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PHC3 (polyhomeotic homolog 3)

Identity

Alias_namespolyhomeotic like 3 (Drosophila)
polyhomeotic homolog 3 (Drosophila)
Alias_symbol (synonym)EDR3
FLJ12967
FLJ12729
HPH3
Other alias
HGNC (Hugo) PHC3
LocusID (NCBI) 80012
Atlas_Id 47433
Location 3q26.2  [Link to chromosome band 3q26]
Location_base_pair Starts at 170087580 and ends at 170181749 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PHC3 (3q26.2) / FNDC3B (3q26.31)PHC3 (3q26.2) / NOVA1 (14q12)PHC3 (3q26.2) / PHC3 (3q26.2)
PHC3 (3q26.2) / PRPF4B (6p25.2)PHC3 (3q26.2) / SPACA3 (17q11.2)PHC3 3q26.2 / FNDC3B 3q26.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)PHC3   15682
Cards
Entrez_Gene (NCBI)PHC3  80012  polyhomeotic homolog 3
AliasesEDR3; HPH3
GeneCards (Weizmann)PHC3
Ensembl hg19 (Hinxton)ENSG00000173889 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173889 [Gene_View]  chr3:170087580-170181749 [Contig_View]  PHC3 [Vega]
ICGC DataPortalENSG00000173889
TCGA cBioPortalPHC3
AceView (NCBI)PHC3
Genatlas (Paris)PHC3
WikiGenes80012
SOURCE (Princeton)PHC3
Genetics Home Reference (NIH)PHC3
Genomic and cartography
GoldenPath hg38 (UCSC)PHC3  -     chr3:170087580-170181749 -  3q26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PHC3  -     3q26.2   [Description]    (hg19-Feb_2009)
EnsemblPHC3 - 3q26.2 [CytoView hg19]  PHC3 - 3q26.2 [CytoView hg38]
Mapping of homologs : NCBIPHC3 [Mapview hg19]  PHC3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF380154 AF444193 AI042019 AJ320486 AK022791
RefSeq transcript (Entrez)NM_001308116 NM_024947
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PHC3
Cluster EST : UnigeneHs.694467 [ NCBI ]
CGAP (NCI)Hs.694467
Alternative Splicing GalleryENSG00000173889
Gene ExpressionPHC3 [ NCBI-GEO ]   PHC3 [ EBI - ARRAY_EXPRESS ]   PHC3 [ SEEK ]   PHC3 [ MEM ]
Gene Expression Viewer (FireBrowse)PHC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80012
GTEX Portal (Tissue expression)PHC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NDX5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NDX5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NDX5
Splice isoforms : SwissVarQ8NDX5
PhosPhoSitePlusQ8NDX5
Domaine pattern : Prosite (Expaxy)SAM_DOMAIN (PS50105)    ZF_FCS (PS51024)   
Domains : Interpro (EBI)SAM    SAM/pointed    Znf_FCS   
Domain families : Pfam (Sanger)SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam00536   
Domain families : Smart (EMBL)SAM (SM00454)  
Conserved Domain (NCBI)PHC3
DMDM Disease mutations80012
Blocks (Seattle)PHC3
PDB (SRS)4PZN    4PZO   
PDB (PDBSum)4PZN    4PZO   
PDB (IMB)4PZN    4PZO   
PDB (RSDB)4PZN    4PZO   
Structural Biology KnowledgeBase4PZN    4PZO   
SCOP (Structural Classification of Proteins)4PZN    4PZO   
CATH (Classification of proteins structures)4PZN    4PZO   
SuperfamilyQ8NDX5
Human Protein AtlasENSG00000173889
Peptide AtlasQ8NDX5
HPRD10149
IPIIPI00983054   IPI00658100   IPI00657801   IPI00640223   IPI00978670   IPI00302149   IPI00789502   IPI00980975   IPI00657944   IPI00946919   IPI00974329   IPI00945584   IPI00946367   IPI00945223   IPI00946006   
Protein Interaction databases
DIP (DOE-UCLA)Q8NDX5
IntAct (EBI)Q8NDX5
FunCoupENSG00000173889
BioGRIDPHC3
STRING (EMBL)PHC3
ZODIACPHC3
Ontologies - Pathways
QuickGOQ8NDX5
Ontology : AmiGODNA binding  protein binding  nucleus  nucleoplasm  multicellular organism development  zinc ion binding  PcG protein complex  PRC1 complex  
Ontology : EGO-EBIDNA binding  protein binding  nucleus  nucleoplasm  multicellular organism development  zinc ion binding  PcG protein complex  PRC1 complex  
NDEx NetworkPHC3
Atlas of Cancer Signalling NetworkPHC3
Wikipedia pathwaysPHC3
Orthology - Evolution
OrthoDB80012
GeneTree (enSembl)ENSG00000173889
Phylogenetic Trees/Animal Genes : TreeFamPHC3
HOVERGENQ8NDX5
HOGENOMQ8NDX5
Homologs : HomoloGenePHC3
Homology/Alignments : Family Browser (UCSC)PHC3
Gene fusions - Rearrangements
Fusion : MitelmanPHC3/FNDC3B [3q26.2/3q26.31]  
Fusion: TCGAPHC3 3q26.2 FNDC3B 3q26.31 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPHC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PHC3
dbVarPHC3
ClinVarPHC3
1000_GenomesPHC3 
Exome Variant ServerPHC3
ExAC (Exome Aggregation Consortium)PHC3 (select the gene name)
Genetic variants : HAPMAP80012
Genomic Variants (DGV)PHC3 [DGVbeta]
DECIPHERPHC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPHC3 
Mutations
ICGC Data PortalPHC3 
TCGA Data PortalPHC3 
Broad Tumor PortalPHC3
OASIS PortalPHC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPHC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPHC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PHC3
DgiDB (Drug Gene Interaction Database)PHC3
DoCM (Curated mutations)PHC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PHC3 (select a term)
intoGenPHC3
Cancer3DPHC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPHC3
Genetic Testing Registry PHC3
NextProtQ8NDX5 [Medical]
TSGene80012
GENETestsPHC3
Huge Navigator PHC3 [HugePedia]
snp3D : Map Gene to Disease80012
BioCentury BCIQPHC3
ClinGenPHC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80012
Chemical/Pharm GKB GenePA134886018
Clinical trialPHC3
Miscellaneous
canSAR (ICR)PHC3 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePHC3
EVEXPHC3
GoPubMedPHC3
iHOPPHC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:31:00 CEST 2017

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