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PF4 (platelet factor 4)

Identity

Other namesCXCL4
PF-4
SCYB4
HGNC (Hugo) PF4
LocusID (NCBI) 5196
Location 4q13.3
Location_base_pair Starts at 74846542 and ends at 74847841 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PF4   8861
Cards
Entrez_Gene (NCBI)PF4  5196  platelet factor 4
GeneCards (Weizmann)PF4
Ensembl (Hinxton) [Gene_View]  chr4:74846542-74847841 [Contig_View]  PF4 [Vega]
AceView (NCBI)PF4
Genatlas (Paris)PF4
WikiGenes5196
SOURCE (Princeton)NM_002619
Genomic and cartography
GoldenPath (UCSC)PF4  -  4q13.3   chr4:74846542-74847841 -  4q13.3   [Description]    (hg19-Feb_2009)
EnsemblPF4 - 4q13.3 [CytoView]
Mapping of homologs : NCBIPF4 [Mapview]
OMIM173460   
Gene and transcription
Genbank (Entrez)AJ705588 BC093965 BC112093 CR407677 GD143506
RefSeq transcript (Entrez)NM_002619
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NG_032897 NT_022778 NW_001838914 NW_004929320
Consensus coding sequences : CCDS (NCBI)PF4
Cluster EST : UnigeneHs.81564 [ NCBI ]
CGAP (NCI)Hs.81564
Alternative Splicing : Fast-db (Paris)GSHG0023316
Gene ExpressionPF4 [ NCBI-GEO ]     PF4 [ SEEK ]   PF4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02776 (Uniprot)
NextProtP02776  [Medical]
With graphics : InterProP02776
Splice isoforms : SwissVarP02776 (Swissvar)
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CXC (PS00471)   
Domains : Interpro (EBI)Chemokine_CXC    Chemokine_CXC_CS    Chemokine_IL8-like_dom    PF4   
Related proteins : CluSTrP02776
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
DMDM Disease mutations5196
Blocks (Seattle)P02776
PDB (SRS)1DN3    1F9Q    1F9R    1F9S    1PFM    1PFN    1RHP   
PDB (PDBSum)1DN3    1F9Q    1F9R    1F9S    1PFM    1PFN    1RHP   
PDB (IMB)1DN3    1F9Q    1F9R    1F9S    1PFM    1PFN    1RHP   
PDB (RSDB)1DN3    1F9Q    1F9R    1F9S    1PFM    1PFN    1RHP   
Peptide AtlasP02776
HPRD01426
IPIIPI00022446   
Protein Interaction databases
DIP (DOE-UCLA)P02776
IntAct (EBI)P02776
BioGRIDPF4
InParanoidP02776
Interologous Interaction database P02776
IntegromeDBPF4
STRING (EMBL)PF4
Ontologies - Pathways
Ontology : AmiGOplatelet degranulation  extracellular region  extracellular region  extracellular region  extracellular space  immune response  blood coagulation  chemokine activity  heparin binding  positive regulation of gene expression  positive regulation of macrophage derived foam cell differentiation  negative regulation of angiogenesis  cytokine-mediated signaling pathway  platelet activation  platelet activation  leukocyte chemotaxis  platelet alpha granule lumen  positive regulation of tumor necrosis factor production  negative regulation of MHC class II biosynthetic process  positive regulation of macrophage differentiation  negative regulation of megakaryocyte differentiation  negative regulation of cytolysis  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIplatelet degranulation  extracellular region  extracellular region  extracellular region  extracellular space  immune response  blood coagulation  chemokine activity  heparin binding  positive regulation of gene expression  positive regulation of macrophage derived foam cell differentiation  negative regulation of angiogenesis  cytokine-mediated signaling pathway  platelet activation  platelet activation  leukocyte chemotaxis  platelet alpha granule lumen  positive regulation of tumor necrosis factor production  negative regulation of MHC class II biosynthetic process  positive regulation of macrophage differentiation  negative regulation of megakaryocyte differentiation  negative regulation of cytolysis  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway   
REACTOMEPF4
Protein Interaction DatabasePF4
Wikipedia pathwaysPF4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PF4
SNP (GeneSNP Utah)PF4
SNP : HGBasePF4
Genetic variants : HAPMAPPF4
1000_GenomesPF4 
Somatic Mutations in Cancer : COSMICPF4 
CONAN: Copy Number AnalysisPF4 
Mutations and Diseases : HGMDPF4
OMIM173460   
GENETestsPF4
Disease Genetic AssociationPF4
Huge Navigator PF4 [HugePedia]  PF4 [HugeCancerGEM]
Genomic VariantsPF4  PF4 [DGVbeta]
Exome VariantPF4
dbVarPF4
ClinVarPF4
snp3D : Map Gene to Disease5196
General knowledge
Homologs : HomoloGenePF4
Homology/Alignments : Family Browser (UCSC)PF4
Phylogenetic Trees/Animal Genes : TreeFamPF4
Chemical/Protein Interactions : CTD5196
Chemical/Pharm GKB GenePA33203
Clinical trialPF4
Other databases
Probes
Litterature
PubMed135 Pubmed reference(s) in Entrez
CoreMinePF4
iHOPPF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:53:31 CEST 2014

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