PEAK1 (pseudopodium enriched atypical kinase 1)

2013-08-01  

Identity

HGNC
LOCATION
15q24.3
LOCUSID
ALIAS
SGK269
FUSION GENES

Other Information

Locus ID:

NCBI: 79834
MIM: 614248
HGNC: 29431
Ensembl: ENSG00000173517

Variants:

dbSNP: 79834
ClinVar: 79834
TCGA: ENSG00000173517
COSMIC: PEAK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173517ENST00000312493Q9H792
ENSG00000173517ENST00000558305H0YN99
ENSG00000173517ENST00000560626Q9H792
ENSG00000173517ENST00000564328H3BUZ5
ENSG00000173517ENST00000565820H3BUE6

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124712432002The protein kinase complement of the human genome.2088
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
225892742012KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer.49
252612392014A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer.34
233783382013Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway.32
283815472017eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth.21
262979482015Identification of a PEAK1/ZEB1 signaling axis during TGFβ/fibronectin-induced EMT in breast cancer.20
231051022013Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover.18
262678632015PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer.17
275317442016Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases.7

Citation

Dessen P

PEAK1 (pseudopodium enriched atypical kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53735/peak1