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PGAP6 (post-glycosylphosphatidylinositol attachment to proteins 6)

Identity

Alias (NCBI)GPI-PLA2
M83
TMEM6
TMEM8
TMEM8A
HGNC (Hugo) PGAP6
HGNC Alias symbM83
HGNC Previous nameTMEM6
 TMEM8
HGNC Previous nametransmembrane protein 6
 transmembrane protein 8 (five membrane-spanning domains)
LocusID (NCBI) 58986
Atlas_Id 74989
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 370789 and ends at 381978 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)PGAP6   17205
Cards
Entrez_Gene (NCBI)PGAP6    post-glycosylphosphatidylinositol attachment to proteins 6
AliasesGPI-PLA2; M83; TMEM6; TMEM8; 
TMEM8A
GeneCards (Weizmann)PGAP6
Ensembl hg19 (Hinxton)ENSG00000129925 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129925 [Gene_View]  ENSG00000129925 [Sequence]  chr16:370789-381978 [Contig_View]  PGAP6 [Vega]
ICGC DataPortalENSG00000129925
TCGA cBioPortalPGAP6
AceView (NCBI)PGAP6
Genatlas (Paris)PGAP6
SOURCE (Princeton)PGAP6
Genetics Home Reference (NIH)PGAP6
Genomic and cartography
GoldenPath hg38 (UCSC)PGAP6  -     chr16:370789-381978 -  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PGAP6  -     16p13.3   [Description]    (hg19-Feb_2009)
GoldenPathPGAP6 - 16p13.3 [CytoView hg19]  PGAP6 - 16p13.3 [CytoView hg38]
ImmunoBaseENSG00000129925
Genome Data Viewer NCBIPGAP6 [Mapview hg19]  
OMIM619342   
Gene and transcription
Genbank (Entrez)AB045292 AI678371 AK024725 AK091823 AL537021
RefSeq transcript (Entrez)NM_021259
Consensus coding sequences : CCDS (NCBI)PGAP6
Gene ExpressionPGAP6 [ NCBI-GEO ]   PGAP6 [ EBI - ARRAY_EXPRESS ]   PGAP6 [ SEEK ]   PGAP6 [ MEM ]
Gene Expression Viewer (FireBrowse)PGAP6 [ Firebrowse - Broad ]
GenevisibleExpression of PGAP6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)58986
GTEX Portal (Tissue expression)PGAP6
Human Protein AtlasENSG00000129925-PGAP6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCN3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCN3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCN3
PhosPhoSitePlusQ9HCN3
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_dom    NGX6/PGAP6/MYMK   
Domain families : Pfam (Sanger)DUF3522 (PF12036)   
Domain families : Pfam (NCBI)pfam12036   
Conserved Domain (NCBI)PGAP6
SuperfamilyQ9HCN3
AlphaFold pdb e-kbQ9HCN3   
Human Protein Atlas [tissue]ENSG00000129925-PGAP6 [tissue]
HPRD11636
Protein Interaction databases
DIP (DOE-UCLA)Q9HCN3
IntAct (EBI)Q9HCN3
BioGRIDPGAP6
STRING (EMBL)PGAP6
ZODIACPGAP6
Ontologies - Pathways
QuickGOQ9HCN3
Ontology : AmiGOmolecular_function  phospholipase A2 activity  protein binding  lysosomal membrane  plasma membrane  integral component of plasma membrane  biological_process  extracellular exosome  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  
Ontology : EGO-EBImolecular_function  phospholipase A2 activity  protein binding  lysosomal membrane  plasma membrane  integral component of plasma membrane  biological_process  extracellular exosome  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  
NDEx NetworkPGAP6
Atlas of Cancer Signalling NetworkPGAP6
Wikipedia pathwaysPGAP6
Orthology - Evolution
OrthoDB58986
GeneTree (enSembl)ENSG00000129925
Phylogenetic Trees/Animal Genes : TreeFamPGAP6
Homologs : HomoloGenePGAP6
Homology/Alignments : Family Browser (UCSC)PGAP6
Gene fusions - Rearrangements
Fusion : QuiverPGAP6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPGAP6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PGAP6
dbVarPGAP6
ClinVarPGAP6
MonarchPGAP6
1000_GenomesPGAP6 
Exome Variant ServerPGAP6
GNOMAD BrowserENSG00000129925
Varsome BrowserPGAP6
ACMGPGAP6 variants
VarityQ9HCN3
Genomic Variants (DGV)PGAP6 [DGVbeta]
DECIPHERPGAP6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPGAP6 
Mutations
ICGC Data PortalPGAP6 
TCGA Data PortalPGAP6 
Broad Tumor PortalPGAP6
OASIS PortalPGAP6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPGAP6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPGAP6
Mutations and Diseases : HGMDPGAP6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPGAP6
DgiDB (Drug Gene Interaction Database)PGAP6
DoCM (Curated mutations)PGAP6
CIViC (Clinical Interpretations of Variants in Cancer)PGAP6
Cancer3DPGAP6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM619342   
Orphanet
DisGeNETPGAP6
MedgenPGAP6
Genetic Testing Registry PGAP6
NextProtQ9HCN3 [Medical]
GENETestsPGAP6
Target ValidationPGAP6
Huge Navigator PGAP6 [HugePedia]
ClinGenPGAP6
Clinical trials, drugs, therapy
MyCancerGenomePGAP6
Protein Interactions : CTDPGAP6
Pharm GKB GenePA38211
PharosQ9HCN3
Clinical trialPGAP6
Miscellaneous
canSAR (ICR)PGAP6
HarmonizomePGAP6
DataMed IndexPGAP6
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPGAP6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:15:59 CEST 2021

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