Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PGR (progesterone receptor)

Identity

Other namesNR3C3
PR
HGNC (Hugo) PGR
LocusID (NCBI) 5241
Atlas_Id 41700
Location 11q22.1  [Link to chromosome band 11q22]
Location_base_pair Starts at 100900355 and ends at 101000544 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARHGAP42 (11q22.1) / PGR (11q22.1)ARHGAP42 11q22.1 / PGR 11q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Soft Tissues: Aggressive angiomyxoma
Soft Tissues: Desmoid-type fibromatosis
Breast: Ductal carcinoma
Uterus: Leiomyoma
Nervous System: Neurofibroma
Head and Neck: Salivary gland tumors: Warthin's tumors

External links

Nomenclature
HGNC (Hugo)PGR   8910
Cards
Entrez_Gene (NCBI)PGR  5241  progesterone receptor
AliasesNR3C3; PR
GeneCards (Weizmann)PGR
Ensembl hg19 (Hinxton)ENSG00000082175 [Gene_View]  chr11:100900355-101000544 [Contig_View]  PGR [Vega]
Ensembl hg38 (Hinxton)ENSG00000082175 [Gene_View]  chr11:100900355-101000544 [Contig_View]  PGR [Vega]
ICGC DataPortalENSG00000082175
TCGA cBioPortalPGR
AceView (NCBI)PGR
Genatlas (Paris)PGR
WikiGenes5241
SOURCE (Princeton)PGR
Genomic and cartography
GoldenPath hg19 (UCSC)PGR  -     chr11:100900355-101000544 -  11q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PGR  -     11q22.1   [Description]    (hg38-Dec_2013)
EnsemblPGR - 11q22.1 [CytoView hg19]  PGR - 11q22.1 [CytoView hg38]
Mapping of homologs : NCBIPGR [Mapview hg19]  PGR [Mapview hg38]
OMIM264080   607311   
Gene and transcription
Genbank (Entrez)AB084248 AB085683 AB085843 AB085844 AB085845
RefSeq transcript (Entrez)NM_000926 NM_001202474 NM_001271161 NM_001271162
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_016475 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)PGR
Cluster EST : UnigeneHs.742403 [ NCBI ]
CGAP (NCI)Hs.742403
Alternative Splicing GalleryENSG00000082175
Gene ExpressionPGR [ NCBI-GEO ]   PGR [ EBI - ARRAY_EXPRESS ]   PGR [ SEEK ]   PGR [ MEM ]
Gene Expression Viewer (FireBrowse)PGR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5241
GTEX Portal (Tissue expression)PGR
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06401 (Uniprot)
NextProtP06401  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06401
Splice isoforms : SwissVarP06401 (Swissvar)
PhosPhoSitePlusP06401
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    Progest_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    Prog_receptor (PF02161)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam02161    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
DMDM Disease mutations5241
Blocks (Seattle)PGR
PDB (SRS)1A28    1E3K    1SQN    1SR7    1ZUC    2C7A    2OVH    2OVM    2W8Y    3D90    3G8O    3HQ5    3KBA    3ZR7    3ZRA    3ZRB    4A2J    4APU    4OAR    5CC0   
PDB (PDBSum)1A28    1E3K    1SQN    1SR7    1ZUC    2C7A    2OVH    2OVM    2W8Y    3D90    3G8O    3HQ5    3KBA    3ZR7    3ZRA    3ZRB    4A2J    4APU    4OAR    5CC0   
PDB (IMB)1A28    1E3K    1SQN    1SR7    1ZUC    2C7A    2OVH    2OVM    2W8Y    3D90    3G8O    3HQ5    3KBA    3ZR7    3ZRA    3ZRB    4A2J    4APU    4OAR    5CC0   
PDB (RSDB)1A28    1E3K    1SQN    1SR7    1ZUC    2C7A    2OVH    2OVM    2W8Y    3D90    3G8O    3HQ5    3KBA    3ZR7    3ZRA    3ZRB    4A2J    4APU    4OAR    5CC0   
Structural Biology KnowledgeBase1A28    1E3K    1SQN    1SR7    1ZUC    2C7A    2OVH    2OVM    2W8Y    3D90    3G8O    3HQ5    3KBA    3ZR7    3ZRA    3ZRB    4A2J    4APU    4OAR    5CC0   
SCOP (Structural Classification of Proteins)1A28    1E3K    1SQN    1SR7    1ZUC    2C7A    2OVH    2OVM    2W8Y    3D90    3G8O    3HQ5    3KBA    3ZR7    3ZRA    3ZRB    4A2J    4APU    4OAR    5CC0   
CATH (Classification of proteins structures)1A28    1E3K    1SQN    1SR7    1ZUC    2C7A    2OVH    2OVM    2W8Y    3D90    3G8O    3HQ5    3KBA    3ZR7    3ZRA    3ZRB    4A2J    4APU    4OAR    5CC0   
SuperfamilyP06401
Human Protein AtlasENSG00000082175
Peptide AtlasP06401
HPRD07077
IPIIPI00297419   IPI00219021   IPI00798113   IPI01014750   IPI00982805   IPI00982228   IPI00979321   IPI00168906   
Protein Interaction databases
DIP (DOE-UCLA)P06401
IntAct (EBI)P06401
FunCoupENSG00000082175
BioGRIDPGR
STRING (EMBL)PGR
ZODIACPGR
Ontologies - Pathways
QuickGOP06401
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  DNA binding  steroid hormone receptor activity  receptor binding  steroid binding  protein binding  nucleoplasm  mitochondrial outer membrane  transcription initiation from RNA polymerase II promoter  signal transduction  cell-cell signaling  zinc ion binding  negative regulation of gene expression  enzyme binding  steroid hormone mediated signaling pathway  positive regulation of transcription from RNA polymerase II promoter  ATPase binding  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  DNA binding  steroid hormone receptor activity  receptor binding  steroid binding  protein binding  nucleoplasm  mitochondrial outer membrane  transcription initiation from RNA polymerase II promoter  signal transduction  cell-cell signaling  zinc ion binding  negative regulation of gene expression  enzyme binding  steroid hormone mediated signaling pathway  positive regulation of transcription from RNA polymerase II promoter  ATPase binding  
Pathways : BIOCARTAHow Progesterone Initiates the Oocyte Maturation [Genes]   
Pathways : KEGGOocyte meiosis    Progesterone-mediated oocyte maturation   
NDEx Network
Atlas of Cancer Signalling NetworkPGR
Wikipedia pathwaysPGR
Orthology - Evolution
OrthoDB5241
GeneTree (enSembl)ENSG00000082175
Phylogenetic Trees/Animal Genes : TreeFamPGR
Homologs : HomoloGenePGR
Homology/Alignments : Family Browser (UCSC)PGR
Gene fusions - Rearrangements
Fusion: TCGAARHGAP42 11q22.1 PGR 11q22.1 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerPGR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PGR
dbVarPGR
ClinVarPGR
1000_GenomesPGR 
Exome Variant ServerPGR
ExAC (Exome Aggregation Consortium)PGR (select the gene name)
Genetic variants : HAPMAP5241
Genomic Variants (DGV)PGR [DGVbeta]
Mutations
ICGC Data PortalPGR 
TCGA Data PortalPGR 
Broad Tumor PortalPGR
OASIS PortalPGR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPGR 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PGR
DgiDB (Drug Gene Interaction Database)PGR
DoCM (Curated mutations)PGR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PGR (select a term)
intoGenPGR
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:100900355-101000544  ENSG00000082175
CONAN: Copy Number AnalysisPGR 
Mutations and Diseases : HGMDPGR
OMIM264080    607311   
MedgenPGR
Genetic Testing Registry PGR
NextProtP06401 [Medical]
TSGene5241
GENETestsPGR
Huge Navigator PGR [HugePedia]
snp3D : Map Gene to Disease5241
BioCentury BCIQPGR
ClinGenPGR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5241
Chemical/Pharm GKB GenePA266
Clinical trialPGR
Miscellaneous
canSAR (ICR)PGR (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePGR
EVEXPGR
GoPubMedPGR
iHOPPGR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:07:02 CEST 2016

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