PER1 (period circadian regulator 1)

2004-12-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
PER,RIGUI,hPER
FUSION GENES

Other Information

Locus ID:

NCBI: 5187
MIM: 602260
HGNC: 8845
Ensembl: ENSG00000179094

Variants:

dbSNP: 5187
ClinVar: 5187
TCGA: ENSG00000179094
COSMIC: PER1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179094ENST00000317276O15534
ENSG00000179094ENST00000577253J3KSL6
ENSG00000179094ENST00000581082J3KRL7
ENSG00000179094ENST00000581395J3QSH9
ENSG00000179094ENST00000581703J3QL55
ENSG00000179094ENST00000582719J3KTM2
ENSG00000179094ENST00000583559J3QL46
ENSG00000179094ENST00000584202J3QLQ5

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

References

Pubmed IDYearTitleCitations
166781092006The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells.162
188215652008Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.133
157905882005Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers.119
159172222005SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.105
113065572001Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome.101
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
165287482006Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.88
197520892009A role for the clock gene per1 in prostate cancer.75
182285282008Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.60
176215972007Localization of a circadian clock in mammalian photoreceptors.56

Citation

Dessen P

PER1 (period circadian regulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2004-12-01

Online version: http://atlasgeneticsoncology.org/gene/42892/per1