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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

Donate (in Euros)

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PGF (placental growth factor)

Identity

Other namesD12S1900
PGFL
PLGF
PlGF-2
SHGC-10760
HGNC (Hugo) PGF
LocusID (NCBI) 5228
Location 14q24.3
Location_base_pair Starts at 75408533 and ends at 75422467 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PGF   8893
Cards
Entrez_Gene (NCBI)PGF  5228  placental growth factor
GeneCards (Weizmann)PGF
Ensembl hg19 (Hinxton)ENSG00000119630 [Gene_View]  chr14:75408533-75422467 [Contig_View]  PGF [Vega]
Ensembl hg38 (Hinxton)ENSG00000119630 [Gene_View]  chr14:75408533-75422467 [Contig_View]  PGF [Vega]
ICGC DataPortalENSG00000119630
cBioPortalPGF
AceView (NCBI)PGF
Genatlas (Paris)PGF
WikiGenes5228
SOURCE (Princeton)PGF
Genomic and cartography
GoldenPath hg19 (UCSC)PGF  -     chr14:75408533-75422467 -  14q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PGF  -     14q24.3   [Description]    (hg38-Dec_2013)
EnsemblPGF - 14q24.3 [CytoView hg19]  PGF - 14q24.3 [CytoView hg38]
Mapping of homologs : NCBIPGF [Mapview hg19]  PGF [Mapview hg38]
OMIM601121   
Gene and transcription
Genbank (Entrez)A18411 AK309886 AK310608 AK310886 AL543693
RefSeq transcript (Entrez)NM_001207012 NM_001293643 NM_002632
RefSeq genomic (Entrez)AC_000146 NC_000014 NC_018925 NG_029168 NT_026437 NW_001838113 NW_004929393
Consensus coding sequences : CCDS (NCBI)PGF
Cluster EST : UnigeneHs.252820 [ NCBI ]
CGAP (NCI)Hs.252820
Alternative Splicing : Fast-db (Paris)GSHG0009495
Alternative Splicing GalleryENSG00000119630
Gene ExpressionPGF [ NCBI-GEO ]     PGF [ SEEK ]   PGF [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49763 (Uniprot)
NextProtP49763  [Medical]
With graphics : InterProP49763
Splice isoforms : SwissVarP49763 (Swissvar)
Domaine pattern : Prosite (Expaxy)PDGF_1 (PS00249)    PDGF_2 (PS50278)   
Domains : Interpro (EBI)Cystine-knot_cytokine    PD_growth_factor_CS    PDGF/VEGF_dom   
Related proteins : CluSTrP49763
Domain families : Pfam (Sanger)PDGF (PF00341)   
Domain families : Pfam (NCBI)pfam00341   
Domain families : Smart (EMBL)PDGF (SM00141)  
DMDM Disease mutations5228
Blocks (Seattle)P49763
PDB (SRS)1FZV    1RV6   
PDB (PDBSum)1FZV    1RV6   
PDB (IMB)1FZV    1RV6   
PDB (RSDB)1FZV    1RV6   
Human Protein AtlasENSG00000119630
Peptide AtlasP49763
HPRD03076
IPIIPI00028074   IPI00219514   IPI00219515   IPI00384164   IPI01025242   
Protein Interaction databases
DIP (DOE-UCLA)P49763
IntAct (EBI)P49763
FunCoupENSG00000119630
BioGRIDPGF
IntegromeDBPGF
STRING (EMBL)PGF
Ontologies - Pathways
QuickGOP49763
Ontology : AmiGObranching involved in ureteric bud morphogenesis  response to hypoxia  positive regulation of endothelial cell proliferation  sprouting angiogenesis  protein binding  extracellular region  extracellular space  signal transduction  cell-cell signaling  female pregnancy  growth factor activity  heparin binding  positive regulation of cell proliferation  membrane  cell differentiation  organ regeneration  cellular response to hormone stimulus  response to drug  protein homodimerization activity  positive regulation of angiogenesis  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  positive regulation of cell division  regulation of morphogenesis of a branching structure  
Ontology : EGO-EBIbranching involved in ureteric bud morphogenesis  response to hypoxia  positive regulation of endothelial cell proliferation  sprouting angiogenesis  protein binding  extracellular region  extracellular space  signal transduction  cell-cell signaling  female pregnancy  growth factor activity  heparin binding  positive regulation of cell proliferation  membrane  cell differentiation  organ regeneration  cellular response to hormone stimulus  response to drug  protein homodimerization activity  positive regulation of angiogenesis  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  positive regulation of cell division  regulation of morphogenesis of a branching structure  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Focal adhesion    Pathways in cancer   
Protein Interaction DatabasePGF
DoCM (Curated mutations)PGF
Wikipedia pathwaysPGF
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPGF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PGF
dbVarPGF
ClinVarPGF
1000_GenomesPGF 
Exome Variant ServerPGF
SNP (GeneSNP Utah)PGF
SNP : HGBasePGF
Genetic variants : HAPMAPPGF
Genomic Variants (DGV)PGF [DGVbeta]
Mutations
ICGC Data PortalENSG00000119630 
Somatic Mutations in Cancer : COSMICPGF 
CONAN: Copy Number AnalysisPGF 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:75408533-75422467
Mutations and Diseases : HGMDPGF
OMIM601121   
MedgenPGF
NextProtP49763 [Medical]
GENETestsPGF
Disease Genetic AssociationPGF
Huge Navigator PGF [HugePedia]  PGF [HugeCancerGEM]
snp3D : Map Gene to Disease5228
DGIdb (Drug Gene Interaction db)PGF
General knowledge
Homologs : HomoloGenePGF
Homology/Alignments : Family Browser (UCSC)PGF
Phylogenetic Trees/Animal Genes : TreeFamPGF
Chemical/Protein Interactions : CTD5228
Chemical/Pharm GKB GenePA33231
Clinical trialPGF
Cancer Resource (Charite)ENSG00000119630
Other databases
Probes
Litterature
PubMed176 Pubmed reference(s) in Entrez
CoreMinePGF
GoPubMedPGF
iHOPPGF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 17:57:57 CET 2015

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jlhuret@AtlasGeneticsOncology.org.