PICK1 (protein interacting with PRKCA 1)

2010-10-01  

Identity

HGNC
PICK1
LOCATION
22q13.1
LOCUSID
9463
ALIAS
PICK,PRKCABP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9463
MIM: 605926
HGNC: 9394
Ensembl: ENSG00000100151

Variants:

dbSNP: 9463
ClinVar: 9463
TCGA: ENSG00000100151
COSMIC: PICK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100151ENST00000356976Q9NRD5
ENSG00000100151ENST00000356976A0A024R1J5
ENSG00000100151ENST00000404072Q9NRD5
ENSG00000100151ENST00000404072A0A024R1J5
ENSG00000100151ENST00000424694F6V107
ENSG00000100151ENST00000426258E7EX80
ENSG00000100151ENST00000432756E7EX80
ENSG00000100151ENST00000435166F6VY12
ENSG00000100151ENST00000437453F6V3V1
ENSG00000100151ENST00000445628F6TII1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Trafficking of GluR2-containing AMPA receptorsREACTOMER-HSA-416993
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446876Substance-Related DisordersDiseaseClinicalAnnotationassociatedPD17606663
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPD17606663
PA450403methamphetamineChemicalClinicalAnnotationassociatedPD17606663

References

Pubmed IDYearTitleCitations
200186612010Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.48
118912162002The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.43
163148702006Serine racemase binds to PICK1: potential relevance to schizophrenia.37
179144632007Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.36
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
205628962010A newly discovered mutation in PICK1 in a human with globozoospermia.32
192198572009Genetic association studies of methamphetamine use disorders: A systematic review and synthesis.29
227108012012PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor.23
286971772017The TGF-β signalling negative regulator PICK1 represses prostate cancer metastasis to bone.21
223030092012Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway.19

Citation

Dessen P

PICK1 (protein interacting with PRKCA 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51687/pick1