PHPT1 (phosphohistidine phosphatase 1)

2010-03-01  

Identity

HGNC
PHPT1
LOCATION
9q34.3
LOCUSID
29085
ALIAS
CGI-202,HEL-S-132P,HSPC141,PHP,PHP14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29085
MIM: 610167
HGNC: 30033
Ensembl: ENSG00000054148

Variants:

dbSNP: 29085
ClinVar: 29085
TCGA: ENSG00000054148
COSMIC: PHPT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000054148ENST00000247665Q9NRX4
ENSG00000054148ENST00000247665V9HWC4
ENSG00000054148ENST00000371661Q9NRX4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
187966142008Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1.43
123832602002Identification and characterization of a mammalian 14-kDa phosphohistidine phosphatase.22
245232902014Regulation of the epithelial Ca²⁺ channel TRPV5 by reversible histidine phosphorylation mediated by NDPK-B and PHPT1.18
19344975201014-kDa phosphohistidine phosphatase and its role in human lung cancer cell migration and invasion.13
205018722010Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells.7
270340942016Structural and activity characterization of human PHPT1 after oxidative modification.7
162192932005Mutational study of human phosphohistidine phosphatase: effect on enzymatic activity.6
255748162015Phosphohistidine phosphatase 1 (PHPT1) also dephosphorylates phospholysine of chemically phosphorylated histone H1 and polylysine.5
186565142008Reduced viability of neuronal cells after overexpression of protein histidine phosphatase.4
189918132009Solution structure and catalytic mechanism of human protein histidine phosphatase 1.4

Citation

Dessen P

PHPT1 (phosphohistidine phosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51359/phpt1