PHB2 (prohibitin 2)

2007-02-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
BAP,BCAP37,Bap37,PNAS-141,REA,hBAP,p22
FUSION GENES

Other Information

Locus ID:

NCBI: 11331
MIM: 610704
HGNC: 30306
Ensembl: ENSG00000215021

Variants:

dbSNP: 11331
ClinVar: 11331
TCGA: ENSG00000215021
COSMIC: PHB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000215021ENST00000399433J3KPX7
ENSG00000215021ENST00000440277Q99623
ENSG00000215021ENST00000535923Q99623
ENSG00000215021ENST00000536316F5H3X6
ENSG00000215021ENST00000542912F5GY37
ENSG00000215021ENST00000544888F5H0C5
ENSG00000215021ENST00000545167F5GWA7
ENSG00000215021ENST00000545555U3KPZ5
ENSG00000215021ENST00000546111F5H2D2

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170083242006Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2.64
179321042008A repressive role for prohibitin in estrogen signaling.55
151408782004Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases.43
180866712008The PHB1/2 phosphocomplex is required for mitochondrial homeostasis and survival of human T cells.32
196409932009Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.32
238638112013Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.29
199069252010Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein.27
208568742010Prohibitins are required for cancer cell proliferation and adhesion.23
257699262015Estradiol inhibits Th17 cell differentiation through inhibition of RORγT transcription by recruiting the ERα/REA complex to estrogen response elements of the RORγT promoter.20
174533412008EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor.19

Citation

Dessen P

PHB2 (prohibitin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45980/phb2