Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PGGT1B (protein geranylgeranyltransferase type I subunit beta)

Identity

Alias_namesprotein geranylgeranyltransferase type I
Alias_symbol (synonym)GGTI
BGGI
Other alias
HGNC (Hugo) PGGT1B
LocusID (NCBI) 5229
Atlas_Id 43928
Location 5q22.3  [Link to chromosome band 5q22]
Location_base_pair Starts at 115210830 and ends at 115262872 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PGGT1B (5q22.3) / KIAA0825 (5q15)PGGT1B 5q22.3 / KIAA0825 5q15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PGGT1B   8895
Cards
Entrez_Gene (NCBI)PGGT1B  5229  protein geranylgeranyltransferase type I subunit beta
AliasesBGGI; GGTI
GeneCards (Weizmann)PGGT1B
Ensembl hg19 (Hinxton)ENSG00000164219 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164219 [Gene_View]  chr5:115210830-115262872 [Contig_View]  PGGT1B [Vega]
ICGC DataPortalENSG00000164219
TCGA cBioPortalPGGT1B
AceView (NCBI)PGGT1B
Genatlas (Paris)PGGT1B
WikiGenes5229
SOURCE (Princeton)PGGT1B
Genetics Home Reference (NIH)PGGT1B
Genomic and cartography
GoldenPath hg38 (UCSC)PGGT1B  -     chr5:115210830-115262872 -  5q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PGGT1B  -     5q22.3   [Description]    (hg19-Feb_2009)
EnsemblPGGT1B - 5q22.3 [CytoView hg19]  PGGT1B - 5q22.3 [CytoView hg38]
Mapping of homologs : NCBIPGGT1B [Mapview hg19]  PGGT1B [Mapview hg38]
OMIM602031   
Gene and transcription
Genbank (Entrez)AK096154 AL520655 AW382606 AY780790 BC111924
RefSeq transcript (Entrez)NM_005023
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PGGT1B
Cluster EST : UnigeneHs.594968 [ NCBI ]
CGAP (NCI)Hs.594968
Alternative Splicing GalleryENSG00000164219
Gene ExpressionPGGT1B [ NCBI-GEO ]   PGGT1B [ EBI - ARRAY_EXPRESS ]   PGGT1B [ SEEK ]   PGGT1B [ MEM ]
Gene Expression Viewer (FireBrowse)PGGT1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5229
GTEX Portal (Tissue expression)PGGT1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53609   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53609  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53609
Splice isoforms : SwissVarP53609
Catalytic activity : Enzyme2.5.1.59 [ Enzyme-Expasy ]   2.5.1.592.5.1.59 [ IntEnz-EBI ]   2.5.1.59 [ BRENDA ]   2.5.1.59 [ KEGG ]   
PhosPhoSitePlusP53609
Domains : Interpro (EBI)PFTB_repeat    Terpenoid_cyclase/PrenylTrfase   
Domain families : Pfam (Sanger)Prenyltrans (PF00432)   
Domain families : Pfam (NCBI)pfam00432   
Conserved Domain (NCBI)PGGT1B
DMDM Disease mutations5229
Blocks (Seattle)PGGT1B
SuperfamilyP53609
Human Protein AtlasENSG00000164219
Peptide AtlasP53609
HPRD03612
IPIIPI00022759   IPI00549741   
Protein Interaction databases
DIP (DOE-UCLA)P53609
IntAct (EBI)P53609
FunCoupENSG00000164219
BioGRIDPGGT1B
STRING (EMBL)PGGT1B
ZODIACPGGT1B
Ontologies - Pathways
QuickGOP53609
Ontology : AmiGOprotein geranylgeranyltransferase activity  CAAX-protein geranylgeranyltransferase activity  CAAX-protein geranylgeranyltransferase activity  CAAX-protein geranylgeranyltransferase complex  drug binding  zinc ion binding  positive regulation of cell proliferation  protein geranylgeranylation  isoprenoid binding  response to cytokine  peptide binding  positive regulation of cell cycle  negative regulation of nitric-oxide synthase biosynthetic process  
Ontology : EGO-EBIprotein geranylgeranyltransferase activity  CAAX-protein geranylgeranyltransferase activity  CAAX-protein geranylgeranyltransferase activity  CAAX-protein geranylgeranyltransferase complex  drug binding  zinc ion binding  positive regulation of cell proliferation  protein geranylgeranylation  isoprenoid binding  response to cytokine  peptide binding  positive regulation of cell cycle  negative regulation of nitric-oxide synthase biosynthetic process  
NDEx NetworkPGGT1B
Atlas of Cancer Signalling NetworkPGGT1B
Wikipedia pathwaysPGGT1B
Orthology - Evolution
OrthoDB5229
GeneTree (enSembl)ENSG00000164219
Phylogenetic Trees/Animal Genes : TreeFamPGGT1B
HOVERGENP53609
HOGENOMP53609
Homologs : HomoloGenePGGT1B
Homology/Alignments : Family Browser (UCSC)PGGT1B
Gene fusions - Rearrangements
Fusion : MitelmanPGGT1B/KIAA0825 [5q22.3/5q15]  
Fusion: TCGAPGGT1B 5q22.3 KIAA0825 5q15 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPGGT1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PGGT1B
dbVarPGGT1B
ClinVarPGGT1B
1000_GenomesPGGT1B 
Exome Variant ServerPGGT1B
ExAC (Exome Aggregation Consortium)PGGT1B (select the gene name)
Genetic variants : HAPMAP5229
Genomic Variants (DGV)PGGT1B [DGVbeta]
DECIPHERPGGT1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPGGT1B 
Mutations
ICGC Data PortalPGGT1B 
TCGA Data PortalPGGT1B 
Broad Tumor PortalPGGT1B
OASIS PortalPGGT1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPGGT1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPGGT1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PGGT1B
DgiDB (Drug Gene Interaction Database)PGGT1B
DoCM (Curated mutations)PGGT1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PGGT1B (select a term)
intoGenPGGT1B
Cancer3DPGGT1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602031   
Orphanet
MedgenPGGT1B
Genetic Testing Registry PGGT1B
NextProtP53609 [Medical]
TSGene5229
GENETestsPGGT1B
Target ValidationPGGT1B
Huge Navigator PGGT1B [HugePedia]
snp3D : Map Gene to Disease5229
BioCentury BCIQPGGT1B
ClinGenPGGT1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5229
Chemical/Pharm GKB GenePA33233
Clinical trialPGGT1B
Miscellaneous
canSAR (ICR)PGGT1B (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePGGT1B
EVEXPGGT1B
GoPubMedPGGT1B
iHOPPGGT1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:49:13 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.