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PHACTR3 (phosphatase and actin regulator 3)

Identity

Alias (NCBI)C20orf101
H17739
PPP1R123
SCAPIN1
SCAPININ
HGNC (Hugo) PHACTR3
HGNC Alias symbPPP1R123
HGNC Alias nameprotein phosphatase 1, regulatory subunit 123
HGNC Previous nameC20orf101
HGNC Previous namechromosome 20 open reading frame 101
LocusID (NCBI) 116154
Atlas_Id 51442
Location 20q13.33  [Link to chromosome band 20q13]
Location_base_pair Starts at 59721210 and ends at 59847711 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACSS1 (20p11.21) / PHACTR3 (20q13.32)GIMAP1-GIMAP5 (7q36.1) / PHACTR3 (20q13.32)LDLRAD4 (18p11.21) / PHACTR3 (20q13.32)
PHACTR3 (20q13.32) / IGDCC4 (15q22.31)PHACTR3 (20q13.32) / PTPRM (18p11.23)RAB22A (20q13.32) / PHACTR3 (20q13.32)
ACSS1 20p11.21 / PHACTR3 20q13.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(18;20)(p11;q13) LDLRAD4/PHACTR3


External links

 

Nomenclature
HGNC (Hugo)PHACTR3   15833
Cards
Entrez_Gene (NCBI)PHACTR3    phosphatase and actin regulator 3
AliasesC20orf101; H17739; PPP1R123; SCAPIN1; 
SCAPININ
GeneCards (Weizmann)PHACTR3
Ensembl hg19 (Hinxton)ENSG00000087495 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000087495 [Gene_View]  ENSG00000087495 [Sequence]  chr20:59721210-59847711 [Contig_View]  PHACTR3 [Vega]
ICGC DataPortalENSG00000087495
TCGA cBioPortalPHACTR3
AceView (NCBI)PHACTR3
Genatlas (Paris)PHACTR3
SOURCE (Princeton)PHACTR3
Genetics Home Reference (NIH)PHACTR3
Genomic and cartography
GoldenPath hg38 (UCSC)PHACTR3  -     chr20:59721210-59847711 +  20q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PHACTR3  -     20q13.33   [Description]    (hg19-Feb_2009)
GoldenPathPHACTR3 - 20q13.33 [CytoView hg19]  PHACTR3 - 20q13.33 [CytoView hg38]
ImmunoBaseENSG00000087495
Genome Data Viewer NCBIPHACTR3 [Mapview hg19]  
OMIM608725   
Gene and transcription
Genbank (Entrez)AB098521 AB098522 AJ311122 AJ617581 AK090812
RefSeq transcript (Entrez)NM_001199505 NM_001199506 NM_001281507 NM_080672 NM_183244 NM_183246
Consensus coding sequences : CCDS (NCBI)PHACTR3
Gene ExpressionPHACTR3 [ NCBI-GEO ]   PHACTR3 [ EBI - ARRAY_EXPRESS ]   PHACTR3 [ SEEK ]   PHACTR3 [ MEM ]
Gene Expression Viewer (FireBrowse)PHACTR3 [ Firebrowse - Broad ]
GenevisibleExpression of PHACTR3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)116154
GTEX Portal (Tissue expression)PHACTR3
Human Protein AtlasENSG00000087495-PHACTR3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96KR7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96KR7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96KR7
PhosPhoSitePlusQ96KR7
Domaine pattern : Prosite (Expaxy)RPEL (PS51073)   
Domains : Interpro (EBI)Phactr3    RPEL_repeat   
Domain families : Pfam (Sanger)RPEL (PF02755)   
Domain families : Pfam (NCBI)pfam02755   
Domain families : Smart (EMBL)RPEL (SM00707)  
Conserved Domain (NCBI)PHACTR3
SuperfamilyQ96KR7
AlphaFold pdb e-kbQ96KR7   
Human Protein Atlas [tissue]ENSG00000087495-PHACTR3 [tissue]
HPRD10571
Protein Interaction databases
DIP (DOE-UCLA)Q96KR7
IntAct (EBI)Q96KR7
BioGRIDPHACTR3
STRING (EMBL)PHACTR3
ZODIACPHACTR3
Ontologies - Pathways
QuickGOQ96KR7
Ontology : AmiGOactin binding  protein phosphatase inhibitor activity  protein binding  nucleoplasm  protein phosphatase 1 binding  nuclear matrix  actin cytoskeleton organization  negative regulation of phosphoprotein phosphatase activity  
Ontology : EGO-EBIactin binding  protein phosphatase inhibitor activity  protein binding  nucleoplasm  protein phosphatase 1 binding  nuclear matrix  actin cytoskeleton organization  negative regulation of phosphoprotein phosphatase activity  
NDEx NetworkPHACTR3
Atlas of Cancer Signalling NetworkPHACTR3
Wikipedia pathwaysPHACTR3
Orthology - Evolution
OrthoDB116154
GeneTree (enSembl)ENSG00000087495
Phylogenetic Trees/Animal Genes : TreeFamPHACTR3
Homologs : HomoloGenePHACTR3
Homology/Alignments : Family Browser (UCSC)PHACTR3
Gene fusions - Rearrangements
Fusion : MitelmanACSS1/PHACTR3 [20p11.21/20q13.32]  
Fusion : MitelmanPHACTR3/PTPRM [20q13.32/18p11.23]  
Fusion : QuiverPHACTR3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPHACTR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PHACTR3
dbVarPHACTR3
ClinVarPHACTR3
MonarchPHACTR3
1000_GenomesPHACTR3 
Exome Variant ServerPHACTR3
GNOMAD BrowserENSG00000087495
Varsome BrowserPHACTR3
ACMGPHACTR3 variants
VarityQ96KR7
Genomic Variants (DGV)PHACTR3 [DGVbeta]
DECIPHERPHACTR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPHACTR3 
Mutations
ICGC Data PortalPHACTR3 
TCGA Data PortalPHACTR3 
Broad Tumor PortalPHACTR3
OASIS PortalPHACTR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPHACTR3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPHACTR3
Mutations and Diseases : HGMDPHACTR3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPHACTR3
DgiDB (Drug Gene Interaction Database)PHACTR3
DoCM (Curated mutations)PHACTR3
CIViC (Clinical Interpretations of Variants in Cancer)PHACTR3
Cancer3DPHACTR3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608725   
Orphanet
DisGeNETPHACTR3
MedgenPHACTR3
Genetic Testing Registry PHACTR3
NextProtQ96KR7 [Medical]
GENETestsPHACTR3
Target ValidationPHACTR3
Huge Navigator PHACTR3 [HugePedia]
ClinGenPHACTR3
Clinical trials, drugs, therapy
MyCancerGenomePHACTR3
Protein Interactions : CTDPHACTR3
Pharm GKB GenePA128394750
PharosQ96KR7
Clinical trialPHACTR3
Miscellaneous
canSAR (ICR)PHACTR3
HarmonizomePHACTR3
DataMed IndexPHACTR3
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPHACTR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:25:05 CEST 2021

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