PENK (proenkephalin)

2007-02-01  

Identity

HGNC
LOCATION
8q12.1
LOCUSID
ALIAS
PE,PENK-A

Other Information

Locus ID:

NCBI: 5179
MIM: 131330
HGNC: 8831
Ensembl: ENSG00000181195

Variants:

dbSNP: 5179
ClinVar: 5179
TCGA: ENSG00000181195
COSMIC: PENK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181195ENST00000314922P01210
ENSG00000181195ENST00000314922A0A024R7V4
ENSG00000181195ENST00000451791P01210
ENSG00000181195ENST00000451791A0A024R7V4
ENSG00000181195ENST00000517415H0YBT5
ENSG00000181195ENST00000518770E5RJ72
ENSG00000181195ENST00000518974E5RFR1
ENSG00000181195ENST00000523051E5RIP6

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
120007092002Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma.55
266343082015Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7.49
223918642012Prefrontal dopaminergic and enkephalinergic synaptic accommodation in HIV-associated neurocognitive disorders and encephalitis.45
242893282013Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer.40
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
175034812007The opioid system in alcohol and drug dependence: family-based association study.33
181848002008Opioid neuropeptide genotypes in relation to heroin abuse: dopamine tone contributes to reversed mesolimbic proenkephalin expression.33

Citation

Dessen P

PENK (proenkephalin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46058/penk