Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PICK1 (protein interacting with PRKCA 1)

Identity

Alias (NCBI)PICK
PRKCABP
HGNC (Hugo) PICK1
HGNC Alias symbdJ1039K5
MGC15204
HGNC Previous namePRKCABP
HGNC Previous nameprotein kinase C, alpha binding protein
 protein interacting with PRKCA
LocusID (NCBI) 9463
Atlas_Id 51687
Location 22q13.1  [Link to chromosome band 22q13]
Location_base_pair Starts at 38057404 and ends at 38075701 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PICK1 (22q13.1) / EIF4ENIF1 (22q12.2)PICK1 (22q13.1) / PICK1 (22q13.1)PICK1 (22q13.1) / POLR2F (22q13.1)
PICK1 (22q13.1) / SPINT2 (19q13.2)PICK1 22q13.1 / EIF4ENIF1 22q12.2PICK1 22q13.1 / POLR2F 22q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Langerhans cell histiocytosis


External links

Nomenclature
HGNC (Hugo)PICK1   9394
Cards
Entrez_Gene (NCBI)PICK1    protein interacting with PRKCA 1
AliasesPICK; PRKCABP
GeneCards (Weizmann)PICK1
Ensembl hg19 (Hinxton)ENSG00000100151 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100151 [Gene_View]  ENSG00000100151 [Sequence]  chr22:38057404-38075701 [Contig_View]  PICK1 [Vega]
ICGC DataPortalENSG00000100151
TCGA cBioPortalPICK1
AceView (NCBI)PICK1
Genatlas (Paris)PICK1
SOURCE (Princeton)PICK1
Genetics Home Reference (NIH)PICK1
Genomic and cartography
GoldenPath hg38 (UCSC)PICK1  -     chr22:38057404-38075701 +  22q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PICK1  -     22q13.1   [Description]    (hg19-Feb_2009)
GoldenPathPICK1 - 22q13.1 [CytoView hg19]  PICK1 - 22q13.1 [CytoView hg38]
ImmunoBaseENSG00000100151
genome Data Viewer NCBIPICK1 [Mapview hg19]  
OMIM605926   
Gene and transcription
Genbank (Entrez)AB026491 AF231710 AK000875 AK092818 AK222640
RefSeq transcript (Entrez)NM_001039583 NM_001039584 NM_012407
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PICK1
Alternative Splicing GalleryENSG00000100151
Gene ExpressionPICK1 [ NCBI-GEO ]   PICK1 [ EBI - ARRAY_EXPRESS ]   PICK1 [ SEEK ]   PICK1 [ MEM ]
Gene Expression Viewer (FireBrowse)PICK1 [ Firebrowse - Broad ]
GenevisibleExpression of PICK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9463
GTEX Portal (Tissue expression)PICK1
Human Protein AtlasENSG00000100151-PICK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRD5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRD5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRD5
Splice isoforms : SwissVarQ9NRD5
PhosPhoSitePlusQ9NRD5
Domaine pattern : Prosite (Expaxy)AH (PS50870)    PDZ (PS50106)   
Domains : Interpro (EBI)AH/BAR_dom_sf    AH_dom    Arfaptin_fam    PDZ    PDZ_sf    PICK1_BAR   
Domain families : Pfam (Sanger)Arfaptin (PF06456)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam06456    pfam00595   
Domain families : Smart (EMBL)Arfaptin (SM01015)  PDZ (SM00228)  
Conserved Domain (NCBI)PICK1
Blocks (Seattle)PICK1
PDB (RSDB)2GZV    6AR4    6BJN    6BJO   
PDB Europe2GZV    6AR4    6BJN    6BJO   
PDB (PDBSum)2GZV    6AR4    6BJN    6BJO   
PDB (IMB)2GZV    6AR4    6BJN    6BJO   
Structural Biology KnowledgeBase2GZV    6AR4    6BJN    6BJO   
SCOP (Structural Classification of Proteins)2GZV    6AR4    6BJN    6BJO   
CATH (Classification of proteins structures)2GZV    6AR4    6BJN    6BJO   
SuperfamilyQ9NRD5
Human Protein Atlas [tissue]ENSG00000100151-PICK1 [tissue]
Peptide AtlasQ9NRD5
HPRD16176
IPIIPI00160369   IPI00893491   IPI00983551   IPI00893094   IPI00893321   IPI00892705   IPI00889725   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRD5
IntAct (EBI)Q9NRD5
BioGRIDPICK1
STRING (EMBL)PICK1
ZODIACPICK1
Ontologies - Pathways
QuickGOQ9NRD5
Ontology : AmiGOG protein-coupled receptor binding  positive regulation of receptor internalization  positive regulation of receptor internalization  protein kinase C binding  protein kinase C binding  signaling receptor binding  protein binding  phospholipid binding  cytoplasm  Golgi apparatus  cytosol  cytoskeleton  plasma membrane  plasma membrane  protein phosphorylation  intracellular protein transport  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  protein kinase C-activating G protein-coupled receptor signaling pathway  synaptic vesicle  protein C-terminus binding  postsynaptic density  monoamine transport  enzyme binding  protein domain specific binding  glial cell development  endocytic vesicle membrane  trans-Golgi network membrane  regulation of Arp2/3 complex-mediated actin nucleation  negative regulation of Arp2/3 complex-mediated actin nucleation  cellular response to decreased oxygen levels  cellular response to glucose starvation  presynaptic membrane  identical protein binding  identical protein binding  neuron projection  neuron projection  DNA methylation involved in embryo development  DNA methylation involved in gamete generation  receptor clustering  receptor clustering  neuronal ion channel clustering  synapse  metal ion binding  perinuclear region of cytoplasm  regulation of insulin secretion  actin filament binding  long-term synaptic depression  Arp2/3 complex binding  dendritic spine organization  dendritic spine maintenance  dendritic spine maintenance  postsynaptic early endosome  membrane curvature sensor activity  
Ontology : EGO-EBIG protein-coupled receptor binding  positive regulation of receptor internalization  positive regulation of receptor internalization  protein kinase C binding  protein kinase C binding  signaling receptor binding  protein binding  phospholipid binding  cytoplasm  Golgi apparatus  cytosol  cytoskeleton  plasma membrane  plasma membrane  protein phosphorylation  intracellular protein transport  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  protein kinase C-activating G protein-coupled receptor signaling pathway  synaptic vesicle  protein C-terminus binding  postsynaptic density  monoamine transport  enzyme binding  protein domain specific binding  glial cell development  endocytic vesicle membrane  trans-Golgi network membrane  regulation of Arp2/3 complex-mediated actin nucleation  negative regulation of Arp2/3 complex-mediated actin nucleation  cellular response to decreased oxygen levels  cellular response to glucose starvation  presynaptic membrane  identical protein binding  identical protein binding  neuron projection  neuron projection  DNA methylation involved in embryo development  DNA methylation involved in gamete generation  receptor clustering  receptor clustering  neuronal ion channel clustering  synapse  metal ion binding  perinuclear region of cytoplasm  regulation of insulin secretion  actin filament binding  long-term synaptic depression  Arp2/3 complex binding  dendritic spine organization  dendritic spine maintenance  dendritic spine maintenance  postsynaptic early endosome  membrane curvature sensor activity  
NDEx NetworkPICK1
Atlas of Cancer Signalling NetworkPICK1
Wikipedia pathwaysPICK1
Orthology - Evolution
OrthoDB9463
GeneTree (enSembl)ENSG00000100151
Phylogenetic Trees/Animal Genes : TreeFamPICK1
HOGENOMQ9NRD5
Homologs : HomoloGenePICK1
Homology/Alignments : Family Browser (UCSC)PICK1
Gene fusions - Rearrangements
Fusion : MitelmanPICK1/EIF4ENIF1 [22q13.1/22q12.2]  
Fusion : MitelmanPICK1/POLR2F [22q13.1/22q13.1]  
Fusion PortalPICK1 22q13.1 EIF4ENIF1 22q12.2 PRAD
Fusion PortalPICK1 22q13.1 POLR2F 22q13.1 BRCA
Fusion : QuiverPICK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPICK1 [hg38]
dbVarPICK1
ClinVarPICK1
MonarchPICK1
1000_GenomesPICK1 
Exome Variant ServerPICK1
GNOMAD BrowserENSG00000100151
Varsome BrowserPICK1
Genomic Variants (DGV)PICK1 [DGVbeta]
DECIPHERPICK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPICK1 
Mutations
ICGC Data PortalPICK1 
TCGA Data PortalPICK1 
Broad Tumor PortalPICK1
OASIS PortalPICK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPICK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPICK1
Mutations and Diseases : HGMDPICK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PICK1
DgiDB (Drug Gene Interaction Database)PICK1
DoCM (Curated mutations)PICK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PICK1 (select a term)
intoGenPICK1
Cancer3DPICK1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605926   
Orphanet17932   
DisGeNETPICK1
MedgenPICK1
Genetic Testing Registry PICK1
NextProtQ9NRD5 [Medical]
GENETestsPICK1
Target ValidationPICK1
Huge Navigator PICK1 [HugePedia]
ClinGenPICK1
Clinical trials, drugs, therapy
MyCancerGenomePICK1
Protein Interactions : CTD
Pharm GKB GenePA33760
PharosQ9NRD5
Clinical trialPICK1
Miscellaneous
canSAR (ICR)PICK1 (select the gene name)
HarmonizomePICK1
DataMed IndexPICK1
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPICK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:39:16 CET 2021

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