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PGF (placental growth factor)

Identity

Alias (NCBI)D12S1900
PGFL
PIGF
PLGF
PlGF-2
SHGC-10760
HGNC (Hugo) PGF
HGNC Alias symbPLGF
PlGF-2
PlGF
SHGC-10760
D12S1900
PIGF
HGNC Alias nameplacenta growth factor
HGNC Previous namePGFL
HGNC Previous nameplacental growth factor-like
 placental growth factor, vascular endothelial growth factor-related protein
LocusID (NCBI) 5228
Atlas_Id 41696
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 74941830 and ends at 74955764 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Kidney: Clear cell sarcoma with t(10;17)(q22;p13) YWHAE/NUTM2E


External links

Nomenclature
HGNC (Hugo)PGF   8893
Cards
Entrez_Gene (NCBI)PGF  5228  placental growth factor
AliasesD12S1900; PGFL; PIGF; PLGF; 
PlGF-2; SHGC-10760
GeneCards (Weizmann)PGF
Ensembl hg19 (Hinxton)ENSG00000119630 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119630 [Gene_View]  ENSG00000119630 [Sequence]  chr14:74941830-74955764 [Contig_View]  PGF [Vega]
ICGC DataPortalENSG00000119630
TCGA cBioPortalPGF
AceView (NCBI)PGF
Genatlas (Paris)PGF
WikiGenes5228
SOURCE (Princeton)PGF
Genetics Home Reference (NIH)PGF
Genomic and cartography
GoldenPath hg38 (UCSC)PGF  -     chr14:74941830-74955764 -  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PGF  -     14q24.3   [Description]    (hg19-Feb_2009)
GoldenPathPGF - 14q24.3 [CytoView hg19]  PGF - 14q24.3 [CytoView hg38]
ImmunoBaseENSG00000119630
genome Data Viewer NCBIPGF [Mapview hg19]  
OMIM601121   
Gene and transcription
Genbank (Entrez)A18411 AK023843 AK309886 AK310608 AK310886
RefSeq transcript (Entrez)NM_001207012 NM_001293643 NM_002632
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PGF
Alternative Splicing GalleryENSG00000119630
Gene ExpressionPGF [ NCBI-GEO ]   PGF [ EBI - ARRAY_EXPRESS ]   PGF [ SEEK ]   PGF [ MEM ]
Gene Expression Viewer (FireBrowse)PGF [ Firebrowse - Broad ]
GenevisibleExpression of PGF in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5228
GTEX Portal (Tissue expression)PGF
Human Protein AtlasENSG00000119630-PGF [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49763   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49763  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49763
Splice isoforms : SwissVarP49763
PhosPhoSitePlusP49763
Domaine pattern : Prosite (Expaxy)PDGF_1 (PS00249)    PDGF_2 (PS50278)   
Domains : Interpro (EBI)Cystine-knot_cytokine    PD_growth_factor_CS    PDGF/VEGF_dom   
Domain families : Pfam (Sanger)PDGF (PF00341)   
Domain families : Pfam (NCBI)pfam00341   
Domain families : Smart (EMBL)PDGF (SM00141)  
Conserved Domain (NCBI)PGF
DMDM Disease mutations5228
Blocks (Seattle)PGF
PDB (RSDB)1FZV    1RV6   
PDB Europe1FZV    1RV6   
PDB (PDBSum)1FZV    1RV6   
PDB (IMB)1FZV    1RV6   
Structural Biology KnowledgeBase1FZV    1RV6   
SCOP (Structural Classification of Proteins)1FZV    1RV6   
CATH (Classification of proteins structures)1FZV    1RV6   
SuperfamilyP49763
Human Protein Atlas [tissue]ENSG00000119630-PGF [tissue]
Peptide AtlasP49763
HPRD03076
IPIIPI00028074   IPI00219514   IPI00219515   IPI00384164   IPI01025242   
Protein Interaction databases
DIP (DOE-UCLA)P49763
IntAct (EBI)P49763
FunCoupENSG00000119630
BioGRIDPGF
STRING (EMBL)PGF
ZODIACPGF
Ontologies - Pathways
QuickGOP49763
Ontology : AmiGOangiogenesis  branching involved in ureteric bud morphogenesis  response to hypoxia  positive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  sprouting angiogenesis  vascular endothelial growth factor receptor binding  protein binding  extracellular region  extracellular space  signal transduction  cell-cell signaling  female pregnancy  growth factor activity  growth factor activity  heparin binding  positive regulation of cell proliferation  membrane  cell differentiation  animal organ regeneration  cellular response to hormone stimulus  vascular endothelial growth factor signaling pathway  chemoattractant activity  response to drug  identical protein binding  protein-containing complex binding  positive regulation of angiogenesis  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  positive chemotaxis  induction of positive chemotaxis  positive regulation of cell division  regulation of morphogenesis of a branching structure  positive regulation of mast cell chemotaxis  
Ontology : EGO-EBIangiogenesis  branching involved in ureteric bud morphogenesis  response to hypoxia  positive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  sprouting angiogenesis  vascular endothelial growth factor receptor binding  protein binding  extracellular region  extracellular space  signal transduction  cell-cell signaling  female pregnancy  growth factor activity  growth factor activity  heparin binding  positive regulation of cell proliferation  membrane  cell differentiation  animal organ regeneration  cellular response to hormone stimulus  vascular endothelial growth factor signaling pathway  chemoattractant activity  response to drug  identical protein binding  protein-containing complex binding  positive regulation of angiogenesis  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  positive chemotaxis  induction of positive chemotaxis  positive regulation of cell division  regulation of morphogenesis of a branching structure  positive regulation of mast cell chemotaxis  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Focal adhesion    Pathways in cancer   
NDEx NetworkPGF
Atlas of Cancer Signalling NetworkPGF
Wikipedia pathwaysPGF
Orthology - Evolution
OrthoDB5228
GeneTree (enSembl)ENSG00000119630
Phylogenetic Trees/Animal Genes : TreeFamPGF
HOGENOMP49763
Homologs : HomoloGenePGF
Homology/Alignments : Family Browser (UCSC)PGF
Gene fusions - Rearrangements
Fusion : QuiverPGF
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPGF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PGF
dbVarPGF
ClinVarPGF
MonarchPGF
1000_GenomesPGF 
Exome Variant ServerPGF
GNOMAD BrowserENSG00000119630
Varsome BrowserPGF
Genetic variants : HAPMAP5228
Genomic Variants (DGV)PGF [DGVbeta]
DECIPHERPGF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPGF 
Mutations
ICGC Data PortalPGF 
TCGA Data PortalPGF 
Broad Tumor PortalPGF
OASIS PortalPGF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPGF  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPGF
Mutations and Diseases : HGMDPGF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PGF
DgiDB (Drug Gene Interaction Database)PGF
DoCM (Curated mutations)PGF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PGF (select a term)
intoGenPGF
Cancer3DPGF(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601121   
Orphanet
DisGeNETPGF
MedgenPGF
Genetic Testing Registry PGF
NextProtP49763 [Medical]
TSGene5228
GENETestsPGF
Target ValidationPGF
Huge Navigator PGF [HugePedia]
snp3D : Map Gene to Disease5228
BioCentury BCIQPGF
ClinGenPGF
Clinical trials, drugs, therapy
Protein Interactions : CTD5228
Pharm GKB GenePA33231
Clinical trialPGF
Miscellaneous
canSAR (ICR)PGF (select the gene name)
HarmonizomePGF
DataMed IndexPGF
Probes
Litterature
PubMed355 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePGF
EVEXPGF
GoPubMedPGF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 14 14:26:29 CEST 2020

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