PFDN1 (prefoldin subunit 1)

2016-08-01  

Identity

HGNC
LOCATION
5q31.3
LOCUSID
ALIAS
PDF,PFD1

Other Information

Locus ID:

NCBI: 5201
MIM: 604897
HGNC: 8866
Ensembl: ENSG00000113068

Variants:

dbSNP: 5201
ClinVar: 5201
TCGA: ENSG00000113068
COSMIC: PFDN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113068ENST00000261813O60925
ENSG00000113068ENST00000510217D6RGG5
ENSG00000113068ENST00000524074E5RGS4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
281835282017Transethnic genome-wide scan identifies novel Alzheimer's disease loci.38
164153412006PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.25
276948982017Prefoldin 1 promotes EMT and lung cancer progression by suppressing cyclin A expression.15
265533182015PFDN1, an indicator for colorectal cancer prognosis, enhances tumor cell proliferation and motility through cytoskeletal reorganization.9

Citation

Dessen P

PFDN1 (prefoldin subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55901/pfdn1