PIAS2 (protein inhibitor of activated STAT 2)

2009-09-01  

Identity

HGNC
LOCATION
18q21.1
LOCUSID
ALIAS
ARIP3,DIP,MIZ1,PIASX,SIZ2,ZMIZ4
FUSION GENES

Other Information

Locus ID:

NCBI: 9063
MIM: 603567
HGNC: 17311
Ensembl: ENSG00000078043

Variants:

dbSNP: 9063
ClinVar: 9063
TCGA: ENSG00000078043
COSMIC: PIAS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078043ENST00000324794O75928
ENSG00000078043ENST00000398654A0A0A0MS92
ENSG00000078043ENST00000545673B4DGW0
ENSG00000078043ENST00000585916O75928
ENSG00000078043ENST00000586953K7ER97
ENSG00000078043ENST00000587810K7EQX5
ENSG00000078043ENST00000589917K7EJT4
ENSG00000078043ENST00000592212A0A087WUY7
ENSG00000078043ENST00000592221K7EMP6

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Jak-STAT signaling pathwayKEGGko04630
Small cell lung cancerKEGGko05222
Ubiquitin mediated proteolysisKEGGhsa04120
Jak-STAT signaling pathwayKEGGhsa04630
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127169072003PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4.31
155802672005Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage.26
211563242011MDA5 is SUMOylated by PIAS2β in the upregulation of type I interferon signaling.22
167135782006PIASxalpha differentially regulates the amplitudes of transcriptional responses following activation of the ERK and p38 MAPK pathways.20
164608272006Sumoylation of Rta of Epstein-Barr virus is preferentially enhanced by PIASxbeta.16
243441342014PIASxα ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase.14
161480102005FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family.6
264034032015PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS.4
289739982017Protein Inhibitor of Activated STAT2 Restricts HCV Replication by Modulating Viral Proteins Degradation.3
310842432019The investigation of relevancy between PIAS1 and PIAS2 gene expression and disease severity of multiple sclerosis.1

Citation

Dessen P

PIAS2 (protein inhibitor of activated STAT 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51129/pias2