PFDN5 (prefoldin subunit 5)

2003-02-01  

Identity

HGNC
PFDN5
LOCATION
12q13.13
LOCUSID
5204
ALIAS
MM-1,MM1,PFD5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5204
MIM: 604899
HGNC: 8869
Ensembl: ENSG00000123349

Variants:

dbSNP: 5204
ClinVar: 5204
TCGA: ENSG00000123349
COSMIC: PFDN5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123349ENST00000243040Q99471
ENSG00000123349ENST00000334478Q99471
ENSG00000123349ENST00000351500Q99471
ENSG00000123349ENST00000547130F8VNW6
ENSG00000123349ENST00000549759H3BPF6
ENSG00000123349ENST00000550846H3BMQ1
ENSG00000123349ENST00000550880F8VQZ2
ENSG00000123349ENST00000551018Q99471
ENSG00000123349ENST00000552742F8VNW6
ENSG00000123349ENST00000628881F8VQZ2

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
118447942002Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function.22
237207552013Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation.20
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.17
182810352008Negative regulation of the Wnt signal by MM-1 through inhibiting expression of the wnt4 gene.15
183987002008Hepatitis C virus ARFP/F protein interacts with cellular MM-1 protein and enhances the gene trans-activation activity of c-Myc.15
228445322012Rabring7 degrades c-Myc through complex formation with MM-1.7
161730812006Distinct localizations and repression activities of MM-1 isoforms toward c-Myc.5

Citation

Dessen P

PFDN5 (prefoldin subunit 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41694/pfdn5