PGF (placental growth factor)

2003-02-01  

Identity

HGNC
PGF
LOCATION
14q24.3
LOCUSID
5228
ALIAS
D12S1900,PGFL,PIGF,PLGF,PlGF-2,SHGC-10760

Other Information

Locus ID:

NCBI: 5228
MIM: 601121
HGNC: 8893
Ensembl: ENSG00000119630

Variants:

dbSNP: 5228
ClinVar: 5228
TCGA: ENSG00000119630
COSMIC: PGF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119630ENST00000238607G3XA84
ENSG00000119630ENST00000405431P49763
ENSG00000119630ENST00000553716P49763
ENSG00000119630ENST00000555567P49763
ENSG00000119630ENST00000555567Q53XY6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Focal adhesionKEGGhsa04510
Pathways in cancerKEGGhsa05200
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGF ligand-receptor interactionsREACTOMER-HSA-194313
VEGF binds to VEGFR leading to receptor dimerizationREACTOMER-HSA-195399

References

Pubmed IDYearTitleCitations
212157062011HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.216
181752412008A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate.187
120918802002Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment.132
167026042006Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality.96
125482142003Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies.83
234528542013Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.80
241909342013Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study.68
158862532005Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normotensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor.61
220006722012The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients.60
217031892011Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer.52

Citation

Dessen P

PGF (placental growth factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41696/pgf