PDS5B (PDS5 cohesin associated factor B)

2003-02-01  

Identity

HGNC
LOCATION
13q13.1
LOCUSID
ALIAS
APRIN,AS3,CG008
FUSION GENES

Other Information

Locus ID:

NCBI: 23047
MIM: 605333
HGNC: 20418
Ensembl: ENSG00000083642

Variants:

dbSNP: 23047
ClinVar: 23047
TCGA: ENSG00000083642
COSMIC: PDS5B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000083642ENST00000315596Q9NTI5
ENSG00000083642ENST00000447833A9IYQ1
ENSG00000083642ENST00000450460Q9NTI5

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Establishment of Sister Chromatid CohesionREACTOMER-HSA-2468052
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Mitotic Telophase/CytokinesisREACTOMER-HSA-68884
Cohesin Loading onto ChromatinREACTOMER-HSA-2470946

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
292175912017Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.92
269714922016Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics.44
194125482009Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.36
222937512012APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.26
283439652017The N-Terminal Non-Kinase-Domain-Mediated Binding of Haspin to Pds5B Protects Centromeric Cohesion in Mitosis.19
275497422016Topology and structure of an engineered human cohesin complex bound to Pds5B.17
296793392018Long non-coding RNA (lncRNA) MAGI2-AS3 inhibits breast cancer cell growth by targeting the Fas/FasL signalling pathway.17
279240112016Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction.14
283439692017Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.14
238504942013Frameshift mutations of chromosome cohesion-related genes SGOL1 and PDS5B in gastric and colorectal cancers with high microsatellite instability.12

Citation

Dessen P

PDS5B (PDS5 cohesin associated factor B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/681/pds5b