) 54704
Location 8q22.1
Location_base_pair Starts at 94929175 and ends at 94938296 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)PDP1   9279
Cards
Entrez_Gene (NCBI)PDP1  54704  pyruvate dehyrogenase phosphatase catalytic subunit 1
GeneCards (Weizmann)PDP1
Ensembl hg19 (Hinxton)ENSG00000164951 [Gene_View]  chr8:94929175-94938296 [Contig_View]  PDP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164951 [Gene_View]  chr8:94929175-94938296 [Contig_View]  PDP1 [Vega]
ICGC DataPortalENSG00000164951
cBioPortalPDP1
AceView (NCBI)PDP1
Genatlas (Paris)PDP1
WikiGenes54704
SOURCE (Princeton)PDP1
Genomic and cartography
GoldenPath hg19 (UCSC)PDP1  -     chr8:94929175-94938296 +  8q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PDP1  -     8q22.1   [Description]    (hg38-Dec_2013)
EnsemblPDP1 - 8q22.1 [CytoView hg19]  PDP1 - 8q22.1 [CytoView hg38]
Mapping of homologs : NCBIPDP1 [Mapview hg19]  PDP1 [Mapview hg38]
OMIM605993   608782   
Gene and transcription
Genbank (Entrez)AF155661 AK022057 AK057079 AK126862 AK302651
RefSeq transcript (Entrez)NM_001161778 NM_001161779 NM_001161780 NM_001161781 NM_018444
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NG_012233 NT_008046 NW_001839136 NW_004929340
Consensus coding sequences : CCDS (NCBI)PDP1
Cluster EST : UnigeneHs.22265 [ NCBI ]
CGAP (NCI)Hs.22265
Alternative Splicing : Fast-db (Paris)GSHG0029144
Alternative Splicing GalleryENSG00000164951
Gene ExpressionPDP1 [ NCBI-GEO ]     PDP1 [ SEEK ]   PDP1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P0J1 (Uniprot)
NextProtQ9P0J1  [Medical]
With graphics : InterProQ9P0J1
Splice isoforms : SwissVarQ9P0J1 (Swissvar)
Catalytic activity : Enzyme3.1.3.43 [ Enzyme-Expasy ]   3.1.3.433.1.3.43 [ IntEnz-EBI ]   3.1.3.43 [ BRENDA ]   3.1.3.43 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PP2C (PS01032)   
Domains : Interpro (EBI)PP2C-like_dom    PP2C_Mn2_Asp60_BS    Protein_Pase_2C   
Related proteins : CluSTrQ9P0J1
Domain families : Pfam (Sanger)PP2C (PF00481)   
Domain families : Pfam (NCBI)pfam00481   
Domain families : Smart (EMBL)PP2C_SIG (SM00331)  PP2Cc (SM00332)  
DMDM Disease mutations54704
Blocks (Seattle)Q9P0J1
Human Protein AtlasENSG00000164951
Peptide AtlasQ9P0J1
HPRD16185
IPIIPI00218971   IPI00794806   IPI00977487   IPI00979563   IPI00980559   IPI00935529   IPI00980234   
Protein Interaction databases
DIP (DOE-UCLA)Q9P0J1
IntAct (EBI)Q9P0J1
FunCoupENSG00000164951
BioGRIDPDP1
IntegromeDBPDP1
STRING (EMBL)PDP1
Ontologies - Pathways
QuickGOQ9P0J1
Ontology : AmiGOprotein serine/threonine phosphatase activity  [pyruvate dehydrogenase (lipoamide)] phosphatase activity  mitochondrial matrix  pyruvate metabolic process  regulation of acetyl-CoA biosynthetic process from pyruvate  peptidyl-threonine dephosphorylation  cellular metabolic process  small molecule metabolic process  metal ion binding  
Ontology : EGO-EBIprotein serine/threonine phosphatase activity  [pyruvate dehydrogenase (lipoamide)] phosphatase activity  mitochondrial matrix  pyruvate metabolic process  regulation of acetyl-CoA biosynthetic process from pyruvate  peptidyl-threonine dephosphorylation  cellular metabolic process  small molecule metabolic process  metal ion binding  
Protein Interaction DatabasePDP1
DoCM (Curated mutations)PDP1
Wikipedia pathwaysPDP1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPDP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDP1
dbVarPDP1
ClinVarPDP1
1000_GenomesPDP1 
Exome Variant ServerPDP1
SNP (GeneSNP Utah)PDP1
SNP : HGBasePDP1
Genetic variants : HAPMAPPDP1
Genomic VariantsPDP1  PDP1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000164951 
Somatic Mutations in Cancer : COSMICPDP1 
CONAN: Copy Number AnalysisPDP1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:94929175-94938296
Mutations and Diseases : HGMDPDP1
OMIM605993    608782   
MedgenPDP1
NextProtQ9P0J1 [Medical]
GENETestsPDP1
Disease Genetic AssociationPDP1
Huge Navigator PDP1 [HugePedia]  PDP1 [HugeCancerGEM]
snp3D : Map Gene to Disease54704
DGIdb (Drug Gene Interaction db)PDP1
General knowledge
Homologs : HomoloGenePDP1
Homology/Alignments : Family Browser (UCSC)PDP1
Phylogenetic Trees/Animal Genes : TreeFamPDP1
Chemical/Protein Interactions : CTD54704
Chemical/Pharm GKB GenePA33607
Clinical trialPDP1
Cancer Resource (Charite)ENSG00000164951
Other databases
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
CoreMinePDP1
GoPubMedPDP1
iHOPPDP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 00:46:38 CET 2014

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