PELP1 (proline, glutamate and leucine rich protein 1)

2007-02-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
MNAR,P160
FUSION GENES

Other Information

Locus ID:

NCBI: 27043
MIM: 609455
HGNC: 30134
Ensembl: ENSG00000141456

Variants:

dbSNP: 27043
ClinVar: 27043
TCGA: ENSG00000141456
COSMIC: PELP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141456ENST00000301396C9JFV4
ENSG00000141456ENST00000436683E7EV54
ENSG00000141456ENST00000570387I3L4P1
ENSG00000141456ENST00000570571I3L445
ENSG00000141456ENST00000572293Q8IZL8
ENSG00000141456ENST00000572293C9JFV4
ENSG00000141456ENST00000574876Q8IZL8
ENSG00000141456ENST00000575101I3L1P4
ENSG00000141456ENST00000575329I3L4M7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Gene ExpressionREACTOMER-HSA-74160
Signaling by PTK6REACTOMER-HSA-8848021
PTK6 ExpressionREACTOMER-HSA-8849473
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
114813232001Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha.65
244690352015Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes.51
204486632010PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity.47
213262112011The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex.46
153749492004Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells.43
161409402005Functional implications of altered subcellular localization of PELP1 in breast cancer cells.43
239754302014Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer.42
175456332007Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptor.41
182617532008MNAR plays an important role in ERa activation of Src/MAPK and PI3K/Akt signaling pathways.40
194959592010The prognostic significance of PELP1 expression in invasive breast cancer with emphasis on the ER-positive luminal-like subtype.40

Citation

Dessen P

PELP1 (proline, glutamate and leucine rich protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45632/pelp1