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PDPK1 (3-phosphoinositide dependent protein kinase 1)

Identity

Other namesPDK1
PDPK2
PRO0461
HGNC (Hugo) PDPK1
LocusID (NCBI) 5170
Location 16p13.3
Location_base_pair Starts at 2587965 and ends at 2653191 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PDPK1   8816
Cards
Entrez_Gene (NCBI)PDPK1  5170  3-phosphoinositide dependent protein kinase 1
GeneCards (Weizmann)PDPK1
Ensembl (Hinxton)ENSG00000140992 [Gene_View]  chr16:2587965-2653191 [Contig_View]  PDPK1 [Vega]
ICGC DataPortalENSG00000140992
cBioPortalPDPK1
AceView (NCBI)PDPK1
Genatlas (Paris)PDPK1
WikiGenes5170
SOURCE (Princeton)NM_001261816 NM_002613 NM_031268
Genomic and cartography
GoldenPath (UCSC)PDPK1  -  16p13.3   chr16:2587965-2653191 +  16p13.3   [Description]    (hg19-Feb_2009)
EnsemblPDPK1 - 16p13.3 [CytoView]
Mapping of homologs : NCBIPDPK1 [Mapview]
OMIM605213   
Gene and transcription
Genbank (Entrez)AB209835 AF017995 AF111845 AJ785968 AK095507
RefSeq transcript (Entrez)NM_001261816 NM_002613 NM_031268
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NT_010393 NW_001838339 NW_004929400
Consensus coding sequences : CCDS (NCBI)PDPK1
Cluster EST : UnigeneHs.459691 [ NCBI ]
CGAP (NCI)Hs.459691
Alternative Splicing : Fast-db (Paris)GSHG0032590
Alternative Splicing GalleryENSG00000140992
Gene ExpressionPDPK1 [ NCBI-GEO ]     PDPK1 [ SEEK ]   PDPK1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15530 (Uniprot)
NextProtO15530  [Medical]
With graphics : InterProO15530
Splice isoforms : SwissVarO15530 (Swissvar)
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom [organisation]   PH_like_dom [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser/Thr_dual-sp_kinase_dom [organisation]   Ser/Thr_kinase_AS [organisation]  
Related proteins : CluSTrO15530
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations5170
Blocks (Seattle)O15530
PDB (SRS)1H1W    1OKY    1OKZ    1UU3    1UU7    1UU8    1UU9    1UVR    1W1D    1W1G    1W1H    1Z5M    2BIY    2PE0    2PE1    2PE2    2R7B    2VKI    2XCH    2XCK    3H9O    3HRC    3HRF    3ION    3IOP    3NAX    3NAY    3NUN    3NUS    3NUU    3NUY    3ORX    3ORZ    3OTU    3PWY    3QC4    3QCQ    3QCS    3QCX    3QCY    3QD0    3QD3    3QD4    3RCJ    3RWP    3RWQ    3SC1    4A06    4A07    4AW0    4AW1   
PDB (PDBSum)1H1W    1OKY    1OKZ    1UU3    1UU7    1UU8    1UU9    1UVR    1W1D    1W1G    1W1H    1Z5M    2BIY    2PE0    2PE1    2PE2    2R7B    2VKI    2XCH    2XCK    3H9O    3HRC    3HRF    3ION    3IOP    3NAX    3NAY    3NUN    3NUS    3NUU    3NUY    3ORX    3ORZ    3OTU    3PWY    3QC4    3QCQ    3QCS    3QCX    3QCY    3QD0    3QD3    3QD4    3RCJ    3RWP    3RWQ    3SC1    4A06    4A07    4AW0    4AW1   
PDB (IMB)1H1W    1OKY    1OKZ    1UU3    1UU7    1UU8    1UU9    1UVR    1W1D    1W1G    1W1H    1Z5M    2BIY    2PE0    2PE1    2PE2    2R7B    2VKI    2XCH    2XCK    3H9O    3HRC    3HRF    3ION    3IOP    3NAX    3NAY    3NUN    3NUS    3NUU    3NUY    3ORX    3ORZ    3OTU    3PWY    3QC4    3QCQ    3QCS    3QCX    3QCY    3QD0    3QD3    3QD4    3RCJ    3RWP    3RWQ    3SC1    4A06    4A07    4AW0    4AW1   
PDB (RSDB)1H1W    1OKY    1OKZ    1UU3    1UU7    1UU8    1UU9    1UVR    1W1D    1W1G    1W1H    1Z5M    2BIY    2PE0    2PE1    2PE2    2R7B    2VKI    2XCH    2XCK    3H9O    3HRC    3HRF    3ION    3IOP    3NAX    3NAY    3NUN    3NUS    3NUU    3NUY    3ORX    3ORZ    3OTU    3PWY    3QC4    3QCQ    3QCS    3QCX    3QCY    3QD0    3QD3    3QD4    3RCJ    3RWP    3RWQ    3SC1    4A06    4A07    4AW0    4AW1   
Human Protein AtlasENSG00000140992 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO15530
HPRD05556
IPIIPI00002538   IPI00216647   IPI00005991   IPI00478389   IPI01012207   IPI00867720   IPI00216877   IPI00216646   
Protein Interaction databases
DIP (DOE-UCLA)O15530
IntAct (EBI)O15530
FunCoupENSG00000140992
BioGRIDPDPK1
InParanoidO15530
Interologous Interaction database O15530
IntegromeDBPDPK1
STRING (EMBL)PDPK1
Ontologies - Pathways
Ontology : AmiGOtype B pancreatic cell development  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  3-phosphoinositide-dependent protein kinase activity  insulin receptor binding  protein binding  ATP binding  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  plasma membrane  focal adhesion  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  protein phosphorylation  negative regulation of protein kinase activity  hyperosmotic response  epidermal growth factor receptor signaling pathway  epidermal growth factor receptor signaling pathway  synaptic transmission  blood coagulation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  positive regulation of phospholipase activity  regulation of endothelial cell migration  negative regulation of cardiac muscle cell apoptotic process  phospholipase activator activity  membrane  cytoplasmic membrane-bounded vesicle  kinase activity  cell migration  peptidyl-threonine phosphorylation  calcium-mediated signaling  protein kinase binding  actin cytoskeleton organization  platelet activation  negative regulation of transforming growth factor beta receptor signaling pathway  T cell costimulation  activation of protein kinase B activity  cellular response to insulin stimulus  negative regulation of toll-like receptor signaling pathway  intracellular signal transduction  Fc-epsilon receptor signaling pathway  cell projection  regulation of I-kappaB kinase/NF-kappaB signaling  phospholipase binding  regulation of mast cell degranulation  innate immune response  protein autophosphorylation  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  focal adhesion assembly  T cell receptor signaling pathway  positive regulation of release of sequestered calcium ion into cytosol  cellular response to epidermal growth factor stimulus  positive regulation of establishment of protein localization to plasma membrane  extrinsic apoptotic signaling pathway  
Ontology : EGO-EBItype B pancreatic cell development  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  3-phosphoinositide-dependent protein kinase activity  insulin receptor binding  protein binding  ATP binding  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  plasma membrane  focal adhesion  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  protein phosphorylation  negative regulation of protein kinase activity  hyperosmotic response  epidermal growth factor receptor signaling pathway  epidermal growth factor receptor signaling pathway  synaptic transmission  blood coagulation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  positive regulation of phospholipase activity  regulation of endothelial cell migration  negative regulation of cardiac muscle cell apoptotic process  phospholipase activator activity  membrane  cytoplasmic membrane-bounded vesicle  kinase activity  cell migration  peptidyl-threonine phosphorylation  calcium-mediated signaling  protein kinase binding  actin cytoskeleton organization  platelet activation  negative regulation of transforming growth factor beta receptor signaling pathway  T cell costimulation  activation of protein kinase B activity  cellular response to insulin stimulus  negative regulation of toll-like receptor signaling pathway  intracellular signal transduction  Fc-epsilon receptor signaling pathway  cell projection  regulation of I-kappaB kinase/NF-kappaB signaling  phospholipase binding  regulation of mast cell degranulation  innate immune response  protein autophosphorylation  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  focal adhesion assembly  T cell receptor signaling pathway  positive regulation of release of sequestered calcium ion into cytosol  cellular response to epidermal growth factor stimulus  positive regulation of establishment of protein localization to plasma membrane  extrinsic apoptotic signaling pathway  
Pathways : BIOCARTARegulation of eIF4e and p70 S6 Kinase [Genes]    mTOR Signaling Pathway [Genes]    Phosphoinositides and their downstream targets. [Genes]    Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway [Genes]    Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages [Genes]    PTEN dependent cell cycle arrest and apoptosis [Genes]    AKT Signaling Pathway [Genes]   
Pathways : KEGGPPAR signaling pathway    FoxO signaling pathway    mTOR signaling pathway    PI3K-Akt signaling pathway    Focal adhesion    T cell receptor signaling pathway    Fc epsilon RI signaling pathway    Neurotrophin signaling pathway    Insulin signaling pathway    Thyroid hormone signaling pathway    Aldosterone-regulated sodium reabsorption    Toxoplasmosis    Hepatitis C    Proteoglycans in cancer    Endometrial cancer    Prostate cancer    Non-small cell lung cancer   
Protein Interaction DatabasePDPK1
Wikipedia pathwaysPDPK1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PDPK1
snp3D : Map Gene to Disease5170
SNP (GeneSNP Utah)PDPK1
SNP : HGBasePDPK1
Genetic variants : HAPMAPPDPK1
Exome VariantPDPK1
1000_GenomesPDPK1 
ICGC programENSG00000140992 
Somatic Mutations in Cancer : COSMICPDPK1 
CONAN: Copy Number AnalysisPDPK1 
Mutations and Diseases : HGMDPDPK1
Mutations and Diseases : intOGenPDPK1
Genomic VariantsPDPK1  PDPK1 [DGVbeta]
dbVarPDPK1
ClinVarPDPK1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM605213   
MedgenPDPK1
GENETestsPDPK1
Disease Genetic AssociationPDPK1
Huge Navigator PDPK1 [HugePedia]  PDPK1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePDPK1
Homology/Alignments : Family Browser (UCSC)PDPK1
Phylogenetic Trees/Animal Genes : TreeFamPDPK1
Chemical/Protein Interactions : CTD5170
Chemical/Pharm GKB GenePA33160
Clinical trialPDPK1
Cancer Resource (Charite)ENSG00000140992
Other databases
Probes
Litterature
PubMed165 Pubmed reference(s) in Entrez
CoreMinePDPK1
iHOPPDPK1
OncoSearchPDPK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:59:19 CEST 2014

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