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PI4KB (phosphatidylinositol 4-kinase beta)

Identity

Alias_namesPIK4CB
phosphatidylinositol 4-kinase
Alias_symbol (synonym)PI4K-BETA
pi4K92
Other aliasNPIK
PI4K92
PI4KBETA
PI4KIIIBETA
HGNC (Hugo) PI4KB
LocusID (NCBI) 5298
Atlas_Id 55325
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 151291797 and ends at 151327715 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FARS2 (6p25.1) / PI4KB (1q21.3)PI4KB (1q21.3) / SYT11 (1q22)PI4KB 1q21.3 / SYT11 1q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PI4KB   8984
Cards
Entrez_Gene (NCBI)PI4KB  5298  phosphatidylinositol 4-kinase beta
AliasesNPIK; PI4K-BETA; PI4K92; PI4KBETA; 
PI4KIIIBETA; PIK4CB
GeneCards (Weizmann)PI4KB
Ensembl hg19 (Hinxton)ENSG00000143393 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143393 [Gene_View]  chr1:151291797-151327715 [Contig_View]  PI4KB [Vega]
ICGC DataPortalENSG00000143393
TCGA cBioPortalPI4KB
AceView (NCBI)PI4KB
Genatlas (Paris)PI4KB
WikiGenes5298
SOURCE (Princeton)PI4KB
Genetics Home Reference (NIH)PI4KB
Genomic and cartography
GoldenPath hg38 (UCSC)PI4KB  -     chr1:151291797-151327715 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PI4KB  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblPI4KB - 1q21.3 [CytoView hg19]  PI4KB - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIPI4KB [Mapview hg19]  PI4KB [Mapview hg38]
OMIM602758   
Gene and transcription
Genbank (Entrez)AB005910 AJ011121 AK054691 AK294606 AK311292
RefSeq transcript (Entrez)NM_001198773 NM_001198774 NM_001198775 NM_001330721 NM_002651
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PI4KB
Cluster EST : UnigeneHs.632465 [ NCBI ]
CGAP (NCI)Hs.632465
Alternative Splicing GalleryENSG00000143393
Gene ExpressionPI4KB [ NCBI-GEO ]   PI4KB [ EBI - ARRAY_EXPRESS ]   PI4KB [ SEEK ]   PI4KB [ MEM ]
Gene Expression Viewer (FireBrowse)PI4KB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5298
GTEX Portal (Tissue expression)PI4KB
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBF8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBF8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBF8
Splice isoforms : SwissVarQ9UBF8
Catalytic activity : Enzyme2.7.1.67 [ Enzyme-Expasy ]   2.7.1.672.7.1.67 [ IntEnz-EBI ]   2.7.1.67 [ BRENDA ]   2.7.1.67 [ KEGG ]   
PhosPhoSitePlusQ9UBF8
Domaine pattern : Prosite (Expaxy)PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)    PIK_HELICAL (PS51545)   
Domains : Interpro (EBI)Kinase-like_dom    PI3/4_kinase_cat_dom    PI3/4_kinase_CS    PI_Kinase    PInositide-3_kin_accessory_dom   
Domain families : Pfam (Sanger)PI3_PI4_kinase (PF00454)   
Domain families : Pfam (NCBI)pfam00454   
Domain families : Smart (EMBL)PI3Kc (SM00146)  
Conserved Domain (NCBI)PI4KB
DMDM Disease mutations5298
Blocks (Seattle)PI4KB
PDB (SRS)2N73    4D0L    4D0M    4WAE    4WAG    5C46    5C4G    5EUQ    5FBL    5FBQ    5FBR    5FBV    5FBW    5LX2   
PDB (PDBSum)2N73    4D0L    4D0M    4WAE    4WAG    5C46    5C4G    5EUQ    5FBL    5FBQ    5FBR    5FBV    5FBW    5LX2   
PDB (IMB)2N73    4D0L    4D0M    4WAE    4WAG    5C46    5C4G    5EUQ    5FBL    5FBQ    5FBR    5FBV    5FBW    5LX2   
PDB (RSDB)2N73    4D0L    4D0M    4WAE    4WAG    5C46    5C4G    5EUQ    5FBL    5FBQ    5FBR    5FBV    5FBW    5LX2   
Structural Biology KnowledgeBase2N73    4D0L    4D0M    4WAE    4WAG    5C46    5C4G    5EUQ    5FBL    5FBQ    5FBR    5FBV    5FBW    5LX2   
SCOP (Structural Classification of Proteins)2N73    4D0L    4D0M    4WAE    4WAG    5C46    5C4G    5EUQ    5FBL    5FBQ    5FBR    5FBV    5FBW    5LX2   
CATH (Classification of proteins structures)2N73    4D0L    4D0M    4WAE    4WAG    5C46    5C4G    5EUQ    5FBL    5FBQ    5FBR    5FBV    5FBW    5LX2   
SuperfamilyQ9UBF8
Human Protein AtlasENSG00000143393
Peptide AtlasQ9UBF8
HPRD11805
IPIIPI00002591   IPI00165547   IPI00976206   IPI00852910   IPI00641770   IPI00852981   IPI00852779   IPI00917885   IPI00980903   IPI00980239   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBF8
IntAct (EBI)Q9UBF8
FunCoupENSG00000143393
BioGRIDPI4KB
STRING (EMBL)PI4KB
ZODIACPI4KB
Ontologies - Pathways
QuickGOQ9UBF8
Ontology : AmiGOGolgi membrane  1-phosphatidylinositol 4-kinase activity  1-phosphatidylinositol 4-kinase activity  protein binding  ATP binding  cytoplasm  mitochondrial outer membrane  endosome  cytosol  phosphatidylinositol biosynthetic process  receptor-mediated endocytosis  signal transduction  rough endoplasmic reticulum membrane  phosphatidylinositol phosphorylation  phosphatidylinositol-mediated signaling  perinuclear region of cytoplasm  14-3-3 protein binding  
Ontology : EGO-EBIGolgi membrane  1-phosphatidylinositol 4-kinase activity  1-phosphatidylinositol 4-kinase activity  protein binding  ATP binding  cytoplasm  mitochondrial outer membrane  endosome  cytosol  phosphatidylinositol biosynthetic process  receptor-mediated endocytosis  signal transduction  rough endoplasmic reticulum membrane  phosphatidylinositol phosphorylation  phosphatidylinositol-mediated signaling  perinuclear region of cytoplasm  14-3-3 protein binding  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx NetworkPI4KB
Atlas of Cancer Signalling NetworkPI4KB
Wikipedia pathwaysPI4KB
Orthology - Evolution
OrthoDB5298
GeneTree (enSembl)ENSG00000143393
Phylogenetic Trees/Animal Genes : TreeFamPI4KB
HOVERGENQ9UBF8
HOGENOMQ9UBF8
Homologs : HomoloGenePI4KB
Homology/Alignments : Family Browser (UCSC)PI4KB
Gene fusions - Rearrangements
Fusion : MitelmanPI4KB/SYT11 [1q21.3/1q22]  
Fusion: TCGAPI4KB 1q21.3 SYT11 1q22 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPI4KB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PI4KB
dbVarPI4KB
ClinVarPI4KB
1000_GenomesPI4KB 
Exome Variant ServerPI4KB
ExAC (Exome Aggregation Consortium)PI4KB (select the gene name)
Genetic variants : HAPMAP5298
Genomic Variants (DGV)PI4KB [DGVbeta]
DECIPHERPI4KB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPI4KB 
Mutations
ICGC Data PortalPI4KB 
TCGA Data PortalPI4KB 
Broad Tumor PortalPI4KB
OASIS PortalPI4KB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPI4KB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPI4KB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PI4KB
DgiDB (Drug Gene Interaction Database)PI4KB
DoCM (Curated mutations)PI4KB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PI4KB (select a term)
intoGenPI4KB
Cancer3DPI4KB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602758   
Orphanet
MedgenPI4KB
Genetic Testing Registry PI4KB
NextProtQ9UBF8 [Medical]
TSGene5298
GENETestsPI4KB
Target ValidationPI4KB
Huge Navigator PI4KB [HugePedia]
snp3D : Map Gene to Disease5298
BioCentury BCIQPI4KB
ClinGenPI4KB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5298
Chemical/Pharm GKB GenePA162399420
Clinical trialPI4KB
Miscellaneous
canSAR (ICR)PI4KB (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePI4KB
EVEXPI4KB
GoPubMedPI4KB
iHOPPI4KB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:49:23 CEST 2017

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