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PGF (placental growth factor)

Identity

Other namesD12S1900
PGFL
PLGF
PlGF-2
SHGC-10760
HGNC (Hugo) PGF
LocusID (NCBI) 5228
Location 14q24.3
Location_base_pair Starts at 75408533 and ends at 75422467 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PGF   8893
Cards
Entrez_Gene (NCBI)PGF  5228  placental growth factor
GeneCards (Weizmann)PGF
Ensembl (Hinxton)ENSG00000119630 [Gene_View]  chr14:75408533-75422467 [Contig_View]  PGF [Vega]
ICGC DataPortalENSG00000119630
cBioPortalPGF
AceView (NCBI)PGF
Genatlas (Paris)PGF
WikiGenes5228
SOURCE (Princeton)NM_001207012 NM_001293643 NM_002632
Genomic and cartography
GoldenPath (UCSC)PGF  -  14q24.3   chr14:75408533-75422467 -  14q24.3   [Description]    (hg19-Feb_2009)
EnsemblPGF - 14q24.3 [CytoView]
Mapping of homologs : NCBIPGF [Mapview]
OMIM601121   
Gene and transcription
Genbank (Entrez)A18411 AK309886 AK310608 AK310886 AL543693
RefSeq transcript (Entrez)NM_001207012 NM_001293643 NM_002632
RefSeq genomic (Entrez)AC_000146 NC_000014 NC_018925 NG_029168 NT_026437 NW_001838113 NW_004929393
Consensus coding sequences : CCDS (NCBI)PGF
Cluster EST : UnigeneHs.252820 [ NCBI ]
CGAP (NCI)Hs.252820
Alternative Splicing : Fast-db (Paris)GSHG0009495
Alternative Splicing GalleryENSG00000119630
Gene ExpressionPGF [ NCBI-GEO ]     PGF [ SEEK ]   PGF [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49763 (Uniprot)
NextProtP49763  [Medical]
With graphics : InterProP49763
Splice isoforms : SwissVarP49763 (Swissvar)
Domaine pattern : Prosite (Expaxy)PDGF_1 (PS00249)    PDGF_2 (PS50278)   
Domains : Interpro (EBI)Cystine-knot_cytokine [organisation]   PD_growth_factor_CS [organisation]   PDGF/VEGF_dom [organisation]  
Related proteins : CluSTrP49763
Domain families : Pfam (Sanger)PDGF (PF00341)   
Domain families : Pfam (NCBI)pfam00341   
Domain families : Smart (EMBL)PDGF (SM00141)  
DMDM Disease mutations5228
Blocks (Seattle)P49763
PDB (SRS)1FZV    1RV6   
PDB (PDBSum)1FZV    1RV6   
PDB (IMB)1FZV    1RV6   
PDB (RSDB)1FZV    1RV6   
Human Protein AtlasENSG00000119630 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP49763
HPRD03076
IPIIPI00028074   IPI00219514   IPI00219515   IPI00384164   IPI01025242   
Protein Interaction databases
DIP (DOE-UCLA)P49763
IntAct (EBI)P49763
FunCoupENSG00000119630
BioGRIDPGF
InParanoidP49763
Interologous Interaction database P49763
IntegromeDBPGF
STRING (EMBL)PGF
Ontologies - Pathways
Ontology : AmiGObranching involved in ureteric bud morphogenesis  response to hypoxia  positive regulation of endothelial cell proliferation  sprouting angiogenesis  protein binding  extracellular region  extracellular space  signal transduction  cell-cell signaling  female pregnancy  growth factor activity  heparin binding  positive regulation of cell proliferation  membrane  cell differentiation  organ regeneration  cellular response to hormone stimulus  response to drug  protein homodimerization activity  positive regulation of angiogenesis  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  positive regulation of cell division  regulation of morphogenesis of a branching structure  
Ontology : EGO-EBIbranching involved in ureteric bud morphogenesis  response to hypoxia  positive regulation of endothelial cell proliferation  sprouting angiogenesis  protein binding  extracellular region  extracellular space  signal transduction  cell-cell signaling  female pregnancy  growth factor activity  heparin binding  positive regulation of cell proliferation  membrane  cell differentiation  organ regeneration  cellular response to hormone stimulus  response to drug  protein homodimerization activity  positive regulation of angiogenesis  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  positive regulation of cell division  regulation of morphogenesis of a branching structure  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Focal adhesion    Pathways in cancer   
Protein Interaction DatabasePGF
Wikipedia pathwaysPGF
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PGF
snp3D : Map Gene to Disease5228
SNP (GeneSNP Utah)PGF
SNP : HGBasePGF
Genetic variants : HAPMAPPGF
Exome VariantPGF
1000_GenomesPGF 
ICGC programENSG00000119630 
Somatic Mutations in Cancer : COSMICPGF 
CONAN: Copy Number AnalysisPGF 
Mutations and Diseases : HGMDPGF
Mutations and Diseases : intOGenPGF
Genomic VariantsPGF  PGF [DGVbeta]
dbVarPGF
ClinVarPGF
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM601121   
MedgenPGF
GENETestsPGF
Disease Genetic AssociationPGF
Huge Navigator PGF [HugePedia]  PGF [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePGF
Homology/Alignments : Family Browser (UCSC)PGF
Phylogenetic Trees/Animal Genes : TreeFamPGF
Chemical/Protein Interactions : CTD5228
Chemical/Pharm GKB GenePA33231
Clinical trialPGF
Cancer Resource (Charite)ENSG00000119630
Other databases
Probes
Litterature
PubMed176 Pubmed reference(s) in Entrez
CoreMinePGF
iHOPPGF
OncoSearchPGF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:59:28 CEST 2014

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