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PIAS2 (protein inhibitor of activated STAT 2)

Identity

Alias_namesMIZ-type containing 4
Alias_symbol (synonym)PIASX-BETA
miz
PIASX-ALPHA
ZMIZ4
Other aliasARIP3
DIP
MIZ
MIZ1
PIASX
SIZ2
HGNC (Hugo) PIAS2
LocusID (NCBI) 9063
Atlas_Id 51129
Location 18q21.1  [Link to chromosome band 18q21]
Location_base_pair Starts at 46803225 and ends at 46917532 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PIAS2 (18q21.1) / PIAS2 (18q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIAS2   17311
Cards
Entrez_Gene (NCBI)PIAS2  9063  protein inhibitor of activated STAT 2
AliasesARIP3; DIP; MIZ; MIZ1; 
PIASX; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4
GeneCards (Weizmann)PIAS2
Ensembl hg19 (Hinxton)ENSG00000078043 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000078043 [Gene_View]  chr18:46803225-46917532 [Contig_View]  PIAS2 [Vega]
ICGC DataPortalENSG00000078043
TCGA cBioPortalPIAS2
AceView (NCBI)PIAS2
Genatlas (Paris)PIAS2
WikiGenes9063
SOURCE (Princeton)PIAS2
Genetics Home Reference (NIH)PIAS2
Genomic and cartography
GoldenPath hg38 (UCSC)PIAS2  -     chr18:46803225-46917532 -  18q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIAS2  -     18q21.1   [Description]    (hg19-Feb_2009)
EnsemblPIAS2 - 18q21.1 [CytoView hg19]  PIAS2 - 18q21.1 [CytoView hg38]
Mapping of homologs : NCBIPIAS2 [Mapview hg19]  PIAS2 [Mapview hg38]
OMIM603567   
Gene and transcription
Genbank (Entrez)AA701927 AF077953 AF077954 AF086240 AF361054
RefSeq transcript (Entrez)NM_001324046 NM_001324047 NM_001324048 NM_001324049 NM_001324051 NM_001324052 NM_001324053 NM_001324054 NM_001324055 NM_001324057 NM_001324058 NM_001324059 NM_001324060 NM_004671 NM_173206
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIAS2
Cluster EST : UnigeneHs.657844 [ NCBI ]
CGAP (NCI)Hs.657844
Alternative Splicing GalleryENSG00000078043
Gene ExpressionPIAS2 [ NCBI-GEO ]   PIAS2 [ EBI - ARRAY_EXPRESS ]   PIAS2 [ SEEK ]   PIAS2 [ MEM ]
Gene Expression Viewer (FireBrowse)PIAS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9063
GTEX Portal (Tissue expression)PIAS2
Human Protein AtlasENSG00000078043-PIAS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75928   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75928  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75928
Splice isoforms : SwissVarO75928
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusO75928
Domaine pattern : Prosite (Expaxy)PINIT (PS51466)    SAP (PS50800)    ZF_SP_RING (PS51044)   
Domains : Interpro (EBI)PIAS2    PINIT    SAP_dom    Znf_MIZ    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)PINIT (PF14324)    zf-MIZ (PF02891)   
Domain families : Pfam (NCBI)pfam14324    pfam02891   
Domain families : Smart (EMBL)SAP (SM00513)  
Conserved Domain (NCBI)PIAS2
DMDM Disease mutations9063
Blocks (Seattle)PIAS2
PDB (SRS)2ASQ    4FO9   
PDB (PDBSum)2ASQ    4FO9   
PDB (IMB)2ASQ    4FO9   
PDB (RSDB)2ASQ    4FO9   
Structural Biology KnowledgeBase2ASQ    4FO9   
SCOP (Structural Classification of Proteins)2ASQ    4FO9   
CATH (Classification of proteins structures)2ASQ    4FO9   
SuperfamilyO75928
Human Protein Atlas [tissue]ENSG00000078043-PIAS2 [tissue]
Peptide AtlasO75928
HPRD06944
IPIIPI00005836   IPI00244407   IPI00477352   IPI00902964   IPI00872687   
Protein Interaction databases
DIP (DOE-UCLA)O75928
IntAct (EBI)O75928
FunCoupENSG00000078043
BioGRIDPIAS2
STRING (EMBL)PIAS2
ZODIACPIAS2
Ontologies - Pathways
QuickGOO75928
Ontology : AmiGODNA binding  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription, DNA-templated  transcription factor binding  zinc ion binding  PML body  nuclear speck  ligase activity  protein sumoylation  protein sumoylation  SUMO transferase activity  androgen receptor signaling pathway  ubiquitin protein ligase binding  regulation of osteoblast differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  androgen receptor binding  negative regulation of androgen receptor signaling pathway  SUMO ligase activity  
Ontology : EGO-EBIDNA binding  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription, DNA-templated  transcription factor binding  zinc ion binding  PML body  nuclear speck  ligase activity  protein sumoylation  protein sumoylation  SUMO transferase activity  androgen receptor signaling pathway  ubiquitin protein ligase binding  regulation of osteoblast differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  androgen receptor binding  negative regulation of androgen receptor signaling pathway  SUMO ligase activity  
Pathways : BIOCARTASumoylation by RanBP2 Regulates Transcriptional Repression [Genes]   
Pathways : KEGGUbiquitin mediated proteolysis    Jak-STAT signaling pathway    Pathways in cancer    Small cell lung cancer   
NDEx NetworkPIAS2
Atlas of Cancer Signalling NetworkPIAS2
Wikipedia pathwaysPIAS2
Orthology - Evolution
OrthoDB9063
GeneTree (enSembl)ENSG00000078043
Phylogenetic Trees/Animal Genes : TreeFamPIAS2
HOVERGENO75928
HOGENOMO75928
Homologs : HomoloGenePIAS2
Homology/Alignments : Family Browser (UCSC)PIAS2
Gene fusions - Rearrangements
Tumor Fusion PortalPIAS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIAS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIAS2
dbVarPIAS2
ClinVarPIAS2
1000_GenomesPIAS2 
Exome Variant ServerPIAS2
ExAC (Exome Aggregation Consortium)ENSG00000078043
GNOMAD BrowserENSG00000078043
Genetic variants : HAPMAP9063
Genomic Variants (DGV)PIAS2 [DGVbeta]
DECIPHERPIAS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIAS2 
Mutations
ICGC Data PortalPIAS2 
TCGA Data PortalPIAS2 
Broad Tumor PortalPIAS2
OASIS PortalPIAS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIAS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIAS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIAS2
DgiDB (Drug Gene Interaction Database)PIAS2
DoCM (Curated mutations)PIAS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIAS2 (select a term)
intoGenPIAS2
Cancer3DPIAS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603567   
Orphanet
DisGeNETPIAS2
MedgenPIAS2
Genetic Testing Registry PIAS2
NextProtO75928 [Medical]
TSGene9063
GENETestsPIAS2
Target ValidationPIAS2
Huge Navigator PIAS2 [HugePedia]
snp3D : Map Gene to Disease9063
BioCentury BCIQPIAS2
ClinGenPIAS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9063
Chemical/Pharm GKB GenePA134933292
Clinical trialPIAS2
Miscellaneous
canSAR (ICR)PIAS2 (select the gene name)
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIAS2
EVEXPIAS2
GoPubMedPIAS2
iHOPPIAS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:28:41 CET 2017

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