Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PHLDA2 (pleckstrin homology like domain family A member 2)

Identity

Alias_namesTSSC3
tumor suppressing subtransferable candidate 3
pleckstrin homology-like domain, family A, member 2
Alias_symbol (synonym)IPL
BWR1C
HLDA2
Other aliasBRW1C
HGNC (Hugo) PHLDA2
LocusID (NCBI) 7262
Atlas_Id 41708
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 2928273 and ends at 2929420 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PHLDA2   12385
LRG (Locus Reference Genomic)LRG_1043
Cards
Entrez_Gene (NCBI)PHLDA2  7262  pleckstrin homology like domain family A member 2
AliasesBRW1C; BWR1C; HLDA2; IPL; 
TSSC3
GeneCards (Weizmann)PHLDA2
Ensembl hg19 (Hinxton)ENSG00000181649 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181649 [Gene_View]  chr11:2928273-2929420 [Contig_View]  PHLDA2 [Vega]
ICGC DataPortalENSG00000181649
TCGA cBioPortalPHLDA2
AceView (NCBI)PHLDA2
Genatlas (Paris)PHLDA2
WikiGenes7262
SOURCE (Princeton)PHLDA2
Genetics Home Reference (NIH)PHLDA2
Genomic and cartography
GoldenPath hg38 (UCSC)PHLDA2  -     chr11:2928273-2929420 -  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PHLDA2  -     11p15.4   [Description]    (hg19-Feb_2009)
EnsemblPHLDA2 - 11p15.4 [CytoView hg19]  PHLDA2 - 11p15.4 [CytoView hg38]
Mapping of homologs : NCBIPHLDA2 [Mapview hg19]  PHLDA2 [Mapview hg38]
OMIM602131   
Gene and transcription
Genbank (Entrez)AF001294 AF019953 AF035444 AI659266 AK223027
RefSeq transcript (Entrez)NM_003311
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_009266 NT_187585
Consensus coding sequences : CCDS (NCBI)PHLDA2
Cluster EST : UnigeneHs.154036 [ NCBI ]
CGAP (NCI)Hs.154036
Alternative Splicing GalleryENSG00000181649
Gene ExpressionPHLDA2 [ NCBI-GEO ]   PHLDA2 [ EBI - ARRAY_EXPRESS ]   PHLDA2 [ SEEK ]   PHLDA2 [ MEM ]
Gene Expression Viewer (FireBrowse)PHLDA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7262
GTEX Portal (Tissue expression)PHLDA2
Human Protein AtlasENSG00000181649-PHLDA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ53GA4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ53GA4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ53GA4
Splice isoforms : SwissVarQ53GA4
PhosPhoSitePlusQ53GA4
Domains : Interpro (EBI)PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)PH (SM00233)  
Conserved Domain (NCBI)PHLDA2
DMDM Disease mutations7262
Blocks (Seattle)PHLDA2
SuperfamilyQ53GA4
Human Protein Atlas [tissue]ENSG00000181649-PHLDA2 [tissue]
Peptide AtlasQ53GA4
HPRD03679
IPIIPI00019551   
Protein Interaction databases
DIP (DOE-UCLA)Q53GA4
IntAct (EBI)Q53GA4
FunCoupENSG00000181649
BioGRIDPHLDA2
STRING (EMBL)PHLDA2
ZODIACPHLDA2
Ontologies - Pathways
QuickGOQ53GA4
Ontology : AmiGOplacenta development  cytoplasm  apoptotic process  animal organ morphogenesis  regulation of gene expression  membrane  regulation of cell migration  regulation of spongiotrophoblast cell proliferation  regulation of glycogen metabolic process  regulation of growth hormone activity  
Ontology : EGO-EBIplacenta development  cytoplasm  apoptotic process  animal organ morphogenesis  regulation of gene expression  membrane  regulation of cell migration  regulation of spongiotrophoblast cell proliferation  regulation of glycogen metabolic process  regulation of growth hormone activity  
NDEx NetworkPHLDA2
Atlas of Cancer Signalling NetworkPHLDA2
Wikipedia pathwaysPHLDA2
Orthology - Evolution
OrthoDB7262
GeneTree (enSembl)ENSG00000181649
Phylogenetic Trees/Animal Genes : TreeFamPHLDA2
HOVERGENQ53GA4
HOGENOMQ53GA4
Homologs : HomoloGenePHLDA2
Homology/Alignments : Family Browser (UCSC)PHLDA2
Gene fusions - Rearrangements
Tumor Fusion PortalPHLDA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPHLDA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PHLDA2
dbVarPHLDA2
ClinVarPHLDA2
1000_GenomesPHLDA2 
Exome Variant ServerPHLDA2
ExAC (Exome Aggregation Consortium)ENSG00000181649
GNOMAD BrowserENSG00000181649
Genetic variants : HAPMAP7262
Genomic Variants (DGV)PHLDA2 [DGVbeta]
DECIPHERPHLDA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPHLDA2 
Mutations
ICGC Data PortalPHLDA2 
TCGA Data PortalPHLDA2 
Broad Tumor PortalPHLDA2
OASIS PortalPHLDA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPHLDA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPHLDA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PHLDA2
DgiDB (Drug Gene Interaction Database)PHLDA2
DoCM (Curated mutations)PHLDA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PHLDA2 (select a term)
intoGenPHLDA2
Cancer3DPHLDA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602131   
Orphanet
DisGeNETPHLDA2
MedgenPHLDA2
Genetic Testing Registry PHLDA2
NextProtQ53GA4 [Medical]
TSGene7262
GENETestsPHLDA2
Target ValidationPHLDA2
Huge Navigator PHLDA2 [HugePedia]
snp3D : Map Gene to Disease7262
BioCentury BCIQPHLDA2
ClinGenPHLDA2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7262
Chemical/Pharm GKB GenePA37053
Clinical trialPHLDA2
Miscellaneous
canSAR (ICR)PHLDA2 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePHLDA2
EVEXPHLDA2
GoPubMedPHLDA2
iHOPPHLDA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:28:39 CET 2017

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