PHF20 (PHD finger protein 20)

2010-04-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
C20orf104,GLEA2,HCA58,NZF,TDRD20A,TZP
FUSION GENES

Other Information

Locus ID:

NCBI: 51230
MIM: 610335
HGNC: 16098
Ensembl: ENSG00000025293

Variants:

dbSNP: 51230
ClinVar: 51230
TCGA: ENSG00000025293
COSMIC: PHF20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000025293ENST00000339089Q5JWZ0
ENSG00000025293ENST00000374000Q5JXL1
ENSG00000025293ENST00000374012Q9BVI0
ENSG00000025293ENST00000420233B0QZ19
ENSG00000025293ENST00000449988B0QYY0
ENSG00000025293ENST00000452270F8WCQ1

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through Association with Co-factorsREACTOMER-HSA-6804759

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194737192010Identification of genes associated with non-small-cell lung cancer promotion and progression.40
159063532005Autoantibodies against GLEA2 and PHF3 in glioblastoma: tumor-associated autoantibodies correlated with prolonged survival.28
228642872012PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.28
237976022013PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.26
269605732016G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.18
224499722012Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins.13
229756852013PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.12
277603182016PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.12
184781112008Increased seroreactivity to glioma-expressed antigen 2 in brain tumor patients under radiation.6
294524182018PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4.4

Citation

Dessen P

PHF20 (PHD finger protein 20)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51408/phf20