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PGLYRP2 (peptidoglycan recognition protein 2)

Identity

Alias (NCBI)HMFT0141
PGLYRPL
PGRP-L
PGRPL
TAGL-like
tagL
tagL-alpha
tagl-beta
HGNC (Hugo) PGLYRP2
HGNC Alias symbPGRP-L
PGLYRPL
TAGL-like
tagL
tagL-alpha
tagl-beta
PGRPL
HGNC Alias namepeptidoglycan recognition protein L precursor
 peptidoglycan recognition protein-like
 N-acetylmuramoyl-L-alanine amidase
LocusID (NCBI) 114770
Atlas_Id 71864
Location 19p13.12  [Link to chromosome band 19p13]
Location_base_pair Starts at 15468646 and ends at 15479501 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PGLYRP2   30013
Cards
Entrez_Gene (NCBI)PGLYRP2    peptidoglycan recognition protein 2
AliasesHMFT0141; PGLYRPL; PGRP-L; PGRPL; 
TAGL-like; tagL; tagL-alpha; tagl-beta
GeneCards (Weizmann)PGLYRP2
Ensembl hg19 (Hinxton)ENSG00000161031 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161031 [Gene_View]  ENSG00000161031 [Sequence]  chr19:15468646-15479501 [Contig_View]  PGLYRP2 [Vega]
ICGC DataPortalENSG00000161031
TCGA cBioPortalPGLYRP2
AceView (NCBI)PGLYRP2
Genatlas (Paris)PGLYRP2
SOURCE (Princeton)PGLYRP2
Genetics Home Reference (NIH)PGLYRP2
Genomic and cartography
GoldenPath hg38 (UCSC)PGLYRP2  -     chr19:15468646-15479501 -  19p13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PGLYRP2  -     19p13.12   [Description]    (hg19-Feb_2009)
GoldenPathPGLYRP2 - 19p13.12 [CytoView hg19]  PGLYRP2 - 19p13.12 [CytoView hg38]
ImmunoBaseENSG00000161031
Genome Data Viewer NCBIPGLYRP2 [Mapview hg19]  
OMIM608199   
Gene and transcription
Genbank (Entrez)AB073610 AF384856 AK055882 AK289415 AK292292
RefSeq transcript (Entrez)NM_001363546 NM_052890
Consensus coding sequences : CCDS (NCBI)PGLYRP2
Gene ExpressionPGLYRP2 [ NCBI-GEO ]   PGLYRP2 [ EBI - ARRAY_EXPRESS ]   PGLYRP2 [ SEEK ]   PGLYRP2 [ MEM ]
Gene Expression Viewer (FireBrowse)PGLYRP2 [ Firebrowse - Broad ]
GenevisibleExpression of PGLYRP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)114770
GTEX Portal (Tissue expression)PGLYRP2
Human Protein AtlasENSG00000161031-PGLYRP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PD5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PD5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PD5
Catalytic activity : Enzyme3.5.1.28 [ Enzyme-Expasy ]   3.5.1.283.5.1.28 [ IntEnz-EBI ]   3.5.1.28 [ BRENDA ]   3.5.1.28 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ96PD5
Domains : Interpro (EBI)Amidase/PGRP_sf    Amidase_domain    PGRP    PGRP_domain_met/bac   
Domain families : Pfam (Sanger)Amidase_2 (PF01510)   
Domain families : Pfam (NCBI)pfam01510   
Domain families : Smart (EMBL)Ami_2 (SM00644)  PGRP (SM00701)  
Conserved Domain (NCBI)PGLYRP2
SuperfamilyQ96PD5
AlphaFold pdb e-kbQ96PD5   
Human Protein Atlas [tissue]ENSG00000161031-PGLYRP2 [tissue]
HPRD10495
Protein Interaction databases
DIP (DOE-UCLA)Q96PD5
IntAct (EBI)Q96PD5
BioGRIDPGLYRP2
STRING (EMBL)PGLYRP2
ZODIACPGLYRP2
Ontologies - Pathways
QuickGOQ96PD5
Ontology : AmiGOpeptide amidation  extracellular region  zinc ion binding  N-acetylmuramoyl-L-alanine amidase activity  N-acetylmuramoyl-L-alanine amidase activity  peptidoglycan catabolic process  peptidoglycan immune receptor activity  peptidoglycan immune receptor activity  membrane  detection of bacterium  detection of bacterium  antimicrobial humoral response  negative regulation of interferon-gamma production  negative regulation of natural killer cell differentiation involved in immune response  peptidoglycan binding  peptidoglycan binding  innate immune response  regulation of inflammatory response  defense response to Gram-positive bacterium  defense response to Gram-positive bacterium  biological process involved in interaction with host  extracellular exosome  
Ontology : EGO-EBIpeptide amidation  extracellular region  zinc ion binding  N-acetylmuramoyl-L-alanine amidase activity  N-acetylmuramoyl-L-alanine amidase activity  peptidoglycan catabolic process  peptidoglycan immune receptor activity  peptidoglycan immune receptor activity  membrane  detection of bacterium  detection of bacterium  antimicrobial humoral response  negative regulation of interferon-gamma production  negative regulation of natural killer cell differentiation involved in immune response  peptidoglycan binding  peptidoglycan binding  innate immune response  regulation of inflammatory response  defense response to Gram-positive bacterium  defense response to Gram-positive bacterium  biological process involved in interaction with host  extracellular exosome  
Pathways : KEGGPeptidoglycan biosynthesis   
NDEx NetworkPGLYRP2
Atlas of Cancer Signalling NetworkPGLYRP2
Wikipedia pathwaysPGLYRP2
Orthology - Evolution
OrthoDB114770
GeneTree (enSembl)ENSG00000161031
Phylogenetic Trees/Animal Genes : TreeFamPGLYRP2
Homologs : HomoloGenePGLYRP2
Homology/Alignments : Family Browser (UCSC)PGLYRP2
Gene fusions - Rearrangements
Fusion : QuiverPGLYRP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPGLYRP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PGLYRP2
dbVarPGLYRP2
ClinVarPGLYRP2
MonarchPGLYRP2
1000_GenomesPGLYRP2 
Exome Variant ServerPGLYRP2
GNOMAD BrowserENSG00000161031
Varsome BrowserPGLYRP2
ACMGPGLYRP2 variants
VarityQ96PD5
Genomic Variants (DGV)PGLYRP2 [DGVbeta]
DECIPHERPGLYRP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPGLYRP2 
Mutations
ICGC Data PortalPGLYRP2 
TCGA Data PortalPGLYRP2 
Broad Tumor PortalPGLYRP2
OASIS PortalPGLYRP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPGLYRP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPGLYRP2
Mutations and Diseases : HGMDPGLYRP2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPGLYRP2
DgiDB (Drug Gene Interaction Database)PGLYRP2
DoCM (Curated mutations)PGLYRP2
CIViC (Clinical Interpretations of Variants in Cancer)PGLYRP2
Cancer3DPGLYRP2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608199   
Orphanet
DisGeNETPGLYRP2
MedgenPGLYRP2
Genetic Testing Registry PGLYRP2
NextProtQ96PD5 [Medical]
GENETestsPGLYRP2
Target ValidationPGLYRP2
Huge Navigator PGLYRP2 [HugePedia]
ClinGenPGLYRP2
Clinical trials, drugs, therapy
MyCancerGenomePGLYRP2
Protein Interactions : CTDPGLYRP2
Pharm GKB GenePA134929965
PharosQ96PD5
Clinical trialPGLYRP2
Miscellaneous
canSAR (ICR)PGLYRP2
HarmonizomePGLYRP2
DataMed IndexPGLYRP2
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPGLYRP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 16:16:01 CEST 2021

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