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PGC (progastricsin (pepsinogen C))

Identity

Other namesPEPC
PGII
HGNC (Hugo) PGC
LocusID (NCBI) 5225
Atlas_Id 43776
Location 6p21.1
Location_base_pair Starts at 41708576 and ends at 41715139 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GTF2H3 (12q24.31) / PGC (6p21.1)NCOR2 (12q24.31) / PGC (6p21.1)PGC (6p21.1) / PGC (6p21.1)
TFEB (6p21.1) / PGC (6p21.1)GTF2H3 12q24.31 / PGC 6p21.1NCOR2 12q24.31 / PGC 6p21.1
TFEB 6p21.1 / PGC 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PGC   8890
Cards
Entrez_Gene (NCBI)PGC  5225  progastricsin (pepsinogen C)
AliasesPEPC; PGII
GeneCards (Weizmann)PGC
Ensembl hg19 (Hinxton)ENSG00000096088 [Gene_View]  chr6:41708576-41715139 [Contig_View]  PGC [Vega]
Ensembl hg38 (Hinxton)ENSG00000096088 [Gene_View]  chr6:41708576-41715139 [Contig_View]  PGC [Vega]
ICGC DataPortalENSG00000096088
TCGA cBioPortalPGC
AceView (NCBI)PGC
Genatlas (Paris)PGC
WikiGenes5225
SOURCE (Princeton)PGC
Genomic and cartography
GoldenPath hg19 (UCSC)PGC  -     chr6:41708576-41715139 -  6p21.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PGC  -     6p21.1   [Description]    (hg38-Dec_2013)
EnsemblPGC - 6p21.1 [CytoView hg19]  PGC - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIPGC [Mapview hg19]  PGC [Mapview hg38]
OMIM169740   
Gene and transcription
Genbank (Entrez)AK223274 AK301298 AK301325 BC042578 BC073740
RefSeq transcript (Entrez)NM_001166424 NM_002630
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_007592 NW_004929326
Consensus coding sequences : CCDS (NCBI)PGC
Cluster EST : UnigeneHs.1867 [ NCBI ]
CGAP (NCI)Hs.1867
Alternative Splicing GalleryENSG00000096088
Gene ExpressionPGC [ NCBI-GEO ]   PGC [ EBI - ARRAY_EXPRESS ]   PGC [ SEEK ]   PGC [ MEM ]
Gene Expression Viewer (FireBrowse)PGC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5225
GTEX Portal (Tissue expression)PGC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20142 (Uniprot)
NextProtP20142  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20142
Splice isoforms : SwissVarP20142 (Swissvar)
Catalytic activity : Enzyme3.4.23.3 [ Enzyme-Expasy ]   3.4.23.33.4.23.3 [ IntEnz-EBI ]   3.4.23.3 [ BRENDA ]   3.4.23.3 [ KEGG ]   
PhosPhoSitePlusP20142
Domaine pattern : Prosite (Expaxy)ASP_PROTEASE (PS00141)    PEPTIDASE_A1 (PS51767)   
Domains : Interpro (EBI)Aspartic_peptidase_A1    Aspartic_peptidase_AS    Aspartic_peptidase_N    Peptidase_aspartic_dom   
Domain families : Pfam (Sanger)A1_Propeptide (PF07966)   
Domain families : Pfam (NCBI)pfam07966   
DMDM Disease mutations5225
Blocks (Seattle)PGC
PDB (SRS)1AVF    1HTR   
PDB (PDBSum)1AVF    1HTR   
PDB (IMB)1AVF    1HTR   
PDB (RSDB)1AVF    1HTR   
Structural Biology KnowledgeBase1AVF    1HTR   
SCOP (Structural Classification of Proteins)1AVF    1HTR   
CATH (Classification of proteins structures)1AVF    1HTR   
SuperfamilyP20142
Human Protein AtlasENSG00000096088
Peptide AtlasP20142
HPRD01357
IPIIPI00022213   IPI00383359   IPI00910787   IPI00607684   IPI00792533   
Protein Interaction databases
DIP (DOE-UCLA)P20142
IntAct (EBI)P20142
FunCoupENSG00000096088
BioGRIDPGC
STRING (EMBL)PGC
ZODIACPGC
Ontologies - Pathways
QuickGOP20142
Ontology : AmiGOpositive regulation of antibacterial peptide production  aspartic-type endopeptidase activity  extracellular space  proteolysis  digestion  protein catabolic process  extracellular exosome  
Ontology : EGO-EBIpositive regulation of antibacterial peptide production  aspartic-type endopeptidase activity  extracellular space  proteolysis  digestion  protein catabolic process  extracellular exosome  
NDEx Network
Atlas of Cancer Signalling NetworkPGC
Wikipedia pathwaysPGC
Orthology - Evolution
OrthoDB5225
GeneTree (enSembl)ENSG00000096088
Phylogenetic Trees/Animal Genes : TreeFamPGC
Homologs : HomoloGenePGC
Homology/Alignments : Family Browser (UCSC)PGC
Gene fusions - Rearrangements
Fusion: TCGAGTF2H3 12q24.31 PGC 6p21.1 GBM
Fusion: TCGANCOR2 12q24.31 PGC 6p21.1 LUAD
Fusion: TCGATFEB 6p21.1 PGC 6p21.1 OV
Polymorphisms : SNP, variants
NCBI Variation ViewerPGC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PGC
dbVarPGC
ClinVarPGC
1000_GenomesPGC 
Exome Variant ServerPGC
ExAC (Exome Aggregation Consortium)PGC (select the gene name)
Genetic variants : HAPMAP5225
Genomic Variants (DGV)PGC [DGVbeta]
Mutations
ICGC Data PortalPGC 
TCGA Data PortalPGC 
Broad Tumor PortalPGC
OASIS PortalPGC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPGC 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PGC
DgiDB (Drug Gene Interaction Database)PGC
DoCM (Curated mutations)PGC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PGC (select a term)
intoGenPGC
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:41708576-41715139  ENSG00000096088
CONAN: Copy Number AnalysisPGC 
Mutations and Diseases : HGMDPGC
OMIM169740   
MedgenPGC
Genetic Testing Registry PGC
NextProtP20142 [Medical]
TSGene5225
GENETestsPGC
Huge Navigator PGC [HugePedia]
snp3D : Map Gene to Disease5225
BioCentury BCIQPGC
ClinGenPGC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5225
Chemical/Pharm GKB GenePA33228
Clinical trialPGC
Miscellaneous
canSAR (ICR)PGC (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePGC
EVEXPGC
GoPubMedPGC
iHOPPGC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:15:30 CEST 2016

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