PGK1 (phosphoglycerate kinase 1)

2003-05-01  

Identity

HGNC
LOCATION
Xq21.1
LOCUSID
ALIAS
HEL-S-68p,MIG10,PGKA
FUSION GENES

Other Information

Locus ID:

NCBI: 5230
MIM: 311800
HGNC: 8896
Ensembl: ENSG00000102144

Variants:

dbSNP: 5230
ClinVar: 5230
TCGA: ENSG00000102144
COSMIC: PGK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102144ENST00000373316P00558
ENSG00000102144ENST00000373316V9HWF4
ENSG00000102144ENST00000644362P00558

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Glycolysis / GluconeogenesisKEGGhsa00010
Metabolic pathwaysKEGGhsa01100
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Glycolysis, core module involving three-carbon compoundsKEGGhsa_M00002
Gluconeogenesis, oxaloacetate => fructose-6PKEGGhsa_M00003
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
Glycolysis, core module involving three-carbon compoundsKEGGM00002
Gluconeogenesis, oxaloacetate => fructose-6PKEGGM00003
HIF-1 signaling pathwayKEGGhsa04066
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GlycolysisREACTOMER-HSA-70171
GluconeogenesisREACTOMER-HSA-70263

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA450163lamivudineChemicalPathwayassociated

References

Pubmed IDYearTitleCitations
269426752016Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.73
111307272000Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide reductase.69
282386512017Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy.44
191102652009Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia.43
289238572017MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway.41
200681852010Characterization of phosphoglycerate kinase-1 expression of stromal cells derived from tumor microenvironment in prostate cancer progression.38
196888242010Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer.34
237277902013Phosphoglycerate kinase 1 as a promoter of metastasis in colon cancer.31
121748672002Overexpression of human phosphoglycerate kinase 1 (PGK1) induces a multidrug resistance phenotype.29
258672752015Phosphoglycerate kinase-1 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in breast cancer.27

Citation

Dessen P

PGK1 (phosphoglycerate kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41697/pgk1