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PGR (progesterone receptor)

Identity

Other namesNR3C3
PR
HGNC (Hugo) PGR
LocusID (NCBI) 5241
Location 11q22.1
Location_base_pair Starts at 100900355 and ends at 101000544 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945 MedulloblastomaID5065 rhab5004

External links

Nomenclature
HGNC (Hugo)PGR   8910
Cards
Entrez_Gene (NCBI)PGR  5241  progesterone receptor
GeneCards (Weizmann)PGR
Ensembl (Hinxton)ENSG00000082175 [Gene_View]  chr11:100900355-101000544 [Contig_View]  PGR [Vega]
ICGC DataPortalENSG00000082175
cBioPortalPGR
AceView (NCBI)PGR
Genatlas (Paris)PGR
WikiGenes5241
SOURCE (Princeton)NM_000926 NM_001202474 NM_001271161 NM_001271162
Genomic and cartography
GoldenPath (UCSC)PGR  -  11q22.1   chr11:100900355-101000544 -  11q22.1   [Description]    (hg19-Feb_2009)
EnsemblPGR - 11q22.1 [CytoView]
Mapping of homologs : NCBIPGR [Mapview]
OMIM264080   607311   
Gene and transcription
Genbank (Entrez)AB084248 AB085683 AB085843 AB085844 AB085845
RefSeq transcript (Entrez)NM_000926 NM_001202474 NM_001271161 NM_001271162
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_016475 NT_033899 NW_001838042 NW_004929381
Consensus coding sequences : CCDS (NCBI)PGR
Cluster EST : UnigeneHs.742403 [ NCBI ]
CGAP (NCI)Hs.742403
Alternative Splicing : Fast-db (Paris)GSHG0006118
Alternative Splicing GalleryENSG00000082175
Gene ExpressionPGR [ NCBI-GEO ]     PGR [ SEEK ]   PGR [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06401 (Uniprot)
NextProtP06401  [Medical]
With graphics : InterProP06401
Splice isoforms : SwissVarP06401 (Swissvar)
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)Nucl_hormone_rcpt_ligand-bd [organisation]   Nucl_hrmn_rcpt_lig-bd_core [organisation]   Progest_rcpt [organisation]   Str_hrmn_rcpt [organisation]   Znf_hrmn_rcpt [organisation]   Znf_NHR/GATA [organisation]  
Related proteins : CluSTrP06401
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    Prog_receptor (PF02161)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam02161    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
DMDM Disease mutations5241
Blocks (Seattle)P06401
PDB (SRS)1A28    1E3K    1SQN    1SR7    1ZUC    2C7A    2OVH    2OVM    2W8Y    3D90    3G8O    3HQ5    3KBA    3ZR7    3ZRA    3ZRB    4A2J    4APU   
PDB (PDBSum)1A28    1E3K    1SQN    1SR7    1ZUC    2C7A    2OVH    2OVM    2W8Y    3D90    3G8O    3HQ5    3KBA    3ZR7    3ZRA    3ZRB    4A2J    4APU   
PDB (IMB)1A28    1E3K    1SQN    1SR7    1ZUC    2C7A    2OVH    2OVM    2W8Y    3D90    3G8O    3HQ5    3KBA    3ZR7    3ZRA    3ZRB    4A2J    4APU   
PDB (RSDB)1A28    1E3K    1SQN    1SR7    1ZUC    2C7A    2OVH    2OVM    2W8Y    3D90    3G8O    3HQ5    3KBA    3ZR7    3ZRA    3ZRB    4A2J    4APU   
Human Protein AtlasENSG00000082175 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP06401
HPRD07077
IPIIPI00297419   IPI00219021   IPI00798113   IPI01014750   IPI00982805   IPI00982228   IPI00979321   IPI00168906   
Protein Interaction databases
DIP (DOE-UCLA)P06401
IntAct (EBI)P06401
FunCoupENSG00000082175
BioGRIDPGR
InParanoidP06401
Interologous Interaction database P06401
IntegromeDBPGR
STRING (EMBL)PGR
Ontologies - Pathways
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  ovulation from ovarian follicle  epithelial cell maturation  DNA binding  steroid hormone receptor activity  ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity  receptor binding  steroid binding  protein binding  nucleoplasm  mitochondrial outer membrane  transcription initiation from RNA polymerase II promoter  signal transduction  cell-cell signaling  zinc ion binding  gene expression  negative regulation of gene expression  enzyme binding  steroid hormone mediated signaling pathway  positive regulation of transcription from RNA polymerase II promoter  regulation of epithelial cell proliferation  progesterone receptor signaling pathway  tertiary branching involved in mammary gland duct morphogenesis  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  ovulation from ovarian follicle  epithelial cell maturation  DNA binding  steroid hormone receptor activity  ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity  receptor binding  steroid binding  protein binding  nucleoplasm  mitochondrial outer membrane  transcription initiation from RNA polymerase II promoter  signal transduction  cell-cell signaling  zinc ion binding  gene expression  negative regulation of gene expression  enzyme binding  steroid hormone mediated signaling pathway  positive regulation of transcription from RNA polymerase II promoter  regulation of epithelial cell proliferation  progesterone receptor signaling pathway  tertiary branching involved in mammary gland duct morphogenesis  
Pathways : BIOCARTAHow Progesterone Initiates the Oocyte Maturation [Genes]   
Pathways : KEGGOocyte meiosis    Progesterone-mediated oocyte maturation   
Protein Interaction DatabasePGR
Wikipedia pathwaysPGR
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PGR
snp3D : Map Gene to Disease5241
SNP (GeneSNP Utah)PGR
SNP : HGBasePGR
Genetic variants : HAPMAPPGR
Exome VariantPGR
1000_GenomesPGR 
ICGC programENSG00000082175 
Somatic Mutations in Cancer : COSMICPGR 
CONAN: Copy Number AnalysisPGR 
Mutations and Diseases : HGMDPGR
Mutations and Diseases : intOGenPGR
Genomic VariantsPGR  PGR [DGVbeta]
dbVarPGR
ClinVarPGR
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM264080    607311   
MedgenPGR
GENETestsPGR
Disease Genetic AssociationPGR
Huge Navigator PGR [HugePedia]  PGR [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePGR
Homology/Alignments : Family Browser (UCSC)PGR
Phylogenetic Trees/Animal Genes : TreeFamPGR
Chemical/Protein Interactions : CTD5241
Chemical/Pharm GKB GenePA266
Clinical trialPGR
Cancer Resource (Charite)ENSG00000082175
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMinePGR
iHOPPGR
OncoSearchPGR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:59:30 CEST 2014

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