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PGF (placental growth factor)

Identity

Other namesD12S1900
PGFL
PLGF
PlGF-2
SHGC-10760
HGNC (Hugo) PGF
LocusID (NCBI) 5228
Atlas_Id 41696
Location 14q24.3
Location_base_pair Starts at 75408533 and ends at 75422467 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Kidney: Clear cell sarcoma with t(10;17)(q22;p13) YWHAE/NUTM2E

External links

Nomenclature
HGNC (Hugo)PGF   8893
Cards
Entrez_Gene (NCBI)PGF  5228  placental growth factor
GeneCards (Weizmann)PGF
Ensembl hg19 (Hinxton)ENSG00000119630 [Gene_View]  chr14:75408533-75422467 [Contig_View]  PGF [Vega]
Ensembl hg38 (Hinxton)ENSG00000119630 [Gene_View]  chr14:75408533-75422467 [Contig_View]  PGF [Vega]
ICGC DataPortalENSG00000119630
TCGA cBioPortalPGF
AceView (NCBI)PGF
Genatlas (Paris)PGF
WikiGenes5228
SOURCE (Princeton)PGF
Genomic and cartography
GoldenPath hg19 (UCSC)PGF  -     chr14:75408533-75422467 -  14q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PGF  -     14q24.3   [Description]    (hg38-Dec_2013)
EnsemblPGF - 14q24.3 [CytoView hg19]  PGF - 14q24.3 [CytoView hg38]
Mapping of homologs : NCBIPGF [Mapview hg19]  PGF [Mapview hg38]
OMIM601121   
Gene and transcription
Genbank (Entrez)A18411 AK023843 AK309886 AK310608 AK310886
RefSeq transcript (Entrez)NM_001207012 NM_001293643 NM_002632
RefSeq genomic (Entrez)NC_000014 NC_018925 NG_029168 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)PGF
Cluster EST : UnigeneHs.252820 [ NCBI ]
CGAP (NCI)Hs.252820
Alternative Splicing GalleryENSG00000119630
Gene ExpressionPGF [ NCBI-GEO ]   PGF [ EBI - ARRAY_EXPRESS ]   PGF [ SEEK ]   PGF [ MEM ]
Gene Expression Viewer (FireBrowse)PGF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5228
GTEX Portal (Tissue expression)PGF
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49763 (Uniprot)
NextProtP49763  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49763
Splice isoforms : SwissVarP49763 (Swissvar)
PhosPhoSitePlusP49763
Domaine pattern : Prosite (Expaxy)PDGF_1 (PS00249)    PDGF_2 (PS50278)   
Domains : Interpro (EBI)Cystine-knot_cytokine    PD_growth_factor_CS    PDGF/VEGF_dom   
Domain families : Pfam (Sanger)PDGF (PF00341)   
Domain families : Pfam (NCBI)pfam00341   
Domain families : Smart (EMBL)PDGF (SM00141)  
DMDM Disease mutations5228
Blocks (Seattle)PGF
PDB (SRS)1FZV    1RV6   
PDB (PDBSum)1FZV    1RV6   
PDB (IMB)1FZV    1RV6   
PDB (RSDB)1FZV    1RV6   
Structural Biology KnowledgeBase1FZV    1RV6   
SCOP (Structural Classification of Proteins)1FZV    1RV6   
CATH (Classification of proteins structures)1FZV    1RV6   
SuperfamilyP49763
Human Protein AtlasENSG00000119630
Peptide AtlasP49763
HPRD03076
IPIIPI00028074   IPI00219514   IPI00219515   IPI00384164   IPI01025242   
Protein Interaction databases
DIP (DOE-UCLA)P49763
IntAct (EBI)P49763
FunCoupENSG00000119630
BioGRIDPGF
STRING (EMBL)PGF
ZODIACPGF
Ontologies - Pathways
QuickGOP49763
Ontology : AmiGObranching involved in ureteric bud morphogenesis  response to hypoxia  positive regulation of endothelial cell proliferation  sprouting angiogenesis  protein binding  extracellular region  extracellular space  signal transduction  cell-cell signaling  female pregnancy  growth factor activity  heparin binding  positive regulation of cell proliferation  membrane  cell differentiation  organ regeneration  cellular response to hormone stimulus  response to drug  protein homodimerization activity  positive regulation of angiogenesis  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  positive regulation of cell division  regulation of morphogenesis of a branching structure  
Ontology : EGO-EBIbranching involved in ureteric bud morphogenesis  response to hypoxia  positive regulation of endothelial cell proliferation  sprouting angiogenesis  protein binding  extracellular region  extracellular space  signal transduction  cell-cell signaling  female pregnancy  growth factor activity  heparin binding  positive regulation of cell proliferation  membrane  cell differentiation  organ regeneration  cellular response to hormone stimulus  response to drug  protein homodimerization activity  positive regulation of angiogenesis  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  positive regulation of cell division  regulation of morphogenesis of a branching structure  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Focal adhesion    Pathways in cancer   
NDEx Network
Atlas of Cancer Signalling NetworkPGF
Wikipedia pathwaysPGF
Orthology - Evolution
OrthoDB5228
GeneTree (enSembl)ENSG00000119630
Phylogenetic Trees/Animal Genes : TreeFamPGF
Homologs : HomoloGenePGF
Homology/Alignments : Family Browser (UCSC)PGF
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPGF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PGF
dbVarPGF
ClinVarPGF
1000_GenomesPGF 
Exome Variant ServerPGF
ExAC (Exome Aggregation Consortium)PGF (select the gene name)
Genetic variants : HAPMAP5228
Genomic Variants (DGV)PGF [DGVbeta]
Mutations
ICGC Data PortalPGF 
TCGA Data PortalPGF 
Broad Tumor PortalPGF
OASIS PortalPGF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPGF 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PGF
DgiDB (Drug Gene Interaction Database)PGF
DoCM (Curated mutations)PGF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PGF (select a term)
intoGenPGF
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:75408533-75422467  ENSG00000119630
CONAN: Copy Number AnalysisPGF 
Mutations and Diseases : HGMDPGF
OMIM601121   
MedgenPGF
Genetic Testing Registry PGF
NextProtP49763 [Medical]
TSGene5228
GENETestsPGF
Huge Navigator PGF [HugePedia]
snp3D : Map Gene to Disease5228
BioCentury BCIQPGF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5228
Chemical/Pharm GKB GenePA33231
Clinical trialPGF
Miscellaneous
canSAR (ICR)PGF (select the gene name)
Probes
Litterature
PubMed227 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePGF
EVEXPGF
GoPubMedPGF
iHOPPGF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sun May 8 19:00:04 CEST 2016

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