PI4KB (phosphatidylinositol 4-kinase beta)

2015-08-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
NPIK,PI4K-BETA,PI4K92,PI4KBETA,PI4KIII,PI4KIIIBETA,PIK4CB
FUSION GENES

Other Information

Locus ID:

NCBI: 5298
MIM: 602758
HGNC: 8984
Ensembl: ENSG00000143393

Variants:

dbSNP: 5298
ClinVar: 5298
TCGA: ENSG00000143393
COSMIC: PI4KB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143393ENST00000368873Q9UBF8
ENSG00000143393ENST00000368875A0A0B4J1S8
ENSG00000143393ENST00000430800F8W860
ENSG00000143393ENST00000438243A0A0A0MSL0
ENSG00000143393ENST00000446339H0Y4F8
ENSG00000143393ENST00000455060A6PVV8
ENSG00000143393ENST00000489223E9PL47
ENSG00000143393ENST00000489889H0YCW3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGhsa_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGM00130
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the Golgi membraneREACTOMER-HSA-1660514

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196054712009Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.105
222582602012The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIβ.79
196086262009Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening.78
221243282012ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites.77
119232872002Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments.70
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
170030432006Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi.56
156346692005Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases.53
232582252013The lipid kinase PI4KIIIβ preserves lysosomal identity.42
245279952014Phosphatidylinositol-4 kinase III beta and oxysterol-binding protein accumulate unesterified cholesterol on poliovirus-induced membrane structure.40

Citation

Dessen P

PI4KB (phosphatidylinositol 4-kinase beta)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55325/pi4kb