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PGC (progastricsin (pepsinogen C))

Identity

Other namesPEPC
PGII
HGNC (Hugo) PGC
LocusID (NCBI) 5225
Location 6p21.1
Location_base_pair Starts at 41708576 and ends at 41715139 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PGC   8890
Cards
Entrez_Gene (NCBI)PGC  5225  progastricsin (pepsinogen C)
GeneCards (Weizmann)PGC
Ensembl (Hinxton)ENSG00000096088 [Gene_View]  chr6:41708576-41715139 [Contig_View]  PGC [Vega]
ICGC DataPortalENSG00000096088
cBioPortalPGC
AceView (NCBI)PGC
Genatlas (Paris)PGC
WikiGenes5225
SOURCE (Princeton)NM_001166424 NM_002630
Genomic and cartography
GoldenPath (UCSC)PGC  -  6p21.1   chr6:41708576-41715139 -  6p21.1   [Description]    (hg19-Feb_2009)
EnsemblPGC - 6p21.1 [CytoView]
Mapping of homologs : NCBIPGC [Mapview]
OMIM169740   
Gene and transcription
Genbank (Entrez)AK223274 AK301298 AK301325 BC042578 BC073740
RefSeq transcript (Entrez)NM_001166424 NM_002630
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NT_007592 NW_001838981 NW_004929326
Consensus coding sequences : CCDS (NCBI)PGC
Cluster EST : UnigeneHs.1867 [ NCBI ]
CGAP (NCI)Hs.1867
Alternative Splicing : Fast-db (Paris)GSHG0026605
Alternative Splicing GalleryENSG00000096088
Gene ExpressionPGC [ NCBI-GEO ]     PGC [ SEEK ]   PGC [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20142 (Uniprot)
NextProtP20142  [Medical]
With graphics : InterProP20142
Splice isoforms : SwissVarP20142 (Swissvar)
Catalytic activity : Enzyme3.4.23.3 [ Enzyme-Expasy ]   3.4.23.33.4.23.3 [ IntEnz-EBI ]   3.4.23.3 [ BRENDA ]   3.4.23.3 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)ASP_PROTEASE (PS00141)   
Domains : Interpro (EBI)Aspartic_peptidase [organisation]   Aspartic_peptidase_AS [organisation]   Aspartic_peptidase_N [organisation]   Peptidase_aspartic_dom [organisation]  
Related proteins : CluSTrP20142
Domain families : Pfam (Sanger)A1_Propeptide (PF07966)    Asp (PF00026)   
Domain families : Pfam (NCBI)pfam07966    pfam00026   
DMDM Disease mutations5225
Blocks (Seattle)P20142
PDB (SRS)1AVF    1HTR   
PDB (PDBSum)1AVF    1HTR   
PDB (IMB)1AVF    1HTR   
PDB (RSDB)1AVF    1HTR   
Human Protein AtlasENSG00000096088 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP20142
HPRD01357
IPIIPI00022213   IPI00383359   IPI00910787   IPI00607684   IPI00792533   
Protein Interaction databases
DIP (DOE-UCLA)P20142
IntAct (EBI)P20142
FunCoupENSG00000096088
BioGRIDPGC
InParanoidP20142
Interologous Interaction database P20142
IntegromeDBPGC
STRING (EMBL)PGC
Ontologies - Pathways
Ontology : AmiGOaspartic-type endopeptidase activity  extracellular space  proteolysis  digestion  extracellular vesicular exosome  
Ontology : EGO-EBIaspartic-type endopeptidase activity  extracellular space  proteolysis  digestion  extracellular vesicular exosome  
Protein Interaction DatabasePGC
Wikipedia pathwaysPGC
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PGC
snp3D : Map Gene to Disease5225
SNP (GeneSNP Utah)PGC
SNP : HGBasePGC
Genetic variants : HAPMAPPGC
Exome VariantPGC
1000_GenomesPGC 
ICGC programENSG00000096088 
Somatic Mutations in Cancer : COSMICPGC 
CONAN: Copy Number AnalysisPGC 
Mutations and Diseases : HGMDPGC
Genomic VariantsPGC  PGC [DGVbeta]
dbVarPGC
ClinVarPGC
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM169740   
MedgenPGC
GENETestsPGC
Disease Genetic AssociationPGC
Huge Navigator PGC [HugePedia]  PGC [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePGC
Homology/Alignments : Family Browser (UCSC)PGC
Phylogenetic Trees/Animal Genes : TreeFamPGC
Chemical/Protein Interactions : CTD5225
Chemical/Pharm GKB GenePA33228
Clinical trialPGC
Cancer Resource (Charite)ENSG00000096088
Other databases
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
CoreMinePGC
iHOPPGC
OncoSearchPGC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:42:56 CEST 2014

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