Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PER2 (period circadian regulator 2)

Identity

Alias_namesperiod (Drosophila) homolog 2
period homolog 2 (Drosophila)
Alias_symbol (synonym)KIAA0347
Other aliasFASPS
FASPS1
HGNC (Hugo) PER2
LocusID (NCBI) 8864
Atlas_Id 46410
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 238244038 and ends at 238288566 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM98B (15q14) / PER2 (2q37.3)ILKAP (2q37.3) / PER2 (2q37.3)LRSAM1 (9q33.3) / PER2 (2q37.3)
PER2 (2q37.3) / PER2 (2q37.3)ILKAP 2q37.3 / PER2 2q37.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ILKAP/PER2 (2q37)


External links

Nomenclature
HGNC (Hugo)PER2   8846
Cards
Entrez_Gene (NCBI)PER2  8864  period circadian regulator 2
AliasesFASPS; FASPS1
GeneCards (Weizmann)PER2
Ensembl hg19 (Hinxton)ENSG00000132326 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132326 [Gene_View]  ENSG00000132326 [Sequence]  chr2:238244038-238288566 [Contig_View]  PER2 [Vega]
ICGC DataPortalENSG00000132326
TCGA cBioPortalPER2
AceView (NCBI)PER2
Genatlas (Paris)PER2
WikiGenes8864
SOURCE (Princeton)PER2
Genetics Home Reference (NIH)PER2
Genomic and cartography
GoldenPath hg38 (UCSC)PER2  -     chr2:238244038-238288566 -  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PER2  -     2q37.3   [Description]    (hg19-Feb_2009)
EnsemblPER2 - 2q37.3 [CytoView hg19]  PER2 - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBIPER2 [Mapview hg19]  PER2 [Mapview hg38]
OMIM603426   604348   
Gene and transcription
Genbank (Entrez)AB002345 AB012614 AK294876 AK304108 DA226434
RefSeq transcript (Entrez)NM_003894 NM_022817
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PER2
Cluster EST : UnigeneHs.58756 [ NCBI ]
CGAP (NCI)Hs.58756
Alternative Splicing GalleryENSG00000132326
Gene ExpressionPER2 [ NCBI-GEO ]   PER2 [ EBI - ARRAY_EXPRESS ]   PER2 [ SEEK ]   PER2 [ MEM ]
Gene Expression Viewer (FireBrowse)PER2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8864
GTEX Portal (Tissue expression)PER2
Human Protein AtlasENSG00000132326-PER2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15055   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15055  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15055
Splice isoforms : SwissVarO15055
PhosPhoSitePlusO15055
Domaine pattern : Prosite (Expaxy)PAS (PS50112)   
Domains : Interpro (EBI)PAS    PAS-like_dom_sf    PAS_fold_3    Period_circadian-like_C   
Domain families : Pfam (Sanger)PAS_3 (PF08447)    Period_C (PF12114)   
Domain families : Pfam (NCBI)pfam08447    pfam12114   
Domain families : Smart (EMBL)PAS (SM00091)  
Conserved Domain (NCBI)PER2
DMDM Disease mutations8864
Blocks (Seattle)PER2
SuperfamilyO15055
Human Protein Atlas [tissue]ENSG00000132326-PER2 [tissue]
Peptide AtlasO15055
HPRD04575
IPIIPI00004516   IPI00022072   IPI01012525   IPI00915864   
Protein Interaction databases
DIP (DOE-UCLA)O15055
IntAct (EBI)O15055
FunCoupENSG00000132326
BioGRIDPER2
STRING (EMBL)PER2
ZODIACPER2
Ontologies - Pathways
QuickGOO15055
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  transcription regulatory region sequence-specific DNA binding  transcription regulatory region sequence-specific DNA binding  transcription corepressor binding  response to ischemia  transcription coactivator activity  protein binding  nucleus  nucleus  nucleus  nucleolus  cytoplasm  glycogen biosynthetic process  gluconeogenesis  fatty acid metabolic process  circadian rhythm  transcription factor binding  response to light stimulus  regulation of vasoconstriction  lactate biosynthetic process  negative regulation of protein ubiquitination  circadian regulation of gene expression  circadian regulation of gene expression  regulation of circadian rhythm  negative regulation of circadian rhythm  entrainment of circadian clock by photoperiod  negative regulation of transcription, DNA-templated  perinuclear region of cytoplasm  regulation of neurogenesis  regulation of insulin secretion  white fat cell differentiation  regulation of cell cycle  regulation of glutamate uptake involved in transmission of nerve impulse  negative regulation of fat cell proliferation  histone H3 deacetylation  circadian regulation of translation  positive regulation of cold-induced thermogenesis  positive regulation of nucleic acid-templated transcription  negative regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  transcription regulatory region sequence-specific DNA binding  transcription regulatory region sequence-specific DNA binding  transcription corepressor binding  response to ischemia  transcription coactivator activity  protein binding  nucleus  nucleus  nucleus  nucleolus  cytoplasm  glycogen biosynthetic process  gluconeogenesis  fatty acid metabolic process  circadian rhythm  transcription factor binding  response to light stimulus  regulation of vasoconstriction  lactate biosynthetic process  negative regulation of protein ubiquitination  circadian regulation of gene expression  circadian regulation of gene expression  regulation of circadian rhythm  negative regulation of circadian rhythm  entrainment of circadian clock by photoperiod  negative regulation of transcription, DNA-templated  perinuclear region of cytoplasm  regulation of neurogenesis  regulation of insulin secretion  white fat cell differentiation  regulation of cell cycle  regulation of glutamate uptake involved in transmission of nerve impulse  negative regulation of fat cell proliferation  histone H3 deacetylation  circadian regulation of translation  positive regulation of cold-induced thermogenesis  positive regulation of nucleic acid-templated transcription  negative regulation of transcription regulatory region DNA binding  
Pathways : KEGGCircadian rhythm    Circadian entrainment    Herpes simplex infection    Transcriptional misregulation in cancer   
NDEx NetworkPER2
Atlas of Cancer Signalling NetworkPER2
Wikipedia pathwaysPER2
Orthology - Evolution
OrthoDB8864
GeneTree (enSembl)ENSG00000132326
Phylogenetic Trees/Animal Genes : TreeFamPER2
HOVERGENO15055
HOGENOMO15055
Homologs : HomoloGenePER2
Homology/Alignments : Family Browser (UCSC)PER2
Gene fusions - Rearrangements
Fusion : MitelmanILKAP/PER2 [2q37.3/2q37.3]  [t(2;2)(q37;q37)]  
Fusion PortalILKAP 2q37.3 PER2 2q37.3 BRCA
Fusion : QuiverPER2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPER2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PER2
dbVarPER2
ClinVarPER2
1000_GenomesPER2 
Exome Variant ServerPER2
ExAC (Exome Aggregation Consortium)ENSG00000132326
GNOMAD BrowserENSG00000132326
Varsome BrowserPER2
Genetic variants : HAPMAP8864
Genomic Variants (DGV)PER2 [DGVbeta]
DECIPHERPER2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPER2 
Mutations
ICGC Data PortalPER2 
TCGA Data PortalPER2 
Broad Tumor PortalPER2
OASIS PortalPER2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPER2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPER2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PER2
DgiDB (Drug Gene Interaction Database)PER2
DoCM (Curated mutations)PER2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PER2 (select a term)
intoGenPER2
Cancer3DPER2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603426    604348   
Orphanet17568   
DisGeNETPER2
MedgenPER2
Genetic Testing Registry PER2
NextProtO15055 [Medical]
TSGene8864
GENETestsPER2
Target ValidationPER2
Huge Navigator PER2 [HugePedia]
snp3D : Map Gene to Disease8864
BioCentury BCIQPER2
ClinGenPER2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8864
Chemical/Pharm GKB GenePA33185
Clinical trialPER2
Miscellaneous
canSAR (ICR)PER2 (select the gene name)
Probes
Litterature
PubMed143 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePER2
EVEXPER2
GoPubMedPER2
iHOPPER2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:29:26 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.