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PGA4 (pepsinogen 4, group I (pepsinogen A))

Identity

Other alias-
HGNC (Hugo) PGA4
LocusID (NCBI) 643847
Atlas_Id 71851
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 61222349 and ends at 61231695 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PGA4   8886
Cards
Entrez_Gene (NCBI)PGA4  643847  pepsinogen 4, group I (pepsinogen A)
Aliases
GeneCards (Weizmann)PGA4
Ensembl hg19 (Hinxton)ENSG00000229183 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000229183 [Gene_View]  chr11:61222349-61231695 [Contig_View]  PGA4 [Vega]
ICGC DataPortalENSG00000229183
TCGA cBioPortalPGA4
AceView (NCBI)PGA4
Genatlas (Paris)PGA4
WikiGenes643847
SOURCE (Princeton)PGA4
Genetics Home Reference (NIH)PGA4
Genomic and cartography
GoldenPath hg38 (UCSC)PGA4  -     chr11:61222349-61231695 +  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PGA4  -     11q12.2   [Description]    (hg19-Feb_2009)
EnsemblPGA4 - 11q12.2 [CytoView hg19]  PGA4 - 11q12.2 [CytoView hg38]
Mapping of homologs : NCBIPGA4 [Mapview hg19]  PGA4 [Mapview hg38]
OMIM169720   
Gene and transcription
Genbank (Entrez)AK291864 AK301305 BC150659 BC152844 BC171808
RefSeq transcript (Entrez)NM_001079808
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PGA4
Cluster EST : UnigeneHs.661883 [ NCBI ]
CGAP (NCI)Hs.661883
Alternative Splicing GalleryENSG00000229183
Gene ExpressionPGA4 [ NCBI-GEO ]   PGA4 [ EBI - ARRAY_EXPRESS ]   PGA4 [ SEEK ]   PGA4 [ MEM ]
Gene Expression Viewer (FireBrowse)PGA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)643847
GTEX Portal (Tissue expression)PGA4
Human Protein AtlasENSG00000229183-PGA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0DJD7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0DJD7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0DJD7
Splice isoforms : SwissVarP0DJD7
Catalytic activity : Enzyme3.4.23.1 [ Enzyme-Expasy ]   3.4.23.13.4.23.1 [ IntEnz-EBI ]   3.4.23.1 [ BRENDA ]   3.4.23.1 [ KEGG ]   
PhosPhoSitePlusP0DJD7
Domaine pattern : Prosite (Expaxy)ASP_PROTEASE (PS00141)    PEPTIDASE_A1 (PS51767)   
Domains : Interpro (EBI)Aspartic_peptidase_A1    Aspartic_peptidase_AS    Aspartic_peptidase_N    Pepsin_A    PEPTIDASE_A1    Peptidase_aspartic_dom   
Domain families : Pfam (Sanger)A1_Propeptide (PF07966)    Asp (PF00026)   
Domain families : Pfam (NCBI)pfam07966    pfam00026   
Conserved Domain (NCBI)PGA4
DMDM Disease mutations643847
Blocks (Seattle)PGA4
PDB (SRS)1FLH    1PSN    1PSO    1QRP    3UTL   
PDB (PDBSum)1FLH    1PSN    1PSO    1QRP    3UTL   
PDB (IMB)1FLH    1PSN    1PSO    1QRP    3UTL   
PDB (RSDB)1FLH    1PSN    1PSO    1QRP    3UTL   
Structural Biology KnowledgeBase1FLH    1PSN    1PSO    1QRP    3UTL   
SCOP (Structural Classification of Proteins)1FLH    1PSN    1PSO    1QRP    3UTL   
CATH (Classification of proteins structures)1FLH    1PSN    1PSO    1QRP    3UTL   
SuperfamilyP0DJD7
Human Protein Atlas [tissue]ENSG00000229183-PGA4 [tissue]
Peptide AtlasP0DJD7
Protein Interaction databases
DIP (DOE-UCLA)P0DJD7
IntAct (EBI)P0DJD7
FunCoupENSG00000229183
BioGRIDPGA4
STRING (EMBL)PGA4
ZODIACPGA4
Ontologies - Pathways
QuickGOP0DJD7
Ontology : AmiGOaspartic-type endopeptidase activity  proteolysis  autophagy  digestion  peptidase activity  protein catabolic process  cellular protein metabolic process  extracellular exosome  multivesicular body lumen  
Ontology : EGO-EBIaspartic-type endopeptidase activity  proteolysis  autophagy  digestion  peptidase activity  protein catabolic process  cellular protein metabolic process  extracellular exosome  multivesicular body lumen  
Pathways : KEGGProtein digestion and absorption   
NDEx NetworkPGA4
Atlas of Cancer Signalling NetworkPGA4
Wikipedia pathwaysPGA4
Orthology - Evolution
OrthoDB643847
GeneTree (enSembl)ENSG00000229183
Phylogenetic Trees/Animal Genes : TreeFamPGA4
HOVERGENP0DJD7
HOGENOMP0DJD7
Homologs : HomoloGenePGA4
Homology/Alignments : Family Browser (UCSC)PGA4
Gene fusions - Rearrangements
Tumor Fusion PortalPGA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPGA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PGA4
dbVarPGA4
ClinVarPGA4
1000_GenomesPGA4 
Exome Variant ServerPGA4
ExAC (Exome Aggregation Consortium)ENSG00000229183
GNOMAD BrowserENSG00000229183
Genetic variants : HAPMAP643847
Genomic Variants (DGV)PGA4 [DGVbeta]
DECIPHERPGA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPGA4 
Mutations
ICGC Data PortalPGA4 
TCGA Data PortalPGA4 
Broad Tumor PortalPGA4
OASIS PortalPGA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPGA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPGA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PGA4
DgiDB (Drug Gene Interaction Database)PGA4
DoCM (Curated mutations)PGA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PGA4 (select a term)
intoGenPGA4
Cancer3DPGA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM169720   
Orphanet
DisGeNETPGA4
MedgenPGA4
Genetic Testing Registry PGA4
NextProtP0DJD7 [Medical]
TSGene643847
GENETestsPGA4
Target ValidationPGA4
Huge Navigator PGA4 [HugePedia]
snp3D : Map Gene to Disease643847
BioCentury BCIQPGA4
ClinGenPGA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD643847
Chemical/Pharm GKB GenePA33223
Clinical trialPGA4
Miscellaneous
canSAR (ICR)PGA4 (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePGA4
EVEXPGA4
GoPubMedPGA4
iHOPPGA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:25:00 CET 2017

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