Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PHB2 (prohibitin 2)

Identity

Alias_symbol (synonym)REA
BCAP37
Bap37
p22
Other aliasBAP
PNAS-141
hBAP
HGNC (Hugo) PHB2
LocusID (NCBI) 11331
Atlas_Id 45980
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 6965352 and ends at 6970753 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PHB2 (12p13.31) / BTN3A2 (6p22.2)PHB2 (12p13.31) / COL3A1 (2q32.2)PHB2 (12p13.31) / FHL1 (Xq26.3)
PHB2 (12p13.31) / PHB2 (12p13.31)PHB2 (12p13.31) / SPINT1 (15q15.1)PHB2 (12p13.31) / UBXN4 (2q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PHB2   30306
Cards
Entrez_Gene (NCBI)PHB2  11331  prohibitin 2
AliasesBAP; BCAP37; Bap37; PNAS-141; 
REA; hBAP; p22
GeneCards (Weizmann)PHB2
Ensembl hg19 (Hinxton)ENSG00000215021 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000215021 [Gene_View]  chr12:6965352-6970753 [Contig_View]  PHB2 [Vega]
ICGC DataPortalENSG00000215021
TCGA cBioPortalPHB2
AceView (NCBI)PHB2
Genatlas (Paris)PHB2
WikiGenes11331
SOURCE (Princeton)PHB2
Genetics Home Reference (NIH)PHB2
Genomic and cartography
GoldenPath hg38 (UCSC)PHB2  -     chr12:6965352-6970753 -  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PHB2  -     12p13.31   [Description]    (hg19-Feb_2009)
EnsemblPHB2 - 12p13.31 [CytoView hg19]  PHB2 - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBIPHB2 [Mapview hg19]  PHB2 [Mapview hg38]
OMIM610704   
Gene and transcription
Genbank (Entrez)AF126021 AF150962 AF178980 AF279895 AK298217
RefSeq transcript (Entrez)NM_001144831 NM_001267700
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PHB2
Cluster EST : UnigeneHs.504620 [ NCBI ]
CGAP (NCI)Hs.504620
Alternative Splicing GalleryENSG00000215021
Gene ExpressionPHB2 [ NCBI-GEO ]   PHB2 [ EBI - ARRAY_EXPRESS ]   PHB2 [ SEEK ]   PHB2 [ MEM ]
Gene Expression Viewer (FireBrowse)PHB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11331
GTEX Portal (Tissue expression)PHB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99623   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99623  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99623
Splice isoforms : SwissVarQ99623
PhosPhoSitePlusQ99623
Domains : Interpro (EBI)Band_7    Prohibitin   
Domain families : Pfam (Sanger)Band_7 (PF01145)   
Domain families : Pfam (NCBI)pfam01145   
Domain families : Smart (EMBL)PHB (SM00244)  
Conserved Domain (NCBI)PHB2
DMDM Disease mutations11331
Blocks (Seattle)PHB2
SuperfamilyQ99623
Human Protein AtlasENSG00000215021
Peptide AtlasQ99623
HPRD17843
IPIIPI00027252   IPI00797822   IPI01013292   IPI01011917   IPI01013219   IPI01011178   IPI01012506   IPI01010252   IPI01011576   
Protein Interaction databases
DIP (DOE-UCLA)Q99623
IntAct (EBI)Q99623
FunCoupENSG00000215021
BioGRIDPHB2
STRING (EMBL)PHB2
ZODIACPHB2
Ontologies - Pathways
QuickGOQ99623
Ontology : AmiGOprotein import into nucleus, translocation  protein binding  nucleus  nucleus  cytoplasm  mitochondrion  mitochondrial outer membrane  mitochondrial inner membrane  transcription, DNA-templated  mitochondrion organization  sister chromatid cohesion  protein C-terminus binding  cell surface  nuclear matrix  estrogen receptor binding  regulation of complement activation  positive regulation of exit from mitosis  negative regulation of intracellular estrogen receptor signaling pathway  amide binding  negative regulation of mammary gland epithelial cell proliferation  negative regulation of apoptotic process  protein complex  negative regulation of sequence-specific DNA binding transcription factor activity  negative regulation of transcription, DNA-templated  protein N-terminus binding  protein stabilization  positive regulation of sequence-specific DNA binding transcription factor activity  mammary gland branching involved in thelarche  mammary gland alveolus development  regulation of branching involved in mammary gland duct morphogenesis  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  cell periphery  positive regulation of cell cycle G1/S phase transition  
Ontology : EGO-EBIprotein import into nucleus, translocation  protein binding  nucleus  nucleus  cytoplasm  mitochondrion  mitochondrial outer membrane  mitochondrial inner membrane  transcription, DNA-templated  mitochondrion organization  sister chromatid cohesion  protein C-terminus binding  cell surface  nuclear matrix  estrogen receptor binding  regulation of complement activation  positive regulation of exit from mitosis  negative regulation of intracellular estrogen receptor signaling pathway  amide binding  negative regulation of mammary gland epithelial cell proliferation  negative regulation of apoptotic process  protein complex  negative regulation of sequence-specific DNA binding transcription factor activity  negative regulation of transcription, DNA-templated  protein N-terminus binding  protein stabilization  positive regulation of sequence-specific DNA binding transcription factor activity  mammary gland branching involved in thelarche  mammary gland alveolus development  regulation of branching involved in mammary gland duct morphogenesis  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  cell periphery  positive regulation of cell cycle G1/S phase transition  
Pathways : BIOCARTACARM1 and Regulation of the Estrogen Receptor [Genes]   
NDEx NetworkPHB2
Atlas of Cancer Signalling NetworkPHB2
Wikipedia pathwaysPHB2
Orthology - Evolution
OrthoDB11331
GeneTree (enSembl)ENSG00000215021
Phylogenetic Trees/Animal Genes : TreeFamPHB2
HOVERGENQ99623
HOGENOMQ99623
Homologs : HomoloGenePHB2
Homology/Alignments : Family Browser (UCSC)PHB2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPHB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PHB2
dbVarPHB2
ClinVarPHB2
1000_GenomesPHB2 
Exome Variant ServerPHB2
ExAC (Exome Aggregation Consortium)PHB2 (select the gene name)
Genetic variants : HAPMAP11331
Genomic Variants (DGV)PHB2 [DGVbeta]
DECIPHERPHB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPHB2 
Mutations
ICGC Data PortalPHB2 
TCGA Data PortalPHB2 
Broad Tumor PortalPHB2
OASIS PortalPHB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPHB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPHB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PHB2
DgiDB (Drug Gene Interaction Database)PHB2
DoCM (Curated mutations)PHB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PHB2 (select a term)
intoGenPHB2
Cancer3DPHB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610704   
Orphanet
MedgenPHB2
Genetic Testing Registry PHB2
NextProtQ99623 [Medical]
TSGene11331
GENETestsPHB2
Huge Navigator PHB2 [HugePedia]
snp3D : Map Gene to Disease11331
BioCentury BCIQPHB2
ClinGenPHB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11331
Chemical/Pharm GKB GenePA142671181
Clinical trialPHB2
Miscellaneous
canSAR (ICR)PHB2 (select the gene name)
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePHB2
EVEXPHB2
GoPubMedPHB2
iHOPPHB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:31:00 CEST 2017

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