Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PGA3 (pepsinogen A3)

Identity

Alias (NCBI)-
HGNC (Hugo) PGA3
HGNC Alias namepepsin A
HGNC Previous namepepsinogen 3, group I (pepsinogen A)
LocusID (NCBI) 643834
Atlas_Id 43715
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 61203515 and ends at 61213098 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARMC8 (3q22.3) / PGA3 (11q12.2)HDAC1 (1p35.1) / PGA3 (11q12.2)LIPF (10q23.31) / PGA3 (11q12.2)
PHF20L1 (8q24.22) / PGA3 (11q12.2)RAPGEF4 (2q31.1) / PGA3 (11q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PGA3   8885
Cards
Entrez_Gene (NCBI)PGA3  643834  pepsinogen A3
Aliases
GeneCards (Weizmann)PGA3
Ensembl hg19 (Hinxton)ENSG00000229859 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000229859 [Gene_View]  ENSG00000229859 [Sequence]  chr11:61203515-61213098 [Contig_View]  PGA3 [Vega]
ICGC DataPortalENSG00000229859
TCGA cBioPortalPGA3
AceView (NCBI)PGA3
Genatlas (Paris)PGA3
WikiGenes643834
SOURCE (Princeton)PGA3
Genetics Home Reference (NIH)PGA3
Genomic and cartography
GoldenPath hg38 (UCSC)PGA3  -     chr11:61203515-61213098 +  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PGA3  -     11q12.2   [Description]    (hg19-Feb_2009)
GoldenPathPGA3 - 11q12.2 [CytoView hg19]  PGA3 - 11q12.2 [CytoView hg38]
ImmunoBaseENSG00000229859
genome Data Viewer NCBIPGA3 [Mapview hg19]  
OMIM169710   
Gene and transcription
Genbank (Entrez)AK125628 AK225669 AK225674 AK225679 AK301286
RefSeq transcript (Entrez)NM_001079807
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PGA3
Alternative Splicing GalleryENSG00000229859
Gene ExpressionPGA3 [ NCBI-GEO ]   PGA3 [ EBI - ARRAY_EXPRESS ]   PGA3 [ SEEK ]   PGA3 [ MEM ]
Gene Expression Viewer (FireBrowse)PGA3 [ Firebrowse - Broad ]
GenevisibleExpression of PGA3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)643834
GTEX Portal (Tissue expression)PGA3
Human Protein AtlasENSG00000229859-PGA3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0DJD8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0DJD8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0DJD8
Splice isoforms : SwissVarP0DJD8
Catalytic activity : Enzyme3.4.23.1 [ Enzyme-Expasy ]   3.4.23.13.4.23.1 [ IntEnz-EBI ]   3.4.23.1 [ BRENDA ]   3.4.23.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP0DJD8
Domaine pattern : Prosite (Expaxy)ASP_PROTEASE (PS00141)    PEPTIDASE_A1 (PS51767)   
Domains : Interpro (EBI)Aspartic_peptidase_A1    Aspartic_peptidase_AS    Aspartic_peptidase_N    Pepsin_A    PEPTIDASE_A1    Peptidase_aspartic_dom_sf   
Domain families : Pfam (Sanger)A1_Propeptide (PF07966)    Asp (PF00026)   
Domain families : Pfam (NCBI)pfam07966    pfam00026   
Conserved Domain (NCBI)PGA3
DMDM Disease mutations643834
Blocks (Seattle)PGA3
SuperfamilyP0DJD8
Human Protein Atlas [tissue]ENSG00000229859-PGA3 [tissue]
Peptide AtlasP0DJD8
IPIIPI00019641   IPI00909126   IPI00942240   IPI00939676   IPI01010178   IPI01015115   IPI01011402   IPI00736755   IPI01009743   IPI00181304   IPI01014749   IPI01011978   IPI01012330   
Protein Interaction databases
DIP (DOE-UCLA)P0DJD8
IntAct (EBI)P0DJD8
FunCoupENSG00000229859
BioGRIDPGA3
STRING (EMBL)PGA3
ZODIACPGA3
Ontologies - Pathways
QuickGOP0DJD8
Ontology : AmiGOdigestion  cellular protein metabolic process  extracellular exosome  multivesicular body lumen  
Ontology : EGO-EBIdigestion  cellular protein metabolic process  extracellular exosome  multivesicular body lumen  
Pathways : KEGGProtein digestion and absorption   
NDEx NetworkPGA3
Atlas of Cancer Signalling NetworkPGA3
Wikipedia pathwaysPGA3
Orthology - Evolution
OrthoDB643834
GeneTree (enSembl)ENSG00000229859
Phylogenetic Trees/Animal Genes : TreeFamPGA3
HOGENOMP0DJD8
Homologs : HomoloGenePGA3
Homology/Alignments : Family Browser (UCSC)PGA3
Gene fusions - Rearrangements
Fusion : QuiverPGA3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPGA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PGA3
dbVarPGA3
ClinVarPGA3
1000_GenomesPGA3 
Exome Variant ServerPGA3
GNOMAD BrowserENSG00000229859
Varsome BrowserPGA3
Genetic variants : HAPMAP643834
Genomic Variants (DGV)PGA3 [DGVbeta]
DECIPHERPGA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPGA3 
Mutations
ICGC Data PortalPGA3 
TCGA Data PortalPGA3 
Broad Tumor PortalPGA3
OASIS PortalPGA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPGA3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPGA3
Mutations and Diseases : HGMDPGA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PGA3
DgiDB (Drug Gene Interaction Database)PGA3
DoCM (Curated mutations)PGA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PGA3 (select a term)
intoGenPGA3
Cancer3DPGA3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM169710   
Orphanet
DisGeNETPGA3
MedgenPGA3
Genetic Testing Registry PGA3
NextProtP0DJD8 [Medical]
TSGene643834
GENETestsPGA3
Target ValidationPGA3
Huge Navigator PGA3 [HugePedia]
snp3D : Map Gene to Disease643834
BioCentury BCIQPGA3
ClinGenPGA3
Clinical trials, drugs, therapy
Protein Interactions : CTD643834
Pharm GKB GenePA33222
Clinical trialPGA3
Miscellaneous
canSAR (ICR)PGA3 (select the gene name)
HarmonizomePGA3
DataMed IndexPGA3
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePGA3
EVEXPGA3
GoPubMedPGA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:29:28 CEST 2020
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