PDX1 (pancreatic and duodenal homeobox 1)

Identity

Other names	GSF
	IDX-1
	IPF1
	IUF1
	MODY4
	PDX-1
	STF-1
HGNC	PDX1
Location	13q12.1
Location_base_pair	Starts at 27392168 and ends at 27398451 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

External links

	Nomenclature
HGNC	PDX1   6107
Entrez_Gene	PDX1  3651  pancreatic and duodenal homeobox 1
	Cards
GeneCards	PDX1
Ensembl	PDX1 [Search_View]   ENSG00000139515 [Gene_View]
Genatlas	PDX1
GeneLynx	PDX1
eGenome	PDX1
euGene	3651
	Genomic and cartography
GoldenPath	PDX1  -  13q12.1   chr13:27392168-27398451 +  13q12.2   [Description]    (hg18-March_2006)
Ensembl	PDX1 - 13q12.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PDX1
	Gene and transcription
Genbank	AF049893 [ ENTREZ ]
Genbank	BC111592 [ ENTREZ ]
Genbank	CA771381 [ ENTREZ ]
Genbank	CA848737 [ ENTREZ ]
Genbank	U30329 [ ENTREZ ]
RefSeq	NM_000209 [ SRS ]    NM_000209 [ ENTREZ ]
RefSeq	AC_000056 [ SRS ]    AC_000056 [ ENTREZ ]
RefSeq	AC_000145 [ SRS ]    AC_000145 [ ENTREZ ]
RefSeq	NC_000013 [ SRS ]    NC_000013 [ ENTREZ ]
RefSeq	NG_008183 [ SRS ]    NG_008183 [ ENTREZ ]
RefSeq	NT_024524 [ SRS ]    NT_024524 [ ENTREZ ]
RefSeq	NW_001838071 [ SRS ]    NW_001838071 [ ENTREZ ]
RefSeq	NW_925473 [ SRS ]    NW_925473 [ ENTREZ ]
AceView	PDX1 AceView - NCBI
Unigene	Hs.32938 [ SRS ]    Hs.32938 [ NCBI ]     HS32938 [ spliceNest ]
Fast-db	1907 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P52945 [ SRS]    P52945 [ EXPASY ]     P52945 [ INTERPRO ]     P52945 [ UNIPROT ]
Prosite	PS00032 ANTENNAPEDIA [ SRS ]    PS00032 ANTENNAPEDIA [ Expasy ]
Prosite	PS00027 HOMEOBOX_1 [ SRS ]    PS00027 HOMEOBOX_1 [ Expasy ]
Prosite	PS50071 HOMEOBOX_2 [ SRS ]    PS50071 HOMEOBOX_2 [ Expasy ]
Interpro	IPR001827 Antennapedia [ SRS ]    IPR001827 Antennapedia [ EBI ]
Interpro	IPR001356 Homeobox [ SRS ]    IPR001356 Homeobox [ EBI ]
Interpro	IPR012287 Homeodomain-rel [ SRS ]    IPR012287 Homeodomain-rel [ EBI ]
Interpro	IPR000047 HTH_lambrepressr [ SRS ]    IPR000047 HTH_lambrepressr [ EBI ]
CluSTr	P52945
Pfam	PF00046 Homeobox [ SRS ]    PF00046 Homeobox [ Sanger ]    pfam00046 [ NCBI-CDD ]
Smart	SM00389 HOX [EMBL]
Prodom	PD000010 Homeobox[INRA-Toulouse]
Prodom	P52945 PDX1_HUMAN [ Domain structure ]   P52945 PDX1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P52945
HPRD	02843
	Protein Interaction databases
DIP	P52945
IntAct	P52945
	Polymorphism : SNP, mutations, diseases
OMIM	125853;260370;600733    [ map ]
GENECLINICS	125853;260370;600733
SNP	PDX1 [dbSNP-NCBI]
SNP	NM_000209 [SNP-NCI]
SNP	PDX1 [GeneSNPs - Utah]  PDX1] [HGBASE - SRS]
HAPMAP	PDX1 [HAPMAP]
HGMD	PDX1
	General knowledge
Family Browser	PDX1 [UCSC Family Browser]
SOURCE	NM_000209
SMD	Hs.32938
SAGE	Hs.32938
GO	transcription factor activity [Amigo]  transcription factor activity
GO	specific RNA polymerase II transcription factor activity [Amigo]  specific RNA polymerase II transcription factor activity
GO	nucleus [Amigo]  nucleus
GO	glucose metabolic process [Amigo]  glucose metabolic process
GO	generation of precursor metabolites and energy [Amigo]  generation of precursor metabolites and energy
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	nitric oxide mediated signal transduction [Amigo]  nitric oxide mediated signal transduction
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	organ morphogenesis [Amigo]  organ morphogenesis
GO	transcription activator activity [Amigo]  transcription activator activity
GO	insulin secretion [Amigo]  insulin secretion
GO	cell differentiation [Amigo]  cell differentiation
GO	pancreas development [Amigo]  pancreas development
GO	regulation of cell proliferation [Amigo]  regulation of cell proliferation
GO	sequence-specific DNA binding [Amigo]  sequence-specific DNA binding
GO	positive regulation of transcription from RNA polymerase II promoter [Amigo]  positive regulation of transcription from RNA polymerase II promoter
KEGG	Type II diabetes mellitus
KEGG	Maturity onset diabetes of the young
PubGene	PDX1
TreeFam	PDX1
CTD	3651 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PDX1 Related clones (RZPD - Berlin)
	PubMed
PubMed	68 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:25:14 2008