PHGDH (phosphoglycerate dehydrogenase)

2011-10-01  

Identity

HGNC
LOCATION
1p12
LOCUSID
ALIAS
3-PGDH,3PGDH,HEL-S-113,NLS,NLS1,PDG,PGAD,PGD,PGDH,PHGDHD,SERA
FUSION GENES

Other Information

Locus ID:

NCBI: 26227
MIM: 606879
HGNC: 8923
Ensembl: ENSG00000092621

Variants:

dbSNP: 26227
ClinVar: 26227
TCGA: ENSG00000092621
COSMIC: PHGDH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092621ENST00000369409A0A2C9F2M7
ENSG00000092621ENST00000493622A0A286YFE1
ENSG00000092621ENST00000641023O43175
ENSG00000092621ENST00000641074A0A286YFL2
ENSG00000092621ENST00000641115A0A286YFA2
ENSG00000092621ENST00000641213A0A286YFB2
ENSG00000092621ENST00000641247A0A286YER3
ENSG00000092621ENST00000641272A0A286YFM8
ENSG00000092621ENST00000641371A0A286YFK5
ENSG00000092621ENST00000641375A0A286YFB2
ENSG00000092621ENST00000641491A0A286YFB2
ENSG00000092621ENST00000641513A0A286YFB2
ENSG00000092621ENST00000641570A0A286YFC8
ENSG00000092621ENST00000641587A0A286YFF3
ENSG00000092621ENST00000641597O43175
ENSG00000092621ENST00000641720A0A286YF34
ENSG00000092621ENST00000641756A0A286YEZ0
ENSG00000092621ENST00000641811A0A286YF78
ENSG00000092621ENST00000641891A0A286YFB2
ENSG00000092621ENST00000641947A0A286YF22
ENSG00000092621ENST00000642041A0A286YER3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Glycine, serine and threonine metabolismKEGGhsa00260
Metabolic pathwaysKEGGhsa01100
Serine biosynthesis, glycerate-3P => serineKEGGhsa_M00020
Serine biosynthesis, glycerate-3P => serineKEGGM00020
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614
Serine biosynthesisREACTOMER-HSA-977347

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
217605892011Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.533
218045462011Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.388
219819742011PHGDH amplification and altered glucose metabolism in human melanoma.42
286147152017PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis.31
254047302015p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation.27
278369732016Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.21
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.18
251524572014Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway.18
289514582017PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma.15
305757412018Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism.14

Citation

Dessen P

PHGDH (phosphoglycerate dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52399/phgdh