PELO (pelota mRNA surveillance and ribosome rescue factor)

2016-10-01  

Identity

HGNC
LOCATION
5q11.2
LOCUSID
ALIAS
CGI-17,PRO1770

Other Information

Locus ID:

NCBI: 53918
MIM: 605757
HGNC: 8829
Ensembl: ENSG00000152684

Variants:

dbSNP: 53918
ClinVar: 53918
TCGA: ENSG00000152684
COSMIC: PELO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152684ENST00000274311Q9BRX2

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
214481322011Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.111
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
276814152016Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets.37
203062912010A three-stage genome-wide association study of general cognitive ability: hunting the small effects.36
236672532013The Hbs1-Dom34 protein complex functions in non-stop mRNA decay in mammalian cells.33
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
282133792017Slowed decay of mRNAs enhances platelet specific translation.10
176695162007Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2.9
204064612010Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.7
275438242016Conserved functions of human Pelota in mRNA quality control of nonstop mRNA.7

Citation

Dessen P

PELO (pelota mRNA surveillance and ribosome rescue factor)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56038/pelo