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PICK1 (protein interacting with PRKCA 1)

Identity

Alias_namesPRKCABP
protein kinase C, alpha binding protein
protein interacting with PRKCA
Alias_symbol (synonym)dJ1039K5
MGC15204
Other aliasPICK
HGNC (Hugo) PICK1
LocusID (NCBI) 9463
Atlas_Id 51687
Location 22q13.1  [Link to chromosome band 22q13]
Location_base_pair Starts at 38057255 and ends at 38075701 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PICK1 (22q13.1) / EIF4ENIF1 (22q12.2)PICK1 (22q13.1) / PICK1 (22q13.1)PICK1 (22q13.1) / POLR2F (22q13.1)
PICK1 (22q13.1) / SPINT2 (19q13.2)PICK1 22q13.1 / EIF4ENIF1 22q12.2PICK1 22q13.1 / POLR2F 22q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PICK1   9394
Cards
Entrez_Gene (NCBI)PICK1  9463  protein interacting with PRKCA 1
AliasesPICK; PRKCABP
GeneCards (Weizmann)PICK1
Ensembl hg19 (Hinxton)ENSG00000100151 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100151 [Gene_View]  chr22:38057255-38075701 [Contig_View]  PICK1 [Vega]
ICGC DataPortalENSG00000100151
TCGA cBioPortalPICK1
AceView (NCBI)PICK1
Genatlas (Paris)PICK1
WikiGenes9463
SOURCE (Princeton)PICK1
Genetics Home Reference (NIH)PICK1
Genomic and cartography
GoldenPath hg38 (UCSC)PICK1  -     chr22:38057255-38075701 +  22q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PICK1  -     22q13.1   [Description]    (hg19-Feb_2009)
EnsemblPICK1 - 22q13.1 [CytoView hg19]  PICK1 - 22q13.1 [CytoView hg38]
Mapping of homologs : NCBIPICK1 [Mapview hg19]  PICK1 [Mapview hg38]
OMIM605926   
Gene and transcription
Genbank (Entrez)AB026491 AF231710 AK000875 AK092818 AK222640
RefSeq transcript (Entrez)NM_001039583 NM_001039584 NM_012407
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PICK1
Cluster EST : UnigeneHs.180871 [ NCBI ]
CGAP (NCI)Hs.180871
Alternative Splicing GalleryENSG00000100151
Gene ExpressionPICK1 [ NCBI-GEO ]   PICK1 [ EBI - ARRAY_EXPRESS ]   PICK1 [ SEEK ]   PICK1 [ MEM ]
Gene Expression Viewer (FireBrowse)PICK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9463
GTEX Portal (Tissue expression)PICK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRD5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRD5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRD5
Splice isoforms : SwissVarQ9NRD5
PhosPhoSitePlusQ9NRD5
Domaine pattern : Prosite (Expaxy)AH (PS50870)    PDZ (PS50106)   
Domains : Interpro (EBI)AH/BAR-dom    AH_dom    Arfaptin_fam    PDZ   
Domain families : Pfam (Sanger)Arfaptin (PF06456)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam06456    pfam00595   
Domain families : Smart (EMBL)Arfaptin (SM01015)  PDZ (SM00228)  
Conserved Domain (NCBI)PICK1
DMDM Disease mutations9463
Blocks (Seattle)PICK1
PDB (SRS)2GZV   
PDB (PDBSum)2GZV   
PDB (IMB)2GZV   
PDB (RSDB)2GZV   
Structural Biology KnowledgeBase2GZV   
SCOP (Structural Classification of Proteins)2GZV   
CATH (Classification of proteins structures)2GZV   
SuperfamilyQ9NRD5
Human Protein AtlasENSG00000100151
Peptide AtlasQ9NRD5
HPRD16176
IPIIPI00160369   IPI00893491   IPI00983551   IPI00893094   IPI00893321   IPI00892705   IPI00889725   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRD5
IntAct (EBI)Q9NRD5
FunCoupENSG00000100151
BioGRIDPICK1
STRING (EMBL)PICK1
ZODIACPICK1
Ontologies - Pathways
QuickGOQ9NRD5
Ontology : AmiGOG-protein coupled receptor binding  positive regulation of receptor internalization  protein kinase C binding  receptor binding  protein binding  cytoplasm  mitochondrion  Golgi apparatus  cytosol  cytoskeleton  plasma membrane  plasma membrane  protein phosphorylation  retrograde vesicle-mediated transport, Golgi to ER  protein kinase C-activating G-protein coupled receptor signaling pathway  protein C-terminus binding  postsynaptic density  monoamine transport  aggresome  ATPase activity  enzyme binding  protein domain specific binding  glial cell development  cell junction  endocytic vesicle membrane  regulation of Arp2/3 complex-mediated actin nucleation  negative regulation of Arp2/3 complex-mediated actin nucleation  cellular response to decreased oxygen levels  cellular response to glucose starvation  presynaptic membrane  identical protein binding  neuron projection  DNA methylation involved in embryo development  DNA methylation involved in gamete generation  receptor clustering  neuronal ion channel clustering  synapse  postsynaptic membrane  metal ion binding  perinuclear region of cytoplasm  actin filament binding  long term synaptic depression  Arp2/3 complex binding  dendritic spine organization  dendritic spine maintenance  
Ontology : EGO-EBIG-protein coupled receptor binding  positive regulation of receptor internalization  protein kinase C binding  receptor binding  protein binding  cytoplasm  mitochondrion  Golgi apparatus  cytosol  cytoskeleton  plasma membrane  plasma membrane  protein phosphorylation  retrograde vesicle-mediated transport, Golgi to ER  protein kinase C-activating G-protein coupled receptor signaling pathway  protein C-terminus binding  postsynaptic density  monoamine transport  aggresome  ATPase activity  enzyme binding  protein domain specific binding  glial cell development  cell junction  endocytic vesicle membrane  regulation of Arp2/3 complex-mediated actin nucleation  negative regulation of Arp2/3 complex-mediated actin nucleation  cellular response to decreased oxygen levels  cellular response to glucose starvation  presynaptic membrane  identical protein binding  neuron projection  DNA methylation involved in embryo development  DNA methylation involved in gamete generation  receptor clustering  neuronal ion channel clustering  synapse  postsynaptic membrane  metal ion binding  perinuclear region of cytoplasm  actin filament binding  long term synaptic depression  Arp2/3 complex binding  dendritic spine organization  dendritic spine maintenance  
NDEx NetworkPICK1
Atlas of Cancer Signalling NetworkPICK1
Wikipedia pathwaysPICK1
Orthology - Evolution
OrthoDB9463
GeneTree (enSembl)ENSG00000100151
Phylogenetic Trees/Animal Genes : TreeFamPICK1
HOVERGENQ9NRD5
HOGENOMQ9NRD5
Homologs : HomoloGenePICK1
Homology/Alignments : Family Browser (UCSC)PICK1
Gene fusions - Rearrangements
Fusion : MitelmanPICK1/EIF4ENIF1 [22q13.1/22q12.2]  
Fusion : MitelmanPICK1/POLR2F [22q13.1/22q13.1]  [t(22;22)(q13;q13)]  
Fusion: TCGAPICK1 22q13.1 EIF4ENIF1 22q12.2 PRAD
Fusion: TCGAPICK1 22q13.1 POLR2F 22q13.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPICK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PICK1
dbVarPICK1
ClinVarPICK1
1000_GenomesPICK1 
Exome Variant ServerPICK1
ExAC (Exome Aggregation Consortium)PICK1 (select the gene name)
Genetic variants : HAPMAP9463
Genomic Variants (DGV)PICK1 [DGVbeta]
DECIPHERPICK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPICK1 
Mutations
ICGC Data PortalPICK1 
TCGA Data PortalPICK1 
Broad Tumor PortalPICK1
OASIS PortalPICK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPICK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPICK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PICK1
DgiDB (Drug Gene Interaction Database)PICK1
DoCM (Curated mutations)PICK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PICK1 (select a term)
intoGenPICK1
Cancer3DPICK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605926   
Orphanet17932   
MedgenPICK1
Genetic Testing Registry PICK1
NextProtQ9NRD5 [Medical]
TSGene9463
GENETestsPICK1
Huge Navigator PICK1 [HugePedia]
snp3D : Map Gene to Disease9463
BioCentury BCIQPICK1
ClinGenPICK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9463
Chemical/Pharm GKB GenePA33760
Clinical trialPICK1
Miscellaneous
canSAR (ICR)PICK1 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePICK1
EVEXPICK1
GoPubMedPICK1
iHOPPICK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:31:09 CEST 2017

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