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PIAS2 (protein inhibitor of activated STAT 2)

Identity

Alias (NCBI)ARIP3
DIP
MIZ1
PIASX
SIZ2
ZMIZ4
HGNC (Hugo) PIAS2
HGNC Alias symbPIASX-BETA
miz
PIASX-ALPHA
ZMIZ4
ARIP3
HGNC Alias namezinc finger, MIZ-type containing 4
LocusID (NCBI) 9063
Atlas_Id 51129
Location 18q21.1  [Link to chromosome band 18q21]
Location_base_pair Starts at 46815711 and ends at 46917507 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PIAS2 (18q21.1) / PIAS2 (18q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PIAS2   17311
Cards
Entrez_Gene (NCBI)PIAS2    protein inhibitor of activated STAT 2
AliasesARIP3; DIP; MIZ1; PIASX; 
SIZ2; ZMIZ4
GeneCards (Weizmann)PIAS2
Ensembl hg19 (Hinxton)ENSG00000078043 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000078043 [Gene_View]  ENSG00000078043 [Sequence]  chr18:46815711-46917507 [Contig_View]  PIAS2 [Vega]
ICGC DataPortalENSG00000078043
TCGA cBioPortalPIAS2
AceView (NCBI)PIAS2
Genatlas (Paris)PIAS2
SOURCE (Princeton)PIAS2
Genetics Home Reference (NIH)PIAS2
Genomic and cartography
GoldenPath hg38 (UCSC)PIAS2  -     chr18:46815711-46917507 -  18q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIAS2  -     18q21.1   [Description]    (hg19-Feb_2009)
GoldenPathPIAS2 - 18q21.1 [CytoView hg19]  PIAS2 - 18q21.1 [CytoView hg38]
ImmunoBaseENSG00000078043
Genome Data Viewer NCBIPIAS2 [Mapview hg19]  
OMIM603567   
Gene and transcription
Genbank (Entrez)AA701927 AF077953 AF077954 AF086240 AF361054
RefSeq transcript (Entrez)NM_001324046 NM_001324047 NM_001324048 NM_001324049 NM_001324051 NM_001324052 NM_001324053 NM_001324054 NM_001324055 NM_001324057 NM_001324058 NM_001324059 NM_001324060 NM_001354033 NM_001354034 NM_001354035 NM_001354036 NM_001354037 NM_001354038 NM_001354039 NM_004671 NM_173206
Consensus coding sequences : CCDS (NCBI)PIAS2
Gene ExpressionPIAS2 [ NCBI-GEO ]   PIAS2 [ EBI - ARRAY_EXPRESS ]   PIAS2 [ SEEK ]   PIAS2 [ MEM ]
Gene Expression Viewer (FireBrowse)PIAS2 [ Firebrowse - Broad ]
GenevisibleExpression of PIAS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9063
GTEX Portal (Tissue expression)PIAS2
Human Protein AtlasENSG00000078043-PIAS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75928   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75928  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75928
Catalytic activity : Enzyme2.3.2.- [ Enzyme-Expasy ]   2.3.2.-2.3.2.- [ IntEnz-EBI ]   2.3.2.- [ BRENDA ]   2.3.2.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO75928
Domaine pattern : Prosite (Expaxy)PINIT (PS51466)    SAP (PS50800)    ZF_SP_RING (PS51044)   
Domains : Interpro (EBI)PIAS2    PINIT    PINIT_sf    SAP_dom    SAP_dom_sf    Znf_MIZ    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)PINIT (PF14324)    zf-MIZ (PF02891)   
Domain families : Pfam (NCBI)pfam14324    pfam02891   
Domain families : Smart (EMBL)SAP (SM00513)  
Conserved Domain (NCBI)PIAS2
PDB (RSDB)2ASQ    4FO9   
PDB Europe2ASQ    4FO9   
PDB (PDBSum)2ASQ    4FO9   
PDB (IMB)2ASQ    4FO9   
Structural Biology KnowledgeBase2ASQ    4FO9   
SCOP (Structural Classification of Proteins)2ASQ    4FO9   
CATH (Classification of proteins structures)2ASQ    4FO9   
SuperfamilyO75928
AlphaFold pdb e-kbO75928   
Human Protein Atlas [tissue]ENSG00000078043-PIAS2 [tissue]
HPRD06944
Protein Interaction databases
DIP (DOE-UCLA)O75928
IntAct (EBI)O75928
BioGRIDPIAS2
STRING (EMBL)PIAS2
ZODIACPIAS2
Ontologies - Pathways
QuickGOO75928
Ontology : AmiGODNA binding  transcription coregulator activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription factor binding  zinc ion binding  PML body  nuclear speck  protein sumoylation  protein sumoylation  protein sumoylation  SUMO transferase activity  ubiquitin protein ligase binding  negative regulation of androgen receptor signaling pathway  RNA polymerase II-specific DNA-binding transcription factor binding  SUMO ligase activity  SUMO ligase activity  
Ontology : EGO-EBIDNA binding  transcription coregulator activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription factor binding  zinc ion binding  PML body  nuclear speck  protein sumoylation  protein sumoylation  protein sumoylation  SUMO transferase activity  ubiquitin protein ligase binding  negative regulation of androgen receptor signaling pathway  RNA polymerase II-specific DNA-binding transcription factor binding  SUMO ligase activity  SUMO ligase activity  
Pathways : BIOCARTASumoylation by RanBP2 Regulates Transcriptional Repression [Genes]   
Pathways : KEGGUbiquitin mediated proteolysis    Jak-STAT signaling pathway    Pathways in cancer    Small cell lung cancer   
NDEx NetworkPIAS2
Atlas of Cancer Signalling NetworkPIAS2
Wikipedia pathwaysPIAS2
Orthology - Evolution
OrthoDB9063
GeneTree (enSembl)ENSG00000078043
Phylogenetic Trees/Animal Genes : TreeFamPIAS2
Homologs : HomoloGenePIAS2
Homology/Alignments : Family Browser (UCSC)PIAS2
Gene fusions - Rearrangements
Fusion : QuiverPIAS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIAS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIAS2
dbVarPIAS2
ClinVarPIAS2
MonarchPIAS2
1000_GenomesPIAS2 
Exome Variant ServerPIAS2
GNOMAD BrowserENSG00000078043
Varsome BrowserPIAS2
ACMGPIAS2 variants
VarityO75928
Genomic Variants (DGV)PIAS2 [DGVbeta]
DECIPHERPIAS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIAS2 
Mutations
ICGC Data PortalPIAS2 
TCGA Data PortalPIAS2 
Broad Tumor PortalPIAS2
OASIS PortalPIAS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIAS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPIAS2
Mutations and Diseases : HGMDPIAS2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPIAS2
DgiDB (Drug Gene Interaction Database)PIAS2
DoCM (Curated mutations)PIAS2
CIViC (Clinical Interpretations of Variants in Cancer)PIAS2
Cancer3DPIAS2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603567   
Orphanet
DisGeNETPIAS2
MedgenPIAS2
Genetic Testing Registry PIAS2
NextProtO75928 [Medical]
GENETestsPIAS2
Target ValidationPIAS2
Huge Navigator PIAS2 [HugePedia]
ClinGenPIAS2
Clinical trials, drugs, therapy
MyCancerGenomePIAS2
Protein Interactions : CTDPIAS2
Pharm GKB GenePA134933292
PharosO75928
Clinical trialPIAS2
Miscellaneous
canSAR (ICR)PIAS2
HarmonizomePIAS2
DataMed IndexPIAS2
Probes
Litterature
PubMed117 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPIAS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:14 CEST 2021

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