Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5173
MIM: 131340
HGNC: 8820
Ensembl: ENSG00000101327
Variants:
dbSNP: 5173
ClinVar: 5173
TCGA: ENSG00000101327
COSMIC: PDYN
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA445043 | Opioid-Related Disorders | Disease | ClinicalAnnotation | associated | PD | 19298317 | |
| PA452618 | opioids | Chemical | ClinicalAnnotation | associated | PD | 19298317 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37177778 | 2023 | Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms. | 0 |
| 37177778 | 2023 | Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms. | 0 |
| 32597371 | 2022 | Prodynorphin (PDYN) gene polymorphisms in Turkish patients with methamphetamine use disorder, changes in PDYN serum levels in withdrawal and the relationship between PDYN, temperament and depression. | 1 |
| 32597371 | 2022 | Prodynorphin (PDYN) gene polymorphisms in Turkish patients with methamphetamine use disorder, changes in PDYN serum levels in withdrawal and the relationship between PDYN, temperament and depression. | 1 |
| 32526201 | 2020 | Alpha-neoendorphin can reduce UVB-induced skin photoaging by activating cellular autophagy. | 7 |
| 32526201 | 2020 | Alpha-neoendorphin can reduce UVB-induced skin photoaging by activating cellular autophagy. | 7 |
| 30936032 | 2019 | Association of variants of prodynorphin promoter 68-bp repeats in caucasians with opioid dependence diagnosis: Effect on age trajectory of heroin use. | 3 |
| 31510971 | 2019 | Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis. | 2 |
| 30936032 | 2019 | Association of variants of prodynorphin promoter 68-bp repeats in caucasians with opioid dependence diagnosis: Effect on age trajectory of heroin use. | 3 |
| 31510971 | 2019 | Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis. | 2 |
| 28830794 | 2018 | Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor. | 13 |
| 28968778 | 2018 | Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain. | 4 |
| 29383684 | 2018 | Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics. | 10 |
| 29925858 | 2018 | Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics. | 10 |
| 28830794 | 2018 | Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor. | 13 |
Citation
Dessen P
PDYN (prodynorphin)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45605/pdyn
