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PDPK1 (3-phosphoinositide dependent protein kinase 1)

Identity

Other namesPDK1
PDPK2
PDPK2P
PRO0461
HGNC (Hugo) PDPK1
LocusID (NCBI) 5170
Atlas_Id 41686
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 2587965 and ends at 2653191 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DHRS2 (14q11.2) / PDPK1 (16p13.3)PDPK1 (16p13.3) / CCNF (16p13.3)PDPK1 (16p13.3) / CNTNAP1 (17q21.2)
PDPK1 (16p13.3) / SFTPC (8p21.3)PDPK1 (16p13.3) / VPS28 (8q24.3)PDPK1 16p13.3 / CCNF 16p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDPK1   8816
Cards
Entrez_Gene (NCBI)PDPK1  5170  3-phosphoinositide dependent protein kinase 1
AliasesPDK1; PDPK2; PDPK2P; PRO0461
GeneCards (Weizmann)PDPK1
Ensembl hg19 (Hinxton)ENSG00000140992 [Gene_View]  chr16:2587965-2653191 [Contig_View]  PDPK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000140992 [Gene_View]  chr16:2587965-2653191 [Contig_View]  PDPK1 [Vega]
ICGC DataPortalENSG00000140992
TCGA cBioPortalPDPK1
AceView (NCBI)PDPK1
Genatlas (Paris)PDPK1
WikiGenes5170
SOURCE (Princeton)PDPK1
Genomic and cartography
GoldenPath hg19 (UCSC)PDPK1  -     chr16:2587965-2653191 +  16p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PDPK1  -     16p13.3   [Description]    (hg38-Dec_2013)
EnsemblPDPK1 - 16p13.3 [CytoView hg19]  PDPK1 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIPDPK1 [Mapview hg19]  PDPK1 [Mapview hg38]
OMIM605213   
Gene and transcription
Genbank (Entrez)AB209835 AF017995 AF111845 AJ785968 AK095507
RefSeq transcript (Entrez)NM_001261816 NM_002613 NM_031268
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010393 NW_004929400
Consensus coding sequences : CCDS (NCBI)PDPK1
Cluster EST : UnigeneHs.459691 [ NCBI ]
CGAP (NCI)Hs.459691
Alternative Splicing GalleryENSG00000140992
Gene ExpressionPDPK1 [ NCBI-GEO ]   PDPK1 [ EBI - ARRAY_EXPRESS ]   PDPK1 [ SEEK ]   PDPK1 [ MEM ]
Gene Expression Viewer (FireBrowse)PDPK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5170
GTEX Portal (Tissue expression)PDPK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15530 (Uniprot)
NextProtO15530  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15530
Splice isoforms : SwissVarO15530 (Swissvar)
PhosPhoSitePlusO15530
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    PH_dom-like    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations5170
Blocks (Seattle)PDPK1
PDB (SRS)1H1W    1OKY    1OKZ    1UU3    1UU7    1UU8    1UU9    1UVR    1W1D    1W1G    1W1H    1Z5M    2BIY    2PE0    2PE1    2PE2    2R7B    2VKI    2XCH    2XCK    3H9O    3HRC    3HRF    3ION    3IOP    3NAX    3NAY    3NUN    3NUS    3NUU    3NUY    3ORX    3ORZ    3OTU    3PWY    3QC4    3QCQ    3QCS    3QCX    3QCY    3QD0    3QD3    3QD4    3RCJ    3RWP    3RWQ    3SC1    4A06    4A07    4AW0    4AW1    4CT1    4CT2    4RQK    4RQV    4RRV    4XX9    5ACK   
PDB (PDBSum)1H1W    1OKY    1OKZ    1UU3    1UU7    1UU8    1UU9    1UVR    1W1D    1W1G    1W1H    1Z5M    2BIY    2PE0    2PE1    2PE2    2R7B    2VKI    2XCH    2XCK    3H9O    3HRC    3HRF    3ION    3IOP    3NAX    3NAY    3NUN    3NUS    3NUU    3NUY    3ORX    3ORZ    3OTU    3PWY    3QC4    3QCQ    3QCS    3QCX    3QCY    3QD0    3QD3    3QD4    3RCJ    3RWP    3RWQ    3SC1    4A06    4A07    4AW0    4AW1    4CT1    4CT2    4RQK    4RQV    4RRV    4XX9    5ACK   
PDB (IMB)1H1W    1OKY    1OKZ    1UU3    1UU7    1UU8    1UU9    1UVR    1W1D    1W1G    1W1H    1Z5M    2BIY    2PE0    2PE1    2PE2    2R7B    2VKI    2XCH    2XCK    3H9O    3HRC    3HRF    3ION    3IOP    3NAX    3NAY    3NUN    3NUS    3NUU    3NUY    3ORX    3ORZ    3OTU    3PWY    3QC4    3QCQ    3QCS    3QCX    3QCY    3QD0    3QD3    3QD4    3RCJ    3RWP    3RWQ    3SC1    4A06    4A07    4AW0    4AW1    4CT1    4CT2    4RQK    4RQV    4RRV    4XX9    5ACK   
PDB (RSDB)1H1W    1OKY    1OKZ    1UU3    1UU7    1UU8    1UU9    1UVR    1W1D    1W1G    1W1H    1Z5M    2BIY    2PE0    2PE1    2PE2    2R7B    2VKI    2XCH    2XCK    3H9O    3HRC    3HRF    3ION    3IOP    3NAX    3NAY    3NUN    3NUS    3NUU    3NUY    3ORX    3ORZ    3OTU    3PWY    3QC4    3QCQ    3QCS    3QCX    3QCY    3QD0    3QD3    3QD4    3RCJ    3RWP    3RWQ    3SC1    4A06    4A07    4AW0    4AW1    4CT1    4CT2    4RQK    4RQV    4RRV    4XX9    5ACK   
Structural Biology KnowledgeBase1H1W    1OKY    1OKZ    1UU3    1UU7    1UU8    1UU9    1UVR    1W1D    1W1G    1W1H    1Z5M    2BIY    2PE0    2PE1    2PE2    2R7B    2VKI    2XCH    2XCK    3H9O    3HRC    3HRF    3ION    3IOP    3NAX    3NAY    3NUN    3NUS    3NUU    3NUY    3ORX    3ORZ    3OTU    3PWY    3QC4    3QCQ    3QCS    3QCX    3QCY    3QD0    3QD3    3QD4    3RCJ    3RWP    3RWQ    3SC1    4A06    4A07    4AW0    4AW1    4CT1    4CT2    4RQK    4RQV    4RRV    4XX9    5ACK   
SCOP (Structural Classification of Proteins)1H1W    1OKY    1OKZ    1UU3    1UU7    1UU8    1UU9    1UVR    1W1D    1W1G    1W1H    1Z5M    2BIY    2PE0    2PE1    2PE2    2R7B    2VKI    2XCH    2XCK    3H9O    3HRC    3HRF    3ION    3IOP    3NAX    3NAY    3NUN    3NUS    3NUU    3NUY    3ORX    3ORZ    3OTU    3PWY    3QC4    3QCQ    3QCS    3QCX    3QCY    3QD0    3QD3    3QD4    3RCJ    3RWP    3RWQ    3SC1    4A06    4A07    4AW0    4AW1    4CT1    4CT2    4RQK    4RQV    4RRV    4XX9    5ACK   
CATH (Classification of proteins structures)1H1W    1OKY    1OKZ    1UU3    1UU7    1UU8    1UU9    1UVR    1W1D    1W1G    1W1H    1Z5M    2BIY    2PE0    2PE1    2PE2    2R7B    2VKI    2XCH    2XCK    3H9O    3HRC    3HRF    3ION    3IOP    3NAX    3NAY    3NUN    3NUS    3NUU    3NUY    3ORX    3ORZ    3OTU    3PWY    3QC4    3QCQ    3QCS    3QCX    3QCY    3QD0    3QD3    3QD4    3RCJ    3RWP    3RWQ    3SC1    4A06    4A07    4AW0    4AW1    4CT1    4CT2    4RQK    4RQV    4RRV    4XX9    5ACK   
SuperfamilyO15530
Human Protein AtlasENSG00000140992
Peptide AtlasO15530
HPRD05556
IPIIPI00002538   IPI00216647   IPI00005991   IPI00478389   IPI01012207   IPI00867720   IPI00216877   IPI00216646   
Protein Interaction databases
DIP (DOE-UCLA)O15530
IntAct (EBI)O15530
FunCoupENSG00000140992
BioGRIDPDPK1
STRING (EMBL)PDPK1
ZODIACPDPK1
Ontologies - Pathways
QuickGOO15530
Ontology : AmiGOstimulatory C-type lectin receptor signaling pathway  type B pancreatic cell development  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  3-phosphoinositide-dependent protein kinase activity  insulin receptor binding  protein binding  ATP binding  intracellular  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  plasma membrane  focal adhesion  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  negative regulation of protein kinase activity  hyperosmotic response  epidermal growth factor receptor signaling pathway  positive regulation of phospholipase activity  regulation of endothelial cell migration  negative regulation of cardiac muscle cell apoptotic process  phospholipase activator activity  membrane  cytoplasmic, membrane-bounded vesicle  kinase activity  cell migration  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  calcium-mediated signaling  protein kinase binding  actin cytoskeleton organization  platelet activation  negative regulation of transforming growth factor beta receptor signaling pathway  T cell costimulation  activation of protein kinase B activity  cellular response to insulin stimulus  negative regulation of toll-like receptor signaling pathway  intracellular signal transduction  intracellular signal transduction  Fc-epsilon receptor signaling pathway  cell projection  regulation of I-kappaB kinase/NF-kappaB signaling  phospholipase binding  regulation of mast cell degranulation  protein autophosphorylation  phosphatidylinositol-mediated signaling  focal adhesion assembly  T cell receptor signaling pathway  positive regulation of release of sequestered calcium ion into cytosol  cellular response to epidermal growth factor stimulus  positive regulation of establishment of protein localization to plasma membrane  extrinsic apoptotic signaling pathway  neuronal postsynaptic density  
Ontology : EGO-EBIstimulatory C-type lectin receptor signaling pathway  type B pancreatic cell development  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  3-phosphoinositide-dependent protein kinase activity  insulin receptor binding  protein binding  ATP binding  intracellular  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  plasma membrane  focal adhesion  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  negative regulation of protein kinase activity  hyperosmotic response  epidermal growth factor receptor signaling pathway  positive regulation of phospholipase activity  regulation of endothelial cell migration  negative regulation of cardiac muscle cell apoptotic process  phospholipase activator activity  membrane  cytoplasmic, membrane-bounded vesicle  kinase activity  cell migration  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  calcium-mediated signaling  protein kinase binding  actin cytoskeleton organization  platelet activation  negative regulation of transforming growth factor beta receptor signaling pathway  T cell costimulation  activation of protein kinase B activity  cellular response to insulin stimulus  negative regulation of toll-like receptor signaling pathway  intracellular signal transduction  intracellular signal transduction  Fc-epsilon receptor signaling pathway  cell projection  regulation of I-kappaB kinase/NF-kappaB signaling  phospholipase binding  regulation of mast cell degranulation  protein autophosphorylation  phosphatidylinositol-mediated signaling  focal adhesion assembly  T cell receptor signaling pathway  positive regulation of release of sequestered calcium ion into cytosol  cellular response to epidermal growth factor stimulus  positive regulation of establishment of protein localization to plasma membrane  extrinsic apoptotic signaling pathway  neuronal postsynaptic density  
Pathways : BIOCARTARegulation of eIF4e and p70 S6 Kinase [Genes]    mTOR Signaling Pathway [Genes]    Phosphoinositides and their downstream targets. [Genes]    Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway [Genes]    Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages [Genes]    PTEN dependent cell cycle arrest and apoptosis [Genes]    AKT Signaling Pathway [Genes]   
Pathways : KEGGPPAR signaling pathway    FoxO signaling pathway    mTOR signaling pathway    PI3K-Akt signaling pathway    Focal adhesion    T cell receptor signaling pathway    Fc epsilon RI signaling pathway    Neurotrophin signaling pathway    Insulin signaling pathway    Thyroid hormone signaling pathway    Aldosterone-regulated sodium reabsorption    Toxoplasmosis    Hepatitis C    Proteoglycans in cancer    Endometrial cancer    Prostate cancer    Non-small cell lung cancer   
NDEx Network
Atlas of Cancer Signalling NetworkPDPK1
Wikipedia pathwaysPDPK1
Orthology - Evolution
OrthoDB5170
GeneTree (enSembl)ENSG00000140992
Phylogenetic Trees/Animal Genes : TreeFamPDPK1
Homologs : HomoloGenePDPK1
Homology/Alignments : Family Browser (UCSC)PDPK1
Gene fusions - Rearrangements
Fusion: TCGAPDPK1 16p13.3 CCNF 16p13.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerPDPK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDPK1
dbVarPDPK1
ClinVarPDPK1
1000_GenomesPDPK1 
Exome Variant ServerPDPK1
ExAC (Exome Aggregation Consortium)PDPK1 (select the gene name)
Genetic variants : HAPMAP5170
Genomic Variants (DGV)PDPK1 [DGVbeta]
Mutations
ICGC Data PortalPDPK1 
TCGA Data PortalPDPK1 
Broad Tumor PortalPDPK1
OASIS PortalPDPK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDPK1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDPK1
DgiDB (Drug Gene Interaction Database)PDPK1
DoCM (Curated mutations)PDPK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDPK1 (select a term)
intoGenPDPK1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)16:2587965-2653191  ENSG00000140992
CONAN: Copy Number AnalysisPDPK1 
Mutations and Diseases : HGMDPDPK1
OMIM605213   
MedgenPDPK1
Genetic Testing Registry PDPK1
NextProtO15530 [Medical]
TSGene5170
GENETestsPDPK1
Huge Navigator PDPK1 [HugePedia]
snp3D : Map Gene to Disease5170
BioCentury BCIQPDPK1
ClinGenPDPK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5170
Chemical/Pharm GKB GenePA33160
Clinical trialPDPK1
Miscellaneous
canSAR (ICR)PDPK1 (select the gene name)
Probes
Litterature
PubMed195 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDPK1
EVEXPDPK1
GoPubMedPDPK1
iHOPPDPK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:06:55 CEST 2016

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