PFN2 (profilin 2)

2012-02-01  

Identity

HGNC
LOCATION
3q25.1
LOCUSID
ALIAS
D3S1319E,PFL
FUSION GENES

Other Information

Locus ID:

NCBI: 5217
MIM: 176590
HGNC: 8882
Ensembl: ENSG00000070087

Variants:

dbSNP: 5217
ClinVar: 5217
TCGA: ENSG00000070087
COSMIC: PFN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070087ENST00000239940P35080
ENSG00000070087ENST00000423691G5E9Q6
ENSG00000070087ENST00000452853P35080
ENSG00000070087ENST00000460404C9J5V8
ENSG00000070087ENST00000461868C9JQ45
ENSG00000070087ENST00000461930C9J5V8
ENSG00000070087ENST00000468323F2Z3G0
ENSG00000070087ENST00000475518C9J712
ENSG00000070087ENST00000481275C9J712
ENSG00000070087ENST00000481767C9J0J7
ENSG00000070087ENST00000489155C9J712
ENSG00000070087ENST00000490975C9J2N0
ENSG00000070087ENST00000494827C9J0J7
ENSG00000070087ENST00000497148C9J712
ENSG00000070087ENST00000498169F2Z3G0
ENSG00000070087ENST00000498307C9J712
ENSG00000070087ENST00000649949C9J712

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
ShigellosisKEGGhsa05131
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185738802008Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation.60
263542292015Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis.36
238270102013Profilin-1 versus profilin-2: two faces of the same coin?9
259649822015Profilin 2 promotes migration, invasion, and stemness of HT29 human colorectal cancer stem cells.9
271884582016PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma.9
173825172007Identification of Rgl3 as a potential binding partner for Rap-family small G-proteins and profilin II.7
267644072016Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2.7
217256082011Decreased expression of profilin 2 in oral squamous cell carcinoma and its clinicopathological implications.6
284056902017MicroRNA-30a-5p suppresses epithelial-mesenchymal transition by targeting profilin-2 in high invasive non-small cell lung cancer cell lines.5
285464282017The myocardin-related transcription factor MKL co-regulates the cellular levels of two profilin isoforms.4

Citation

Dessen P

PFN2 (profilin 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52601/pfn2