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PHB (prohibitin)

Identity

Alias_symbol (synonym)PHB1
Other aliasHEL-215
HEL-S-54e
HGNC (Hugo) PHB
LocusID (NCBI) 5245
Atlas_Id 41701
Location 17q21.33  [Link to chromosome band 17q21]
Location_base_pair Starts at 49404048 and ends at 49414858 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PHB (17q21.33) / LSM1 (8p11.23)PHB (17q21.33) / SPOP (17q21.33)TANC2 (17q23.2) / PHB (17q21.33)
PHB 17q21.33 / LSM1 8p11.23TANC2 17q23.2 / PHB 17q21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hereditary breast cancer


External links

Nomenclature
HGNC (Hugo)PHB   8912
Cards
Entrez_Gene (NCBI)PHB  5245  prohibitin
AliasesHEL-215; HEL-S-54e; PHB1
GeneCards (Weizmann)PHB
Ensembl hg19 (Hinxton)ENSG00000167085 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167085 [Gene_View]  chr17:49404048-49414858 [Contig_View]  PHB [Vega]
ICGC DataPortalENSG00000167085
TCGA cBioPortalPHB
AceView (NCBI)PHB
Genatlas (Paris)PHB
WikiGenes5245
SOURCE (Princeton)PHB
Genetics Home Reference (NIH)PHB
Genomic and cartography
GoldenPath hg38 (UCSC)PHB  -     chr17:49404048-49414858 -  17q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PHB  -     17q21.33   [Description]    (hg19-Feb_2009)
EnsemblPHB - 17q21.33 [CytoView hg19]  PHB - 17q21.33 [CytoView hg38]
Mapping of homologs : NCBIPHB [Mapview hg19]  PHB [Mapview hg38]
OMIM114480   176705   
Gene and transcription
Genbank (Entrez)AA357151 AA709387 AK223181 AK290766 AK302258
RefSeq transcript (Entrez)NM_001281496 NM_001281497 NM_001281715 NM_002634
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PHB
Cluster EST : UnigeneHs.514303 [ NCBI ]
CGAP (NCI)Hs.514303
Alternative Splicing GalleryENSG00000167085
Gene ExpressionPHB [ NCBI-GEO ]   PHB [ EBI - ARRAY_EXPRESS ]   PHB [ SEEK ]   PHB [ MEM ]
Gene Expression Viewer (FireBrowse)PHB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5245
GTEX Portal (Tissue expression)PHB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35232   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35232  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35232
Splice isoforms : SwissVarP35232
PhosPhoSitePlusP35232
Domains : Interpro (EBI)Band_7    Prohibitin   
Domain families : Pfam (Sanger)Band_7 (PF01145)   
Domain families : Pfam (NCBI)pfam01145   
Domain families : Smart (EMBL)PHB (SM00244)  
Conserved Domain (NCBI)PHB
DMDM Disease mutations5245
Blocks (Seattle)PHB
PDB (SRS)1LU7   
PDB (PDBSum)1LU7   
PDB (IMB)1LU7   
PDB (RSDB)1LU7   
Structural Biology KnowledgeBase1LU7   
SCOP (Structural Classification of Proteins)1LU7   
CATH (Classification of proteins structures)1LU7   
SuperfamilyP35232
Human Protein AtlasENSG00000167085
Peptide AtlasP35232
HPRD01454
IPIIPI00017334   IPI00909721   IPI00816719   IPI00977506   IPI00791634   IPI01011461   IPI01011045   
Protein Interaction databases
DIP (DOE-UCLA)P35232
IntAct (EBI)P35232
FunCoupENSG00000167085
BioGRIDPHB
STRING (EMBL)PHB
ZODIACPHB
Ontologies - Pathways
QuickGOP35232
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription factor activity, sequence-specific DNA binding  osteoblast differentiation  complement component C3a binding  complement component C3b binding  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  early endosome  plasma membrane  integral component of plasma membrane  regulation of transcription, DNA-templated  mitochondrion organization  signal transduction  protein C-terminus binding  negative regulation of cell proliferation  cell surface  positive regulation of gene expression  positive regulation of cell death  negative regulation of transcription by competitive promoter binding  membrane  histone deacetylation  enzyme binding  negative regulation of cell growth  proteinase activated receptor binding  negative regulation of protein catabolic process  histone deacetylase binding  regulation of apoptotic process  myelin sheath  transcription regulatory region DNA binding  positive regulation of G-protein coupled receptor protein signaling pathway  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of complement activation  protein stabilization  progesterone receptor signaling pathway  negative regulation of androgen receptor signaling pathway  negative regulation of androgen receptor signaling pathway  extracellular exosome  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  cellular response to interleukin-6  DNA biosynthetic process  negative regulation of glucocorticoid receptor signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription factor activity, sequence-specific DNA binding  osteoblast differentiation  complement component C3a binding  complement component C3b binding  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  early endosome  plasma membrane  integral component of plasma membrane  regulation of transcription, DNA-templated  mitochondrion organization  signal transduction  protein C-terminus binding  negative regulation of cell proliferation  cell surface  positive regulation of gene expression  positive regulation of cell death  negative regulation of transcription by competitive promoter binding  membrane  histone deacetylation  enzyme binding  negative regulation of cell growth  proteinase activated receptor binding  negative regulation of protein catabolic process  histone deacetylase binding  regulation of apoptotic process  myelin sheath  transcription regulatory region DNA binding  positive regulation of G-protein coupled receptor protein signaling pathway  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of complement activation  protein stabilization  progesterone receptor signaling pathway  negative regulation of androgen receptor signaling pathway  negative regulation of androgen receptor signaling pathway  extracellular exosome  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  cellular response to interleukin-6  DNA biosynthetic process  negative regulation of glucocorticoid receptor signaling pathway  
NDEx NetworkPHB
Atlas of Cancer Signalling NetworkPHB
Wikipedia pathwaysPHB
Orthology - Evolution
OrthoDB5245
GeneTree (enSembl)ENSG00000167085
Phylogenetic Trees/Animal Genes : TreeFamPHB
HOVERGENP35232
HOGENOMP35232
Homologs : HomoloGenePHB
Homology/Alignments : Family Browser (UCSC)PHB
Gene fusions - Rearrangements
Fusion : MitelmanPHB/LSM1 [17q21.33/8p11.23]  
Fusion : MitelmanTANC2/PHB [17q23.2/17q21.33]  [t(17;17)(q21;q23)]  
Fusion: TCGAPHB 17q21.33 LSM1 8p11.23 BRCA
Fusion: TCGATANC2 17q23.2 PHB 17q21.33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPHB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PHB
dbVarPHB
ClinVarPHB
1000_GenomesPHB 
Exome Variant ServerPHB
ExAC (Exome Aggregation Consortium)PHB (select the gene name)
Genetic variants : HAPMAP5245
Genomic Variants (DGV)PHB [DGVbeta]
DECIPHERPHB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPHB 
Mutations
ICGC Data PortalPHB 
TCGA Data PortalPHB 
Broad Tumor PortalPHB
OASIS PortalPHB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPHB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPHB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PHB
DgiDB (Drug Gene Interaction Database)PHB
DoCM (Curated mutations)PHB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PHB (select a term)
intoGenPHB
Cancer3DPHB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114480    176705   
Orphanet
MedgenPHB
Genetic Testing Registry PHB
NextProtP35232 [Medical]
TSGene5245
GENETestsPHB
Huge Navigator PHB [HugePedia]
snp3D : Map Gene to Disease5245
BioCentury BCIQPHB
ClinGenPHB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5245
Chemical/Pharm GKB GenePA33251
Clinical trialPHB
Miscellaneous
canSAR (ICR)PHB (select the gene name)
Probes
Litterature
PubMed231 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePHB
EVEXPHB
GoPubMedPHB
iHOPPHB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:31:00 CEST 2017

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