Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PIAS4 (protein inhibitor of activated STAT 4)

Identity

Alias_namesMIZ-type containing 6
Alias_symbol (synonym)Piasg
PIASY
FLJ12419
ZMIZ6
Other aliasPIAS-gamma
HGNC (Hugo) PIAS4
LocusID (NCBI) 51588
Atlas_Id 45557
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 4007598 and ends at 4039386 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PIAS4 (19p13.3) / NID2 (14q22.1)PIAS4 (19p13.3) / PIAS4 (19p13.3)PIAS4 (19p13.3) / ZFR2 (19p13.3)
SBNO2 (19p13.3) / PIAS4 (19p13.3)UHRF1 (19p13.3) / PIAS4 (19p13.3)PIAS4 19p13.3 / ZFR2 19p13.3
SBNO2 19p13.3 / PIAS4 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIAS4   17002
Cards
Entrez_Gene (NCBI)PIAS4  51588  protein inhibitor of activated STAT 4
AliasesPIAS-gamma; PIASY; Piasg; ZMIZ6
GeneCards (Weizmann)PIAS4
Ensembl hg19 (Hinxton)ENSG00000105229 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105229 [Gene_View]  chr19:4007598-4039386 [Contig_View]  PIAS4 [Vega]
ICGC DataPortalENSG00000105229
TCGA cBioPortalPIAS4
AceView (NCBI)PIAS4
Genatlas (Paris)PIAS4
WikiGenes51588
SOURCE (Princeton)PIAS4
Genetics Home Reference (NIH)PIAS4
Genomic and cartography
GoldenPath hg38 (UCSC)PIAS4  -     chr19:4007598-4039386 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIAS4  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblPIAS4 - 19p13.3 [CytoView hg19]  PIAS4 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIPIAS4 [Mapview hg19]  PIAS4 [Mapview hg38]
OMIM605989   
Gene and transcription
Genbank (Entrez)AA758531 AF077952 AF164437 AK022481 AK222726
RefSeq transcript (Entrez)NM_015897 NM_016149
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIAS4
Cluster EST : UnigeneHs.105779 [ NCBI ]
CGAP (NCI)Hs.105779
Alternative Splicing GalleryENSG00000105229
Gene ExpressionPIAS4 [ NCBI-GEO ]   PIAS4 [ EBI - ARRAY_EXPRESS ]   PIAS4 [ SEEK ]   PIAS4 [ MEM ]
Gene Expression Viewer (FireBrowse)PIAS4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51588
GTEX Portal (Tissue expression)PIAS4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N2W9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N2W9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N2W9
Splice isoforms : SwissVarQ8N2W9
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ8N2W9
Domaine pattern : Prosite (Expaxy)PINIT (PS51466)    SAP (PS50800)    ZF_SP_RING (PS51044)   
Domains : Interpro (EBI)PIAS4    PINIT    SAP_dom    Znf_MIZ    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)PINIT (PF14324)    zf-MIZ (PF02891)   
Domain families : Pfam (NCBI)pfam14324    pfam02891   
Domain families : Smart (EMBL)SAP (SM00513)  
Conserved Domain (NCBI)PIAS4
DMDM Disease mutations51588
Blocks (Seattle)PIAS4
SuperfamilyQ8N2W9
Human Protein AtlasENSG00000105229
Peptide AtlasQ8N2W9
HPRD06910
IPIIPI00166500   
Protein Interaction databases
DIP (DOE-UCLA)Q8N2W9
IntAct (EBI)Q8N2W9
FunCoupENSG00000105229
BioGRIDPIAS4
STRING (EMBL)PIAS4
ZODIACPIAS4
Ontologies - Pathways
QuickGOQ8N2W9
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  DNA binding  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  double-strand break repair via nonhomologous end joining  transcription, DNA-templated  protein C-terminus binding  zinc ion binding  negative regulation of tumor necrosis factor-mediated signaling pathway  Wnt signaling pathway  nuclear matrix  PML body  protein sumoylation  protein sumoylation  protein sumoylation  protein sumoylation  SUMO transferase activity  SUMO transferase activity  SUMO transferase activity  ubiquitin protein ligase binding  negative regulation of NF-kappaB transcription factor activity  positive regulation of protein sumoylation  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  SUMO ligase activity  positive regulation of keratinocyte apoptotic process  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  transferase complex  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  DNA binding  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  double-strand break repair via nonhomologous end joining  transcription, DNA-templated  protein C-terminus binding  zinc ion binding  negative regulation of tumor necrosis factor-mediated signaling pathway  Wnt signaling pathway  nuclear matrix  PML body  protein sumoylation  protein sumoylation  protein sumoylation  protein sumoylation  SUMO transferase activity  SUMO transferase activity  SUMO transferase activity  ubiquitin protein ligase binding  negative regulation of NF-kappaB transcription factor activity  positive regulation of protein sumoylation  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  SUMO ligase activity  positive regulation of keratinocyte apoptotic process  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  transferase complex  
Pathways : KEGGNF-kappa B signaling pathway    Ubiquitin mediated proteolysis    Jak-STAT signaling pathway   
NDEx NetworkPIAS4
Atlas of Cancer Signalling NetworkPIAS4
Wikipedia pathwaysPIAS4
Orthology - Evolution
OrthoDB51588
GeneTree (enSembl)ENSG00000105229
Phylogenetic Trees/Animal Genes : TreeFamPIAS4
HOVERGENQ8N2W9
HOGENOMQ8N2W9
Homologs : HomoloGenePIAS4
Homology/Alignments : Family Browser (UCSC)PIAS4
Gene fusions - Rearrangements
Fusion : MitelmanPIAS4/ZFR2 [19p13.3/19p13.3]  
Fusion : MitelmanSBNO2/PIAS4 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion: TCGAPIAS4 19p13.3 ZFR2 19p13.3 LGG
Fusion: TCGASBNO2 19p13.3 PIAS4 19p13.3 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIAS4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIAS4
dbVarPIAS4
ClinVarPIAS4
1000_GenomesPIAS4 
Exome Variant ServerPIAS4
ExAC (Exome Aggregation Consortium)PIAS4 (select the gene name)
Genetic variants : HAPMAP51588
Genomic Variants (DGV)PIAS4 [DGVbeta]
DECIPHERPIAS4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIAS4 
Mutations
ICGC Data PortalPIAS4 
TCGA Data PortalPIAS4 
Broad Tumor PortalPIAS4
OASIS PortalPIAS4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIAS4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIAS4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIAS4
DgiDB (Drug Gene Interaction Database)PIAS4
DoCM (Curated mutations)PIAS4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIAS4 (select a term)
intoGenPIAS4
Cancer3DPIAS4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605989   
Orphanet
MedgenPIAS4
Genetic Testing Registry PIAS4
NextProtQ8N2W9 [Medical]
TSGene51588
GENETestsPIAS4
Target ValidationPIAS4
Huge Navigator PIAS4 [HugePedia]
snp3D : Map Gene to Disease51588
BioCentury BCIQPIAS4
ClinGenPIAS4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51588
Chemical/Pharm GKB GenePA134945903
Clinical trialPIAS4
Miscellaneous
canSAR (ICR)PIAS4 (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIAS4
EVEXPIAS4
GoPubMedPIAS4
iHOPPIAS4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:24:43 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.