Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PHC2 (polyhomeotic homolog 2)

Identity

Alias_namesEDR2
early development regulator 2 (homolog of polyhomeotic 2)
polyhomeotic-like 2 (Drosophila)
polyhomeotic homolog 2 (Drosophila)
Alias_symbol (synonym)HPH2
Other aliasPH2
HGNC (Hugo) PHC2
LocusID (NCBI) 1912
Atlas_Id 47229
Location 1p35.1  [Link to chromosome band 1p35]
Location_base_pair Starts at 33323623 and ends at 33375593 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CD74 (5q32) / PHC2 (1p35.1)CSMD2 (1p35.1) / PHC2 (1p35.1)KIAA0319L (1p34.3) / PHC2 (1p35.1)
LOC100506963 () / PHC2 (1p35.1)PHC2 (1p35.1) / C9orf78 (9q34.11)PHC2 (1p35.1) / CSMD2 (1p35.1)
PHC2 (1p35.1) / HSP90AA1 (14q32.31)PHC2 (1p35.1) / ZSCAN20 (1p35.1)KIAA0319L 1p34.3 / PHC2 1p35.1
PHC2 1p35.1 / CSMD2 1p35.1PHC2 1p35.1 / HSP90AA1 14q32.31PHC2 1p35.1 / ZSCAN20 1p35.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PHC2   3183
Cards
Entrez_Gene (NCBI)PHC2  1912  polyhomeotic homolog 2
AliasesEDR2; HPH2; PH2
GeneCards (Weizmann)PHC2
Ensembl hg19 (Hinxton)ENSG00000134686 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134686 [Gene_View]  chr1:33323623-33375593 [Contig_View]  PHC2 [Vega]
ICGC DataPortalENSG00000134686
TCGA cBioPortalPHC2
AceView (NCBI)PHC2
Genatlas (Paris)PHC2
WikiGenes1912
SOURCE (Princeton)PHC2
Genetics Home Reference (NIH)PHC2
Genomic and cartography
GoldenPath hg38 (UCSC)PHC2  -     chr1:33323623-33375593 -  1p35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PHC2  -     1p35.1   [Description]    (hg19-Feb_2009)
EnsemblPHC2 - 1p35.1 [CytoView hg19]  PHC2 - 1p35.1 [CytoView hg38]
Mapping of homologs : NCBIPHC2 [Mapview hg19]  PHC2 [Mapview hg38]
OMIM602979   
Gene and transcription
Genbank (Entrez)AJ242730 AJ419231 AK055807 AK056429 AK091856
RefSeq transcript (Entrez)NM_001330488 NM_004427 NM_198040
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PHC2
Cluster EST : UnigeneHs.674410 [ NCBI ]
CGAP (NCI)Hs.674410
Alternative Splicing GalleryENSG00000134686
Gene ExpressionPHC2 [ NCBI-GEO ]   PHC2 [ EBI - ARRAY_EXPRESS ]   PHC2 [ SEEK ]   PHC2 [ MEM ]
Gene Expression Viewer (FireBrowse)PHC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1912
GTEX Portal (Tissue expression)PHC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IXK0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IXK0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IXK0
Splice isoforms : SwissVarQ8IXK0
PhosPhoSitePlusQ8IXK0
Domaine pattern : Prosite (Expaxy)SAM_DOMAIN (PS50105)    ZF_FCS (PS51024)   
Domains : Interpro (EBI)SAM    SAM/pointed    Znf_FCS   
Domain families : Pfam (Sanger)SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam00536   
Domain families : Smart (EMBL)SAM (SM00454)  
Conserved Domain (NCBI)PHC2
DMDM Disease mutations1912
Blocks (Seattle)PHC2
SuperfamilyQ8IXK0
Human Protein AtlasENSG00000134686
Peptide AtlasQ8IXK0
HPRD10340
IPIIPI00943102   IPI00419684   IPI00647439   IPI00876858   IPI00443448   IPI00384597   
Protein Interaction databases
DIP (DOE-UCLA)Q8IXK0
IntAct (EBI)Q8IXK0
FunCoupENSG00000134686
BioGRIDPHC2
STRING (EMBL)PHC2
ZODIACPHC2
Ontologies - Pathways
QuickGOQ8IXK0
Ontology : AmiGOheterochromatin  DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  multicellular organism development  spermatogenesis  zinc ion binding  PcG protein complex  PRC1 complex  identical protein binding  
Ontology : EGO-EBIheterochromatin  DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  multicellular organism development  spermatogenesis  zinc ion binding  PcG protein complex  PRC1 complex  identical protein binding  
NDEx NetworkPHC2
Atlas of Cancer Signalling NetworkPHC2
Wikipedia pathwaysPHC2
Orthology - Evolution
OrthoDB1912
GeneTree (enSembl)ENSG00000134686
Phylogenetic Trees/Animal Genes : TreeFamPHC2
HOVERGENQ8IXK0
HOGENOMQ8IXK0
Homologs : HomoloGenePHC2
Homology/Alignments : Family Browser (UCSC)PHC2
Gene fusions - Rearrangements
Fusion : MitelmanKIAA0319L/PHC2 [1p34.3/1p35.1]  [t(1;1)(p34;p35)]  
Fusion : MitelmanPHC2/CSMD2 [1p35.1/1p35.1]  [t(1;1)(p34;p35)]  
Fusion : MitelmanPHC2/HSP90AA1 [1p35.1/14q32.31]  [t(1;14)(p35;q32)]  
Fusion : MitelmanPHC2/ZSCAN20 [1p35.1/1p35.1]  [t(1;1)(p35;p35)]  
Fusion: TCGAKIAA0319L 1p34.3 PHC2 1p35.1 BRCA
Fusion: TCGAPHC2 1p35.1 CSMD2 1p35.1 LUAD
Fusion: TCGAPHC2 1p35.1 HSP90AA1 14q32.31 PRAD
Fusion: TCGAPHC2 1p35.1 ZSCAN20 1p35.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPHC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PHC2
dbVarPHC2
ClinVarPHC2
1000_GenomesPHC2 
Exome Variant ServerPHC2
ExAC (Exome Aggregation Consortium)PHC2 (select the gene name)
Genetic variants : HAPMAP1912
Genomic Variants (DGV)PHC2 [DGVbeta]
DECIPHERPHC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPHC2 
Mutations
ICGC Data PortalPHC2 
TCGA Data PortalPHC2 
Broad Tumor PortalPHC2
OASIS PortalPHC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPHC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPHC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PHC2
DgiDB (Drug Gene Interaction Database)PHC2
DoCM (Curated mutations)PHC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PHC2 (select a term)
intoGenPHC2
Cancer3DPHC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602979   
Orphanet
MedgenPHC2
Genetic Testing Registry PHC2
NextProtQ8IXK0 [Medical]
TSGene1912
GENETestsPHC2
Target ValidationPHC2
Huge Navigator PHC2 [HugePedia]
snp3D : Map Gene to Disease1912
BioCentury BCIQPHC2
ClinGenPHC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1912
Chemical/Pharm GKB GenePA27620
Clinical trialPHC2
Miscellaneous
canSAR (ICR)PHC2 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePHC2
EVEXPHC2
GoPubMedPHC2
iHOPPHC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 14:03:11 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.