PI3 (peptidase inhibitor 3)

2010-05-01  

Identity

HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
ESI,SKALP,WAP3,WFDC14,cementoin
FUSION GENES

Other Information

Locus ID:

NCBI: 5266
MIM: 182257
HGNC: 8947
Ensembl: ENSG00000124102

Variants:

dbSNP: 5266
ClinVar: 5266
TCGA: ENSG00000124102
COSMIC: PI3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124102ENST00000243924P19957

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Developmental BiologyREACTOMER-HSA-1266738
Antimicrobial peptidesREACTOMER-HSA-6803157
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203714632010Elafin is a biomarker of graft-versus-host disease of the skin.85
198249182010Trappin-2/Elafin: a novel innate anti-human immunodeficiency virus-1 molecule of the human female reproductive tract.58
179640572008Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family.55
150340712004Adenoviral gene delivery of elafin and secretory leukocyte protease inhibitor attenuates NF-kappa B-dependent inflammatory responses of human endothelial cells and macrophages to atherogenic stimuli.41
180923252008Experimental anti-angiogenesis causes upregulation of genes associated with poor survival in glioblastoma.34
182039722008A genome-wide expression analysis in blood identifies pre-elafin as a biomarker in ARDS.32
201264742010Overexpression of elafin in ovarian carcinoma is driven by genomic gains and activation of the nuclear factor kappaB pathway and is associated with poor overall survival.31
114664032001Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection.30
187994642008Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis.27
163004112005Elafin and its precursor trappin-2 still inhibit neutrophil serine proteinases when they are covalently bound to extracellular matrix proteins by tissue transglutaminase.25

Citation

Dessen P

PI3 (peptidase inhibitor 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51476/pi3