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PI3 (peptidase inhibitor 3)

Identity

Other namesESI
SKALP
WAP3
WFDC14
cementoin
HGNC (Hugo) PI3
LocusID (NCBI) 5266
Atlas_Id 51476
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 43803540 and ends at 43805185 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CPNE1 (20q11.22) / PI3 (20q13.12)RBM12 (20q11.22) / PI3 (20q13.12)WFDC2 (20q13.12) / PI3 (20q13.12)
WFDC2 20q13.12 / PI3 20q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PI3   8947
Cards
Entrez_Gene (NCBI)PI3  5266  peptidase inhibitor 3
AliasesESI; SKALP; WAP3; WFDC14; 
cementoin
GeneCards (Weizmann)PI3
Ensembl hg19 (Hinxton)ENSG00000124102 [Gene_View]  chr20:43803540-43805185 [Contig_View]  PI3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000124102 [Gene_View]  chr20:43803540-43805185 [Contig_View]  PI3 [Vega]
ICGC DataPortalENSG00000124102
TCGA cBioPortalPI3
AceView (NCBI)PI3
Genatlas (Paris)PI3
WikiGenes5266
SOURCE (Princeton)PI3
Genomic and cartography
GoldenPath hg19 (UCSC)PI3  -     chr20:43803540-43805185 +  20q13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PI3  -     20q13.12   [Description]    (hg38-Dec_2013)
EnsemblPI3 - 20q13.12 [CytoView hg19]  PI3 - 20q13.12 [CytoView hg38]
Mapping of homologs : NCBIPI3 [Mapview hg19]  PI3 [Mapview hg38]
OMIM182257   
Gene and transcription
Genbank (Entrez)AA583773 BC010952 CR542234 DQ892710 DQ895962
RefSeq transcript (Entrez)NM_002638
RefSeq genomic (Entrez)NC_000020 NC_018931 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)PI3
Cluster EST : UnigeneHs.112341 [ NCBI ]
CGAP (NCI)Hs.112341
Alternative Splicing GalleryENSG00000124102
Gene ExpressionPI3 [ NCBI-GEO ]   PI3 [ EBI - ARRAY_EXPRESS ]   PI3 [ SEEK ]   PI3 [ MEM ]
Gene Expression Viewer (FireBrowse)PI3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5266
GTEX Portal (Tissue expression)PI3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19957 (Uniprot)
NextProtP19957  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19957
Splice isoforms : SwissVarP19957 (Swissvar)
PhosPhoSitePlusP19957
Domaine pattern : Prosite (Expaxy)SVP_I (PS00313)    WAP (PS51390)   
Domains : Interpro (EBI)SVP_I    Trappin_transglut-bd_rpt    WAP_dom   
Domain families : Pfam (Sanger)Cementoin (PF10511)    WAP (PF00095)   
Domain families : Pfam (NCBI)pfam10511    pfam00095   
Domain families : Smart (EMBL)WAP (SM00217)  
DMDM Disease mutations5266
Blocks (Seattle)PI3
PDB (SRS)1FLE    2REL   
PDB (PDBSum)1FLE    2REL   
PDB (IMB)1FLE    2REL   
PDB (RSDB)1FLE    2REL   
Structural Biology KnowledgeBase1FLE    2REL   
SCOP (Structural Classification of Proteins)1FLE    2REL   
CATH (Classification of proteins structures)1FLE    2REL   
SuperfamilyP19957
Human Protein AtlasENSG00000124102
Peptide AtlasP19957
HPRD15947
IPIIPI00021434   
Protein Interaction databases
DIP (DOE-UCLA)P19957
IntAct (EBI)P19957
FunCoupENSG00000124102
BioGRIDPI3
STRING (EMBL)PI3
ZODIACPI3
Ontologies - Pathways
QuickGOP19957
Ontology : AmiGOendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  proteinaceous extracellular matrix  copulation  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  extracellular exosome  
Ontology : EGO-EBIendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  proteinaceous extracellular matrix  copulation  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  extracellular exosome  
NDEx Network
Atlas of Cancer Signalling NetworkPI3
Wikipedia pathwaysPI3
Orthology - Evolution
OrthoDB5266
GeneTree (enSembl)ENSG00000124102
Phylogenetic Trees/Animal Genes : TreeFamPI3
Homologs : HomoloGenePI3
Homology/Alignments : Family Browser (UCSC)PI3
Gene fusions - Rearrangements
Fusion: TCGAWFDC2 20q13.12 PI3 20q13.12 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerPI3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PI3
dbVarPI3
ClinVarPI3
1000_GenomesPI3 
Exome Variant ServerPI3
ExAC (Exome Aggregation Consortium)PI3 (select the gene name)
Genetic variants : HAPMAP5266
Genomic Variants (DGV)PI3 [DGVbeta]
Mutations
ICGC Data PortalPI3 
TCGA Data PortalPI3 
Broad Tumor PortalPI3
OASIS PortalPI3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPI3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PI3
DgiDB (Drug Gene Interaction Database)PI3
DoCM (Curated mutations)PI3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PI3 (select a term)
intoGenPI3
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)20:43803540-43805185  ENSG00000124102
CONAN: Copy Number AnalysisPI3 
Mutations and Diseases : HGMDPI3
OMIM182257   
MedgenPI3
Genetic Testing Registry PI3
NextProtP19957 [Medical]
TSGene5266
GENETestsPI3
Huge Navigator PI3 [HugePedia]
snp3D : Map Gene to Disease5266
BioCentury BCIQPI3
ClinGenPI3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5266
Chemical/Pharm GKB GenePA33283
Clinical trialPI3
Miscellaneous
canSAR (ICR)PI3 (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePI3
EVEXPI3
GoPubMedPI3
iHOPPI3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:07:04 CEST 2016

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