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PIAS4 (protein inhibitor of activated STAT 4)

Identity

Alias (NCBI)PIAS-gamma
PIASY
Piasg
ZMIZ6
HGNC (Hugo) PIAS4
HGNC Alias symbPiasg
PIASY
FLJ12419
ZMIZ6
HGNC Alias namezinc finger, MIZ-type containing 6
LocusID (NCBI) 51588
Atlas_Id 45557
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 4007736 and ends at 4039386 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PIAS4 (19p13.3) / NID2 (14q22.1)PIAS4 (19p13.3) / PIAS4 (19p13.3)PIAS4 (19p13.3) / ZFR2 (19p13.3)
SBNO2 (19p13.3) / PIAS4 (19p13.3)UHRF1 (19p13.3) / PIAS4 (19p13.3)PIAS4 19p13.3 / ZFR2 19p13.3
SBNO2 19p13.3 / PIAS4 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(19;19)(p13;p13) PIAS4/ZBTB7A


External links

 

Nomenclature
HGNC (Hugo)PIAS4   17002
Cards
Entrez_Gene (NCBI)PIAS4    protein inhibitor of activated STAT 4
AliasesPIAS-gamma; PIASY; Piasg; ZMIZ6
GeneCards (Weizmann)PIAS4
Ensembl hg19 (Hinxton)ENSG00000105229 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105229 [Gene_View]  ENSG00000105229 [Sequence]  chr19:4007736-4039386 [Contig_View]  PIAS4 [Vega]
ICGC DataPortalENSG00000105229
TCGA cBioPortalPIAS4
AceView (NCBI)PIAS4
Genatlas (Paris)PIAS4
SOURCE (Princeton)PIAS4
Genetics Home Reference (NIH)PIAS4
Genomic and cartography
GoldenPath hg38 (UCSC)PIAS4  -     chr19:4007736-4039386 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIAS4  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathPIAS4 - 19p13.3 [CytoView hg19]  PIAS4 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000105229
Genome Data Viewer NCBIPIAS4 [Mapview hg19]  
OMIM605989   
Gene and transcription
Genbank (Entrez)AA758531 AF077952 AF164437 AK022481 AK222726
RefSeq transcript (Entrez)NM_015897 NM_016149
Consensus coding sequences : CCDS (NCBI)PIAS4
Gene ExpressionPIAS4 [ NCBI-GEO ]   PIAS4 [ EBI - ARRAY_EXPRESS ]   PIAS4 [ SEEK ]   PIAS4 [ MEM ]
Gene Expression Viewer (FireBrowse)PIAS4 [ Firebrowse - Broad ]
GenevisibleExpression of PIAS4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51588
GTEX Portal (Tissue expression)PIAS4
Human Protein AtlasENSG00000105229-PIAS4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N2W9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N2W9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N2W9
PhosPhoSitePlusQ8N2W9
Domaine pattern : Prosite (Expaxy)PINIT (PS51466)    SAP (PS50800)    ZF_SP_RING (PS51044)   
Domains : Interpro (EBI)PIAS4    PINIT    PINIT_sf    SAP_dom    SAP_dom_sf    Znf_MIZ    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)PINIT (PF14324)    zf-MIZ (PF02891)   
Domain families : Pfam (NCBI)pfam14324    pfam02891   
Domain families : Smart (EMBL)SAP (SM00513)  
Conserved Domain (NCBI)PIAS4
SuperfamilyQ8N2W9
AlphaFold pdb e-kbQ8N2W9   
Human Protein Atlas [tissue]ENSG00000105229-PIAS4 [tissue]
HPRD06910
Protein Interaction databases
DIP (DOE-UCLA)Q8N2W9
IntAct (EBI)Q8N2W9
BioGRIDPIAS4
STRING (EMBL)PIAS4
ZODIACPIAS4
Ontologies - Pathways
QuickGOQ8N2W9
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  DNA binding  transcription coregulator activity  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  double-strand break repair  double-strand break repair via nonhomologous end joining  regulation of transcription by RNA polymerase II  protein C-terminus binding  zinc ion binding  negative regulation of tumor necrosis factor-mediated signaling pathway  Wnt signaling pathway  nuclear matrix  PML body  protein sumoylation  protein sumoylation  protein sumoylation  protein sumoylation  protein sumoylation  SUMO transferase activity  SUMO transferase activity  ubiquitin protein ligase binding  negative regulation of NF-kappaB transcription factor activity  positive regulation of protein sumoylation  vitamin D metabolic process  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  RNA polymerase II-specific DNA-binding transcription factor binding  SUMO ligase activity  SUMO ligase activity  positive regulation of keratinocyte apoptotic process  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  transferase complex  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  DNA binding  transcription coregulator activity  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  double-strand break repair  double-strand break repair via nonhomologous end joining  regulation of transcription by RNA polymerase II  protein C-terminus binding  zinc ion binding  negative regulation of tumor necrosis factor-mediated signaling pathway  Wnt signaling pathway  nuclear matrix  PML body  protein sumoylation  protein sumoylation  protein sumoylation  protein sumoylation  protein sumoylation  SUMO transferase activity  SUMO transferase activity  ubiquitin protein ligase binding  negative regulation of NF-kappaB transcription factor activity  positive regulation of protein sumoylation  vitamin D metabolic process  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  RNA polymerase II-specific DNA-binding transcription factor binding  SUMO ligase activity  SUMO ligase activity  positive regulation of keratinocyte apoptotic process  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  transferase complex  
Pathways : KEGGNF-kappa B signaling pathway    Ubiquitin mediated proteolysis    Jak-STAT signaling pathway   
NDEx NetworkPIAS4
Atlas of Cancer Signalling NetworkPIAS4
Wikipedia pathwaysPIAS4
Orthology - Evolution
OrthoDB51588
GeneTree (enSembl)ENSG00000105229
Phylogenetic Trees/Animal Genes : TreeFamPIAS4
Homologs : HomoloGenePIAS4
Homology/Alignments : Family Browser (UCSC)PIAS4
Gene fusions - Rearrangements
Fusion : MitelmanPIAS4/ZFR2 [19p13.3/19p13.3]  
Fusion : MitelmanSBNO2/PIAS4 [19p13.3/19p13.3]  
Fusion : QuiverPIAS4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIAS4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIAS4
dbVarPIAS4
ClinVarPIAS4
MonarchPIAS4
1000_GenomesPIAS4 
Exome Variant ServerPIAS4
GNOMAD BrowserENSG00000105229
Varsome BrowserPIAS4
ACMGPIAS4 variants
VarityQ8N2W9
Genomic Variants (DGV)PIAS4 [DGVbeta]
DECIPHERPIAS4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIAS4 
Mutations
ICGC Data PortalPIAS4 
TCGA Data PortalPIAS4 
Broad Tumor PortalPIAS4
OASIS PortalPIAS4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIAS4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPIAS4
Mutations and Diseases : HGMDPIAS4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPIAS4
DgiDB (Drug Gene Interaction Database)PIAS4
DoCM (Curated mutations)PIAS4
CIViC (Clinical Interpretations of Variants in Cancer)PIAS4
Cancer3DPIAS4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605989   
Orphanet
DisGeNETPIAS4
MedgenPIAS4
Genetic Testing Registry PIAS4
NextProtQ8N2W9 [Medical]
GENETestsPIAS4
Target ValidationPIAS4
Huge Navigator PIAS4 [HugePedia]
ClinGenPIAS4
Clinical trials, drugs, therapy
MyCancerGenomePIAS4
Protein Interactions : CTDPIAS4
Pharm GKB GenePA134945903
PharosQ8N2W9
Clinical trialPIAS4
Miscellaneous
canSAR (ICR)PIAS4
HarmonizomePIAS4
DataMed IndexPIAS4
Probes
Litterature
PubMed129 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPIAS4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:14 CEST 2021

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