PDYN (prodynorphin)

2007-02-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
ADCA,PENKB,SCA23

Other Information

Locus ID:

NCBI: 5173
MIM: 131340
HGNC: 8820
Ensembl: ENSG00000101327

Variants:

dbSNP: 5173
ClinVar: 5173
TCGA: ENSG00000101327
COSMIC: PDYN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101327ENST00000217305P01213
ENSG00000101327ENST00000539905P01213
ENSG00000101327ENST00000540134P01213
ENSG00000101327ENST00000650824A0A494C1J4
ENSG00000101327ENST00000650874A0A494C0B1
ENSG00000101327ENST00000650937A0A494C197
ENSG00000101327ENST00000651328A0A494C1U2
ENSG00000101327ENST00000651684A0A494C0B3
ENSG00000101327ENST00000651882A0A494C0X3
ENSG00000101327ENST00000651996A0A494C0Y8
ENSG00000101327ENST00000652436A0A494C1E3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Opioid SignallingREACTOMER-HSA-111885
G-protein activationREACTOMER-HSA-202040

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD19298317
PA452618opioidsChemicalClinicalAnnotationassociatedPD19298317

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
162742632005Ancient and recent positive selection transformed opioid cis-regulation in humans.72
169242692006Association of the kappa-opioid system with alcohol dependence.64
169242692006Association of the kappa-opioid system with alcohol dependence.64
215214242011Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics.53
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
190940852008Changes in prodynorphin gene expression and neuronal morphology in the hypothalamus of postmenopausal women.35
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
181848002008Opioid neuropeptide genotypes in relation to heroin abuse: dopamine tone contributes to reversed mesolimbic proenkephalin expression.33
181848002008Opioid neuropeptide genotypes in relation to heroin abuse: dopamine tone contributes to reversed mesolimbic proenkephalin expression.33

Citation

Dessen P

PDYN (prodynorphin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45605/pdyn