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PHB2 (prohibitin 2)

Identity

Alias (NCBI)BAP
BCAP37
Bap37
PNAS-141
REA
hBAP
p22
HGNC (Hugo) PHB2
HGNC Alias symbREA
BCAP37
Bap37
p22
HGNC Alias nameB cell receptor associated protein 37
LocusID (NCBI) 11331
Atlas_Id 45980
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 6965352 and ends at 6970753 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PHB2 (12p13.31) / BTN3A2 (6p22.2)PHB2 (12p13.31) / COL3A1 (2q32.2)PHB2 (12p13.31) / FHL1 (Xq26.3)
PHB2 (12p13.31) / PHB2 (12p13.31)PHB2 (12p13.31) / SPINT1 (15q15.1)PHB2 (12p13.31) / UBXN4 (2q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PHB2   30306
Cards
Entrez_Gene (NCBI)PHB2    prohibitin 2
AliasesBAP; BCAP37; Bap37; PNAS-141; 
REA; hBAP; p22
GeneCards (Weizmann)PHB2
Ensembl hg19 (Hinxton)ENSG00000215021 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000215021 [Gene_View]  ENSG00000215021 [Sequence]  chr12:6965352-6970753 [Contig_View]  PHB2 [Vega]
ICGC DataPortalENSG00000215021
TCGA cBioPortalPHB2
AceView (NCBI)PHB2
Genatlas (Paris)PHB2
SOURCE (Princeton)PHB2
Genetics Home Reference (NIH)PHB2
Genomic and cartography
GoldenPath hg38 (UCSC)PHB2  -     chr12:6965352-6970753 -  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PHB2  -     12p13.31   [Description]    (hg19-Feb_2009)
GoldenPathPHB2 - 12p13.31 [CytoView hg19]  PHB2 - 12p13.31 [CytoView hg38]
ImmunoBaseENSG00000215021
Genome Data Viewer NCBIPHB2 [Mapview hg19]  
OMIM610704   
Gene and transcription
Genbank (Entrez)AF126021 AF150962 AF178980 AF279895 AK298217
RefSeq transcript (Entrez)NM_001144831 NM_001267700
Consensus coding sequences : CCDS (NCBI)PHB2
Gene ExpressionPHB2 [ NCBI-GEO ]   PHB2 [ EBI - ARRAY_EXPRESS ]   PHB2 [ SEEK ]   PHB2 [ MEM ]
Gene Expression Viewer (FireBrowse)PHB2 [ Firebrowse - Broad ]
GenevisibleExpression of PHB2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11331
GTEX Portal (Tissue expression)PHB2
Human Protein AtlasENSG00000215021-PHB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99623   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99623  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99623
PhosPhoSitePlusQ99623
Domains : Interpro (EBI)Band_7    Band_7/SPFH_dom_sf    Prohibitin   
Domain families : Pfam (Sanger)Band_7 (PF01145)   
Domain families : Pfam (NCBI)pfam01145   
Domain families : Smart (EMBL)PHB (SM00244)  
Conserved Domain (NCBI)PHB2
PDB (RSDB)6IQE   
PDB Europe6IQE   
PDB (PDBSum)6IQE   
PDB (IMB)6IQE   
Structural Biology KnowledgeBase6IQE   
SCOP (Structural Classification of Proteins)6IQE   
CATH (Classification of proteins structures)6IQE   
SuperfamilyQ99623
AlphaFold pdb e-kbQ99623   
Human Protein Atlas [tissue]ENSG00000215021-PHB2 [tissue]
HPRD17843
Protein Interaction databases
DIP (DOE-UCLA)Q99623
IntAct (EBI)Q99623
BioGRIDPHB2
STRING (EMBL)PHB2
ZODIACPHB2
Ontologies - Pathways
QuickGOQ99623
Ontology : AmiGOactivation of MAPK activity  mitophagy  positive regulation of immunoglobulin production  protein binding  nucleus  nucleus  nucleus  cytoplasm  mitochondrion  mitochondrion  mitochondrion  mitochondrial outer membrane  mitochondrial inner membrane  mitochondrial inner membrane  mitochondrial inner membrane  plasma membrane  protein import into nucleus  mitochondrial calcium ion transmembrane transport  mitochondrion organization  mitochondrion organization  sister chromatid cohesion  activation of phospholipase C activity  protein C-terminus binding  response to wounding  cell surface  postsynaptic density  nuclear matrix  cell migration  CD40 signaling pathway  estrogen receptor binding  axon  regulation of complement activation  positive regulation of exit from mitosis  protein-containing complex  negative regulation of intracellular estrogen receptor signaling pathway  amide binding  negative regulation of mammary gland epithelial cell proliferation  mitochondrial prohibitin complex  induction by virus of host autophagy  RIG-I signaling pathway  B cell activation  identical protein binding  protein homodimerization activity  negative regulation of apoptotic process  negative regulation of DNA-binding transcription factor activity  negative regulation of transcription, DNA-templated  sphingolipid binding  protein heterodimerization activity  protein N-terminus binding  presynaptic active zone  protein stabilization  positive regulation of DNA-binding transcription factor activity  mammary gland branching involved in thelarche  mammary gland alveolus development  regulation of branching involved in mammary gland duct morphogenesis  positive regulation of ERK1 and ERK2 cascade  cellular response to retinoic acid  cellular response to hypoxia  cell periphery  glutamatergic synapse  GABA-ergic synapse  antiviral innate immune response  regulation of cardiolipin metabolic process  positive regulation of NIK/NF-kappaB signaling  positive regulation of cell cycle G1/S phase transition  regulation of cytochrome-c oxidase activity  activation of protein kinase C activity  
Ontology : EGO-EBIactivation of MAPK activity  mitophagy  positive regulation of immunoglobulin production  protein binding  nucleus  nucleus  nucleus  cytoplasm  mitochondrion  mitochondrion  mitochondrion  mitochondrial outer membrane  mitochondrial inner membrane  mitochondrial inner membrane  mitochondrial inner membrane  plasma membrane  protein import into nucleus  mitochondrial calcium ion transmembrane transport  mitochondrion organization  mitochondrion organization  sister chromatid cohesion  activation of phospholipase C activity  protein C-terminus binding  response to wounding  cell surface  postsynaptic density  nuclear matrix  cell migration  CD40 signaling pathway  estrogen receptor binding  axon  regulation of complement activation  positive regulation of exit from mitosis  protein-containing complex  negative regulation of intracellular estrogen receptor signaling pathway  amide binding  negative regulation of mammary gland epithelial cell proliferation  mitochondrial prohibitin complex  induction by virus of host autophagy  RIG-I signaling pathway  B cell activation  identical protein binding  protein homodimerization activity  negative regulation of apoptotic process  negative regulation of DNA-binding transcription factor activity  negative regulation of transcription, DNA-templated  sphingolipid binding  protein heterodimerization activity  protein N-terminus binding  presynaptic active zone  protein stabilization  positive regulation of DNA-binding transcription factor activity  mammary gland branching involved in thelarche  mammary gland alveolus development  regulation of branching involved in mammary gland duct morphogenesis  positive regulation of ERK1 and ERK2 cascade  cellular response to retinoic acid  cellular response to hypoxia  cell periphery  glutamatergic synapse  GABA-ergic synapse  antiviral innate immune response  regulation of cardiolipin metabolic process  positive regulation of NIK/NF-kappaB signaling  positive regulation of cell cycle G1/S phase transition  regulation of cytochrome-c oxidase activity  activation of protein kinase C activity  
Pathways : BIOCARTACARM1 and Regulation of the Estrogen Receptor [Genes]   
NDEx NetworkPHB2
Atlas of Cancer Signalling NetworkPHB2
Wikipedia pathwaysPHB2
Orthology - Evolution
OrthoDB11331
GeneTree (enSembl)ENSG00000215021
Phylogenetic Trees/Animal Genes : TreeFamPHB2
Homologs : HomoloGenePHB2
Homology/Alignments : Family Browser (UCSC)PHB2
Gene fusions - Rearrangements
Fusion : QuiverPHB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPHB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PHB2
dbVarPHB2
ClinVarPHB2
MonarchPHB2
1000_GenomesPHB2 
Exome Variant ServerPHB2
GNOMAD BrowserENSG00000215021
Varsome BrowserPHB2
ACMGPHB2 variants
VarityQ99623
Genomic Variants (DGV)PHB2 [DGVbeta]
DECIPHERPHB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPHB2 
Mutations
ICGC Data PortalPHB2 
TCGA Data PortalPHB2 
Broad Tumor PortalPHB2
OASIS PortalPHB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPHB2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPHB2
Mutations and Diseases : HGMDPHB2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPHB2
DgiDB (Drug Gene Interaction Database)PHB2
DoCM (Curated mutations)PHB2
CIViC (Clinical Interpretations of Variants in Cancer)PHB2
Cancer3DPHB2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610704   
Orphanet
DisGeNETPHB2
MedgenPHB2
Genetic Testing Registry PHB2
NextProtQ99623 [Medical]
GENETestsPHB2
Target ValidationPHB2
Huge Navigator PHB2 [HugePedia]
ClinGenPHB2
Clinical trials, drugs, therapy
MyCancerGenomePHB2
Protein Interactions : CTDPHB2
Pharm GKB GenePA142671181
PharosQ99623
Clinical trialPHB2
Miscellaneous
canSAR (ICR)PHB2
HarmonizomePHB2
DataMed IndexPHB2
Probes
Litterature
PubMed210 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPHB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:06 CEST 2021

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