Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PDYN (prodynorphin)

Identity

Alias_namesSCA23
spinocerebellar ataxia 23
Alias_symbol (synonym)PENKB
ADCA
Other alias
HGNC (Hugo) PDYN
LocusID (NCBI) 5173
Atlas_Id 45605
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 1978756 and ends at 1994285 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDYN   8820
LRG (Locus Reference Genomic)LRG_667
Cards
Entrez_Gene (NCBI)PDYN  5173  prodynorphin
AliasesADCA; PENKB; SCA23
GeneCards (Weizmann)PDYN
Ensembl hg19 (Hinxton)ENSG00000101327 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101327 [Gene_View]  ENSG00000101327 [Sequence]  chr20:1978756-1994285 [Contig_View]  PDYN [Vega]
ICGC DataPortalENSG00000101327
TCGA cBioPortalPDYN
AceView (NCBI)PDYN
Genatlas (Paris)PDYN
WikiGenes5173
SOURCE (Princeton)PDYN
Genetics Home Reference (NIH)PDYN
Genomic and cartography
GoldenPath hg38 (UCSC)PDYN  -     chr20:1978756-1994285 -  20p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDYN  -     20p13   [Description]    (hg19-Feb_2009)
EnsemblPDYN - 20p13 [CytoView hg19]  PDYN - 20p13 [CytoView hg38]
Mapping of homologs : NCBIPDYN [Mapview hg19]  PDYN [Mapview hg38]
OMIM131340   610245   
Gene and transcription
Genbank (Entrez)AK289618 AK295512 AK308747 AK316076 BC026334
RefSeq transcript (Entrez)NM_001190892 NM_001190898 NM_001190899 NM_001190900 NM_024411
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDYN
Cluster EST : UnigeneHs.22584 [ NCBI ]
CGAP (NCI)Hs.22584
Alternative Splicing GalleryENSG00000101327
Gene ExpressionPDYN [ NCBI-GEO ]   PDYN [ EBI - ARRAY_EXPRESS ]   PDYN [ SEEK ]   PDYN [ MEM ]
Gene Expression Viewer (FireBrowse)PDYN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5173
GTEX Portal (Tissue expression)PDYN
Human Protein AtlasENSG00000101327-PDYN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01213   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01213  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01213
Splice isoforms : SwissVarP01213
PhosPhoSitePlusP01213
Domaine pattern : Prosite (Expaxy)OPIOIDS_PRECURSOR (PS01252)   
Domains : Interpro (EBI)Opioid_neupept    Proenkphlin_B   
Domain families : Pfam (Sanger)Opiods_neuropep (PF01160)   
Domain families : Pfam (NCBI)pfam01160   
Conserved Domain (NCBI)PDYN
DMDM Disease mutations5173
Blocks (Seattle)PDYN
PDB (SRS)2N2F   
PDB (PDBSum)2N2F   
PDB (IMB)2N2F   
PDB (RSDB)2N2F   
Structural Biology KnowledgeBase2N2F   
SCOP (Structural Classification of Proteins)2N2F   
CATH (Classification of proteins structures)2N2F   
SuperfamilyP01213
Human Protein Atlas [tissue]ENSG00000101327-PDYN [tissue]
Peptide AtlasP01213
HPRD08838
IPIIPI00000832   
Protein Interaction databases
DIP (DOE-UCLA)P01213
IntAct (EBI)P01213
FunCoupENSG00000101327
BioGRIDPDYN
STRING (EMBL)PDYN
ZODIACPDYN
Ontologies - Pathways
QuickGOP01213
Ontology : AmiGOopioid peptide activity  extracellular region  plasma membrane  plasma membrane  G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  chemical synaptic transmission  regulation of signaling receptor activity  dendrite  neuronal cell body  axon terminus  
Ontology : EGO-EBIopioid peptide activity  extracellular region  plasma membrane  plasma membrane  G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  chemical synaptic transmission  regulation of signaling receptor activity  dendrite  neuronal cell body  axon terminus  
Pathways : KEGGCocaine addiction    Amphetamine addiction    Alcoholism   
NDEx NetworkPDYN
Atlas of Cancer Signalling NetworkPDYN
Wikipedia pathwaysPDYN
Orthology - Evolution
OrthoDB5173
GeneTree (enSembl)ENSG00000101327
Phylogenetic Trees/Animal Genes : TreeFamPDYN
HOVERGENP01213
HOGENOMP01213
Homologs : HomoloGenePDYN
Homology/Alignments : Family Browser (UCSC)PDYN
Gene fusions - Rearrangements
Fusion : QuiverPDYN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDYN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDYN
dbVarPDYN
ClinVarPDYN
1000_GenomesPDYN 
Exome Variant ServerPDYN
ExAC (Exome Aggregation Consortium)ENSG00000101327
GNOMAD BrowserENSG00000101327
Varsome BrowserPDYN
Genetic variants : HAPMAP5173
Genomic Variants (DGV)PDYN [DGVbeta]
DECIPHERPDYN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDYN 
Mutations
ICGC Data PortalPDYN 
TCGA Data PortalPDYN 
Broad Tumor PortalPDYN
OASIS PortalPDYN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDYN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDYN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDYN
DgiDB (Drug Gene Interaction Database)PDYN
DoCM (Curated mutations)PDYN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDYN (select a term)
intoGenPDYN
Cancer3DPDYN(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131340    610245   
Orphanet14819   
DisGeNETPDYN
MedgenPDYN
Genetic Testing Registry PDYN
NextProtP01213 [Medical]
TSGene5173
GENETestsPDYN
Target ValidationPDYN
Huge Navigator PDYN [HugePedia]
snp3D : Map Gene to Disease5173
BioCentury BCIQPDYN
ClinGenPDYN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5173
Chemical/Pharm GKB GenePA33163
Clinical trialPDYN
Miscellaneous
canSAR (ICR)PDYN (select the gene name)
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDYN
EVEXPDYN
GoPubMedPDYN
iHOPPDYN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:29:21 CET 2018

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