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PHF21A (PHD finger protein 21A)

Identity

Alias_symbol (synonym)BHC80
KIAA1696
BM-006
Other alias
HGNC (Hugo) PHF21A
LocusID (NCBI) 51317
Atlas_Id 54533
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 45950870 and ends at 46142985 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CLOCK (4q12) / PHF21A (11p11.2)CYP19A1 (15q21.2) / PHF21A (11p11.2)GLIS2 (16p13.3) / PHF21A (11p11.2)
GNA13 (17q24.1) / PHF21A (11p11.2)NNT (5p12) / PHF21A (11p11.2)PHF21A (11p11.2) / ALKBH3 (11p11.2)
PHF21A (11p11.2) / AMBRA1 (11p11.2)PHF21A (11p11.2) / ARHGAP1 (11p11.2)PHF21A (11p11.2) / CAMK1D (10p13)
PHF21A (11p11.2) / CCDC178 (18q12.1)PHF21A (11p11.2) / GLIS2 (16p13.3)PHF21A (11p11.2) / PACSIN3 (11p11.2)
PHF21A (11p11.2) / PHF21A (11p11.2)CLOCK 4q12 / PHF21A 11p11.2PHF21A 11p11.2 / ALKBH3 11p11.2
PHF21A 11p11.2 / AMBRA1 11p11.2PHF21A 11p11.2 / ARHGAP1 11p11.2PHF21A 11p11.2 C18orf34
PHF21A 11p11.2 / CAMK1D 10p13PHF21A 11p11.2 / GLIS2 16p13.3PHF21A 11p11.2 / PACSIN3 11p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PHF21A   24156
Cards
Entrez_Gene (NCBI)PHF21A  51317  PHD finger protein 21A
AliasesBHC80; BM-006
GeneCards (Weizmann)PHF21A
Ensembl hg19 (Hinxton)ENSG00000135365 [Gene_View]  chr11:45950870-46142985 [Contig_View]  PHF21A [Vega]
Ensembl hg38 (Hinxton)ENSG00000135365 [Gene_View]  chr11:45950870-46142985 [Contig_View]  PHF21A [Vega]
ICGC DataPortalENSG00000135365
TCGA cBioPortalPHF21A
AceView (NCBI)PHF21A
Genatlas (Paris)PHF21A
WikiGenes51317
SOURCE (Princeton)PHF21A
Genetics Home Reference (NIH)PHF21A
Genomic and cartography
GoldenPath hg19 (UCSC)PHF21A  -     chr11:45950870-46142985 -  11p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PHF21A  -     11p11.2   [Description]    (hg38-Dec_2013)
EnsemblPHF21A - 11p11.2 [CytoView hg19]  PHF21A - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIPHF21A [Mapview hg19]  PHF21A [Mapview hg38]
OMIM608325   
Gene and transcription
Genbank (Entrez)AB051483 AF208848 AK021530 AK023258 AL359593
RefSeq transcript (Entrez)NM_001101802 NM_016621
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)PHF21A
Cluster EST : UnigeneHs.502458 [ NCBI ]
CGAP (NCI)Hs.502458
Alternative Splicing GalleryENSG00000135365
Gene ExpressionPHF21A [ NCBI-GEO ]   PHF21A [ EBI - ARRAY_EXPRESS ]   PHF21A [ SEEK ]   PHF21A [ MEM ]
Gene Expression Viewer (FireBrowse)PHF21A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51317
GTEX Portal (Tissue expression)PHF21A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96BD5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96BD5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96BD5
Splice isoforms : SwissVarQ96BD5
PhosPhoSitePlusQ96BD5
Domaine pattern : Prosite (Expaxy)ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)   
Domains : Interpro (EBI)AT_hook_DNA-bd_motif    Zinc_finger_PHD-type_CS    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)PHD (PF00628)   
Domain families : Pfam (NCBI)pfam00628   
Domain families : Smart (EMBL)AT_hook (SM00384)  PHD (SM00249)  RING (SM00184)  
Conserved Domain (NCBI)PHF21A
DMDM Disease mutations51317
Blocks (Seattle)PHF21A
PDB (SRS)2PUY    2YQL   
PDB (PDBSum)2PUY    2YQL   
PDB (IMB)2PUY    2YQL   
PDB (RSDB)2PUY    2YQL   
Structural Biology KnowledgeBase2PUY    2YQL   
SCOP (Structural Classification of Proteins)2PUY    2YQL   
CATH (Classification of proteins structures)2PUY    2YQL   
SuperfamilyQ96BD5
Human Protein AtlasENSG00000135365
Peptide AtlasQ96BD5
IPIIPI00054460   IPI00041959   IPI00737174   IPI00984085   IPI00977220   IPI00979967   IPI00984637   IPI00976654   IPI00983481   IPI00978748   IPI00978101   IPI00979364   IPI00976005   IPI00977828   
Protein Interaction databases
DIP (DOE-UCLA)Q96BD5
IntAct (EBI)Q96BD5
FunCoupENSG00000135365
BioGRIDPHF21A
STRING (EMBL)PHF21A
ZODIACPHF21A
Ontologies - Pathways
QuickGOQ96BD5
Ontology : AmiGOhistone deacetylase complex  negative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  chromatin binding  transcription cofactor activity  histone deacetylase activity  protein binding  nucleoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  blood coagulation  zinc ion binding  histone deacetylation  histone binding  DNA repair complex  
Ontology : EGO-EBIhistone deacetylase complex  negative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  chromatin binding  transcription cofactor activity  histone deacetylase activity  protein binding  nucleoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  blood coagulation  zinc ion binding  histone deacetylation  histone binding  DNA repair complex  
NDEx NetworkPHF21A
Atlas of Cancer Signalling NetworkPHF21A
Wikipedia pathwaysPHF21A
Orthology - Evolution
OrthoDB51317
GeneTree (enSembl)ENSG00000135365
Phylogenetic Trees/Animal Genes : TreeFamPHF21A
HOVERGENQ96BD5
HOGENOMQ96BD5
Homologs : HomoloGenePHF21A
Homology/Alignments : Family Browser (UCSC)PHF21A
Gene fusions - Rearrangements
Fusion : MitelmanCLOCK/PHF21A [4q12/11p11.2]  [t(4;11)(q12;p11)]  
Fusion : MitelmanGLIS2/PHF21A [16p13.3/11p11.2]  [t(11;16)(p11;p13)]  
Fusion : MitelmanPHF21A/ALKBH3 [11p11.2/11p11.2]  [t(11;11)(p11;p11)]  
Fusion : MitelmanPHF21A/AMBRA1 [11p11.2/11p11.2]  [t(11;11)(p11;p11)]  
Fusion : MitelmanPHF21A/ARHGAP1 [11p11.2/11p11.2]  [t(11;11)(p11;p11)]  
Fusion : MitelmanPHF21A/CAMK1D [11p11.2/10p13]  [t(10;11)(p13;p11)]  
Fusion : MitelmanPHF21A/CCDC178 [11p11.2/18q12.1]  [t(11;18)(p11;q12)]  
Fusion : MitelmanPHF21A/GLIS2 [11p11.2/16p13.3]  [t(11;16)(p11;p13)]  
Fusion : MitelmanPHF21A/PACSIN3 [11p11.2/11p11.2]  [t(11;11)(p11;p11)]  
Fusion: TCGACLOCK 4q12 PHF21A 11p11.2 LUAD
Fusion: TCGAPHF21A 11p11.2 ALKBH3 11p11.2 LUAD
Fusion: TCGAPHF21A 11p11.2 AMBRA1 11p11.2 LUAD
Fusion: TCGAPHF21A 11p11.2 ARHGAP1 11p11.2 BLCA
Fusion: TCGAPHF21A 11p11.2 C18orf34 BRCA
Fusion: TCGAPHF21A 11p11.2 CAMK1D 10p13 BRCA
Fusion: TCGAPHF21A 11p11.2 GLIS2 16p13.3 HNSC LAML
Fusion: TCGAPHF21A 11p11.2 PACSIN3 11p11.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPHF21A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PHF21A
dbVarPHF21A
ClinVarPHF21A
1000_GenomesPHF21A 
Exome Variant ServerPHF21A
ExAC (Exome Aggregation Consortium)PHF21A (select the gene name)
Genetic variants : HAPMAP51317
Genomic Variants (DGV)PHF21A [DGVbeta]
DECIPHER (Syndromes)11:45950870-46142985  ENSG00000135365
CONAN: Copy Number AnalysisPHF21A 
Mutations
ICGC Data PortalPHF21A 
TCGA Data PortalPHF21A 
Broad Tumor PortalPHF21A
OASIS PortalPHF21A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPHF21A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPHF21A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PHF21A
DgiDB (Drug Gene Interaction Database)PHF21A
DoCM (Curated mutations)PHF21A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PHF21A (select a term)
intoGenPHF21A
Cancer3DPHF21A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608325   
Orphanet10684   
MedgenPHF21A
Genetic Testing Registry PHF21A
NextProtQ96BD5 [Medical]
TSGene51317
GENETestsPHF21A
Huge Navigator PHF21A [HugePedia]
snp3D : Map Gene to Disease51317
BioCentury BCIQPHF21A
ClinGenPHF21A (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51317
Chemical/Pharm GKB GenePA134977844
Clinical trialPHF21A
Miscellaneous
canSAR (ICR)PHF21A (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePHF21A
EVEXPHF21A
GoPubMedPHF21A
iHOPPHF21A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:14:13 CEST 2017

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