Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PENK (proenkephalin)

Identity

Other aliasPE
PENK-A
HGNC (Hugo) PENK
LocusID (NCBI) 5179
Atlas_Id 46058
Location 8q12.1  [Link to chromosome band 8q12]
Location_base_pair Starts at 56440954 and ends at 56446734 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PENK   8831
Cards
Entrez_Gene (NCBI)PENK  5179  proenkephalin
AliasesPE; PENK-A
GeneCards (Weizmann)PENK
Ensembl hg19 (Hinxton)ENSG00000181195 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181195 [Gene_View]  chr8:56440954-56446734 [Contig_View]  PENK [Vega]
ICGC DataPortalENSG00000181195
TCGA cBioPortalPENK
AceView (NCBI)PENK
Genatlas (Paris)PENK
WikiGenes5179
SOURCE (Princeton)PENK
Genetics Home Reference (NIH)PENK
Genomic and cartography
GoldenPath hg38 (UCSC)PENK  -     chr8:56440954-56446734 -  8q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PENK  -     8q12.1   [Description]    (hg19-Feb_2009)
EnsemblPENK - 8q12.1 [CytoView hg19]  PENK - 8q12.1 [CytoView hg38]
Mapping of homologs : NCBIPENK [Mapview hg19]  PENK [Mapview hg38]
OMIM131330   
Gene and transcription
Genbank (Entrez)AK309758 AK314908 BC032505 BC107706 BI496610
RefSeq transcript (Entrez)NM_001135690 NM_006211
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PENK
Cluster EST : UnigeneHs.339831 [ NCBI ]
CGAP (NCI)Hs.339831
Alternative Splicing GalleryENSG00000181195
Gene ExpressionPENK [ NCBI-GEO ]   PENK [ EBI - ARRAY_EXPRESS ]   PENK [ SEEK ]   PENK [ MEM ]
Gene Expression Viewer (FireBrowse)PENK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5179
GTEX Portal (Tissue expression)PENK
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01210   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01210  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01210
Splice isoforms : SwissVarP01210
PhosPhoSitePlusP01210
Domaine pattern : Prosite (Expaxy)OPIOIDS_PRECURSOR (PS01252)   
Domains : Interpro (EBI)Opioid_neupept    Proenkphlin_A   
Domain families : Pfam (Sanger)Opiods_neuropep (PF01160)   
Domain families : Pfam (NCBI)pfam01160   
Conserved Domain (NCBI)PENK
DMDM Disease mutations5179
Blocks (Seattle)PENK
PDB (SRS)1PLW    1PLX    2LWC    5E33    5E3A   
PDB (PDBSum)1PLW    1PLX    2LWC    5E33    5E3A   
PDB (IMB)1PLW    1PLX    2LWC    5E33    5E3A   
PDB (RSDB)1PLW    1PLX    2LWC    5E33    5E3A   
Structural Biology KnowledgeBase1PLW    1PLX    2LWC    5E33    5E3A   
SCOP (Structural Classification of Proteins)1PLW    1PLX    2LWC    5E33    5E3A   
CATH (Classification of proteins structures)1PLW    1PLX    2LWC    5E33    5E3A   
SuperfamilyP01210
Human Protein AtlasENSG00000181195
Peptide AtlasP01210
HPRD08837
IPIIPI00000828   IPI00981432   IPI00975534   IPI00974066   IPI00973943   
Protein Interaction databases
DIP (DOE-UCLA)P01210
IntAct (EBI)P01210
FunCoupENSG00000181195
BioGRIDPENK
STRING (EMBL)PENK
ZODIACPENK
Ontologies - Pathways
QuickGOP01210
Ontology : AmiGOopioid peptide activity  osteoblast differentiation  behavioral fear response  response to hypoxia  startle response  aggressive behavior  neuropeptide hormone activity  extracellular region  plasma membrane  signal transduction  neuropeptide signaling pathway  chemical synaptic transmission  aging  sensory perception  response to radiation  response to toxic substance  glial cell proliferation  sensory perception of pain  axon  dendrite  opioid receptor binding  symmetric synapse  response to estradiol  response to lipopolysaccharide  cellular response to oxidative stress  response to nicotine  locomotory exploration behavior  neuronal cell body  perikaryon  response to morphine  axon terminus  response to ethanol  response to calcium ion  general adaptation syndrome, behavioral process  cell body fiber  cellular response to vitamin D  cellular response to cAMP  cellular response to transforming growth factor beta"stimtl}s  response to epinephrine  cellular response to virus  positive regulation of behavioral fear response  
Ontology : EGO-EBIopioid peptide activity  osteoblast differentiation  behavioral fear response  response to hypoxia  startle response  aggressive behavior  neuropeptide hormone activity  extracellular region  plasma membrane  signal transduction  neuropeptide signaling pathway  chemical synaptic transmission  aging  sensory perception  response to radiation  response to toxic substance  glial cell proliferation  sensory perception of pain  axon  dendrite  opioid receptor binding  symmetric synapse  response to estradiol  response to lipopolysaccharIde¦nbsp; cellular response to oxidative stress  response to nicotine  locomotory exploration behavior  neuronal cell body  perikaryon  response to morphine  axon terminus  response to ethanol  response to calcium ion  general adaptation syndrome, behavioral process  cell body fiber  cellular response to vitamin D  cellular response to cAMP  cellular response to transforming growth factor beta stimulus  response to epinephrine  cellular response to virus  positive regulation of behavioral fear response  
NDEx NetworkPENK
Atlas of Cancer Signalling NetworkPENK
Wikipedia pathwaysPENK
Orthology - Evolution
OrthoDB5179
GeneTree (enSembl)ENSG00000181195
Phylogenetic Trees/Animal Genes : TreeFamPENK
HOVERGENP01210
HOGENOMP01210
Homologs : HomoloGenePENK
Homology/Alignments : Family Browser (UCSC)PENK
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPENK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PENK
dbVarPENK
ClinVarPENK
1000_GenomesPENK 
Exome Variant ServerPENK
ExAC (Exome Aggregation Consortium)PENK (select the gene name)
Genetic variants : HAPMAP5179
Genomic Variants (DGV)PENK [DGVbeta]
DECIPHERPENK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPENK 
Mutations
ICGC Data PortalPENK 
TCGA Data PortalPENK 
Broad Tumor PortalPENK
OASIS PortalPENK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPENK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPENK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch PENK
DgiDB (Drug Gene Interaction Database)PENK
DoCM (Curated mutations)PENK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PENK (select a term)
intoGenPENK
Cancer3DPENK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131330   
Orphanet
MedgenPENK
Genetic Testing Registry PENK
NextProtP01210 [Medical]
TSGene5179
GENETestsPENK
Target ValidationPENK
Huge Navigator PENK [HugePedia]
snp3D : Map Gene to Disease5179
BioCentury BCIQPENK
ClinGenPENK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5179
Chemical/Pharm GKB GenePA33176
Clinical trialPENK
Miscellaneous
canSAR (ICR)PENK (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePENK
EVEXPENK
GoPubMedPENK
iHOPPENK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:24:23 CEST 2017

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