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PHYKPL (5-phosphohydroxy-L-lysine phospho-lyase)

Identity

Alias_namesAGXT2L2
alanine-glyoxylate aminotransferase 2-like 2
Alias_symbol (synonym)MGC15875
Other aliasPHLU
HGNC (Hugo) PHYKPL
LocusID (NCBI) 85007
Atlas_Id 71900
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 178208474 and ends at 178232822 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PHYKPL (5q35.3) / ARNTL (11p15.2)PHYKPL (5q35.3) / GPI (19q13.11)PHYKPL (5q35.3) / MBP (18q23)
PHYKPL (5q35.3) / STMN1 (1p36.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PHYKPL   28249
Cards
Entrez_Gene (NCBI)PHYKPL  85007  5-phosphohydroxy-L-lysine phospho-lyase
AliasesAGXT2L2; PHLU
GeneCards (Weizmann)PHYKPL
Ensembl hg19 (Hinxton)ENSG00000175309 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175309 [Gene_View]  chr5:178208474-178232822 [Contig_View]  PHYKPL [Vega]
ICGC DataPortalENSG00000175309
TCGA cBioPortalPHYKPL
AceView (NCBI)PHYKPL
Genatlas (Paris)PHYKPL
WikiGenes85007
SOURCE (Princeton)PHYKPL
Genetics Home Reference (NIH)PHYKPL
Genomic and cartography
GoldenPath hg38 (UCSC)PHYKPL  -     chr5:178208474-178232822 -  5q35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PHYKPL  -     5q35.3   [Description]    (hg19-Feb_2009)
EnsemblPHYKPL - 5q35.3 [CytoView hg19]  PHYKPL - 5q35.3 [CytoView hg38]
Mapping of homologs : NCBIPHYKPL [Mapview hg19]  PHYKPL [Mapview hg38]
OMIM614683   615011   
Gene and transcription
Genbank (Entrez)AA862441 AF318375 AK023470 AK024076 AK090397
RefSeq transcript (Entrez)NM_001278346 NM_153373
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PHYKPL
Cluster EST : UnigeneHs.248746 [ NCBI ]
CGAP (NCI)Hs.248746
Alternative Splicing GalleryENSG00000175309
Gene ExpressionPHYKPL [ NCBI-GEO ]   PHYKPL [ EBI - ARRAY_EXPRESS ]   PHYKPL [ SEEK ]   PHYKPL [ MEM ]
Gene Expression Viewer (FireBrowse)PHYKPL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85007
GTEX Portal (Tissue expression)PHYKPL
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IUZ5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IUZ5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IUZ5
Splice isoforms : SwissVarQ8IUZ5
Catalytic activity : Enzyme4.2.3.134 [ Enzyme-Expasy ]   4.2.3.1344.2.3.134 [ IntEnz-EBI ]   4.2.3.134 [ BRENDA ]   4.2.3.134 [ KEGG ]   
PhosPhoSitePlusQ8IUZ5
Domaine pattern : Prosite (Expaxy)AA_TRANSFER_CLASS_3 (PS00600)   
Domains : Interpro (EBI)Aminotrans_3    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_major_sub1    PyrdxlP-dep_Trfase_major_sub2   
Domain families : Pfam (Sanger)Aminotran_3 (PF00202)   
Domain families : Pfam (NCBI)pfam00202   
Conserved Domain (NCBI)PHYKPL
DMDM Disease mutations85007
Blocks (Seattle)PHYKPL
SuperfamilyQ8IUZ5
Human Protein AtlasENSG00000175309
Peptide AtlasQ8IUZ5
HPRD18482
IPIIPI00216928   IPI00845489   IPI00170765   IPI00386203   IPI00853267   IPI00964993   IPI00964525   IPI00965799   IPI00967627   IPI00965571   
Protein Interaction databases
DIP (DOE-UCLA)Q8IUZ5
IntAct (EBI)Q8IUZ5
FunCoupENSG00000175309
BioGRIDPHYKPL
STRING (EMBL)PHYKPL
ZODIACPHYKPL
Ontologies - Pathways
QuickGOQ8IUZ5
Ontology : AmiGOprotein binding  mitochondrion  mitochondrial matrix  lysine catabolic process  alanine-glyoxylate transaminase activity  lyase activity  pyridoxal phosphate binding  collagen catabolic process  identical protein binding  
Ontology : EGO-EBIprotein binding  mitochondrion  mitochondrial matrix  lysine catabolic process  alanine-glyoxylate transaminase activity  lyase activity  pyridoxal phosphate binding  collagen catabolic process  identical protein binding  
NDEx NetworkPHYKPL
Atlas of Cancer Signalling NetworkPHYKPL
Wikipedia pathwaysPHYKPL
Orthology - Evolution
OrthoDB85007
GeneTree (enSembl)ENSG00000175309
Phylogenetic Trees/Animal Genes : TreeFamPHYKPL
HOVERGENQ8IUZ5
HOGENOMQ8IUZ5
Homologs : HomoloGenePHYKPL
Homology/Alignments : Family Browser (UCSC)PHYKPL
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPHYKPL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PHYKPL
dbVarPHYKPL
ClinVarPHYKPL
1000_GenomesPHYKPL 
Exome Variant ServerPHYKPL
ExAC (Exome Aggregation Consortium)PHYKPL (select the gene name)
Genetic variants : HAPMAP85007
Genomic Variants (DGV)PHYKPL [DGVbeta]
DECIPHERPHYKPL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPHYKPL 
Mutations
ICGC Data PortalPHYKPL 
TCGA Data PortalPHYKPL 
Broad Tumor PortalPHYKPL
OASIS PortalPHYKPL [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPHYKPL
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PHYKPL
DgiDB (Drug Gene Interaction Database)PHYKPL
DoCM (Curated mutations)PHYKPL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PHYKPL (select a term)
intoGenPHYKPL
Cancer3DPHYKPL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614683    615011   
Orphanet
MedgenPHYKPL
Genetic Testing Registry PHYKPL
NextProtQ8IUZ5 [Medical]
TSGene85007
GENETestsPHYKPL
Target ValidationPHYKPL
Huge Navigator PHYKPL [HugePedia]
snp3D : Map Gene to Disease85007
BioCentury BCIQPHYKPL
ClinGenPHYKPL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85007
Chemical/Pharm GKB GenePA162376015
Clinical trialPHYKPL
Miscellaneous
canSAR (ICR)PHYKPL (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePHYKPL
EVEXPHYKPL
GoPubMedPHYKPL
iHOPPHYKPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:34:31 CEST 2017

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