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PHIP (pleckstrin homology domain interacting protein)

Identity

Alias_namesWDR11
Alias_symbol (synonym)ndrp
FLJ20705
DCAF14
BRWD2
Other alias
HGNC (Hugo) PHIP
LocusID (NCBI) 55023
Atlas_Id 52801
Location 6q14.1  [Link to chromosome band 6q14]
Location_base_pair Starts at 78934419 and ends at 79078298 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATP1A1 (1p13.1) / PHIP (6q14.1)AZIN2 (1p35.1) / PHIP (6q14.1)GADL1 (3p24.1) / PHIP (6q14.1)
NHLRC3 (13q13.3) / PHIP (6q14.1)PHIP (6q14.1) / FTO (16q12.2)PHIP (6q14.1) / PATJ (1p31.3)
PHIP (6q14.1) / PHIP (6q14.1)PHIP (6q14.1) / ZNF320 (19q13.41)ADC PHIP 6q14.1
PHIP 6q14.1 / FTO 16q12.2PHIP 6q14.1 / INADL 1p31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PHIP   15673
Cards
Entrez_Gene (NCBI)PHIP  55023  pleckstrin homology domain interacting protein
AliasesBRWD2; DCAF14; WDR11; ndrp
GeneCards (Weizmann)PHIP
Ensembl hg19 (Hinxton)ENSG00000146247 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146247 [Gene_View]  chr6:78934419-79078298 [Contig_View]  PHIP [Vega]
ICGC DataPortalENSG00000146247
TCGA cBioPortalPHIP
AceView (NCBI)PHIP
Genatlas (Paris)PHIP
WikiGenes55023
SOURCE (Princeton)PHIP
Genetics Home Reference (NIH)PHIP
Genomic and cartography
GoldenPath hg38 (UCSC)PHIP  -     chr6:78934419-79078298 -  6q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PHIP  -     6q14.1   [Description]    (hg19-Feb_2009)
EnsemblPHIP - 6q14.1 [CytoView hg19]  PHIP - 6q14.1 [CytoView hg38]
Mapping of homologs : NCBIPHIP [Mapview hg19]  PHIP [Mapview hg38]
OMIM612870   
Gene and transcription
Genbank (Entrez)AF310250 AJ303102 AK000712 AK057039 AK075124
RefSeq transcript (Entrez)NM_017934
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PHIP
Cluster EST : UnigeneHs.606356 [ NCBI ]
CGAP (NCI)Hs.606356
Alternative Splicing GalleryENSG00000146247
Gene ExpressionPHIP [ NCBI-GEO ]   PHIP [ EBI - ARRAY_EXPRESS ]   PHIP [ SEEK ]   PHIP [ MEM ]
Gene Expression Viewer (FireBrowse)PHIP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55023
GTEX Portal (Tissue expression)PHIP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WWQ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WWQ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WWQ0
Splice isoforms : SwissVarQ8WWQ0
PhosPhoSitePlusQ8WWQ0
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_1 (PS00633)    BROMODOMAIN_2 (PS50014)    WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Bromodomain    Bromodomain_CS    PHIP    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)Bromodomain (PF00439)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00439    pfam00400   
Domain families : Smart (EMBL)BROMO (SM00297)  WD40 (SM00320)  
Conserved Domain (NCBI)PHIP
DMDM Disease mutations55023
Blocks (Seattle)PHIP
PDB (SRS)3MB3    5ENB    5ENC    5ENE    5ENF    5ENH    5ENI    5ENJ   
PDB (PDBSum)3MB3    5ENB    5ENC    5ENE    5ENF    5ENH    5ENI    5ENJ   
PDB (IMB)3MB3    5ENB    5ENC    5ENE    5ENF    5ENH    5ENI    5ENJ   
PDB (RSDB)3MB3    5ENB    5ENC    5ENE    5ENF    5ENH    5ENI    5ENJ   
Structural Biology KnowledgeBase3MB3    5ENB    5ENC    5ENE    5ENF    5ENH    5ENI    5ENJ   
SCOP (Structural Classification of Proteins)3MB3    5ENB    5ENC    5ENE    5ENF    5ENH    5ENI    5ENJ   
CATH (Classification of proteins structures)3MB3    5ENB    5ENC    5ENE    5ENF    5ENH    5ENI    5ENJ   
SuperfamilyQ8WWQ0
Human Protein AtlasENSG00000146247
Peptide AtlasQ8WWQ0
HPRD10152
IPIIPI00291916   IPI00385943   IPI00978677   
Protein Interaction databases
DIP (DOE-UCLA)Q8WWQ0
IntAct (EBI)Q8WWQ0
FunCoupENSG00000146247
BioGRIDPHIP
STRING (EMBL)PHIP
ZODIACPHIP
Ontologies - Pathways
QuickGOQ8WWQ0
Ontology : AmiGOregulation of protein phosphorylation  insulin receptor binding  protein binding  nucleus  nucleus  cytoskeleton organization  positive regulation of cell proliferation  insulin receptor signaling pathway  regulation of cell shape  regulation of cell morphogenesis  negative regulation of apoptotic process  positive regulation of insulin-like growth factor receptor signaling pathway  positive regulation of mitotic nuclear division  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  extracellular exosome  lysine-acetylated histone binding  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIregulation of protein phosphorylation  insulin receptor binding  protein binding  nucleus  nucleus  cytoskeleton organization  positive regulation of cell proliferation  insulin receptor signaling pathway  regulation of cell shape  regulation of cell morphogenesis  negative regulation of apoptotic process  positive regulation of insulin-like growth factor receptor signaling pathway  positive regulation of mitotic nuclear division  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  extracellular exosome  lysine-acetylated histone binding  negative regulation of extrinsic apoptotic signaling pathway  
NDEx NetworkPHIP
Atlas of Cancer Signalling NetworkPHIP
Wikipedia pathwaysPHIP
Orthology - Evolution
OrthoDB55023
GeneTree (enSembl)ENSG00000146247
Phylogenetic Trees/Animal Genes : TreeFamPHIP
HOVERGENQ8WWQ0
HOGENOMQ8WWQ0
Homologs : HomoloGenePHIP
Homology/Alignments : Family Browser (UCSC)PHIP
Gene fusions - Rearrangements
Fusion : MitelmanGADL1/PHIP [3p24.1/6q14.1]  [t(1;6)(p35;q14)]  
Fusion : MitelmanPHIP/FTO [6q14.1/16q12.2]  [t(6;16)(q14;q12)]  
Fusion : MitelmanPHIP/INADL [6q14.1/1p31.3]  [t(1;6)(p31;q14)]  
Fusion: TCGAADC PHIP 6q14.1 BRCA
Fusion: TCGAPHIP 6q14.1 FTO 16q12.2 LUAD
Fusion: TCGAPHIP 6q14.1 INADL 1p31.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPHIP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PHIP
dbVarPHIP
ClinVarPHIP
1000_GenomesPHIP 
Exome Variant ServerPHIP
ExAC (Exome Aggregation Consortium)PHIP (select the gene name)
Genetic variants : HAPMAP55023
Genomic Variants (DGV)PHIP [DGVbeta]
DECIPHERPHIP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPHIP 
Mutations
ICGC Data PortalPHIP 
TCGA Data PortalPHIP 
Broad Tumor PortalPHIP
OASIS PortalPHIP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPHIP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPHIP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PHIP
DgiDB (Drug Gene Interaction Database)PHIP
DoCM (Curated mutations)PHIP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PHIP (select a term)
intoGenPHIP
Cancer3DPHIP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612870   
Orphanet
MedgenPHIP
Genetic Testing Registry PHIP
NextProtQ8WWQ0 [Medical]
TSGene55023
GENETestsPHIP
Target ValidationPHIP
Huge Navigator PHIP [HugePedia]
snp3D : Map Gene to Disease55023
BioCentury BCIQPHIP
ClinGenPHIP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55023
Chemical/Pharm GKB GenePA33265
Clinical trialPHIP
Miscellaneous
canSAR (ICR)PHIP (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePHIP
EVEXPHIP
GoPubMedPHIP
iHOPPHIP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:03:13 CEST 2017

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